公开(公告)号：US20120142649A1

公开(公告)日：2012-06-07

申请号：US13310240

申请日：2011-12-02

申请人： Jonathan K. Gray ,  Jeffrey C. Marx ,  William F. McKay ,  Josee Roy ,  Danielle L. Clay ,  Jared T. Wilsey ,  John Myers Zanella

发明人： Jonathan K. Gray ,  Jeffrey C. Marx ,  William F. McKay ,  Josee Roy ,  Danielle L. Clay ,  Jared T. Wilsey ,  John Myers Zanella

IPC分类号： A61K31/56 ,  A61P29/00 ,  A61K31/445

CPC分类号： A61K9/0024 ,  A61K31/167 ,  A61K31/4168 ,  A61K31/445 ,  A61K47/34 ,  A61K2300/00

摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of immediate release bupivacaine or lidocaine and a sustained release clonidine at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days or longer.

摘要翻译： 提供长时间有效的疼痛治疗。 通过施用有效量的即时释放布比卡因或利多卡因和持续释放的可乐定，可以缓解由不同来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄 ，造成背痛和关节疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天或更长。

公开(公告)号：US08623396B2

公开(公告)日：2014-01-07

申请号：US13310240

申请日：2011-12-02

申请人： Jonathan K. Gray ,  Jeffrey C. Marx ,  William F. McKay ,  Josee Roy ,  Danielle L. Clay ,  Jared T. Wilsey ,  John Myers Zanella

发明人： Jonathan K. Gray ,  Jeffrey C. Marx ,  William F. McKay ,  Josee Roy ,  Danielle L. Clay ,  Jared T. Wilsey ,  John Myers Zanella

IPC分类号： A61F2/00 ,  A61K9/00

CPC分类号： A61K9/0024 ,  A61K31/167 ,  A61K31/4168 ,  A61K31/445 ,  A61K47/34 ,  A61K2300/00

摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of immediate release bupivacaine or lidocaine and a sustained release clonidine at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days or longer.

摘要翻译： 提供长时间有效的疼痛治疗。 通过施用有效量的即时释放布比卡因或利多卡因和持续释放的可乐定，可以缓解由不同来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄 ，造成背痛和关节疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天或更长。

公开(公告)号：US20120142747A1

公开(公告)日：2012-06-07

申请号：US13309759

申请日：2011-12-02

申请人： Jared T. Wilsey ,  Danielle L. Biggs ,  Jonathan K. Gray ,  Jeffrey C. Marx ,  William F. McKay ,  Josee Roy ,  John Myers Zanella

发明人： Jared T. Wilsey ,  Danielle L. Biggs ,  Jonathan K. Gray ,  Jeffrey C. Marx ,  William F. McKay ,  Josee Roy ,  John Myers Zanella

IPC分类号： A61K31/4168 ,  A61P29/00

CPC分类号： A61K31/4168 ,  A61K9/00 ,  A61K9/0024

摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of immediate release clonidine and a sustained release clonidine at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days or longer.

摘要翻译： 提供长时间有效的疼痛治疗。 通过在目标部位或其附近施用有效量的立即释放可乐定和持续释放的可乐定，可以减轻由不同来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊柱狭窄，狭窄，椎间盘突出 背痛和关节疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天或更长。

公开(公告)号：US20120142648A1

公开(公告)日：2012-06-07

申请号：US13309725

申请日：2011-12-02

申请人： Danielle L. Biggs ,  Jonathan K. Gray ,  Jeffrey C. Marx ,  William F. McKay ,  Josee Roy ,  Jared T. Wilsey ,  John Myers Zanella

发明人： Danielle L. Biggs ,  Jonathan K. Gray ,  Jeffrey C. Marx ,  William F. McKay ,  Josee Roy ,  Jared T. Wilsey ,  John Myers Zanella

IPC分类号： A61K31/56 ,  A61P29/00

CPC分类号： A61K45/06 ,  A61K9/0019 ,  A61K9/0024 ,  A61K31/4168 ,  A61K31/573 ,  A61K47/34 ,  A61K2300/00

摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of clonidine and a steroid at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.

摘要翻译： 提供长时间有效的疼痛治疗。 通过在目标部位或附近施用有效量的可乐定和类固醇，可以减轻由多种来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，椎间盘背痛和关节 疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天。

公开(公告)号：US20120142643A1

公开(公告)日：2012-06-07

申请号：US13309766

申请日：2011-12-02

申请人： Jared T. Wilsey ,  Danielle L. Biggs ,  Jeffrey C. Marx ,  William F. McKay ,  Josee Roy ,  John Myers Zanella

发明人： Jared T. Wilsey ,  Danielle L. Biggs ,  Jeffrey C. Marx ,  William F. McKay ,  Josee Roy ,  John Myers Zanella

IPC分类号： A61K31/662 ,  A61P29/00 ,  A61K31/4168

CPC分类号： A61K31/195 ,  A61K9/0024 ,  A61K31/4168 ,  A61K31/662 ,  A61K45/06 ,  A61K47/34

摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of clonidine and a gamma-aminobutyric acid compound at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.

摘要翻译： 提供长时间有效的疼痛治疗。 通过在目标部位或其附近施用有效量的可乐定和γ-氨基丁酸化合物，可以缓解由不同来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，椎间盘突出 背痛和关节疼痛，以及手术附带的疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天。

公开(公告)号：US09301946B2

公开(公告)日：2016-04-05

申请号：US13309766

申请日：2011-12-02

申请人： Jared T. Wilsey ,  Danielle L. Biggs ,  Jeffrey C. Marx ,  William F. McKay ,  Josee Roy ,  John Myers Zanella

发明人： Jared T. Wilsey ,  Danielle L. Biggs ,  Jeffrey C. Marx ,  William F. McKay ,  Josee Roy ,  John Myers Zanella

IPC分类号： A61K31/66 ,  A61K31/415 ,  A61K31/4168 ,  A61K9/00 ,  A61K45/06 ,  A61K31/662 ,  A61K47/34

CPC分类号： A61K31/195 ,  A61K9/0024 ,  A61K31/4168 ,  A61K31/662 ,  A61K45/06 ,  A61K47/34

摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of clonidine and a gamma-aminobutyric acid compound at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.

摘要翻译： 提供长时间有效的疼痛治疗。 通过在目标部位或其附近施用有效量的可乐定和γ-氨基丁酸化合物，可以缓解由不同来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，椎间盘突出 背痛和关节疼痛，以及手术附带的疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天。

公开(公告)号：US08591935B2

公开(公告)日：2013-11-26

申请号：US13110618

申请日：2011-05-18

申请人： William F. McKay ,  John Myers Zanella

发明人： William F. McKay ,  John Myers Zanella

IPC分类号： A61K31/351 ,  A61K9/14 ,  A61P25/04

CPC分类号： A61K9/0024 ,  A61K9/0019 ,  A61K9/0085 ,  A61K9/06 ,  A61K9/1641 ,  A61K9/1647 ,  A61K31/21 ,  A61K31/351 ,  A61K31/366 ,  A61K31/40 ,  A61K31/404 ,  A61K31/435 ,  A61K31/47 ,  A61K31/505 ,  A61K47/10 ,  A61K47/32

摘要： Methods and compositions are provided for reducing, treating or preventing pain and/or inflammation in a patient in need of such treatment, the methods and compositions comprising administering a therapeutically effective amount of a statin or pharmaceutically acceptable salt thereof to a target tissue site beneath the skin.

摘要翻译： 提供了用于减少，治疗或预防需要这种治疗的患者的疼痛和/或炎症的方法和组合物，所述方法和组合物包括将治疗有效量的他汀类药物或其药学上可接受的盐施用于靶组织部位 皮肤。

公开(公告)号：US08946277B2

公开(公告)日：2015-02-03

申请号：US12420197

申请日：2009-04-08

申请人： John Myers Zanella ,  Christopher M. Hobot ,  Danielle L. Biggs ,  Katara Shaw ,  Phillip Edward McDonald ,  Vanja Margareta King ,  William F. McKay ,  Kathy L. Remsen

发明人： John Myers Zanella ,  Christopher M. Hobot ,  Danielle L. Biggs ,  Katara Shaw ,  Phillip Edward McDonald ,  Vanja Margareta King ,  William F. McKay ,  Kathy L. Remsen

IPC分类号： A01N43/00 ,  A61K31/33 ,  A01N43/50 ,  A61K31/415 ,  A61K31/4162 ,  A61K9/00 ,  A61K9/20 ,  A61K47/34

CPC分类号： A61K31/4168 ,  A61K9/0024 ,  A61K9/204 ,  A61K31/4162 ,  A61K47/34

摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of clonidine at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.

摘要翻译： 提供长时间有效的疼痛治疗。 通过在目标部位处或附近施用有效量的可乐定，可以减轻由多种来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，椎间盘背痛和关节疼痛，如 以及手术附带的疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天。

公开(公告)号：US08702677B2

公开(公告)日：2014-04-22

申请号：US12262823

申请日：2008-10-31

申请人： Thomas A. Simonton ,  Sean M. Haddock ,  John Myers Zanella ,  William F. McKay

发明人： Thomas A. Simonton ,  Sean M. Haddock ,  John Myers Zanella ,  William F. McKay

IPC分类号： A61M31/00 ,  A61M5/00 ,  A61M5/178 ,  A61M25/00

CPC分类号： A61M25/00 ,  A61B5/04001 ,  A61B5/4893 ,  A61M25/007 ,  A61M25/0084

摘要： Drug depot delivery devices and methods are provided for delivering one or more drug depots to one or more sites beneath the skin of a patient with or without repositioning the cannula. The device has a cannula capable of insertion to the site beneath the skin of the patient and one or more side port openings for delivering a drug depot. The side port openings are spaced a distance from the blunt tip, which will allow the user to implant at a set distance from a nerve. The device may also include an electronic monitor for detecting the proximity of the tip of the cannula to a nerve. In some embodiments, a method of delivering a drug depot is provided by detecting the nerve and delivering the drug depot at or near the nerve.

摘要翻译： 提供药物库递送装置和方法用于将一个或多个药物储存器递送到具有或不具有重新定位插管的患者皮肤下方的一个或多个部位。 该装置具有能够插入到患者皮肤下方的部位的插管和用于递送药物库的一个或多个侧口开口。 侧端口与钝头间隔开一段距离，这将允许使用者以距离神经一定距离植入。 该装置还可以包括用于检测套管尖端与神经的接近的电子监视器。 在一些实施方案中，通过检测神经并将药物贮存库输送到神经中或附近来提供递送药物库的方法。

公开(公告)号：US09125917B2

公开(公告)日：2015-09-08

申请号：US12413197

申请日：2009-03-27

申请人： William F McKay ,  Christopher M Hobot ,  Danielle Biggs ,  Katara Shaw ,  John Myers Zanella ,  Vanja M King ,  Stephen Mark Cox ,  Kathy L Remsen

发明人： William F McKay ,  Christopher M Hobot ,  Danielle Biggs ,  Katara Shaw ,  John Myers Zanella ,  Vanja M King ,  Stephen Mark Cox ,  Kathy L Remsen

IPC分类号： A61F13/00 ,  A61K31/58 ,  A61K31/585 ,  A61K9/00 ,  A61K9/16

CPC分类号： A61K31/58 ,  A61K9/0024 ,  A61K9/1647 ,  A61K31/585 ,  A61K47/34

摘要： Effective treatments of pain and inflammation are provided. Through the administration of an effective amount of fluocinolone at or near a target site, one can reduce, prevent or treat inflammation and pain and autoimmune disorders. In various embodiments, fluocinolone formulations may be provided within biodegradable polymers to reduce, prevent or treat sciatic pain and/or inflammation. In various embodiments, prevent transplant rejection for at least twenty-five days. In some embodiments, the pain relief can be for at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.

摘要翻译： 提供有效的疼痛和炎症治疗。 通过在靶位点附近施用有效量的氟轻松，可以减少，预防或治疗炎症和疼痛以及自身免疫性疾病。 在各种实施方案中，可以在可生物降解的聚合物内提供氟轻松制剂以减少，预防或治疗坐骨神经痛和/或炎症。 在各种实施方案中，防止移植排斥至少二十五天。 在一些实施方案中，疼痛缓解可以是至少五十天，至少一百天，至少一百三十五天或至少一百八十天。