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公开(公告)号：US20060134690A1
公开(公告)日：2006-06-22
申请号：US10520883
申请日：2003-07-02
申请人： Jorg Peters , Torsten Minuth , Hans-Georg Dellweg
发明人： Jorg Peters , Torsten Minuth , Hans-Georg Dellweg
IPC分类号： G01N33/53
CPC分类号： G01N33/6869 , C07K14/5406 , G01N2333/5406
摘要： This invention relates generally to a method for purifying Interleukin-4 or related variants from an Escherichia coli culture medium, where Interleukin-4 and its derivatives are expressed as insoluble protein aggregates, so-called inclusion bodies.
摘要翻译： 本发明一般涉及从大肠杆菌培养基中纯化白介素-4或相关变体的方法，其中白细胞介素-4及其衍生物被表达为不溶性蛋白质聚集体，即所谓的包涵体。
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2.发明申请Devices and Methods for Utilizing Mechanical Surgical Devices in a Virtual Environment 有权在虚拟环境中利用机械手术装置的装置和方法公开(公告)号：US20100291520A1
公开(公告)日：2010-11-18
申请号：US12446587
申请日：2007-11-03
IPC分类号： G09B23/28
CPC分类号： A61B17/0469 , A61B17/0491 , A61B34/76 , A61B2017/00371
摘要： Devices and methods that combine an actual surgical instrument handle, for example the handle of an AutoSuture EndoStitch™ device, with a force feedback generator able to create resistance to motion similar to that encountered in a real operating environment. The devices and methods provide a means for repeatedly performing maneuvers that accurately simulate the actual instrument, but in a virtual environment. The devices have haptic capabilities and collision detection so that the virtual device, such as the needle driver of the EndoStitch™ device, is “aware” of instrument contact.
摘要翻译： 将实际手术器械手柄（例如AutoSuture EndoStitch™装置的手柄）与能够产生类似于在实际操作环境中遇到的运动的抵抗力的力反馈发生器组合的装置和方法。 这些设备和方法提供了重复执行准确模拟实际仪器但在虚拟环境中的操纵的手段。 这些设备具有触觉功能和碰撞检测功能，因此虚拟设备（如EndoStitch™设备的针头驱动程序）能够“察觉”仪器接触。
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公开(公告)号：US5744746A
公开(公告)日：1998-04-28
申请号：US566819
申请日：1990-07-12
CPC分类号： F42B12/18
摘要： A tandem warhead for combatting actively armored targets including two shaped or projectile forming charges arranged one behind the other, and an ignition or firing delay unit which causes the ignition of the first charge and then the second charge with a time delay. To avoid the target's active armor plate (which moves when hit by the first charge, from impeding or even destroying the following charge) the tandem warhead is provided with a device for determining the actual angle of the warhead relative to the target, i.e., the firing or attack angle, and an ignition time delay .DELTA.t associated with the respective firing angle .alpha.. To determine the firing angle .alpha., an angle determining device includes a plurality, preferably four, distance measuring devices with which respective distance coordinates between the tandem warhead and the target are measured and used for determining the momentary firing angle .alpha.. Thereafter, the delay time .DELTA.t is determined with the aid of a characteristic curve .DELTA.t=f (.alpha.) which is specific for the particular warhead.
摘要翻译： 一种用于对付主动装甲目标的串联弹头，包括一个彼此排列的两个形状或射弹形成电荷，以及点火或点火延迟单元，其引起第一次充电的点火，然后延迟第二次充电。 为了避免目标的主动装甲板（当第一次起飞时起作用，从妨碍或甚至破坏下列装置），串联弹头设有用于确定弹头相对于目标的实际角度的装置，即 点火或攻角，以及与各自的触发角α相关联的点火时间延迟DELTA t。 为了确定触发角度α，角度确定装置包括多个，优选四个距离测量装置，测量串联弹头和目标之间的相应距离坐标，并用于确定瞬时触发角α。 此后，借助于特定弹头特有的特征曲线DELTA t = f（α）来确定延迟时间DELTA t。
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4.发明授权
公开(公告)号：US4797985A
公开(公告)日：1989-01-17
申请号：US927556
申请日：1986-11-06
申请人： Jurgen Prochnow , Jorg Peters , Ulrich Theis , Klaus D. Karius
发明人： Jurgen Prochnow , Jorg Peters , Ulrich Theis , Klaus D. Karius
CPC分类号： F42B14/02 , C23C4/02 , C23C4/129 , Y10T29/479 , Y10T29/49982
摘要： A method of applying a metallic guide band to the body of a projectile having particularly thin walls comprises making fine particles plastically deformable by heating thereof, and spraying said heated particles at high speed onto a surface section of the projectile body until a desired layer thickness of the guide band is attained. A projectile body having a circumferential guide band is produced by the method of the invention. The thin-walled projectile body has a boundary layer region on its exterior which may be roughened and/or deoxidized. The boundary layer region is formed by an intermediate layer which may be composed of molybdenum, nickel aluminide or nickel oxide and itself has a roughened boundary layer region on its exterior. This results in a particularly intimate physical bond with the particles of alloy of the guide band. The alloy is preferably of a CuZn85/15 type and has a porosity of up to 5 volume percent.
摘要翻译： 将金属引导带施加到具有特别薄壁的射弹的主体的方法包括通过加热使微细颗粒塑性变形，并将所述加热的颗粒高速喷射到射弹体的表面部分上，直到所需的层厚度 引导带达到。 通过本发明的方法制造具有周向引导带的射弹体。 薄壁射弹体在其外部具有可以被粗糙化和/或脱氧的边界层区域。 边界层区域由可由钼，镍铝化物或氧化镍构成的中间层形成，其外部本身具有粗糙化的边界层区域。 这导致与引导带的合金颗粒的特别亲密的物理结合。 该合金优选为CuZn85 / 15型，并且具有高达5体积％的孔隙率。
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5.发明授权Devices and methods for implementing endoscopic surgical procedures and instruments within a virtual environment 有权在虚拟环境中实现内窥镜外科手术和器械的设备和方法公开(公告)号：US08956165B2
公开(公告)日：2015-02-17
申请号：US12864340
申请日：2009-01-26
申请人： Sergei Kurenov , Juan C. Cendan , Jorg Peters , Thomas M. Beaver , Sukitti Punak , William Cance , Kfir Ben-David
发明人： Sergei Kurenov , Juan C. Cendan , Jorg Peters , Thomas M. Beaver , Sukitti Punak , William Cance , Kfir Ben-David
CPC分类号： G09B23/285
摘要： Devices and methods are provided for combining the handle of a surgical instrument with a force feedback generator, able to create resistance to motion similar to that encountered in a real operating environment. The working end of the surgical instrument is recreated in a virtual environment and manipulated by the modified handle through the force feedback generator. Actions of the instrument handle modify a model and display of the virtual environment and transmit a haptic response back to the handle. The devices and methods provide a means for repeatedly performing maneuvers that accurately simulate the actual instrument, but in the virtual environment. The virtual environment is modeled to accurately simulate the use of the instrument including manipulation of and collisions with other virtual objects, such as surgical thread or internal tissues. Training and assessment tools are also provided that coach or assess a user's proficiency with the instrument.
摘要翻译： 提供的装置和方法用于将手术器械的手柄与力反馈发生器组合，能够产生类似于在实际操作环境中遇到的运动的阻力。 手术器械的工作端在虚拟环境中重新创建，并通过力反馈发生器由改进的手柄操纵。 仪器句柄的动作修改模型并显示虚拟环境，并将触觉响应发送回句柄。 这些设备和方法提供了重复执行准确模拟实际仪器但在虚拟环境中的机动的手段。 虚拟环境被建模以准确地模拟仪器的使用，包括与其他虚拟对象（例如外科手术线或内部组织）的操纵和碰撞。 还提供培训和评估工具，指导或评估用户对仪器的熟练程度。
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公开(公告)号：US5181673A
公开(公告)日：1993-01-26
申请号：US795852
申请日：1991-11-22
CPC分类号： F41G7/32 , F41G7/008 , F41G7/2206 , F41G7/2253 , F41G7/2293
摘要： An anti-tank missile system includes a weapons carrier system with a missile including control means for controlling the missile flight path and a searchhead camera for developing target data during flight of the missile. An elevatable platform is mounted on the weapons carrier system and a sighting device camera is disposed on the elevatable platform for sighting a target. Target data is compiled before a launch of the missile with the aid of the sighting device camera. A fire guidance computer in the weapons carrier system calculates a flight course for the missile. A light waveguide is connected between the missile and the weapons carrier system for transmitting target data developed by the searchhead camera for use by the fire guidance computer and for transmitting guidance signals generated by the fire guidance computer for controlling the control means for guiding the missile during its flight; and wherein the sighting device camera is a high resolution camera and the searchhead camera has at least one of a lower resolution and different spectral range than the sighting device camera.
摘要翻译： 反坦克导弹系统包括具有导弹的武器载体系统，包括用于控制导弹飞行路径的控制装置和用于在导弹飞行期间开发目标数据的搜索头照相机。 可升降平台安装在武器载体系统上，瞄准装置摄像机设置在升降平台上用于瞄准目标。 目标数据是在瞄准装置摄像机的帮助下发射导弹之前编制的。 武器载体系统中的消防导弹计算机计算导弹飞行进程。 导弹与武器载体系统之间连接有一个光波导，用于发射由搜索头摄像机开发的目标数据，以供消防导弹计算机使用，并发射由消防导弹计算机产生的引导信号，以控制导弹导弹的控制装置 飞行 并且其中所述瞄准装置相机是高分辨率相机，并且所述搜索头相机具有比所述瞄准装置相机更低分辨率和不同光谱范围中的至少一个。
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7.发明授权Devices and methods for utilizing mechanical surgical devices in a virtual environment 有权在虚拟环境中利用机械手术装置的装置和方法公开(公告)号：US08834170B2
公开(公告)日：2014-09-16
申请号：US12446587
申请日：2007-11-03
IPC分类号： G09B23/28
CPC分类号： A61B17/0469 , A61B17/0491 , A61B34/76 , A61B2017/00371
摘要： Devices and methods that combine an actual surgical instrument handle, for example the handle of an AutoSuture EndoStitch™ device, with a force feedback generator able to create resistance to motion similar to that encountered in a real operating environment. The devices and methods provide a means for repeatedly performing maneuvers that accurately simulate the actual instrument, but in a virtual environment. The devices have haptic capabilities and collision detection so that the virtual device, such as the needle driver of the EndoStitch™ device, is “aware” of instrument contact.
摘要翻译： 将实际手术器械手柄（例如AutoSuture EndoStitch™装置的手柄）与能够产生类似于在实际操作环境中遇到的运动的抵抗力的力反馈发生器组合的装置和方法。 这些设备和方法提供了重复执行准确模拟实际仪器但在虚拟环境中的操纵的手段。 这些设备具有触觉功能和碰撞检测功能，因此虚拟设备（如EndoStitch™设备的针头驱动程序）能够“察觉”仪器接触。
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8.发明申请DEVICES AND METHODS FOR IMPLEMENTING ENDOSCOPIC SURGICAL PROCEDURES AND INSTRUMENTS WITHIN A VIRTUAL ENVIRONMENT 有权在虚拟环境中实施内窥镜手术程序和仪器的装置和方法公开(公告)号：US20110014596A1
公开(公告)日：2011-01-20
申请号：US12864340
申请日：2009-01-26
申请人： Sergei Kurenov , Juan C. Cendan , Jorg Peters , Thomas M. Beaver , Sukiti Punak , William Cance , Kfir Ben-David
发明人： Sergei Kurenov , Juan C. Cendan , Jorg Peters , Thomas M. Beaver , Sukiti Punak , William Cance , Kfir Ben-David
IPC分类号： G09B23/28
CPC分类号： G09B23/285
摘要： Devices and methods are provided for combining the handle of a surgical instrument with a force feedback generator, able to create resistance to motion similar to that encountered in a real operating environment. The working end of the surgical instrument is recreated in a virtual environment and manipulated by the modified handle through the force feedback generator. Actions of the instrument handle modify a model and display of the virtual environment and transmit a haptic response back to the handle. The devices and methods provide a means for repeatedly performing maneuvers that accurately simulate the actual instrument, but in the virtual environment. The virtual environment is modeled to accurately simulate the use of the instrument including manipulation of and collisions with other virtual objects, such as surgical thread or internal tissues. Training and assessment tools are also provided that coach or assess a user's proficiency with the instrument.
摘要翻译： 提供的装置和方法用于将手术器械的手柄与力反馈发生器组合，能够产生类似于在实际操作环境中遇到的运动的阻力。 手术器械的工作端在虚拟环境中重新创建，并通过力反馈发生器由改进的手柄操纵。 仪器句柄的动作修改模型并显示虚拟环境，并将触觉响应发送回句柄。 这些设备和方法提供了重复执行准确模拟实际仪器但在虚拟环境中的机动的手段。 虚拟环境被建模以准确地模拟仪器的使用，包括与其他虚拟对象（例如外科手术线或内部组织）的操纵和碰撞。 还提供培训和评估工具，指导或评估用户对仪器的熟练程度。
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9.发明授权
公开(公告)号：US5523223A
公开(公告)日：1996-06-04
申请号：US284600
申请日：1994-08-11
申请人： Maria-Regina Kula , Jorg Peters
发明人： Maria-Regina Kula , Jorg Peters
IPC分类号： C12N9/02 , C12N9/04 , C12P7/00 , C12P7/62 , C12P41/00 , C12R1/01 , C12R1/38 , C12R1/72 , C12P7/26
CPC分类号： C12N9/0006 , C12P7/62 , Y10S435/921
摘要： A keto ester reductase capable of being used in an NADH-dependent enzymatic reaction for converting .beta., .gamma. and .delta. ketonic acid esters into the corresponding optically active .beta., .gamma. and .delta. hydroxycarboxylic acid esters can be isolated from strains of Candida parapsilosis, Yarrowinia cellobiosa, Rhodococcus erythropolis or Pseudomonas acidovorans, preferably cultivated on a long -chain alkane and/or alkane acid-containing culture medium, approximately in the presence of an inductor. The microorganism is preferrably, Candida parapsilosis DSM 70125. A usable enzyme preparation can be recovered by fractionated PEG-precipitation from the cell raw extract: high specific activities (for example 1855 U/mg) may then be obtained by chromatographic purification. The keto ester reductase is characterized as having a molecular weight of 136 kDa+11 kDa as determined by gel permeation chromatography on Sephadex G-200, a pH optimum for conversion of the keto ester to the hydroxy acid esters between pH 7.8 and 8.0 and for the reverse reaction of converting the acid esters to the keto esters at a pH optimum of 9.5, and a temperature optimum between 36.degree. and 40.degree. C. for conversion of the keto esters to the hydroxy acid esters and from 50.degree. to 56.degree. C. for the reverse reaction of converting the acid esters to the keto esters. Not only (possibly substituted) so-called ketonic esters are accepted, but also number of other oxo-compounds among which diketones, (possibly substituted, in particular halogenated) aliphatic alicyclic and aromatic ketones, as well as ketoacetals and aldehydes. The S-enantiomer-forming reduction is supplemented by the possibility to recover R-enantiomers from racemates by oxidizing the S-enantiomer and separating the oxo-compound.
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10.发明授权Signal transmitting steering cable including optical fiber with fluorescent dye 失效信号发射转向电缆，其中包括具有荧光染料的光纤
公开(公告)号：US5111524A
公开(公告)日：1992-05-05
申请号：US736643
申请日：1991-07-26
CPC分类号： F41G7/32
摘要： A signal transmitting steering cable (4, 40, 40') for remotely-controlled flying bodies (1) which, once the flying body (1) has been launched, can be located and disposed of easily. For this purpose the surface layer (44, 46) of the steering cable (4) includes a material which is fluorescent when illuminated with light of a predetermined wavelength range. Preferably, a dye whose emission spectrum lies approximately between 530 and 690 nm is employed as the fluorescent material.
摘要翻译： 用于远程控制的飞行体（1）的信号传递转向电缆（4,40,40'），一旦飞行体（1）被启动，可以容易地定位和处理。 为此，转向电缆（4）的表面层（44,46）包括当用预定波长范围的光照射时是荧光的材料。 优选使用其发射光谱位于530和690nm之间的染料作为荧光材料。
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