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公开(公告)号：US20090186059A1
公开(公告)日：2009-07-23
申请号：US12353792
申请日：2009-01-14
IPC分类号： A61K31/7088 , A61K9/00
CPC分类号： A61L31/043 , A61L27/227 , A61L27/34 , A61L27/50 , A61L27/54 , A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/258 , A61L2300/606
摘要： Embodiments of the invention include devices and methods for the controlled elution of nucleic acid delivery complexes. In an embodiment, the invention includes a method of making a medical device. The method can include complexing nucleic acids with a carrier agent to form a delivery complex solution, applying the delivery complex solution to a substrate, and applying a polymeric solution to the substrate. In another embodiment, the invention includes a method of making a medical device including complexing nucleic acids with a carrier agent to form nucleic acid delivery complexes, combining the nucleic acid delivery complexes with a polymer solution and a cross-linking agent, wherein the cross-linking agent is positively charged or charge neutral. In an embodiment, the invention includes an implantable medical device including a substrate and a coating disposed on a surface of the substrate, the coating comprising a polymeric matrix and a plurality of disperse nucleic acid delivery complexes disposed within the polymeric matrix. Other embodiments are included herein.
摘要翻译： 本发明的实施方案包括用于核酸递送复合物的受控洗脱的装置和方法。 在一个实施例中，本发明包括制造医疗装置的方法。 该方法可以包括使核酸与载体剂复合以形成递送复合物溶液，将递送复合物溶液施用于底物，以及将聚合物溶液施加到基底上。 在另一个实施方案中，本发明包括制备医疗装置的方法，所述方法包括使载体剂与络合核酸形成核酸递送复合物，将核酸递送复合物与聚合物溶液和交联剂结合， 连接剂带正电或电荷中性。 在一个实施方案中，本发明包括可植入医疗装置，其包括基底和设置在基底表面上的涂层，所述涂层包含聚合物基质和设置在聚合物基质内的多个分散核酸递送复合物。 本文还包括其它实施例。
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公开(公告)号：US20100008966A1
公开(公告)日：2010-01-14
申请号：US12502473
申请日：2009-07-14
IPC分类号： A61K9/14 , A61K31/7088 , A61K9/00 , A61K31/7105 , A61P35/00
CPC分类号： A61L27/54 , A61K48/0041 , A61L27/34 , A61L2300/258 , A61L2300/606
摘要： Embodiments of the invention include devices for the release of nucleic acids and related methods. In an embodiment, the invention includes an active agent eluting coating including a polymeric matrix, a cationic carrier agent disposed with the matrix, and an active agent disposed within the matrix, the active agent including nucleic acids substantially uncomplexed with the cationic carrier agent. In an embodiment, the invention includes a method of making an implantable medical device including selecting a concentration of a cationic carrier agent corresponding to a desired elution profile, combining a matrix forming polymer, an active agent, a solvent, and the cationic carrier agent to form a coating composition having the selected concentration of the cationic carrier agent, the active agent comprising nucleic acids, and depositing the coating composition onto the surface of a substrate. Other embodiments are included herein.
摘要翻译： 本发明的实施方案包括用于释放核酸的装置和相关方法。 在一个实施方案中，本发明包括活性剂洗脱涂层，其包括聚合物基质，与基质一起布置的阳离子载体剂和置于基质内的活性剂，所述活性剂包括与阳离子载体试剂基本上未络合的核酸。 在一个实施方案中，本发明包括制备可植入医疗装置的方法，包括选择对应于所需洗脱曲线的阳离子载体试剂的浓度，将形成基质的聚合物，活性剂，溶剂和阳离子载体试剂组合到 形成具有选定浓度的阳离子载体试剂，活性剂包含核酸并将该涂料组合物沉积在基材表面上的涂料组合物。 本文还包括其它实施例。
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3.发明申请DELIVERY OF NUCLEIC ACID COMPLEXES FROM MATERIALS INCLUDING NEGATIVELY CHARGED GROUPS 审中-公开从材料中提取核酸复合物，包括负价值的组合公开(公告)号：US20090263449A1
公开(公告)日：2009-10-22
申请号：US12421285
申请日：2009-04-09
IPC分类号： A61F2/00 , A61K31/7088
CPC分类号： A61L27/54 , A61L27/34 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/258 , A61L2300/606 , A61L2300/802
摘要： Embodiments of the invention include devices and methods for the controlled elution of nucleic acid delivery complexes. In an embodiment, the invention includes a medical device including a substrate surface, a polymeric coating disposed on the surface, the polymeric coating coupled to the substrate surface through the reaction product of a photoreactive group; the polymeric coating comprising negatively charged species on the surface; and a plurality of nucleic acid delivery complexes disposed on the polymeric coating, the nucleic acid delivery complexes comprising a nucleic acid and a cationic carrier agent complexed to the nucleic acid. Other embodiments are included herein.
摘要翻译： 本发明的实施方案包括用于核酸递送复合物的受控洗脱的装置和方法。 在一个实施方案中，本发明包括医疗装置，其包括基底表面，设置在表面上的聚合物涂层，通过光反应基团的反应产物连接到基底表面的聚合物涂层; 聚合物涂层在表面上包含带负电荷的物质; 以及设置在所述聚合物涂层上的多个核酸递送复合物，所述核酸递送复合物包含核酸和与所述核酸复合的阳离子载体试剂。 本文还包括其它实施例。
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4.发明授权公开(公告)号：US08883208B2
公开(公告)日：2014-11-11
申请号：US12756632
申请日：2010-04-08
IPC分类号： A61L27/48 , A61K9/50 , A61L17/00 , A61L29/12 , C12N15/89 , A61K9/16 , A61K48/00 , A61L31/12 , A61L17/12 , A61L27/54 , A61L31/16 , A61L29/14 , A61K9/00
CPC分类号： A61K9/1641 , A61K9/0024 , A61K9/1647 , A61K9/5084 , A61K48/0041 , A61L17/005 , A61L17/12 , A61L27/48 , A61L27/54 , A61L29/126 , A61L29/148 , A61L31/129 , A61L31/16 , A61L2300/258 , A61L2300/62 , C12N15/89 , C08L67/04
摘要： Embodiments of the invention include devices and methods for the release of nucleic acid complexes. In an embodiment the invention includes a nucleic acid delivery particle. The delivery particle can include a polymeric matrix including a polyethyleneglycol containing copolymer and a nucleic acid complex disposed within the polymeric matrix. The nucleic acid complex can include a nucleic acid and a carrier agent. In an embodiment the invention includes a medical device including a first polymeric matrix comprising a first polymer and a plurality of nucleic acid delivery particles disposed within the first polymeric matrix. The medical device can be configured to release the nucleic acid complex when the medical device is implanted within a subject. Other embodiments are included herein.
摘要翻译： 本发明的实施方案包括用于释放核酸复合物的装置和方法。 在一个实施方案中，本发明包括核酸递送颗粒。 递送颗粒可以包括聚合物基质，其包含含聚乙二醇的共聚物和设置在聚合物基质内的核酸复合物。 核酸复合物可以包括核酸和载体试剂。 在一个实施方案中，本发明包括医疗装置，其包括第一聚合物基质，其包含第一聚合物和设置在第一聚合物基质内的多个核酸递送颗粒。 医疗装置可被配置为当将医疗装置植入受试者内时释放核酸复合物。 本文还包括其它实施例。
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公开(公告)号：US20110319473A1
公开(公告)日：2011-12-29
申请号：US13171171
申请日：2011-06-28
IPC分类号： A61K31/713 , C07H21/02
CPC分类号： A61K9/19 , A61K9/1272 , A61K9/1647 , A61K9/1652 , A61K47/36 , A61K48/0041 , C12N15/88
摘要： Embodiments of the invention include devices and methods for delivery of nucleic acids as active agents. Embodiments of the invention include devices and methods for delivery of nucleic acids as active agents. In an embodiment, an article for delivering an active agent is included. The article can include a dehydrated complex including a nucleic acid, a transfection agent, and a saccharide protectant. The nucleic acid and transfection agent can form a liposome or a lipoplex. The dehydrated complex can be disposed within a polymeric matrix. The dehydrated complex can be disposed within a microparticle. Other embodiments are also included herein.
摘要翻译： 本发明的实施方案包括用于递送核酸作为活性剂的装置和方法。 本发明的实施方案包括用于递送核酸作为活性剂的装置和方法。 在一个实施例中，包括用于递送活性剂的物品。 该制品可以包括脱水复合物，其包括核酸，转染剂和糖类保护剂。 核酸和转染剂可形成脂质体或脂质体。 脱水复合物可以设置在聚合物基质内。 脱水复合物可以设置在微粒内。 本文还包括其它实施例。
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6.发明申请公开(公告)号：US20100260846A1
公开(公告)日：2010-10-14
申请号：US12756632
申请日：2010-04-08
IPC分类号： A61K9/14 , A61K31/7088 , A61K47/48 , B05D7/00
CPC分类号： A61K9/1641 , A61K9/0024 , A61K9/1647 , A61K9/5084 , A61K48/0041 , A61L17/005 , A61L17/12 , A61L27/48 , A61L27/54 , A61L29/126 , A61L29/148 , A61L31/129 , A61L31/16 , A61L2300/258 , A61L2300/62 , C12N15/89 , C08L67/04
摘要： Embodiments of the invention include devices and methods for the release of nucleic acid complexes. In an embodiment the invention includes a nucleic acid delivery particle. The delivery particle can include a polymeric matrix including a polyethyleneglycol containing copolymer and a nucleic acid complex disposed within the polymeric matrix. The nucleic acid complex can include a nucleic acid and a carrier agent. In an embodiment the invention includes a medical device including a first polymeric matrix comprising a first polymer and a plurality of nucleic acid delivery particles disposed within the first polymeric matrix. The medical device can be configured to release the nucleic acid complex when the medical device is implanted within a subject. Other embodiments are included herein.
摘要翻译： 本发明的实施方案包括用于释放核酸复合物的装置和方法。 在一个实施方案中，本发明包括核酸递送颗粒。 递送颗粒可以包括聚合物基质，其包含含聚乙二醇的共聚物和设置在聚合物基质内的核酸复合物。 核酸复合物可以包括核酸和载体试剂。 在一个实施方案中，本发明包括医疗装置，其包括第一聚合物基质，其包含第一聚合物和设置在第一聚合物基质内的多个核酸递送颗粒。 医疗装置可被配置为当将医疗装置植入受试者内时释放核酸复合物。 本文还包括其它实施例。
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7.发明授权公开(公告)号：US08936811B2
公开(公告)日：2015-01-20
申请号：US12437287
申请日：2009-05-07
IPC分类号： A61K9/14 , A61K31/7052 , A61P43/00
CPC分类号： A61K9/1641 , A61K9/0024 , A61K9/1623 , A61K9/1652 , A61K9/1658 , A61K47/543 , A61K47/58 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/61 , A61K47/6921 , A61K47/6923 , A61K47/6957 , A61K48/00 , C12N15/87
摘要： Embodiments of the invention include particles with nucleic acid complexes, medical devices including the same and related methods. In an embodiment, the invention can include a method of making a medical device. The method can include contacting nucleic acids with cationic carrier agents to form nucleic acid complexes, adsorbing the nucleic acid complexes to porous particles to form nucleic acid complex containing particles, mixing the nucleic acid complex containing particles with a polymer solution to form a coating mixture, and applying the coating mixture to a substrate. In an embodiment, the method can include contacting nucleic acids with cationic carrier agents to form nucleic acid complexes, combining the nucleic acid complexes with a material to form nucleic acid complex containing particles in situ, mixing the nucleic acid complex particles with a polymer solution to form a coating mixture, and applying the coating mixture to a substrate. In an embodiment, the invention can include an implantable medical device including a substrate, an elution control matrix disposed on the substrate; a plurality of particles disposed within the elution control matrix, and a plurality of nucleic acid complexes disposed within the particles, the nucleic acid complexes comprising a nucleic acid and a cationic carrier agent. Other embodiments are included herein.
摘要翻译： 本发明的实施方案包括具有核酸复合物的颗粒，包括相同方法的医疗装置。 在一个实施例中，本发明可以包括制造医疗装置的方法。 该方法可以包括使核酸与阳离子载体接触以形成核酸复合物，将核酸复合物吸附到多孔颗粒上以形成含有核酸复合物的颗粒，将含有核酸复合物的颗粒与聚合物溶液混合以形成涂层混合物， 并将涂覆混合物施加到基底上。 在一个实施方案中，该方法可以包括使核酸与阳离子载体试剂接触以形成核酸复合物，将核酸复合物与材料组合以形成原位含有颗粒的核酸复合物，将核酸复合物颗粒与聚合物溶液混合 形成涂料混合物，并将涂料混合物施加到基材上。 在一个实施例中，本发明可以包括可植入医疗装置，其包括基底，设置在基底上的洗脱控制矩阵; 布置在洗脱控制基质内的多个颗粒，以及设置在颗粒内的多个核酸复合物，所述核酸复合物包含核酸和阳离子载体试剂。 本文还包括其它实施例。
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