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1.发明申请COMPOSITIONS AND METHODS FOR DELIVERING CLONIDINE AND BUPIVACAINE TO A TARGET TISSUE SITE 有权将CLONIDINE和BUPIVACAINE递送至目标组织网站的组合物和方法公开(公告)号：US20120142649A1
公开(公告)日：2012-06-07
申请号：US13310240
申请日：2011-12-02
申请人： Jonathan K. Gray , Jeffrey C. Marx , William F. McKay , Josee Roy , Danielle L. Clay , Jared T. Wilsey , John Myers Zanella
发明人： Jonathan K. Gray , Jeffrey C. Marx , William F. McKay , Josee Roy , Danielle L. Clay , Jared T. Wilsey , John Myers Zanella
IPC分类号： A61K31/56 , A61P29/00 , A61K31/445
CPC分类号： A61K9/0024 , A61K31/167 , A61K31/4168 , A61K31/445 , A61K47/34 , A61K2300/00
摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of immediate release bupivacaine or lidocaine and a sustained release clonidine at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days or longer.
摘要翻译： 提供长时间有效的疼痛治疗。 通过施用有效量的即时释放布比卡因或利多卡因和持续释放的可乐定，可以缓解由不同来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄 ，造成背痛和关节疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天或更长。
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2.发明授权Compositions and methods for delivering clonidine and bupivacaine to a target tissue site 有权将可乐定和布比卡因递送至目标组织部位的组合物和方法公开(公告)号：US08623396B2
公开(公告)日：2014-01-07
申请号：US13310240
申请日：2011-12-02
申请人： Jonathan K. Gray , Jeffrey C. Marx , William F. McKay , Josee Roy , Danielle L. Clay , Jared T. Wilsey , John Myers Zanella
发明人： Jonathan K. Gray , Jeffrey C. Marx , William F. McKay , Josee Roy , Danielle L. Clay , Jared T. Wilsey , John Myers Zanella
CPC分类号： A61K9/0024 , A61K31/167 , A61K31/4168 , A61K31/445 , A61K47/34 , A61K2300/00
摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of immediate release bupivacaine or lidocaine and a sustained release clonidine at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days or longer.
摘要翻译： 提供长时间有效的疼痛治疗。 通过施用有效量的即时释放布比卡因或利多卡因和持续释放的可乐定，可以缓解由不同来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄 ，造成背痛和关节疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天或更长。
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公开(公告)号：US08735504B2
公开(公告)日：2014-05-27
申请号：US13462395
申请日：2012-05-02
申请人： Danielle L. Clay
发明人： Danielle L. Clay
IPC分类号： C08G63/91
CPC分类号： C08L67/04 , A61K31/4168 , A61K47/34 , B29C45/00 , B29K2995/006 , C08G85/002 , C08J3/00 , C08J2367/04
摘要： Methods are provided for preparing polymer mixtures having low residual monomer content. The methods comprise mixing the at least two polymers in a solvent to form a polymeric mixture, the polymeric mixture comprising at least one residual monomer; and adding an antisolvent to the polymeric mixture so as to separate the at least two polymers from the polymeric mixture, where the residual monomer is soluble in the antisolvent. In some embodiments, methods are provided for preparing at least two polymers having low residual monomer content, the methods comprise adding an antisolvent to a mixture of at least two polymers dissolved in a solvent so as to precipitate the at least two polymers from the solvent and anti-solvent. The methods provided avoid steps in dry blending of polymers and produces polymer blends that have low residual monomer content.
摘要翻译： 提供了制备具有低残留单体含量的聚合物混合物的方法。 所述方法包括在溶剂中混合所述至少两种聚合物以形成聚合物混合物，所述聚合物混合物包含至少一种残余单体; 以及向所述聚合物混合物中加入抗溶剂以便将所述至少两种聚合物与所述聚合物混合物分离，其中所述残余单体可溶于所述反溶剂中。 在一些实施方案中，提供了用于制备至少两种具有低残留单体含量的聚合物的方法，所述方法包括向溶解在溶剂中的至少两种聚合物的混合物中加入抗溶剂以从溶剂中沉淀出至少两种聚合物，以及 反溶剂。 所提供的方法避免了聚合物干混合中的步骤，并产生具有低残留单体含量的聚合物共混物。
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公开(公告)号：US09511018B2
公开(公告)日：2016-12-06
申请号：US13439971
申请日：2012-04-05
IPC分类号： A61F13/00 , A61K31/415 , A61K9/00 , A61K31/4168 , A61K47/34
CPC分类号： A61K9/0024 , A61K31/4168 , A61K47/34
摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of clonidine in a matrix at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate matrix formulations are provided within biodegradable polymers, this pain relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.
摘要翻译： 提供长时间有效的疼痛治疗。 通过在目标部位或其附近的基质中施用有效量的可乐定，可以减轻由多种来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，椎间盘背痛和关节 疼痛，以及手术附带的疼痛。 当在可生物降解的聚合物内提供适当的基质制剂时，可以持续至少三天的疼痛缓解。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天。
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公开(公告)号：US20130266631A1
公开(公告)日：2013-10-10
申请号：US13439971
申请日：2012-04-05
IPC分类号： A61K9/00 , A61P29/00 , A61K31/4168
CPC分类号： A61K9/0024 , A61K31/4168 , A61K47/34
摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of clonidine in a matrix at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate matrix formulations are provided within biodegradable polymers, this pain relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.
摘要翻译： 提供长时间有效的疼痛治疗。 通过在目标部位或其附近的基质中施用有效量的可乐定，可以减轻由多种来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，椎间盘背痛和关节 疼痛，以及手术附带的疼痛。 当在可生物降解的聚合物内提供适当的基质制剂时，可以持续至少三天的疼痛缓解。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天。
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公开(公告)号：US09211274B2
公开(公告)日：2015-12-15
申请号：US13363469
申请日：2012-02-01
IPC分类号： A61F2/00 , A61K31/165 , A61K9/00 , A61K31/357 , A61K9/70
CPC分类号： A61K31/165 , A61K9/0024 , A61K9/70 , A61K31/357
摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of a TRPV1 compound (e.g., capsaicinoid compound) at or near a target site, one can relieve pain caused by diverse sources, including but not limited to, postoperative pain, spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.
摘要翻译： 提供长时间有效的疼痛治疗。 通过在目标部位或附近施用有效量的TRPV1化合物（例如辣椒素类化合物），可以减轻由多种来源引起的疼痛，包括但不限于术后疼痛，脊髓椎间盘突出症（即坐骨神经痛） 脊柱脱位，狭窄，椎间盘背痛和关节疼痛，以及手术附带的疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天。
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公开(公告)号：US20130296500A1
公开(公告)日：2013-11-07
申请号：US13462395
申请日：2012-05-02
申请人： Danielle L. Clay
发明人： Danielle L. Clay
CPC分类号： C08L67/04 , A61K31/4168 , A61K47/34 , B29C45/00 , B29K2995/006 , C08G85/002 , C08J3/00 , C08J2367/04
摘要： Methods are provided for preparing polymer mixtures having low residual monomer content. The methods comprise mixing the at least two polymers in a solvent to form a polymeric mixture, the polymeric mixture comprising at least one residual monomer; and adding an antisolvent to the polymeric mixture so as to separate the at least two polymers from the polymeric mixture, where the residual monomer is soluble in the antisolvent. In some embodiments, methods are provided for preparing at least two polymers having low residual monomer content, the methods comprise adding an antisolvent to a mixture of at least two polymers dissolved in a solvent so as to precipitate the at least two polymers from the solvent and anti-solvent. The methods provided avoid steps in dry blending of polymers and produces polymer blends that have low residual monomer content.
摘要翻译： 提供了制备具有低残留单体含量的聚合物混合物的方法。 所述方法包括在溶剂中混合所述至少两种聚合物以形成聚合物混合物，所述聚合物混合物包含至少一种残余单体; 以及向所述聚合物混合物中加入抗溶剂以便将所述至少两种聚合物与所述聚合物混合物分离，其中所述残余单体可溶于所述反溶剂中。 在一些实施方案中，提供了用于制备至少两种具有低残留单体含量的聚合物的方法，所述方法包括向溶解在溶剂中的至少两种聚合物的混合物中加入抗溶剂以从溶剂中沉淀出至少两种聚合物，以及 反溶剂。 所提供的方法避免了聚合物干混合中的步骤，并产生具有低残留单体含量的聚合物共混物。
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公开(公告)号：US20130197094A1
公开(公告)日：2013-08-01
申请号：US13363469
申请日：2012-02-01
IPC分类号： A61K31/165 , A61P25/00
CPC分类号： A61K31/165 , A61K9/0024 , A61K9/70 , A61K31/357
摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of a TRPV1 compound (e.g., capsaicinoid compound) at or near a target site, one can relieve pain caused by diverse sources, including but not limited to, postoperative pain, spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.
摘要翻译： 提供长时间有效的疼痛治疗。 通过在目标部位或附近施用有效量的TRPV1化合物（例如辣椒素类化合物），可以减轻由多种来源引起的疼痛，包括但不限于术后疼痛，脊髓椎间盘突出症（即坐骨神经痛） 脊柱脱位，狭窄，椎间盘背痛和关节疼痛，以及手术附带的疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天。
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