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1.发明申请Nanobodies Tm Against Amyloid-Beta and Polypeptides Comprising the Same for the Treatment of Degenerative Neural Diseases Such as Alzheimer's Disease 审中-公开纳米抗体Tm对抗淀粉样蛋白β和多肽，包括治疗退行性神经疾病如阿尔茨海默病公开(公告)号：US20080107601A1
公开(公告)日：2008-05-08
申请号：US11665356
申请日：2005-10-13
CPC分类号： C07K16/28 , A61K2039/505 , C07K2317/22 , C07K2317/31 , C07K2317/569
摘要： The present invention relates to anti-A-beta polypeptides comprising at least one Nanobody, or a functional fragment thereof, directed against A-beta, for the treatment of diseases or disorders mediated by A-beta or dysfunction thereof, or mediated by amyloid plaque formation.
摘要翻译： 本发明涉及包含针对A-β的至少一种纳米抗体或其功能片段的抗A-β多肽，用于治疗由A-β或其功能障碍介导的或由淀粉样蛋白斑介导的疾病或病症 形成。
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2.发明申请Methods, compositions and compound assays for inhibiting amyloid-beta protein production 审中-公开用于抑制淀粉样蛋白β蛋白生产的方法，组合物和化合物测定法公开(公告)号：US20050287121A1
公开(公告)日：2005-12-29
申请号：US11127622
申请日：2005-05-12
IPC分类号： A61K48/00 , C12Q1/00 , C12Q1/25 , C12Q1/48 , C12Q1/68 , G01N20060101 , G01N33/53 , G01N33/567 , G01N33/68 , G01N33/74
CPC分类号： C12Q1/37 , A61K48/00 , C12Q1/25 , C12Q1/485 , G01N33/6896 , G01N33/74 , G01N2333/4709 , G01N2333/726 , G01N2333/9015 , G01N2500/00 , G01N2500/02 , G01N2500/04 , G01N2800/2821
摘要： A method for identifying compounds that inhibit aberrant amyloid-beta precursor protein processing in cells, comprising contacting a test compound with a LIGASE polypeptide, or fragment thereof, and measuring a compound-LIGASE property related to the production of amyloid-beta peptide. Cellular assays of the method measure amyloid beta peptide levels. Therapeutic methods, and pharmaceutical compositions including effective amyloid-beta precursor processing-inhibiting amounts of LIGASE DNA expression agents or LIGASE agonists, are useful for treating conditions involving cognitive impairment such as Alzheimers Disease.
摘要翻译： 一种用于鉴定抑制细胞中异常淀粉样蛋白β前体蛋白加工的化合物的方法，包括使测试化合物与LIGASE多肽或其片段接触，并测量与淀粉状蛋白-β肽的生产相关的化合物-LIGASE性质。 该方法的细胞测定法测量淀粉样β肽水平。 包括有效的淀粉样蛋白β前体加工抑制量的LIGASE DNA表达剂或LIGASE激动剂的治疗方法和药物组合物可用于治疗涉及认知障碍的疾病如阿尔茨海默病。
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公开(公告)号：US08614308B2
公开(公告)日：2013-12-24
申请号：US13617248
申请日：2012-09-14
申请人： John E. Park , Cornelia Dorner-Ciossek , Stefan Hoerer , Lothar Kussmaul , Martin Lenter , Katharina Zimmermann , Gerald Beste , Toon Laeremans , Pascal Merchiers , Jo Vercammen
发明人： John E. Park , Cornelia Dorner-Ciossek , Stefan Hoerer , Lothar Kussmaul , Martin Lenter , Katharina Zimmermann , Gerald Beste , Toon Laeremans , Pascal Merchiers , Jo Vercammen
CPC分类号： A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/18 , C07K16/28 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/40 , C07K2317/55 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： The invention relates to biparatopic A-beta binding polypeptides and, more specifically, to biparatopic A-beta binding polypeptides comprising at least two immunoglobulin single variable domains binding to different epitopes of A-beta. The invention also relates to specific sequences of such polypeptides, methods of their production, and methods of using them, including methods of treatment of diseases such as Alzheimer's Disease.
摘要翻译： 本发明涉及双互补位A-β结合多肽，更具体地涉及包含结合至A-β的不同表位的至少两个免疫球蛋白单可变结构域的双互补位A-β结合多肽。 本发明还涉及这种多肽的具体序列，其生产方法及其使用方法，包括治疗疾病如阿尔茨海默病的方法。
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公开(公告)号：US08337845B2
公开(公告)日：2012-12-25
申请号：US13038471
申请日：2011-03-02
申请人： John E. Park , Cornelia Dorner-Ciossek , Stefan Hoerer , Lothar Kussmaul , Martin Lenter , Katharina Zimmermann , Gerald Beste , Toon Laeremans , Pascal Merchiers , Jo Vercammen
发明人： John E. Park , Cornelia Dorner-Ciossek , Stefan Hoerer , Lothar Kussmaul , Martin Lenter , Katharina Zimmermann , Gerald Beste , Toon Laeremans , Pascal Merchiers , Jo Vercammen
IPC分类号： A61K39/395 , C07K16/18
CPC分类号： A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/18 , C07K16/28 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/40 , C07K2317/55 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： The invention relates to biparatopic A-beta binding polypeptides and, more specifically, to biparatopic A-beta binding polypeptides comprising at least two immunoglobulin single variable domains binding to different epitopes of A-beta. The invention also relates to specific sequences of such polypeptides, methods of their production, and methods of using them, including methods of treatment of diseases such as Alzheimer's Disease.
摘要翻译： 本发明涉及双互补位A-β结合多肽，更具体地涉及包含结合至A-β的不同表位的至少两个免疫球蛋白单可变结构域的双互补位A-β结合多肽。 本发明还涉及这种多肽的具体序列，其生产方法及其使用方法，包括治疗疾病如阿尔茨海默病的方法。
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5.发明申请Methods, compositions and compound assays for inhibiting amyloid-beta protein production 审中-公开用于抑制淀粉样蛋白β蛋白生产的方法，组合物和化合物测定法公开(公告)号：US20060281699A1
公开(公告)日：2006-12-14
申请号：US11127581
申请日：2005-05-12
IPC分类号： A61K48/00 , A61K31/165 , C40B30/06 , C40B40/08
CPC分类号： C12Q1/37 , A61K48/00 , C12Q1/25 , C12Q1/485 , G01N33/6896 , G01N33/74 , G01N2333/4709 , G01N2333/726 , G01N2333/9015 , G01N2500/00 , G01N2500/02 , G01N2500/04 , G01N2800/2821
摘要： A method for identifying compounds that inhibit amyloid-beta precursor protein processing in cells, comprising contacting a test compound with a PROTEASE polypeptide, or fragment thereof, and measuring a compound-PROTEASE property related to the production of amyloid-beta peptide. Cellular assays of the method measure indicators including cleaved protease substrate and/or amyloid beta peptide levels. Therapeutic methods, and pharmaceutical compositions including effective amyloid-beta precursor processing-inhibiting amounts of PROTEASE expression inhibitors, are useful for treating conditions involving cognitive impairment such as Alzheimer's disease.
摘要翻译： 用于鉴定抑制细胞中淀粉样蛋白β前体蛋白加工的化合物的方法，包括使测试化合物与PROTEASE多肽或其片段接触，并测量与淀粉状蛋白-β肽的产生相关的化合物-TETEASE性质。 所述方法的细胞测定测量指标，包括切割的蛋白酶底物和/或淀粉样蛋白β肽水平。 包括有效淀粉样蛋白β前体加工抑制量的PROTEASE表达抑制剂的治疗方法和药物组合物可用于治疗涉及认知障碍的症状如阿尔茨海默病。
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6.发明申请Methods, compositions and compound assays for inhibiting amyloid-beta protein production 审中-公开用于抑制淀粉样蛋白β蛋白生产的方法，组合物和化合物测定法公开(公告)号：US20050277612A1
公开(公告)日：2005-12-15
申请号：US11110011
申请日：2005-04-20
CPC分类号： C12N15/1137 , C12N2310/111 , C12N2310/14 , C12N2799/022 , C12Q1/485 , C12Y207/01091 , G01N33/6896 , G01N2500/04 , G01N2500/10
摘要： A method for identifying compounds that inhibit amyloid-beta precursor protein processing in cells, comprising contacting a test compound with a SPHK polypeptide, or fragment thereof, and measuring a compound-SPHK property related to the production of amyloid-beta peptide. Cellular assays of the method measure indicators including phosphorylated kinase substrate and/or amyloid beta peptide levels. Therapeutic methods, and pharmaceutical compositions including effective amyloid-beta precursor processing-inhibiting amounts of SPHK expression inhibitors, are useful for treating conditions involving cognitive impairment such as Alzheimer's Disease.
摘要翻译： 用于鉴定抑制细胞中淀粉样蛋白β前体蛋白处理的化合物的方法，包括使测试化合物与SPHK多肽或其片段接触，并测量与淀粉状蛋白-β肽的产生相关的化合物-SPHK性质。 所述方法的细胞测定法包括磷酸化激酶底物和/或淀粉状蛋白β肽水平。 包括有效淀粉样蛋白β前体加工抑制量的SPHK表达抑制剂的治疗方法和药物组合物可用于治疗涉及认知障碍的症状如阿尔茨海默病。
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7.发明申请公开(公告)号：US20050287565A1
公开(公告)日：2005-12-29
申请号：US11127877
申请日：2005-05-12
IPC分类号： A61K48/00 , C12Q1/00 , C12Q1/25 , C12Q1/48 , C12Q1/68 , G01N20060101 , G01N33/53 , G01N33/567 , G01N33/68 , G01N33/74
CPC分类号： C12Q1/37 , A61K48/00 , C12Q1/25 , C12Q1/485 , G01N33/6896 , G01N33/74 , G01N2333/4709 , G01N2333/726 , G01N2333/9015 , G01N2500/00 , G01N2500/02 , G01N2500/04 , G01N2800/2821
摘要： A method for identifying compounds that inhibit amyloid-beta precursor protein processing in cells, comprising contacting a test compound with a GPCR polypeptide, or fragment thereof, and measuring a compound-GPCR property related to the production of amyloid-beta peptide. Cellular assays of the method measure indicators including second messenger and/or amyloid beta peptide levels. Therapeutic methods, and pharmaceutical compositions including effective amyloid-beta precursor processing-inhibiting amounts of GPCR expression inhibitors, are useful for treating conditions involving cognitive impairment such as Alzheimers Disease.
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8.发明申请Methods, compositions and compound assays for inhibiting amyloid-beta protein production 审中-公开用于抑制淀粉样蛋白β蛋白生产的方法，组合物和化合物测定法公开(公告)号：US20050287519A1
公开(公告)日：2005-12-29
申请号：US11127817
申请日：2005-05-12
IPC分类号： A61K48/00 , C12Q1/00 , C12Q1/25 , C12Q1/48 , C12Q1/68 , G01N20060101 , G01N33/53 , G01N33/567 , G01N33/68 , G01N33/74
CPC分类号： C12Q1/37 , A61K48/00 , C12Q1/25 , C12Q1/485 , G01N33/6896 , G01N33/74 , G01N2333/4709 , G01N2333/726 , G01N2333/9015 , G01N2500/00 , G01N2500/02 , G01N2500/04 , G01N2800/2821
摘要： A method for identifying compounds that inhibit amyloid-beta precursor protein processing in cells, comprising contacting a test compound with a KINASE polypeptide, or fragment thereof, and measuring a compound-KINASE property related to the production of amyloid-beta peptide. Cellular assays of the method measure indicators including phosphorylated kinase substrate and/or amyloid beta peptide levels. Therapeutic methods, and pharmaceutical compositions including effective amyloid-beta precursor processing-inhibiting amounts of KINASE expression inhibitors, are useful for treating conditions involving cognitive impairment such as Alzheimer's disease.
摘要翻译： 一种用于鉴定抑制细胞中淀粉样蛋白β前体蛋白处理的化合物的方法，包括使测试化合物与KINASE多肽或其片段接触，并测量与淀粉状蛋白-β肽的产生相关的化合物 - KINASE性质。 所述方法的细胞测定法包括磷酸化激酶底物和/或淀粉状蛋白β肽水平。 包括有效的淀粉样蛋白β前体加工抑制量的KINASE表达抑制剂的治疗方法和药物组合物可用于治疗涉及认知障碍的症状如阿尔茨海默病。
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9.发明申请Methods, compositions and compound assays for inhibiting amyloid-beta protein production 失效用于抑制淀粉样蛋白β蛋白生产的方法，组合物和化合物测定法公开(公告)号：US20050266502A1
公开(公告)日：2005-12-01
申请号：US11110274
申请日：2005-04-20
IPC分类号： A61K48/00 , A61P25/28 , C12N15/00 , C12Q1/37 , G01N33/53 , G01N33/566 , G01N33/567 , G01N33/68
CPC分类号： C12Q1/37 , G01N33/566 , G01N33/6896 , G01N2333/4709 , G01N2333/726 , G01N2500/00 , G01N2800/2821
摘要： A method for identifying compounds that inhibit amyloid-beta precursor protein processing in cells, comprising contacting a test compound with a GPCR polypeptide, or fragment thereof, and measuring a compound-GPCR property related to the production of amyloid-beta peptide. Cellular assays of the method measure indicators including second messenger and/or amyloid beta peptide levels. Therapeutic methods, and pharmaceutical compositions including effective amyloid-beta precursor processing-inhibiting amounts of GPCR expression inhibitors, are useful for treating conditions involving cognitive impairment such as Alzheimers Disease.
摘要翻译： 鉴定抑制细胞中淀粉样蛋白β前体蛋白加工的化合物的方法，包括使测试化合物与GPCR多肽或其片段接触，并测量与淀粉状蛋白-β肽的产生相关的化合物-GPCR性质。 该方法的细胞测定法测量包括第二信使和/或淀粉样蛋白β肽水平的指标。 包括有效的淀粉样蛋白-β前体加工抑制量的GPCR表达抑制剂的治疗方法和药物组合物可用于治疗涉及认知障碍的疾病如阿尔茨海默病。
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