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    Vaccine Composition Comprising An Antigen And A Peptide Having Adjuvant Properties
    1.
    发明申请
    Vaccine Composition Comprising An Antigen And A Peptide Having Adjuvant Properties 有权
    包含抗原和具有佐剂性质的肽的疫苗组合物

    公开(公告)号：US20090123486A1

    公开(公告)日：2009-05-14

    申请号：US12124785

    申请日：2008-05-21

    申请人： Jorg Fritz ,  Frank Mattner ,  Wolfgang Zauner ,  Eszter Nagy ,  Michael Buschle

    发明人： Jorg Fritz ,  Frank Mattner ,  Wolfgang Zauner ,  Eszter Nagy ,  Michael Buschle

    IPC分类号： A61K39/00 ,  A61K39/39

    CPC分类号： C07K7/06 ,  A61K39/0011 ,  A61K39/39 ,  A61K2039/55516 ,  Y02A50/412

    摘要： The invention relates to a vaccine which comprises at least one antigen and a peptide comprising a sequence R1-XZXZNXZX-R2, whereby N is a whole number between 3 and 7, preferably 5, X is a positively charged natural and/or non-natural amino acid residue, Z is an amino acid residue selected from the group consisting of L, V, I, F and/or W, and R1 and R2 are selected independently one from the other from the  group consisting of —H, —NH2, —COCH3, —COH, a peptide with up to 20 amino acid residues or a peptide reactive group or a peptide linker with or without a peptide; X-R2 may also be an amide, ester or thioester of the C-terminal amino acid residue, as well as the use of said peptide for enhancing a patient's adaptive immune response to an antigen.

    摘要翻译： 本发明涉及包含至少一种抗原和包含序列R1-XZXZNXZX-R2的肽的疫苗，其中N为3至7之间的整数，优选5，X为带正电荷的天然和/或非天然 氨基酸残基，Z是选自L，V，I，F和/或W的氨基酸残基，R 1和R 2彼此独立地选自-H，-NH 2， -COCH 3，-COH，具有多达20个氨基酸残基的肽或肽反应性基团或具有或不具有肽的肽接头; X-R2也可以是C末端氨基酸残基的酰胺，酯或硫酯，以及所述肽用于增强患者对抗原的适应性免疫应答的用途。

    Vaccine composition
    2.
    发明申请
    Vaccine composition 有权
    疫苗组成

    公开(公告)号：US20050063978A1

    公开(公告)日：2005-03-24

    申请号：US10399442

    申请日：2001-10-18

    申请人： Jorg Fritz ,  Frank Mattner ,  Wolfgang Zauner ,  Eszter Nagy ,  Michael Buschle

    发明人： Jorg Fritz ,  Frank Mattner ,  Wolfgang Zauner ,  Eszter Nagy ,  Michael Buschle

    IPC分类号： A61K38/00 ,  A61K39/00 ,  A61K39/39 ,  A61P37/04 ,  A61K39/38

    CPC分类号： C07K7/06 ,  A61K39/0011 ,  A61K39/39 ,  A61K2039/55516 ,  Y02A50/412

    摘要： The invention relates to a vaccine which comprises at least one antigen and a peptide comprising a sequence R1—XZXZNXZX—R2, whereby N is a whole number between 3 and 7, preferably 5, x is a positively charged natural and/or non-natural amino acid residue, Z is an amino acid residue selected from the group consisting of L, V, I, F and/or W, and R1 and R2 are selected independantly one from the other from the group consisting of —H, —NH2, —COCH3, —COH, a peptide with up to 20 amino acid residues or a peptide reactive group or a peptide linker with or without a peptide; X—R2 may also be an amide, ester or thioester of the C-terminal amino acid residue, as well as the use of said peptide for the preparation of an adjuvant for enhancing the immune response to at least one antigen.

    摘要翻译： 本发明涉及包含至少一种抗原和包含序列R1-XZXZNXZX-R2的肽的疫苗，其中N为3至7之间的整数，优选为5，x为带正电荷的天然和/或非天然 氨基酸残基，Z是选自L，V，I，F和/或W的氨基酸残基，R 1和R 2独立地选自-H，-NH 2， -COCH 3，-COH，具有多达20个氨基酸残基的肽或肽反应性基团或具有或不具有肽的肽接头; X-R2也可以是C末端氨基酸残基的酰胺，酯或硫酯，以及所述肽用于制备用于增强对至少一种抗原的免疫应答的佐剂的用途。