利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

7 条记录 (耗时 0.034 秒)

    Antibodies to phosphorylated tau aggregates
    1.
    发明授权
    Antibodies to phosphorylated tau aggregates 有权
    磷酸化tau聚集体的抗体

    公开(公告)号：US09447179B2

    公开(公告)日：2016-09-20

    申请号：US14232659

    申请日：2012-07-16

    申请人： Joris Winderickx ,  Eugeen Vanmechelen ,  Fred Van Leuven

    发明人： Joris Winderickx ,  Eugeen Vanmechelen ,  Fred Van Leuven

    IPC分类号： C07K16/18 ,  A61K47/48 ,  C07K14/47 ,  G01N33/566

    CPC分类号： C07K16/18 ,  C07K14/4711 ,  C07K2317/56 ,  C07K2317/565 ,  G01N33/566

    摘要： This invention concerns affinity tools for oligomeric forms of tau protein. It relates to the field of neurodegeneration, more particularly to the field of tau-related diseases and tauopathy. The invention provides novel tau antibodies and antibody fragments, nucleic acids encoding such antibodies and antibody fragments, cell lines producing such antibodies and antibody fragments, antibody compositions, and kits for the detection of aggregated tau and for the diagnosis of diseases involving aggregated tau. The invention further provides methods for the detection of aggregated tau, for the diagnosis of diseases involving aggregated tau, and for the identification of compositions interfering with the formation and/or stability of tau aggregates.

    摘要翻译： 本发明涉及tau蛋白的寡聚形式的亲和力工具。 它涉及到神经退行性疾病，特别是与tau相关疾病和tau病变的领域。 本发明提供了新颖的tau抗体和抗体片段，编码此类抗体和抗体片段的核酸，产生此类抗体的细胞系和抗体片段，抗体组合物和用于检测聚集的tau和用于诊断涉及聚集的tau的疾病的试剂盒。 本发明还提供了用于检测聚集的tau的方法，用于诊断涉及聚集的tau的疾病，以及用于鉴定干扰tau聚集体的形成和/或稳定性的组合物。

    ANTIBODIES TO PHOSPHORYLATED TAU AGGREGATES
    2.
    发明申请
    ANTIBODIES TO PHOSPHORYLATED TAU AGGREGATES 有权
    抗菌剂对磷酸化聚集体的影响

    公开(公告)号：US20140161875A1

    公开(公告)日：2014-06-12

    申请号：US14232659

    申请日：2012-07-16

    申请人： Joris Winderickx ,  Eugeen Vanmachelen ,  Fred Van Leuven

    发明人： Joris Winderickx ,  Eugeen Vanmachelen ,  Fred Van Leuven

    IPC分类号： C07K16/18 ,  C07K14/47 ,  G01N33/566 ,  A61K47/48

    CPC分类号： C07K16/18 ,  C07K14/4711 ,  C07K2317/56 ,  C07K2317/565 ,  G01N33/566

    摘要： This invention concerns affinity tools for oligomeric forms of tau protein. It relates to the field of neurodegeneration, more particularly to the field of tau-related diseases and tauopathy. The invention provides novel tau antibodies and antibody fragments, nucleic acids encoding such antibodies and antibody fragments, cell lines producing such antibodies and antibody fragments, antibody compositions, and kits for the detection of aggregated tau and for the diagnosis of diseases involving aggregated tau. The invention further provides methods for the detection of aggregated tau, for the diagnosis of diseases involving aggregated tau, and for the identification of compositions interfering with the formation and/or stability of tau aggregates.

    摘要翻译： 本发明涉及tau蛋白的寡聚形式的亲和力工具。 它涉及到神经退行性疾病，特别是与tau相关疾病和tau病变的领域。 本发明提供了新颖的tau抗体和抗体片段，编码此类抗体和抗体片段的核酸，产生此类抗体的细胞系和抗体片段，抗体组合物和用于检测聚集的tau和用于诊断涉及聚集的tau的疾病的试剂盒。 本发明还提供了用于检测聚集的tau的方法，用于诊断涉及聚集的tau的疾病，以及用于鉴定干扰tau聚集体的形成和/或稳定性的组合物。