公开(公告)号：US20120095377A1

公开(公告)日：2012-04-19

申请号：US13274109

申请日：2011-10-14

Applicant: Jonathan Smith ,  Kern Bhugra

Inventor： Jonathan Smith ,  Kern Bhugra

IPC: A61F5/00

CPC classification number: A61F5/0125 ,  A61F5/0102

Abstract: A multi-fit orthotic structure including an attachment system for coupling the orthotic structure to a wide variety of subjects without requiring a custom fit. In one embodiment, active mobility assistance is provided via an orthotic system capable of integrating a linear actuator and linkage system to deliver torque to the lower leg of a subject to facilitate flexion and/or extension motion of the subject's leg. The orthotic structure is attached to the subject using a textile suspension system which does not require the orthotic structure to interface directly in the knee region or at the lateral areas of the thigh and calf of the subject, thus providing an ideal fit for the widest possible range of subjects with the minimum number of required sizes.

Abstract translation: 一种多合适矫形器结构，包括用于将矫形器结构与各种各样的受试者联接而不需要定制配合的附接系统。 在一个实施例中，通过能够集成线性致动器和联动系统的矫正系统来提供主动移动辅助，以将扭矩传递到对象的小腿，以促进对象腿部的屈曲和/或伸展运动。 使用不需要矫正结构的纺织品悬挂系统将矫形器结构附接到受试者，膝关节区域或受试者的大腿和小腿的横向区域直接相接，从而为最广泛的可能性提供理想的适合 具有所需尺寸最小数量的科目范围。

公开(公告)号：US08771210B2

公开(公告)日：2014-07-08

申请号：US13274109

申请日：2011-10-14

Applicant: Jonathan Smith ,  Kern Bhugra

Inventor： Jonathan Smith ,  Kern Bhugra

IPC: A61F5/00 ,  A61H1/00 ,  A61F13/06

CPC classification number: A61F5/0125 ,  A61F5/0102

Abstract: A multi-fit orthotic structure including an attachment system for coupling the orthotic structure to a wide variety of subjects without requiring a custom fit. In one embodiment, active mobility assistance is provided via an orthotic system capable of integrating a linear actuator and linkage system to deliver torque to the lower leg of a subject to facilitate flexion and/or extension motion of the subject's leg. The orthotic structure is attached to the subject using a textile suspension system which does not require the orthotic structure to interface directly in the knee region or at the lateral areas of the thigh and calf of the subject, thus providing an ideal fit for the widest possible range of subjects with the minimum number of required sizes.

Abstract translation: 一种多合适矫形器结构，包括用于将矫形器结构与各种各样的受试者联接而不需要定制配合的附接系统。 在一个实施例中，通过能够集成线性致动器和联动系统的矫正系统来提供主动移动辅助，以将扭矩传递到对象的小腿，以促进对象腿部的屈曲和/或伸展运动。 使用不需要矫正结构的纺织品悬挂系统将矫形器结构附接到受试者，膝关节区域或受试者的大腿和小腿的侧向区域直接接合，从而为最广泛的可能性提供理想的适合 具有所需尺寸最小数量的科目范围。

公开(公告)号：US20090204038A1

公开(公告)日：2009-08-13

申请号：US12366998

申请日：2009-02-06

Applicant: Jonathan Smith ,  Kern Bhugra

Inventor： Jonathan Smith ,  Kern Bhugra

IPC: A61F5/00

CPC classification number: A61F5/0125 ,  A61F5/0102

Abstract: A multi-fit orthotic structure including an attachment system for coupling the orthotic structure to a wide variety of subjects without requiring a custom fit. In one embodiment, active mobility assistance is provided via an orthotic system capable of integrating a linear actuator and linkage system to deliver torque to the lower leg of a subject to facilitate flexion and/or extension motion of the subject's leg. The orthotic structure is attached to the subject using a textile suspension system which does not require the orthotic structure to interface directly in the knee region or at the lateral areas of the thigh and calf of the subject, thus providing an ideal fit for the widest possible range of subjects with the minimum number of required sizes.

Abstract translation: 一种多合适矫形器结构，包括用于将矫形器结构与各种各样的受试者联接而不需要定制配合的附接系统。 在一个实施例中，通过能够集成线性致动器和联动系统的矫正系统来提供主动移动辅助，以将扭矩传递到对象的小腿，以促进对象腿部的屈曲和/或伸展运动。 使用不需要矫正结构的纺织品悬挂系统将矫形器结构附接到受试者，膝关节区域或受试者的大腿和小腿的横向区域直接相接，从而为最广泛的可能性提供理想的适合 具有所需尺寸最小数量的科目范围。

公开(公告)号：US20120316475A1

公开(公告)日：2012-12-13

申请号：US13593366

申请日：2012-08-23

Applicant: Kern Bhugra ,  Robert W. Horst ,  Richard R. Marcus ,  Jonathan Smith

Inventor： Kern Bhugra ,  Robert W. Horst ,  Richard R. Marcus ,  Jonathan Smith

IPC: A61H1/02 ,  F16H19/02

CPC classification number: H02K7/06 ,  A61F2/6607 ,  A61F2/68 ,  A61F2002/5066 ,  A61F2002/701 ,  A61H1/0237 ,  A61H1/0274 ,  A61H2201/5061 ,  A61H2201/5064 ,  Y10T74/18576

Abstract: An actuator system for assisting extension of a biological joint is provided with a motor assembly, a rotary-to-linear mechanism, and an extension stop. The rotary-to-linear mechanism includes a screw that accepts rotational output of the motor assembly, and a nut that cooperates with the screw to convert rotational movement of the screw to linear movement of the nut. The extension stop is driven by linear movement of the nut in an extension direction to cause extension of the biological joint. The motor assembly, the rotary-to-linear mechanism and the extension stop cooperate to allow unpowered flexion of the joint. The system is configured without a flexion stop, and is configured such that the nut cannot drive the joint in a flexion direction. Methods of use are also disclosed.

Abstract translation: 用于辅助生物接头延伸的致动器系统设置有电机组件，旋转到线性机构和延伸止动件。 旋转到直线机构包括接受马达组件的旋转输出的螺钉和与螺钉配合以将螺杆的旋转运动转换成螺母的线性运动的螺母。 延伸止动器由螺母沿延伸方向的线性运动驱动，以使生物接头延伸。 电动机组件，旋转到线性机构和延伸止动器配合以允许接头的无动力弯曲。 该系统配置为没有弯曲停止，并且构造成使得螺母不能在弯曲方向上驱动关节。 还公开了使用方法。

公开(公告)号：US08052629B2

公开(公告)日：2011-11-08

申请号：US12366998

申请日：2009-02-06

Applicant: Jonathan Smith ,  Kern Bhugra

Inventor： Jonathan Smith ,  Kern Bhugra

IPC: A61F5/00 ,  A61H1/00 ,  A61F13/06

CPC classification number: A61F5/0125 ,  A61F5/0102

Abstract: A multi-fit orthotic structure including an attachment system for coupling the orthotic structure to a wide variety of subjects without requiring a custom fit. In one embodiment, active mobility assistance is provided via an orthotic system capable of integrating a linear actuator and linkage system to deliver torque to the lower leg of a subject to facilitate flexion and/or extension motion of the subject's leg. The orthotic structure is attached to the subject using a textile suspension system which does not require the orthotic structure to interface directly in the knee region or at the lateral areas of the thigh and calf of the subject, thus providing an ideal fit for the widest possible range of subjects with the minimum number of required sizes.

Abstract translation: 一种多合适矫形器结构，包括用于将矫形器结构与各种各样的受试者联接而不需要定制配合的附接系统。 在一个实施例中，通过能够集成线性致动器和联动系统的矫正系统来提供主动移动辅助，以将扭矩传递到对象的小腿，以促进对象腿部的屈曲和/或伸展运动。 使用不需要矫正结构的纺织品悬挂系统将矫形器结构附接到受试者，膝关节区域或受试者的大腿和小腿的横向区域直接相接，从而为最广泛的可能性提供理想的适合 具有所需尺寸最小数量的科目范围。

公开(公告)号：US20100038983A1

公开(公告)日：2010-02-18

申请号：US12363577

申请日：2009-01-30

Applicant: Kern Bhugra ,  Robert W. Horst ,  Richard R. Marcus ,  Jonathan Smith

Inventor： Kern Bhugra ,  Robert W. Horst ,  Richard R. Marcus ,  Jonathan Smith

IPC: H02K7/06

CPC classification number: H02K7/06 ,  A61F2/6607 ,  A61F2/68 ,  A61F2002/5066 ,  A61F2002/701 ,  A61H1/0237 ,  A61H1/0274 ,  A61H2201/5061 ,  A61H2201/5064 ,  Y10T74/18576

Abstract: One of the embodiments of the invention is an actuator system for extending and flexing a joint. The actuator system includes a multi-motor assembly for providing a rotational output, a rotary-to-linear mechanism including a screw that accepts the rotational output of the multi-motor assembly and a nut that cooperates with the screw to convert rotational movement of the screw to linear movement of the nut, and a moving rail with a latch that functions to translate linear movement of the nut in both the extension and flexion directions into an extension and flexion of the joint. The actuator has been specifically designed for extending and flexing a joint (such as an ankle, a knee, an elbow, or a shoulder) of a human. The actuator system may, however, be used to move any suitable object through any suitable movement (linear, rotational, or otherwise).

Abstract translation: 本发明的一个实施例是用于延伸和弯曲接头的致动器系统。 致动器系统包括用于提供旋转输出的多电动机组件，包括接受多电动机组件的旋转输出的螺杆的旋转到线性机构和与螺杆配合以转换旋转运动的螺母 螺钉到螺母的线性运动，以及具有闩锁的运动轨道，其用于将螺母在延伸和弯曲方向上的线性运动转化为接头的伸展和弯曲。 致动器专门设计用于伸展和弯曲人体的关节（例如脚踝，膝盖，肘部或肩部）。 然而，致动器系统可以用于通过任何合适的运动（线性，旋转或其他方式）移动任何合适的物体。

公开(公告)号：USD738969S1

公开(公告)日：2015-09-15

申请号：US29484976

申请日：2014-03-14

Applicant: Jonathan Smith

Designer： Jonathan Smith

公开(公告)号：US20130177551A1

公开(公告)日：2013-07-11

申请号：US13683527

申请日：2012-11-21

Applicant: Stanley L. Hazen ,  Michael Kinter ,  Marc S. Penn ,  Jonathan Smith ,  Lemin Zheng

Inventor： Stanley L. Hazen ,  Michael Kinter ,  Marc S. Penn ,  Jonathan Smith ,  Lemin Zheng

IPC: G01N33/92

CPC classification number: G01N33/561 ,  C07K16/18 ,  G01N33/6893 ,  G01N33/92 ,  G01N2333/775 ,  G01N2800/32

Abstract: Provided herein methods for determining whether a subject, particularly a human subject, is at risk of developing, having, or experiencing a complication of cardiovascular disease, and methods of treating subjects who are identified by the current methods of being at risk for cardiovascular disease. In one embodiment, the method comprises determining levels of one or more oxidized apolipoprotien A-I related biomolecules in a bodily sample from the subject. Also, provided are kits and reagents for use in the present methods. Also provided are methods for monitoring the status of cardiovascular disease in a subject or the effects of therapeutic agents on subjects with cardiovascular disease. Such method comprising determining levels of one or more oxidized apolipoprotein A-I related molecules in bodily samples taken from the subject over time or before and after therapy.

Abstract translation: 本文提供用于确定受试者，特别是人类受试者是否处于发展，具有或经历心血管疾病并发症的风险的方法，以及治疗由目前的心血管疾病风险的方法鉴定的受试者的方法。 在一个实施方案中，该方法包括确定来自受试者的身体样品中一种或多种氧化的载脂蛋白A-I相关生物分子的水平。 此外，提供了用于本方法的试剂盒和试剂。 还提供了用于监测受试者心血管疾病状态或治疗剂对心血管疾病受试者的影响的方法。 这种方法包括测定在受试者随时间或治疗之前或之后取自受试者的身体样品中一种或多种氧化的载脂蛋白A-1相关分子的水平。

公开(公告)号：US20070008927A1

公开(公告)日：2007-01-11

申请号：US11412600

申请日：2006-04-26

Applicant: Frederick Herz ,  Jonathan Smith ,  Bhupinder Madan

Inventor： Frederick Herz ,  Jonathan Smith ,  Bhupinder Madan

IPC: H04Q7/00

CPC classification number: H04W84/18 ,  H04B7/18506 ,  H04L45/00 ,  H04L45/22 ,  H04L45/30 ,  H04W40/12 ,  H04W40/18 ,  H04W40/20 ,  H04W40/24 ,  H04W72/04 ,  H04W84/12

Abstract: Autoband's distributed networking intelligence provides a novel architecture capable of dynamically reconfiguring communications pathways consisting of links whose transmission media are opportunistically and dynamically selectable. At least one constituent node in such automatically configurable transient pathways is mobile, for example, information (source) server, intervening router node(s), gateway server and/or client device. Additionally, Autoband's ad hoc communications pathways may seamlessly and dynamically integrate (i.e., “graft”) into standard fixed node networks such as terrestrial networks, other wireless networks or combinations thereof. These communications may consist of point-to-point or multicast links. An economic market-based approach further assures allocation of available network resources (i.e., bandwidth and processing) needed to achieve the most optimally resource efficient communications pathway configurations for the totality of communications. Consequently, optimal network resource allocation and efficiency at a system-wide level is continuously achieved.

Abstract translation: Autoband的分布式网络智能提供了一种新颖的架构，能够动态地重新配置由传输媒介机会主义和动态选择的链路组成的通信路径。 这种自动配置的瞬时路径中的至少一个组成节点是移动的，例如信息（源）服务器，中间路由器节点，网关服务器和/或客户端设备。 此外，Autoband的自组织通信路径可以无缝地和动态地整合（即，“移植”）到诸如地面网络，其他无线网络或其组合的标准固定节点网络中。 这些通信可以由点对点或多播链路组成。 基于经济市场的方法进一步确保为整体通信实现最佳资源有效的通信路径配置所需的可用网络资源（即，带宽和处理）的分配。 因此，不断实现系统级的最优网络资源配置和效率。

公开(公告)号：US20060251681A1

公开(公告)日：2006-11-09

申请号：US11485158

申请日：2006-07-12

Applicant: Michael Heyey ,  Diane Negley ,  Peter Pushko ,  Jonathan Smith ,  Alan Schmaljohn

Inventor： Michael Heyey ,  Diane Negley ,  Peter Pushko ,  Jonathan Smith ,  Alan Schmaljohn

IPC: A61K39/395 ,  A61K39/12

CPC classification number: C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/5256 ,  A61K2039/53 ,  C07K16/10 ,  C12N7/00 ,  C12N15/86 ,  C12N2760/14022 ,  C12N2760/14222 ,  C12N2770/36021 ,  C12N2770/36122 ,  C12N2770/36123 ,  C12N2770/36143 ,  C12N2770/36162

Abstract: Using the MBGV GP, NP, and virion proteins, a method and composition for use in inducing an immune response which is protective against infection with MBGV in nonhuman primates is described.

Abstract translation: 描述了使用MBGV GP，NP和病毒粒子蛋白，用于诱导免疫应答的方法和组合物，其在非人灵长类动物中防止MBGV感染。