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1.发明授权公开(公告)号：US08108038B2
公开(公告)日：2012-01-31
申请号：US11380462
申请日：2006-04-27
IPC分类号： A61B5/0402
CPC分类号： A61B5/0402 , A61B5/0031 , A61B5/02 , A61B5/0245 , A61B5/0476 , A61B5/0816 , A61B5/1135 , A61B5/4094 , A61N1/36064 , A61N1/36082 , A61N1/3611 , A61N1/365 , A61N1/36521 , A61N1/36585 , A61N1/37288 , A61N1/3962
摘要： A medical device system that includes a brain monitoring element, cardiac monitoring element and a processor. The processor is configured to receive a brain signal from the brain monitoring element and a cardiac signal from the cardiac monitoring element. The processor is further configured to determine at least one reference point for a brain event time period by evaluation of the brain signal. The processor further identifies a first portion of the cardiac signal based on the at least one reference point of the brain event time period.
摘要翻译： 一种包括脑部监测元件，心脏监测元件和处理器的医疗装置系统。 处理器被配置为从脑监测元件接收脑信号和来自心脏监测元件的心脏信号。 处理器还被配置为通过评估脑信号来确定大脑事件时间段的至少一个参考点。 处理器还基于大脑事件时间段的至少一个参考点识别心脏信号的第一部分。
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2.发明授权Techniques for data retention upon detection of an event in an implantable medical device 有权检测植入式医疗设备中的事件时的数据保留技术公开(公告)号：US08565864B2
公开(公告)日：2013-10-22
申请号：US13349404
申请日：2012-01-12
申请人： Touby A. Drew , Jonathon E. Giftakis , David L. Carlson , Eric J. Panken , Jonathan C. Werder , Nina M. Graves
发明人： Touby A. Drew , Jonathon E. Giftakis , David L. Carlson , Eric J. Panken , Jonathan C. Werder , Nina M. Graves
IPC分类号： A61B5/04
CPC分类号： A61B5/4094 , A61B5/0006 , A61B5/0031 , A61B5/02055 , A61B5/021 , A61B5/024 , A61B5/031 , A61B5/04001 , A61B5/04012 , A61B5/0402 , A61B5/0476 , A61B5/0816 , A61B5/1118 , A61B5/165 , A61B5/4082 , A61B5/686 , A61B5/7232 , A61B5/7282 , A61N1/36132 , A61N1/36135 , A61N1/36521 , A61N1/36585 , A61N1/3702 , A61N1/37252 , A61N1/37282 , G06F17/30336 , G06F19/00 , G06F19/3418 , G16H10/60 , G16H40/63
摘要： Methods and apparatus for storing data records associated with a medical monitoring event in a data structure. These include initiating loop recording in an implantable medical device upon determination of a neurological event, wherein loop recording comprises storing a data record of a plurality of data records in a data structure, the plurality of data records representing information about determined neurological events. Methods and apparatus can further include determining a priority index for the plurality of data records based on severity levels of the determined neurological events and replacing older data records of the plurality of data records on the data structure with new data records according to the priority index, wherein the new data records selectively replace those data records in the data structure having the lowest associated priority index.
摘要翻译： 用于存储与数据结构中的医疗监视事件相关联的数据记录的方法和装置。 这些包括在确定神经学事件时在可植入医疗装置中启动循环记录，其中循环记录包括将多个数据记录的数据记录存储在数据结构中，所述多个数据记录表示关于确定的神经系统事件的信息。 方法和装置还可以包括基于所确定的神经病学事件的严重性水平确定多个数据记录的优先级索引，并根据优先级索引用新的数据记录替换数据结构上的多个数据记录的较旧的数据记录， 其中新数据记录选择性地替换具有最低相关优先级索引的数据结构中的那些数据记录。
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3.发明授权Techniques for data retention upon detection of an event in an implantable medical device 有权检测植入式医疗设备中的事件时的数据保留技术公开(公告)号：US08108033B2
公开(公告)日：2012-01-31
申请号：US11264974
申请日：2005-11-02
申请人： Touby A. Drew , Jonathon E. Giftakis , David L. Carlson , Eric J. Panken , Jonathan C. Werder , Nina M. Graves
发明人： Touby A. Drew , Jonathon E. Giftakis , David L. Carlson , Eric J. Panken , Jonathan C. Werder , Nina M. Graves
IPC分类号： A61B5/04
CPC分类号： A61B5/4094 , A61B5/0006 , A61B5/0031 , A61B5/02055 , A61B5/021 , A61B5/024 , A61B5/031 , A61B5/04001 , A61B5/04012 , A61B5/0402 , A61B5/0476 , A61B5/0816 , A61B5/1118 , A61B5/165 , A61B5/4082 , A61B5/686 , A61B5/7232 , A61B5/7282 , A61N1/36132 , A61N1/36135 , A61N1/36521 , A61N1/36585 , A61N1/3702 , A61N1/37252 , A61N1/37282 , G06F17/30336 , G06F19/00 , G06F19/3418 , G16H10/60 , G16H40/63
摘要： Methods and apparatus for storing data records associated with a medical monitoring event in a data structure. Upon detection of a possible occurrence of a physiological event by one group of monitoring elements, an implanted device records data received from another group of monitoring elements. The implanted device obtains and stores the data in the data record in a first data structure that is age-based. Before an oldest data record is lost, the oldest data record may be stored in a second data structure that is priority index-based. The priority index may be determined by a severity level and may be further determined by associated factors. The implanted device may organize, off-load, report, and/or display a plurality of data records based on an associated priority index. Additionally, the implanted device may select a subset or composite of physiologic channels from the available physiologic channels based on a selection criterion.
摘要翻译： 用于存储与数据结构中的医疗监视事件相关联的数据记录的方法和装置。 在通过一组监测元件检测到生理事件的可能发生时，植入装置记录从另一组监测元件接收的数据。 植入装置以基于年龄的第一数据结构获得并存储在数据记录中的数据。 在最旧的数据记录丢失之前，最早的数据记录可以存储在基于优先级索引的第二数据结构中。 优先权索引可以由严重性级别确定，并且可以由相关因素进一步确定。 植入的装置可以基于相关联的优先级索引来组织，卸载，报告和/或显示多个数据记录。 另外，植入装置可以基于选择标准从可用生理通道中选择生理通道的子集或复合物。
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4.发明申请TECHNIQUES FOR DATA RETENTION UPON DETECTION OF AN EVENT IN AN IMPLANTABLE MEDICAL DEVICE 有权在可移植医疗设备中检测事件的数据保留技术公开(公告)号：US20120116179A1
公开(公告)日：2012-05-10
申请号：US13349404
申请日：2012-01-12
申请人： Touby A. Drew , Jonathon E. Giftakis , David L. Carlson , Eric J. Panken , Jonathan C. Werder , Nina M. Graves
发明人： Touby A. Drew , Jonathon E. Giftakis , David L. Carlson , Eric J. Panken , Jonathan C. Werder , Nina M. Graves
CPC分类号： A61B5/4094 , A61B5/0006 , A61B5/0031 , A61B5/02055 , A61B5/021 , A61B5/024 , A61B5/031 , A61B5/04001 , A61B5/04012 , A61B5/0402 , A61B5/0476 , A61B5/0816 , A61B5/1118 , A61B5/165 , A61B5/4082 , A61B5/686 , A61B5/7232 , A61B5/7282 , A61N1/36132 , A61N1/36135 , A61N1/36521 , A61N1/36585 , A61N1/3702 , A61N1/37252 , A61N1/37282 , G06F17/30336 , G06F19/00 , G06F19/3418 , G16H10/60 , G16H40/63
摘要： Methods and apparatus for storing data records associated with a medical monitoring event in a data structure. These include initiating loop recording in an implantable medical device upon determination of a neurological event, wherein loop recording comprises storing a data record of a plurality of data records in a data structure, the plurality of data records representing information about determined neurological events. Methods and apparatus can further include determining a priority index for the plurality of data records based on severity levels of the determined neurological events and replacing older data records of the plurality of data records on the data structure with new data records according to the priority index, wherein the new data records selectively replace those data records in the data structure having the lowest associated priority index.
摘要翻译： 用于存储与数据结构中的医疗监视事件相关联的数据记录的方法和装置。 这些包括在确定神经学事件时在可植入医疗装置中启动循环记录，其中循环记录包括将多个数据记录的数据记录存储在数据结构中，所述多个数据记录表示关于确定的神经系统事件的信息。 方法和装置还可以包括基于所确定的神经病学事件的严重性水平确定多个数据记录的优先级索引，并根据优先级索引用新的数据记录替换数据结构上的多个数据记录的较旧的数据记录， 其中新数据记录选择性地替换具有最低相关优先级索引的数据结构中的那些数据记录。
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公开(公告)号：US10369353B2
公开(公告)日：2019-08-06
申请号：US12359037
申请日：2009-01-23
申请人： Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , Eric J. Panken , Timothy J. Denison , Keith A. Miesel , Michele H. Herzog
发明人： Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , Eric J. Panken , Timothy J. Denison , Keith A. Miesel , Michele H. Herzog
摘要： Intracranial pressure of a patient may be monitored in order to evaluate a seizure disorder. In some examples, trends in the intracranial pressure over time may be monitored, e.g., to detect changes to the patient's condition. In addition, in some examples, a seizure metric may be generated for a detected seizure based on sensed intracranial pressures. The seizure metric may indicate, for example, an average, median, or highest relative intracranial pressure value observed during a seizure, a percent change from a baseline value during the seizure, or the time for the intracranial pressure to return to a baseline state after the occurrence of a seizure. In addition to or instead of intracranial pressure, patient motion or posture may be monitored in order to assess the patient's seizure disorder. For example, a seizure type or severity may be determined based on patient motion sensed during a seizure.
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6.发明授权Implantable medical device for treating neurological conditions including ECG sensing 有权用于治疗包括心电图感觉在内的神经病症的植入式医疗装置公开(公告)号：US09014804B2
公开(公告)日：2015-04-21
申请号：US13158099
申请日：2011-06-10
CPC分类号： A61N1/375 , A61N1/36082 , A61N1/36114 , A61N1/36585 , A61N1/37 , A61N1/3756
摘要： An implantable medical device such as an implantable pulse generator that includes EEG sensing for monitoring and treating neurological conditions, and leadless ECG sensing for monitoring cardiac signals. The device includes a connector block with provisions for cardiac leads which may be used/enabled when needed. If significant co-morbid cardiac events are observed in patients via the leadless ECG monitoring, then cardiac leads may be subsequently connected for therapeutic use.
摘要翻译： 可植入的医疗装置，例如植入式脉冲发生器，其包括用于监测和治疗神经病症的脑电图感测，以及用于监测心脏信号的无引导心电图感测。 该装置包括具有用于心脏引线的装置的连接器块，其可以在需要时使用/启用。 如果通过无引导心电图监测在患者中观察到显着的并发心脏事件，则心脏引线可以随后连接用于治疗用途。
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7.发明申请SEIZURE DISORDER EVALUATION BASED ON INTRACRANIAL PRESSURE AND PATIENT MOTION 审中-公开基于内分泌压力和患者运动的癫痫病症评估公开(公告)号：US20100121214A1
公开(公告)日：2010-05-13
申请号：US12359055
申请日：2009-01-23
申请人： Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , Eric J. Panken , Timothy J. Denison , Keith A. Miesel , Michele H. Herzog
发明人： Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , Eric J. Panken , Timothy J. Denison , Keith A. Miesel , Michele H. Herzog
IPC分类号： A61B5/0476 , A61B5/03 , A61B5/11 , A61B5/053
CPC分类号： A61N1/0534 , A61B5/031 , A61B5/4094 , A61N1/36082
摘要： Intracranial pressure of a patient may be monitored in order to evaluate a seizure disorder. In some examples, trends in the intracranial pressure over time may be monitored, e.g., to detect changes to the patient's condition. In addition, in some examples, a seizure metric may be generated for a detected seizure based on sensed intracranial pressures. The seizure metric may indicate, for example, an average, median, or highest relative intracranial pressure value observed during a seizure, a percent change from a baseline value during the seizure, or the time for the intracranial pressure to return to a baseline state after the occurrence of a seizure. In addition to or instead of intracranial pressure, patient motion or posture may be monitored in order to assess the patient's seizure disorder. For example, a seizure type or severity may be determined based on patient motion sensed during a seizure.
摘要翻译： 可以监测患者的颅内压，以评估癫痫发作障碍。 在一些示例中，可以监测颅内压力随时间的趋势，例如以检测患者状况的变化。 此外，在一些示例中，可以基于感测的颅内压力产生针对检测到的发作的发作量度。 癫痫发作度数可以表示例如在癫痫发作期间观察到的平均值，中位数或最高相对颅内压值，在癫痫发作期间从基线值变化的百分比，或颅内压力回到基线状态的时间 发生癫痫发作。 除了或代替颅内压之外，可以监测患者的运动或姿势以评估患者的癫痫发作障碍。 例如，可以基于在癫痫发作期间感测到的患者运动来确定癫痫发作类型或严重程度。
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8.发明授权System and method for utilizing brain state information to modulate cardiac therapy 有权利用脑状态信息调制心脏治疗的系统和方法公开(公告)号：US08209019B2
公开(公告)日：2012-06-26
申请号：US11796577
申请日：2007-04-27
CPC分类号： A61B5/0402 , A61B5/0031 , A61B5/02 , A61B5/0245 , A61B5/0476 , A61B5/0816 , A61B5/1135 , A61B5/4094 , A61N1/36064 , A61N1/36082 , A61N1/3621 , A61N1/365 , A61N1/36521 , A61N1/36585 , A61N1/37288 , A61N1/3962
摘要： A system for regulating or modulating cardiac therapy using brain state information. The modulation may include suppressing standard, prescribed cardiac therapy for a period of time or it may involve modulating the type of cardiac therapy delivered In another embodiment, a system is provided for determining whether a cardiac event is categorized as neurologically matched, and, if so, modulating the therapeutic output to the heart.
摘要翻译： 使用脑状态信息调节或调节心脏治疗的系统。 调节可以包括在一段时间内抑制标准的，规定的心脏治疗，或者可以涉及调节递送的心脏治疗的类型。在另一个实施例中，提供了一种用于确定心脏事件是否被分类为神经学匹配的系统，如果是 调节心脏的治疗输出。
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公开(公告)号：US20100121213A1
公开(公告)日：2010-05-13
申请号：US12359037
申请日：2009-01-23
申请人： Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , Eric J. Panken , Timothy J. Denison , Keith A. Miesel , Michele H. Herzog
发明人： Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , Eric J. Panken , Timothy J. Denison , Keith A. Miesel , Michele H. Herzog
IPC分类号： A61B5/0478 , A61B5/03 , A61B5/103 , A61N1/36
CPC分类号： A61N1/0534 , A61B5/031 , A61B5/4094 , A61N1/36082
摘要： Intracranial pressure of a patient may be monitored in order to evaluate a seizure disorder. In some examples, trends in the intracranial pressure over time may be monitored, e.g., to detect changes to the patient's condition. In addition, in some examples, a seizure metric may be generated for a detected seizure based on sensed intracranial pressures. The seizure metric may indicate, for example, an average, median, or highest relative intracranial pressure value observed during a seizure, a percent change from a baseline value during the seizure, or the time for the intracranial pressure to return to a baseline state after the occurrence of a seizure. In addition to or instead of intracranial pressure, patient motion or posture may be monitored in order to assess the patient's seizure disorder. For example, a seizure type or severity may be determined based on patient motion sensed during a seizure.
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10.发明申请Implantable medical device for treating neurological conditions with an initially disabled cardiac therapy port and leadless ECG sensing 有权用于治疗神经病症的植入式医疗装置，其具有初始禁用的心脏治疗端口和无引导心电图感测公开(公告)号：US20080269842A1
公开(公告)日：2008-10-30
申请号：US11796382
申请日：2007-04-27
IPC分类号： A61N1/36
CPC分类号： A61N1/375 , A61N1/36082 , A61N1/36114 , A61N1/36585 , A61N1/37 , A61N1/3756
摘要： An implantable medical device such as an implantable pulse generator that includes EEG sensing for monitoring and treating neurological conditions, and leadless ECG sensing for monitoring cardiac signals. The device includes a connector block with provisions for cardiac leads which may be used/enabled when needed. If significant co-morbid cardiac events are observed in patients via the leadless ECG monitoring, then cardiac leads may be subsequently connected for therapeutic use.
摘要翻译： 可植入的医疗装置，例如植入式脉冲发生器，其包括用于监测和治疗神经病症的脑电图感测，以及用于监测心脏信号的无引导心电图感测。 该装置包括具有用于心脏引线的装置的连接器块，其可以在需要时使用/启用。 如果通过无引导心电图监测在患者中观察到显着的并发心脏事件，则心脏引线可以随后连接用于治疗用途。
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