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公开(公告)号：US20100015648A1
公开(公告)日：2010-01-21
申请号：US12567860
申请日：2009-09-28
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2800/347 , G01N2800/52
摘要： Methods of assessing the ongoing kidney status in a subject afflicted with chronic renal failure (CRF) by detecting the quantity of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in fluid samples over time is disclosed. NGAL is a small secreted polypeptide that is protease resistant and consequently readily detected in the urine and serum as a result of chronic renal tubule cell injury. Incremental increases in NGAL levels in CRF patients over a prolonged period of time are diagnostic of worsening kidney disease. This increase in NGAL precedes and correlates with other indicators of worsening CRF, such as increased serum creatinine, increased urine protein secretion, and lower glomerular filtration rate (GFR). Proper detection of worsening (or improving, if treatment has been instituted) renal status over time, confirmed by pre- and post-treatment NGAL levels in the patient, can aid the clinical practitioner in designing and/or maintaining a proper treatment regimen to slow or stop the progression of CRF.
摘要翻译： 公开了通过随时间检测流体样品中嗜中性粒细胞明胶酶相关脂质运载蛋白（NGAL）的量来评估患有慢性肾功能衰竭（CRF）的受试者正在进行的肾脏状态的方法。 NGAL是一种小分泌的多肽，其是蛋白酶抗性的，因此由于慢性肾小管细胞损伤在尿液和血清中容易检测到。 长时间的CRF患者NGAL水平的增加增加是肾脏疾病恶化的诊断。 NGAL的这种增加先于CRF恶化的其他指标，如增加血清肌酐，增加尿蛋白分泌，降低肾小球滤过率（GFR）。 通过患者治疗前和治疗后的NGAL水平证实，正确检测恶化（或改善，如果治疗已经建立）肾脏状态，可以帮助临床从业者设计和/或维持适当的治疗方案缓慢 或停止CRF的进展。
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公开(公告)号：US20110143381A1
公开(公告)日：2011-06-16
申请号：US13025272
申请日：2011-02-11
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2800/347 , G01N2800/52
摘要： A method of assessing the ongoing kidney status of a mammal afflicted with or at risk of developing chronic renal injury or disease, including chronic renal failure (CRF) by detecting the quantity of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in urine, serum or plasma samples at discrete time periods, as well as over time. Incremental increases in NGAL levels in CRF patients over a prolonged period of time are diagnostic of worsening kidney disease. This increase in NGAL precedes and correlates with other indicators of worsening chronic renal disease or CRF, such as increased serum creatinine, increased urine protein secretion, and lower glomerular filtration rate (GFR). Proper detection of worsening (or improving, if treatment has been instituted) renal status over time, confirmed by pre- and post-treatment NGAL levels in the patient, can aid the clinical practitioner in designing and/or maintaining a proper treatment regimen to slow or stop the progression of CRF.
摘要翻译： 通过检测尿液，血清或血浆中的嗜中性粒细胞明胶酶相关脂质运载蛋白（NGAL）的量来评估患有慢性肾损伤或疾病的哺乳动物的正在进行的肾脏状态的方法，包括慢性肾功能衰竭（CRF） 样品在离散的时间段，以及随着时间的推移。 长时间的CRF患者NGAL水平的增加增加是肾脏疾病恶化的诊断。 NGAL的这种增加先于慢性肾病或CRF恶化的其他指标，如血清肌酐升高，尿蛋白分泌增加，肾小球滤过率（GFR）降低。 通过患者治疗前和治疗后的NGAL水平证实，正确检测恶化（或改善，如果治疗已经建立）肾脏状态，可以帮助临床从业者设计和/或维持适当的治疗方案缓慢 或停止CRF的进展。
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公开(公告)号：US20100234765A1
公开(公告)日：2010-09-16
申请号：US12785237
申请日：2010-05-21
IPC分类号： A61B5/00
CPC分类号： G01N33/566 , G01N33/6893 , G01N2800/347
摘要： A method of assessing the ongoing kidney status of a mammal afflicted with or at risk of developing chronic renal injury or disease, including chronic renal failure (CRF) by detecting the quantity of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in urine, serum or plasma samples at discrete time periods, as well as over time. Incremental increases in NGAL levels in CRF patients over a prolonged period of time are diagnostic of worsening kidney disease. This increase in NGAL precedes and correlates with other indicators of worsening chronic renal disease or CRF, such as increased serum creatinine, increased urine protein secretion, and lower glomerular filtration rate (GFR). Proper detection of worsening (or improving, if treatment has been instituted) renal status over time, confirmed by pre- and post-treatment NGAL levels in the patient, can aid the clinical practitioner in designing and/or maintaining a proper treatment regimen to slow or stop the progression of CRF.
摘要翻译： 通过检测尿液，血清或血浆中的嗜中性粒细胞明胶酶相关脂质运载蛋白（NGAL）的量来评估患有慢性肾损伤或疾病的哺乳动物的正在进行的肾脏状态的方法，包括慢性肾功能衰竭（CRF） 样品在离散的时间段，以及随着时间的推移。 长时间的CRF患者NGAL水平的增加增加是肾脏疾病恶化的诊断。 NGAL的这种增加先于慢性肾病或CRF恶化的其他指标，如血清肌酐升高，尿蛋白分泌增加，肾小球滤过率（GFR）降低。 通过患者治疗前和治疗后的NGAL水平证实，正确检测恶化（或改善，如果治疗已经建立）肾脏状态，可以帮助临床从业者设计和/或维持适当的治疗方案缓慢 或停止CRF的进展。
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公开(公告)号：US07977110B2
公开(公告)日：2011-07-12
申请号：US12143769
申请日：2008-06-21
CPC分类号： G01N33/70 , G01N2333/47 , G01N2800/347 , Y10T436/145555
摘要： A method for distinguishing between kidney dysfunctions in a mammal, including pre-renal azotemia, an acute renal injury that may progress to acute renal failure, and chronic kidney disease, using a urinary or circulating NGAL assay result that is compared to a predetermined NGAL cutoff level, and a single serum or plasma creatinine measurement. Typically the single creatinine measurement cannot distinguish acute renal injury from chronic kidney disease or pre-renal azotemia, a single measurement of urinary NGAL, combined with the single serum or plasma creatinine measurement, has sufficient sensitivity and specificity to distinguish acute renal injury from normal function, prerenal azotemia, and chronic kidney disease and predicts poor inpatient outcomes. Patients admitted to the emergency department of the hospital with any of acute kidney injury, prerenal azotemia, chronic kidney disease, or even normal kidney function, can be evaluated based on the single measurements of urinary or circulating NGAL, and serum or plasma creatinine. Urinary NGAL level is highly predictive of clinical outcomes, including nephrology consultation, dialysis, and admission to the intensive care unit.
摘要翻译： 使用与预定的NGAL截止值进行比较的尿液或循环NGAL测定结果来区分哺乳动物的肾功能异常的方法，包括肾前氮血症，可能进展为急性肾衰竭的急性肾损伤和慢性肾脏疾病 水平和单次血清或血浆肌酐测量。 通常，单次肌酐测量不能区分急性肾损伤与慢性肾脏疾病或肾前肾动脉血尿，尿NGAL的单次测量结合单次血清或血浆肌酐测量，具有足够的灵敏度和特异性来区分急性肾损伤与正常功能 ，肾前性氮血症和慢性肾脏疾病，并预测住院结果差。 可以根据尿液或循环NGAL和血清或血浆肌酐的单次测量，对住院急诊部患有任何急性肾损伤，肾上腺氮血症，慢性肾脏疾病或甚至正常肾功能的患者进行评估。 泌尿NGAL水平高度预测临床结果，包括肾脏咨询，透析和入院重症监护病房。
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公开(公告)号：US20100184089A1
公开(公告)日：2010-07-22
申请号：US12750241
申请日：2010-03-30
IPC分类号： G01N33/573 , G01N33/566
CPC分类号： G01N33/6893 , G01N2800/347 , G01N2800/50 , G01N2800/56
摘要： A method of assessing the ongoing kidney status of a mammal afflicted with or at risk of developing chronic renal injury or disease, including chronic renal failure (CRF) by detecting the quantity of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in urine, serum or plasma samples at discrete time periods, as well as over time. Incremental increases in NGAL levels in CRF patients over a prolonged period of time are diagnostic of worsening kidney disease. This increase in NGAL precedes and correlates with other indicators of worsening chronic renal disease or CRF, such as increased serum creatinine, increased urine protein secretion, and lower glomerular filtration rate (GFR). Proper detection of worsening (or improving, if treatment has been instituted) renal status over time, confirmed by pre- and post-treatment NGAL levels in the patient, can aid the clinical practitioner in designing and/or maintaining a proper treatment regimen to slow or stop the progression of CRF.
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公开(公告)号：US20090298047A1
公开(公告)日：2009-12-03
申请号：US12143769
申请日：2008-06-21
IPC分类号： C12Q1/25
CPC分类号： G01N33/70 , G01N2333/47 , G01N2800/347 , Y10T436/145555
摘要： A method for distinguishing between kidney dysfunctions in a mammal, including pre-renal azotemia, an acute renal injury that may progress to acute renal failure, and chronic kidney disease, using a urinary or circulating NGAL assay result that is compared to a predetermined NGAL cutoff level, and a single serum or plasma creatinine measurement. Typically the single creatinine measurement cannot distinguish acute renal injury from chronic kidney disease or pre-renal azotemia, a single measurement of urinary NGAL, combined with the single serum or plasma creatinine measurement, has sufficient sensitivity and specificity to distinguish acute renal injury from normal function, prerenal azotemia, and chronic kidney disease and predicts poor inpatient outcomes. Patients admitted to the emergency department of the hospital with any of acute kidney injury, prerenal azotemia, chronic kidney disease, or even normal kidney function, can be evaluated based on the single measurements of urinary or circulating NGAL, and serum or plasma creatinine. Urinary NGAL level is highly predictive of clinical outcomes, including nephrology consultation, dialysis, and admission to the intensive care unit.
摘要翻译： 使用与预定的NGAL截止值进行比较的尿液或循环NGAL测定结果来区分哺乳动物的肾功能异常的方法，包括肾前氮血症，可能进展为急性肾衰竭的急性肾损伤和慢性肾脏疾病 水平和单次血清或血浆肌酐测量。 通常，单次肌酐测量不能区分急性肾损伤与慢性肾脏疾病或肾前肾动脉血尿，尿NGAL的单次测量结合单次血清或血浆肌酐测量，具有足够的灵敏度和特异性来区分急性肾损伤与正常功能 ，肾前性氮血症和慢性肾脏疾病，并预测住院结果差。 可以根据尿液或循环NGAL和血清或血浆肌酐的单次测量，对住院急诊部患有任何急性肾损伤，肾上腺氮血症，慢性肾脏疾病或甚至正常肾功能的患者进行评估。 泌尿NGAL水平高度预测临床结果，包括肾脏咨询，透析和入院重症监护病房。
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公开(公告)号：US20080090304A1
公开(公告)日：2008-04-17
申请号：US11770245
申请日：2007-06-28
CPC分类号： G01N33/6893 , G01N2800/347 , G01N2800/50 , G01N2800/56
摘要： A method of assessing the ongoing kidney status of a mammal afflicted with or at risk of developing chronic renal injury or disease, including chronic renal failure (CRF) by detecting the quantity of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in urine, serum or plasma samples at discrete time periods, as well as over time. Incremental increases in NGAL levels in CRF patients over a prolonged period of time are diagnostic of worsening kidney disease. This increase in NGAL precedes and correlates with other indicators of worsening chronic renal disease or CRF, such as increased serum creatinine, increased urine protein secretion, and lower glomerular filtration rate (GFR). Proper detection of worsening (or improving, if treatment has been instituted) renal status over time, confirmed by pre- and post-treatment NGAL levels in the patient, can aid the clinical practitioner in designing and/or maintaining a proper treatment regimen to slow or stop the progression of CRF.
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公开(公告)号：US20140080155A1
公开(公告)日：2014-03-20
申请号：US14088638
申请日：2013-11-25
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N2800/347 , G01N2800/52
摘要： Methods of assessing the ongoing kidney status in a subject afflicted with chronic renal failure (CRF) by detecting the quantity of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in fluid samples over time. NGAL is a small secreted polypeptide that is protease resistant and consequently readily detected in the urine and serum as a result of chronic renal tubule cell injury. Incremental increases in NGAL levels in CRF patients over a prolonged period of time are diagnostic of worsening kidney disease. This increase in NGAL precedes and correlates with other indicators of worsening CRF, such as increased serum creatinine, increased urine protein secretion, and lower glomerular filtration rate (GFR). Proper detection of worsening (or improving, if treatment has been instituted) renal status over time, confirmed by pre- and post-treatment NGAL levels in the patient, can aid in designing and/or maintaining a proper treatment regimen to slow or stop the progression of CRF.
摘要翻译： 通过随时间检测流体样品中嗜中性粒细胞明胶酶相关脂质运载蛋白（NGAL）的量来评估患有慢性肾功能衰竭（CRF）的受试者正在进行的肾脏状态的方法。 NGAL是一种小分泌的多肽，其是蛋白酶抗性的，因此由于慢性肾小管细胞损伤在尿液和血清中容易检测到。 长时间的CRF患者NGAL水平的增加增加是肾脏疾病恶化的诊断。 NGAL的这种增加先于CRF恶化的其他指标，如增加血清肌酐，增加尿蛋白分泌，降低肾小球滤过率（GFR）。 正确检测恶化（或改善，如果治疗已经建立）肾脏状态随着时间的推移，由患者治疗前和治疗后的NGAL水平证实，可以帮助设计和/或维持适当的治疗方案以减慢或停止 CRF进展。
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公开(公告)号：US20130137122A1
公开(公告)日：2013-05-30
申请号：US13747646
申请日：2013-01-23
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N2800/347 , G01N2800/50 , G01N2800/56
摘要： A method of assessing the ongoing kidney status of a mammal afflicted with or at risk of developing chronic renal injury or disease, including chronic renal failure (CRF) by detecting the quantity of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in urine, serum or plasma samples at discrete time periods, as well as over time. Incremental increases in NGAL levels in CRF patients over a prolonged period of time are diagnostic of worsening kidney disease. This increase in NGAL precedes and correlates with other indicators of worsening chronic renal disease or CRF, such as increased serum creatinine, increased urine protein secretion, and lower glomerular filtration rate (GFR). Proper detection of worsening (or improving, if treatment has been instituted) renal status over time, confirmed by pre- and post-treatment NGAL levels in the patient, can aid the clinical practitioner in designing and/or maintaining a proper treatment regimen to slow or stop the progression of CRF.
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公开(公告)号：US20120219956A1
公开(公告)日：2012-08-30
申请号：US13359772
申请日：2012-01-27
IPC分类号： G01N33/566 , C12Q1/68
CPC分类号： G01N33/6893 , A01N1/0226 , A61K38/1709 , A61K39/025 , G01N33/74 , G01N2333/47 , G01N2800/347 , A61K2300/00
摘要： Use of serum neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker, alone or in conjunction with creatinine to aid in the diagnosis of renal conditions such as acute tubular necrosis and acute renal failure, and a method and a kit for assigning a diagnosis of acute tubular necrosis or acute renal failure to a subject based on the correlation between the levels of NGAL and optionally creatinine in a sample obtained from a subject when compared to a sample obtained from a normal subject not experiencing acute tubular necrosis or acute renal failure.
摘要翻译： 使用血清嗜中性粒细胞明胶酶相关脂质运载蛋白（NGAL）作为生物标志物，单独或与肌酐联合以帮助诊断肾脏疾病如急性肾小管坏死和急性肾衰竭，以及用于分配诊断的方法和试剂盒 与从未经历急性肾小管坏死或急性肾衰竭的正常受试者获得的样品相比，基于从受试者获得的样品中NGAL和任选的肌酸酐水平之间的相关性，对受试者的急性肾小管坏死或急性肾衰竭。
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