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公开(公告)号：US08362208B2
公开(公告)日：2013-01-29
申请号：US12097279
申请日：2006-12-14
申请人： Stephanie Jane Clegg , Jonathan Henry Ellis , Volker Germaschewski , Paul Andrew Hamblin , George Kopsidas , Ruth McAdam , Rabinder Kumar Prinjha
发明人： Stephanie Jane Clegg , Jonathan Henry Ellis , Volker Germaschewski , Paul Andrew Hamblin , George Kopsidas , Ruth McAdam , Rabinder Kumar Prinjha
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , A61K39/40 , C07K17/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/22 , C07K16/465 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to antibodies to NOGO, pharmaceutical formulations containing them and to the use of such antibodies in the treatment and/or prophylaxis of neurological diseases/disorder.
摘要翻译： 本发明涉及NOGO的抗体，含有它们的药物制剂以及这些抗体在治疗和/或预防神经疾病/病症中的用途。
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公开(公告)号：US5994137A
公开(公告)日：1999-11-30
申请号：US075904
申请日：1998-05-11
CPC分类号： C07K14/005 , C07K14/35 , C12N15/74 , C12N7/00 , C12Q1/6897 , C12N2795/10311 , C12N2795/10322 , C12N2795/10343
摘要： This invention is directed to L5 shuttle phasmids capable of delivering foreign DNA into mycobacteria and to methods of producing L5 shuttle phasmids. In addition, this invention is directed to a method of generating mycobacterial mutations and to a method of producing mycobacterial vaccines.
摘要翻译： 本发明涉及能够将外来DNA转运到分枝杆菌中的L5穿梭质粒以及产生L5穿梭质粒的方法。 此外，本发明涉及产生分枝杆菌突变的方法和生产分枝杆菌疫苗的方法。
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公开(公告)号：US20130302335A1
公开(公告)日：2013-11-14
申请号：US13978228
申请日：2012-01-04
IPC分类号： C07K16/28
CPC分类号： C07K16/2863 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C12N1/00 , C12N15/09
摘要： The disclosure provides an anti-TGFbetaRII immunoglobulin single variable domain. Suitably, an anti-TGFbetaRII immunoglobulin single variable domain in accordance with the disclosure is one having an amino acid sequence as set forth in any one of SEQ ID NO:1-28 having up to 5 amino acid substitutions, deletions or additions. The disclosure further provides a polypeptide and pharmaceutical composition for treating a disease associated with TGFbeta signalling and suitably a disease selected from the group of: tissue fibrosis, such as pulmonary fibrosis, including idiopathic pulmonary fibrosis; liver fibrosis, including cirrhosis and chronic hepatitis; rheumatoid arthritis; ocular disorders; fibrosis of the skin, including keloid of skin; Dupuytren's Contracture; kidney fibrosis such as nephritis and nephrosclerosis; wound healing; scarring reduction; and a vascular condition, such as restenosis.
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公开(公告)号：US20110206686A1
公开(公告)日：2011-08-25
申请号：US12681413
申请日：2008-10-03
申请人： Gary Peter Bembridge , Jane Elizabeth Clarkson , Jonathan Henry Ellis , Paul Andrew Hamblin , George Kopsidas , Alan Peter Lewis , Ruth Mcadam
发明人： Gary Peter Bembridge , Jane Elizabeth Clarkson , Jonathan Henry Ellis , Paul Andrew Hamblin , George Kopsidas , Alan Peter Lewis , Ruth Mcadam
IPC分类号： A61K39/395 , C07K16/24 , C12N1/00 , C12N5/10 , A61P29/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P11/00 , A61P3/10 , A61P11/06 , A61P37/08 , A61P37/06
CPC分类号： C07K16/244 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antigen binding proteins to human IL-23, pharmaceutical formulations containing them and to the use of such antigen binding proteins in the treatment and/or prophylaxis of inflammatory diseases such as Rheumatoid Arthritis (RA).
摘要翻译： 本发明涉及到人IL-23的抗原结合蛋白，含有它们的药物制剂以及这种抗原结合蛋白在治疗和/或预防炎性疾病如类风湿关节炎（RA）中的用途。
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5.发明申请Nogo-a neutralising immunoglobulins for treatment of neurological diseases 有权Nogo - 用于治疗神经系统疾病的中和免疫球蛋白公开(公告)号：US20070065430A1
公开(公告)日：2007-03-22
申请号：US10583877
申请日：2004-12-20
申请人： Jonathan Ellis , Alexandre Eon-Duval , Robert Grundy , Farhana Hussain , Ruth McAdam , Christopher Plumpton , Rabinder Prinjha , Paul Wilson
发明人： Jonathan Ellis , Alexandre Eon-Duval , Robert Grundy , Farhana Hussain , Ruth McAdam , Christopher Plumpton , Rabinder Prinjha , Paul Wilson
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/22 , C07K2317/24 , C07K2317/56 , C07K2317/76 , C12N5/0618 , C12N2501/70 , C12N2501/998
摘要： The present invention provides immunoglobulins, particularly antibodies that bind to NOGO and neutralise the activity thereof, polynucleotides encoding such antibodies, pharmaceutical formulations containing said antibodies and to the use of such antibodies in the treatment and/or prophylaxis of neurological diseases.
摘要翻译： 本发明提供免疫球蛋白，特别是结合NOGO并中和其活性的抗体，编码这种抗体的多核苷酸，含有所述抗体的药物制剂，以及这些抗体在治疗和/或预防神经疾病中的用途。
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公开(公告)号：US20100221260A1
公开(公告)日：2010-09-02
申请号：US12097279
申请日：2006-12-14
申请人： Stephanie Jane Clegg , Jonathan Henry Ellis , Volker Germaschewski , Paul Andrew Hamblin , George Kopsidas , Ruth McAdam , Rabinder Kumar Prinjha
发明人： Stephanie Jane Clegg , Jonathan Henry Ellis , Volker Germaschewski , Paul Andrew Hamblin , George Kopsidas , Ruth McAdam , Rabinder Kumar Prinjha
IPC分类号： A61K39/395 , C07K16/00 , C07H21/04 , C07K16/18 , A61P9/10
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/22 , C07K16/465 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to antibodies to NOGO, pharmaceutical formulations containing them and to the use of such antibodies in the treatment and/or prophylaxis of neurological diseases/disorder.
摘要翻译： 本发明涉及NOGO的抗体，含有它们的药物制剂以及这些抗体在治疗和/或预防神经疾病/病症中的用途。
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公开(公告)号：US20130251724A1
公开(公告)日：2013-09-26
申请号：US13989191
申请日：2011-11-21
申请人： Gary Peter Bembridge , Chun-Wa Chung , Maria Feeney , Susannah Karen Ford , Ian Kirby , Ruth McAdam
发明人： Gary Peter Bembridge , Chun-Wa Chung , Maria Feeney , Susannah Karen Ford , Ian Kirby , Ruth McAdam
IPC分类号： C07K16/24
CPC分类号： C07K16/248 , C07K16/24 , C07K16/244 , C07K2317/10 , C07K2317/24 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/76 , C07K2317/92
摘要： The present invention concerns antigen binding proteins and fragments thereof which specifically bind Oncostatin M (OSM), particularly human OSM (hOSM) and which inhibit the binding of OSM to the gp130 receptor but does not directly interact with site II residues. The invention also concerns a method of humanising antibodies. Further disclosed are pharmaceutical compositions, screening and medical treatment methods.
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公开(公告)号：US20120128689A1
公开(公告)日：2012-05-24
申请号：US13262256
申请日：2010-03-30
IPC分类号： A61K39/395 , A61P17/06 , A61P1/00 , A61P1/04 , A61P29/00 , A61P19/04 , A61P25/28 , A61P25/00 , A61P11/00 , A61P17/00 , A61P37/06 , A61P11/06 , A61P37/08 , A61P37/00 , A61P5/16 , A61P27/02 , C12N5/10 , C12N1/21 , C12N1/19 , C07K16/24
CPC分类号： C07K16/244 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antigen binding proteins to human IL-23, pharmaceutical formulations containing them and to the use of such antigen binding proteins in the treatment and/or prophylaxis of inflammatory diseases such as Rheumatoid Arthritis (RA).
摘要翻译： 本发明涉及到人IL-23的抗原结合蛋白，含有它们的药物制剂以及这种抗原结合蛋白在治疗和/或预防炎性疾病如类风湿性关节炎（RA）中的用途。
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9.发明授权NOGO-a neutralising immunoglobulin for treatment of neurological diseases 有权NOGO - 一种用于治疗神经系统疾病的中和免疫球蛋白公开(公告)号：US07988964B2
公开(公告)日：2011-08-02
申请号：US10583877
申请日：2004-12-20
申请人： Jonathan Henry Ellis , Alexandre Eon-Duval , Robert Ian Grundy , Farhana Hussain , Ruth McAdam , Christopher Plumpton , Rabinder Kumar Prinjha , Paul Alexander Wilson
发明人： Jonathan Henry Ellis , Alexandre Eon-Duval , Robert Ian Grundy , Farhana Hussain , Ruth McAdam , Christopher Plumpton , Rabinder Kumar Prinjha , Paul Alexander Wilson
IPC分类号： A61K39/395 , A61K39/00 , A61K38/00 , C12P21/08 , C07K16/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/22 , C07K2317/24 , C07K2317/56 , C07K2317/76 , C12N5/0618 , C12N2501/70 , C12N2501/998
摘要： The present invention provides immunoglobulins, particularly antibodies that bind to NOGO and neutralise the activity thereof, polynucleotides encoding such antibodies, pharmaceutical formulations containing said antibodies and to the use of such antibodies in the treatment and/or prophylaxis of neurological diseases.
摘要翻译： 本发明提供免疫球蛋白，特别是结合NOGO并中和其活性的抗体，编码这种抗体的多核苷酸，含有所述抗体的药物制剂，以及这些抗体在治疗和/或预防神经疾病中的用途。
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公开(公告)号：US20090123479A1
公开(公告)日：2009-05-14
申请号：US12245426
申请日：2008-10-03
申请人： Gary Peter Bembridge , Jane Elizabeth Clarkson , Jonathan Henry Ellis , Paul Andrew Hamblin , George Kopsidas , Alan Peter Lewis , Ruth McAdam
发明人： Gary Peter Bembridge , Jane Elizabeth Clarkson , Jonathan Henry Ellis , Paul Andrew Hamblin , George Kopsidas , Alan Peter Lewis , Ruth McAdam
IPC分类号： A61K39/395 , C07K16/00 , A61P29/00 , A61P37/00 , C12N5/00
CPC分类号： C07K16/244 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antigen binding proteins to human IL-23, pharmaceutical formulations containing them and to the use of such antigen binding proteins in the treatment and/or prophylaxis of inflammatory diseases such as Rheumatoid Arthritis (RA).
摘要翻译： 本发明涉及到人IL-23的抗原结合蛋白，含有它们的药物制剂以及这种抗原结合蛋白在治疗和/或预防炎性疾病如类风湿性关节炎（RA）中的用途。
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