公开(公告)号：US20100008966A1

公开(公告)日：2010-01-14

申请号：US12502473

申请日：2009-07-14

申请人： Joram Slager ,  Joseph Schmidt McGonigle ,  Aron Brent Anderson ,  Robert W. Hergenrother

发明人： Joram Slager ,  Joseph Schmidt McGonigle ,  Aron Brent Anderson ,  Robert W. Hergenrother

IPC分类号： A61K9/14 ,  A61K31/7088 ,  A61K9/00 ,  A61K31/7105 ,  A61P35/00

CPC分类号： A61L27/54 ,  A61K48/0041 ,  A61L27/34 ,  A61L2300/258 ,  A61L2300/606

摘要： Embodiments of the invention include devices for the release of nucleic acids and related methods. In an embodiment, the invention includes an active agent eluting coating including a polymeric matrix, a cationic carrier agent disposed with the matrix, and an active agent disposed within the matrix, the active agent including nucleic acids substantially uncomplexed with the cationic carrier agent. In an embodiment, the invention includes a method of making an implantable medical device including selecting a concentration of a cationic carrier agent corresponding to a desired elution profile, combining a matrix forming polymer, an active agent, a solvent, and the cationic carrier agent to form a coating composition having the selected concentration of the cationic carrier agent, the active agent comprising nucleic acids, and depositing the coating composition onto the surface of a substrate. Other embodiments are included herein.

摘要翻译： 本发明的实施方案包括用于释放核酸的装置和相关方法。 在一个实施方案中，本发明包括活性剂洗脱涂层，其包括聚合物基质，与基质一起布置的阳离子载体剂和置于基质内的活性剂，所述活性剂包括与阳离子载体试剂基本上未络合的核酸。 在一个实施方案中，本发明包括制备可植入医疗装置的方法，包括选择对应于所需洗脱曲线的阳离子载体试剂的浓度，将形成基质的聚合物，活性剂，溶剂和阳离子载体试剂组合到 形成具有选定浓度的阳离子载体试剂，活性剂包含核酸并将该涂料组合物沉积在基材表面上的涂料组合物。 本文还包括其它实施例。

公开(公告)号：US20090186059A1

公开(公告)日：2009-07-23

申请号：US12353792

申请日：2009-01-14

申请人： Elizabeth E. Johnson ,  Aron Brent Anderson ,  Joseph Schmidt McGonigle

发明人： Elizabeth E. Johnson ,  Aron Brent Anderson ,  Joseph Schmidt McGonigle

IPC分类号： A61K31/7088 ,  A61K9/00

CPC分类号： A61L31/043 ,  A61L27/227 ,  A61L27/34 ,  A61L27/50 ,  A61L27/54 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/258 ,  A61L2300/606

摘要： Embodiments of the invention include devices and methods for the controlled elution of nucleic acid delivery complexes. In an embodiment, the invention includes a method of making a medical device. The method can include complexing nucleic acids with a carrier agent to form a delivery complex solution, applying the delivery complex solution to a substrate, and applying a polymeric solution to the substrate. In another embodiment, the invention includes a method of making a medical device including complexing nucleic acids with a carrier agent to form nucleic acid delivery complexes, combining the nucleic acid delivery complexes with a polymer solution and a cross-linking agent, wherein the cross-linking agent is positively charged or charge neutral. In an embodiment, the invention includes an implantable medical device including a substrate and a coating disposed on a surface of the substrate, the coating comprising a polymeric matrix and a plurality of disperse nucleic acid delivery complexes disposed within the polymeric matrix. Other embodiments are included herein.

摘要翻译： 本发明的实施方案包括用于核酸递送复合物的受控洗脱的装置和方法。 在一个实施例中，本发明包括制造医疗装置的方法。 该方法可以包括使核酸与载体剂复合以形成递送复合物溶液，将递送复合物溶液施用于底物，以及将聚合物溶液施加到基底上。 在另一个实施方案中，本发明包括制备医疗装置的方法，所述方法包括使载体剂与络合核酸形成核酸递送复合物，将核酸递送复合物与聚合物溶液和交联剂结合， 连接剂带正电或电荷中性。 在一个实施方案中，本发明包括可植入医疗装置，其包括基底和设置在基底表面上的涂层，所述涂层包含聚合物基质和设置在聚合物基质内的多个分散核酸递送复合物。 本文还包括其它实施例。

公开(公告)号：US20090263449A1

公开(公告)日：2009-10-22

申请号：US12421285

申请日：2009-04-09

申请人： Joseph Schmidt McGonigle ,  Aron Brent Anderson

发明人： Joseph Schmidt McGonigle ,  Aron Brent Anderson

IPC分类号： A61F2/00 ,  A61K31/7088

CPC分类号： A61L27/54 ,  A61L27/34 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/258 ,  A61L2300/606 ,  A61L2300/802

摘要： Embodiments of the invention include devices and methods for the controlled elution of nucleic acid delivery complexes. In an embodiment, the invention includes a medical device including a substrate surface, a polymeric coating disposed on the surface, the polymeric coating coupled to the substrate surface through the reaction product of a photoreactive group; the polymeric coating comprising negatively charged species on the surface; and a plurality of nucleic acid delivery complexes disposed on the polymeric coating, the nucleic acid delivery complexes comprising a nucleic acid and a cationic carrier agent complexed to the nucleic acid. Other embodiments are included herein.

摘要翻译： 本发明的实施方案包括用于核酸递送复合物的受控洗脱的装置和方法。 在一个实施方案中，本发明包括医疗装置，其包括基底表面，设置在表面上的聚合物涂层，通过光反应基团的反应产物连接到基底表面的聚合物涂层; 聚合物涂层在表面上包含带负电荷的物质; 以及设置在所述聚合物涂层上的多个核酸递送复合物，所述核酸递送复合物包含核酸和与所述核酸复合的阳离子载体试剂。 本文还包括其它实施例。