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公开(公告)号：US20090186059A1
公开(公告)日：2009-07-23
申请号：US12353792
申请日：2009-01-14
IPC分类号： A61K31/7088 , A61K9/00
CPC分类号： A61L31/043 , A61L27/227 , A61L27/34 , A61L27/50 , A61L27/54 , A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/258 , A61L2300/606
摘要： Embodiments of the invention include devices and methods for the controlled elution of nucleic acid delivery complexes. In an embodiment, the invention includes a method of making a medical device. The method can include complexing nucleic acids with a carrier agent to form a delivery complex solution, applying the delivery complex solution to a substrate, and applying a polymeric solution to the substrate. In another embodiment, the invention includes a method of making a medical device including complexing nucleic acids with a carrier agent to form nucleic acid delivery complexes, combining the nucleic acid delivery complexes with a polymer solution and a cross-linking agent, wherein the cross-linking agent is positively charged or charge neutral. In an embodiment, the invention includes an implantable medical device including a substrate and a coating disposed on a surface of the substrate, the coating comprising a polymeric matrix and a plurality of disperse nucleic acid delivery complexes disposed within the polymeric matrix. Other embodiments are included herein.
摘要翻译： 本发明的实施方案包括用于核酸递送复合物的受控洗脱的装置和方法。 在一个实施例中，本发明包括制造医疗装置的方法。 该方法可以包括使核酸与载体剂复合以形成递送复合物溶液，将递送复合物溶液施用于底物，以及将聚合物溶液施加到基底上。 在另一个实施方案中，本发明包括制备医疗装置的方法，所述方法包括使载体剂与络合核酸形成核酸递送复合物，将核酸递送复合物与聚合物溶液和交联剂结合， 连接剂带正电或电荷中性。 在一个实施方案中，本发明包括可植入医疗装置，其包括基底和设置在基底表面上的涂层，所述涂层包含聚合物基质和设置在聚合物基质内的多个分散核酸递送复合物。 本文还包括其它实施例。
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公开(公告)号：US09375510B2
公开(公告)日：2016-06-28
申请号：US13811343
申请日：2011-07-19
IPC分类号： A61L24/06 , A61K9/70 , A61K31/165 , C09J4/06 , C09J133/08 , C09J133/10 , A61K31/27 , C08F218/08 , C08F220/56 , C08F220/18
CPC分类号： A61K9/7061 , A61K31/165 , A61K31/27 , A61L24/06 , C08F220/18 , C08F2220/1858 , C09J4/06 , C09J133/08 , C09J133/10 , C08F218/08 , C08F220/56
摘要： A stable transdermal adhesive composition comprising: an adhesive comprising a washed polymerization reaction product of at least two ethylenically unsaturated monomers; and at least one pharmaceutically active compound which is susceptible to oxidative degradation; wherein the at least two ethylenically unsaturated monomers, if present in the adhesive as unreacted monomers, are present at a level of less than 200 ppm of total unreacted monomer, based upon the total weight of the adhesive, methods of making the composition, a transdermal drug delivery device using the composition, methods of making the device, and methods of delivery the pharmaceutically active compound are provided.
摘要翻译： 一种稳定的透皮粘合剂组合物，其包含：粘合剂，其包含至少两种烯属不饱和单体的洗涤聚合反应产物; 和至少一种易于氧化降解的药学活性化合物; 其中所述至少两种烯键式不饱和单体如果作为未反应单体存在于所述粘合剂中，基于所述粘合剂的总重量，低于总共未反应单体的200ppm的水平存在，制备所述组合物的方法，经皮 提供了使用该组合物的药物递送装置，制备该装置的方法和递送药学活性化合物的方法。
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公开(公告)号：US20130122079A1
公开(公告)日：2013-05-16
申请号：US13811343
申请日：2011-07-19
CPC分类号： A61K9/7061 , A61K31/165 , A61K31/27 , A61L24/06 , C08F220/18 , C08F2220/1858 , C09J4/06 , C09J133/08 , C09J133/10 , C08F218/08 , C08F220/56
摘要： A stable transdermal adhesive composition comprising: an adhesive comprising a washed polymerization reaction product of at least two ethylenically unsaturated monomers; and at least one pharmaceutically active compound which is susceptible to oxidative degradation; wherein the at least two ethylenically unsaturated monomers, if present in the adhesive as unreacted monomers, are present at a level of less than 200 ppm of total unreacted monomer, based upon the total weight of the adhesive, methods of making the composition, a transdermal drug delivery device using the composition, methods of making the device, and methods of delivery the pharmaceutically active compound are provided.
摘要翻译： 一种稳定的透皮粘合剂组合物，其包含：粘合剂，其包含至少两种烯属不饱和单体的洗涤聚合反应产物; 和至少一种易于氧化降解的药学活性化合物; 其中所述至少两种烯键式不饱和单体如果作为未反应单体存在于所述粘合剂中，基于所述粘合剂的总重量，低于总共未反应单体的200ppm的水平存在，制备所述组合物的方法，经皮 提供了使用该组合物的药物递送装置，制备该装置的方法和递送药学活性化合物的方法。
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