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公开(公告)号：US07435837B2
公开(公告)日：2008-10-14
申请号：US10970714
申请日：2004-10-21
IPC分类号： C07D307/81 , C07D307/80
CPC分类号： C07D307/81
摘要： Compounds of Formula 1 or pharmaceutically acceptable salts thereof are provided: which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, can be used to treat a variety of central nervous system disorders such as schizophrenia.
摘要翻译： 提供式1化合物或其药学上可接受的盐：其是脑5-羟色胺受体的2C亚型的激动剂或部分激动剂。 化合物和含有这些化合物的组合物可用于治疗各种中枢神经系统疾病如精神分裂症。
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2.发明申请公开(公告)号：US20090082434A1
公开(公告)日：2009-03-26
申请号：US12210568
申请日：2008-09-15
IPC分类号： A61K31/343 , A61P25/00 , A61P25/18
CPC分类号： C07D307/81
摘要： Compounds of Formula 1 or pharmaceutically acceptable salts thereof are provided: which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, can be used to treat a variety of central nervous system disorders such as schizophrenia.
摘要翻译： 提供式1化合物或其药学上可接受的盐：其是脑5-羟色胺受体的2C亚型的激动剂或部分激动剂。 化合物和含有这些化合物的组合物可用于治疗各种中枢神经系统疾病如精神分裂症。
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公开(公告)号：US07365095B2
公开(公告)日：2008-04-29
申请号：US11409467
申请日：2006-04-21
IPC分类号： A61K31/44 , A61K43/40 , A01N43/02 , A01N43/16 , A61N31/335
CPC分类号： C07D311/04 , C07D311/20 , C07D311/58 , C07D313/08 , C07D401/04 , C07D405/04
摘要： Compounds of formula I or pharmaceutically acceptable salts thereof are provided: wherein each of R1, R2, R3, R4, y, m, n, and Ar are as defined, and described in classes and subclasses herein, which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, can be used to treat a variety of central nervous system disorders such as schizophrenia.
摘要翻译： 提供式I化合物或其药学上可接受的盐：其中R 1，R 2，R 3，R 4， y，m，n和Ar如上所定义，并且在本文的类别和亚类中描述，它们是脑5-羟色胺受体的2C亚型的激动剂或部分激动剂。 化合物和含有这些化合物的组合物可用于治疗各种中枢神经系统疾病如精神分裂症。
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公开(公告)号：US07368477B2
公开(公告)日：2008-05-06
申请号：US11408319
申请日：2006-04-21
申请人： Jonathan Laird Gross , Gary Paul Stack , Dahui Zhou , Hong Gao
发明人： Jonathan Laird Gross , Gary Paul Stack , Dahui Zhou , Hong Gao
IPC分类号： A61K31/4433 , A61K31/343 , A61K31/381 , C07D307/81 , C07D401/04
CPC分类号： C07D307/81
摘要： Compounds of formula I or pharmaceutically acceptable salts thereof are provided: wherein each of R1, R1′, R2, R3, R4, n, and Ar are as defined, and described in classes and subclasses herein, which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, can be used to treat a variety of central nervous system disorders such as schizophrenia.
摘要翻译： 提供式I化合物或其药学上可接受的盐：其中R 1，R 1，R 2，R 2，R 2， 3，R 4，n和Ar如上所定义，并在本文的类别和亚类中描述，它们是脑5-羟色胺受体的2C亚型的激动剂或部分激动剂。 化合物和含有这些化合物的组合物可用于治疗各种中枢神经系统疾病如精神分裂症。
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公开(公告)号：US20080200541A1
公开(公告)日：2008-08-21
申请号：US12105804
申请日：2008-04-18
申请人： Jonathan Laird Gross , Gary Paul Stack , Dahui Zhou , Hong Gao
发明人： Jonathan Laird Gross , Gary Paul Stack , Dahui Zhou , Hong Gao
CPC分类号： C07D307/81
摘要： Compounds of formula I or pharmaceutically acceptable salts thereof are provided: wherein each of R1, R1′, R2, R3, R4, n, and Ar are as defined, and described in classes and subclasses herein, which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, can be used to treat a variety of central nervous system disorders such as schizophrenia.
摘要翻译： 提供式I化合物或其药学上可接受的盐：其中R 1，R 1，R 2，R 2，R 2， 3，R 4，n和Ar如上所定义，并在本文的类别和亚类中描述，它们是脑5-羟色胺受体的2C亚型的激动剂或部分激动剂。 化合物和含有这些化合物的组合物可用于治疗各种中枢神经系统疾病如精神分裂症。
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公开(公告)号：US20080182891A1
公开(公告)日：2008-07-31
申请号：US12051368
申请日：2008-03-19
IPC分类号： A61K31/335 , A61K31/352 , A61P25/16 , A61P25/18 , A61P25/30 , A61P25/28 , A61P3/04
CPC分类号： C07D311/04 , C07D311/20 , C07D311/58 , C07D313/08 , C07D401/04 , C07D405/04
摘要： Compounds of formula I or pharmaceutically acceptable salts thereof are provided: wherein each of R1, R2, R3, R4, y, m, n, and Ar are as defined, and described in classes and subclasses herein, which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, can be used to treat a variety of central nervous system disorders such as schizophrenia.
摘要翻译： 提供式I化合物或其药学上可接受的盐：其中R 1，R 2，R 3，R 4， y，m，n和Ar如上所定义，并且在本文的类别和亚类中描述，它们是脑5-羟色胺受体的2C亚型的激动剂或部分激动剂。 化合物和含有这些化合物的组合物可用于治疗各种中枢神经系统疾病如精神分裂症。
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公开(公告)号：US07227023B2
公开(公告)日：2007-06-05
申请号：US10835128
申请日：2004-04-29
IPC分类号： C07D491/04 , C07D491/52 , A61K31/4741
CPC分类号： C07D491/04
摘要： Quinoline 3-amino chroman derivatives and compositions containing such compounds are disclosed. Methods for using the quinoline 3-amino chroman derivatives and compositions containing such compounds in the treatment of serotonin disorders are disclosed. Also disclosed are processes for preparing quinoline 3-amino chroman derivatives.
摘要翻译： 公开了喹啉-3-氨基苯并二氢吡喃衍生物和含有这些化合物的组合物。 公开了使用喹啉3-氨基苯并二氢吡喃衍生物和含有这些化合物的组合物治疗血清素紊乱的方法。 还公开了制备喹啉3-氨基苯并二氢吡喃衍生物的方法。
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8.发明授权Dihydrobenzofuranyl alkanamines and methods for using same as cns agents 失效二氢苯并呋喃基链烷胺及其与cns试剂一起使用的方法公开(公告)号：US07728155B2
公开(公告)日：2010-06-01
申请号：US10970103
申请日：2004-10-21
申请人： Jonathan Laird Gross , Gary Paul Stack , Hong Gao
发明人： Jonathan Laird Gross , Gary Paul Stack , Hong Gao
IPC分类号： C07D307/92
CPC分类号： C07D307/00 , C07D307/92 , C07D307/93
摘要： Compounds of formula 1 or pharmaceutically acceptable salts thereof are provided: which are agonists and partial agonists of the 2c subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, can be used to treat a variety of central nervous system disorders such as schizophrenia.
摘要翻译： 提供式1化合物或其药学上可接受的盐：其是脑5-羟色胺受体的2c亚型的激动剂和部分激动剂。 化合物和含有这些化合物的组合物可用于治疗各种中枢神经系统疾病如精神分裂症。
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公开(公告)号：US07803825B2
公开(公告)日：2010-09-28
申请号：US12173255
申请日：2008-07-15
IPC分类号： A61K31/42
CPC分类号： C07D413/10 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention provides a compound of formula Ia: and the use thereof for the treatment of a central nervous system disorder related to or affected by the histamine-3 receptor.
摘要翻译： 本发明提供式Ia化合物及其用于治疗与组胺-3受体相关或受组胺3受体影响的中枢神经系统疾病的用途。
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公开(公告)号：US20090023707A1
公开(公告)日：2009-01-22
申请号：US12173255
申请日：2008-07-15
IPC分类号： A61K31/55 , C07D235/16 , A61K31/4184 , C07K14/705 , A61P25/18 , A61P25/28 , A61P25/16 , A61K31/5377 , C07D413/14
CPC分类号： C07D413/10 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention provides a compound of formula I: and the use thereof for the treatment of a central nervous system disorder related to or affected by the histamine-3 receptor.
摘要翻译： 本发明提供式I化合物及其用于治疗与组胺-3受体相关或受组胺3受体影响的中枢神经系统病症的用途。
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