专利检索 ap:("Jose R. F. Corvalan" OR "Xiao-Chi Jia" OR "Xiao Feng" OR "Xiao-dong Yang" OR "Francine Chen" OR "Gadi Gazit" OR "Richard Weber" OR "Binyam Bezabeh") AND inv:"Xiao Feng" 第 1 页

1.

发明授权
Antibodies directed to PDGFD and uses thereof 有权

公开(公告)号：US07135174B2

公开(公告)日：2006-11-14

申请号：US10041860

申请日：2002-01-07

申请人： Jose R. F. Corvalan , Xiao-Chi Jia , Xiao Feng , Xiao-dong Yang , Francine Chen , Gadi Gazit , Richard Weber , Binyam Bezabeh

发明人： Jose R. F. Corvalan , Xiao-Chi Jia , Xiao Feng , Xiao-dong Yang , Francine Chen , Gadi Gazit , Richard Weber , Binyam Bezabeh

IPC分类号： A61K39/395 , C07K16/22

CPC分类号： C07K16/22 , C07K2317/21 , C07K2317/56

摘要： The present invention is related to antibodies directed to the antigen PDGFD and uses of such antibodies. In particular, in accordance with the present invention, there are provided fully human monoclonal antibodies directed to the antigen PDGFD. Nucelotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.

2.

发明申请
Antibodies directed to PDGFD and uses thereof 审中-公开

公开(公告)号：US20060293506A1

公开(公告)日：2006-12-28

申请号：US11109181

申请日：2005-04-18

申请人： Jose Corvalan , Xiao-Chi Jia , Xiao Feng , Xiao-dong Yang , Francine Chen , Gadi Gazit , Richard Weber , Binyam Bezabeh

发明人： Jose Corvalan , Xiao-Chi Jia , Xiao Feng , Xiao-dong Yang , Francine Chen , Gadi Gazit , Richard Weber , Binyam Bezabeh

IPC分类号： C07K16/22

CPC分类号： C07K16/22 , C07K2317/21 , C07K2317/56

摘要： The present invention is related to antibodies directed to the antigen PDGFD and uses of such antibodies. In particular, in accordance with the present invention, there are provided fully human monoclonal antibodies directed to the antigen PDGFD. Nucelotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.

3.

发明申请
ANTIBODIES DIRECTED TO THE DELETION MUTANTS OF EPIDERMAL GROWTH FACTOR RECEPTOR AND USES THEREOF 有权

公开(公告)号：US20090155282A1

公开(公告)日：2009-06-18

申请号：US12268352

申请日：2008-11-10

申请人： Richard Weber , Xiao Feng , Orit Foord , Larry Green , Jean M. Gudas , Bruce Keyt , Ying Liu , Palaniswami Rathanaswami , Robert Raya , Xiao Dong Yang , Jose Corvalan , Ian Foltz , Xiao-Chi Jia , Jaspal S. Kang , Chadwick T. King , Scott L. Klakamp , Qiaojuan Jane Su

发明人： Richard Weber , Xiao Feng , Orit Foord , Larry Green , Jean M. Gudas , Bruce Keyt , Ying Liu , Palaniswami Rathanaswami , Robert Raya , Xiao Dong Yang , Jose Corvalan , Ian Foltz , Xiao-Chi Jia , Jaspal S. Kang , Chadwick T. King , Scott L. Klakamp , Qiaojuan Jane Su

IPC分类号： A61K39/395 , C12N5/02 , C07H21/04

CPC分类号： C07K16/30 , A61K47/6803 , A61K47/6849 , A61K47/6897 , A61K2039/505 , B82Y5/00 , C07K16/2863 , C07K2317/21 , C07K2317/34 , C07K2317/77 , C07K2317/92 , Y10S435/81

摘要： The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.

4.

发明授权
Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof 有权

公开(公告)号：US10118968B2

公开(公告)日：2018-11-06

申请号：US12649179

申请日：2009-12-29

申请人： Richard Weber , Xiao Feng , Orit Foord , Larry Green , Jean M. Gudas , Bruce Keyt , Ying Liu , Palaniswami Rathanaswami , Robert Raya , Xiao Dong Yang , Jose Corvalan , Ian Foltz , Xiao-Chi Jia , Jaspal S. Kang , Chadwick T. King , Scott L. Klakamp , Qiaojuan Jane Su

发明人： Richard Weber , Xiao Feng , Orit Foord , Larry Green , Jean M. Gudas , Bruce Keyt , Ying Liu , Palaniswami Rathanaswami , Robert Raya , Xiao Dong Yang , Jose Corvalan , Ian Foltz , Xiao-Chi Jia , Jaspal S. Kang , Chadwick T. King , Scott L. Klakamp , Qiaojuan Jane Su

IPC分类号： A61K47/48 , C07K16/28 , C12P21/08 , A61K39/395 , C07K16/30 , B82Y5/00 , A61K39/00

摘要： The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.

5.

发明授权
Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof 有权
标题翻译：针对表皮生长因子受体的缺失突变体的抗体及其用途

公开(公告)号：US07736644B2

公开(公告)日：2010-06-15

申请号：US10877774

申请日：2004-06-25

申请人： Richard Weber , Xiao Feng , Orit Foord , Larry Green , Jean M. Gudas , Bruce Keyt , Ying Liu , Palaniswami Rathanaswami , Robert Raya , Xiao Dong Yang , Jose Corvalan , Ian Foltz , Xiao-Chi Jia , Jaspal S. Kang , Chadwick T. King , Scott L. Klakamp , Qiaojuan Jane Su

发明人： Richard Weber , Xiao Feng , Orit Foord , Larry Green , Jean M. Gudas , Bruce Keyt , Ying Liu , Palaniswami Rathanaswami , Robert Raya , Xiao Dong Yang , Jose Corvalan , Ian Foltz , Xiao-Chi Jia , Jaspal S. Kang , Chadwick T. King , Scott L. Klakamp , Qiaojuan Jane Su

IPC分类号： A61K39/00 , A61K39/395 , C07K16/00 , C07K16/18 , C07K16/28 , C12P21/08

CPC分类号： C07K16/30 , A61K47/6803 , A61K47/6849 , A61K47/6897 , A61K2039/505 , B82Y5/00 , C07K16/2863 , C07K2317/21 , C07K2317/34 , C07K2317/77 , C07K2317/92 , Y10S435/81

摘要： The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.

摘要翻译： 本发明涉及新型抗体，特别是针对表皮生长因子受体的缺失突变体的抗体，特别涉及III型缺失突变体EGFRvIII的抗体。本发明还涉及针对表皮生长因子受体，特别是EGFRvIII的缺失突变体的人单克隆抗体。还提供了这种抗体的诊断和治疗制剂及其免疫偶联物。

6.

发明授权
Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof 有权
标题翻译：针对表皮生长因子受体的缺失突变体的抗体及其用途

公开(公告)号：US07628986B2

公开(公告)日：2009-12-08

申请号：US10877773

申请日：2004-06-25

申请人： Richard Weber , Xiao Feng , Orit Foord , Larry Green , Jean M. Gudas , Bruce Keyt , Ying Liu , Palaniswami Rathanaswami , Robert Raya , Xiao Dong Yang , Jose Corvalan , Ian Foltz , Xiao-Chi Jia , Jaspal S. Kang , Chadwick T. King , Scott L. Klakamp , Qiaojuan Jane Su

发明人： Richard Weber , Xiao Feng , Orit Foord , Larry Green , Jean M. Gudas , Bruce Keyt , Ying Liu , Palaniswami Rathanaswami , Robert Raya , Xiao Dong Yang , Jose Corvalan , Ian Foltz , Xiao-Chi Jia , Jaspal S. Kang , Chadwick T. King , Scott L. Klakamp , Qiaojuan Jane Su

IPC分类号： A61K39/00 , A61K39/395 , C07K16/00 , C07K16/18 , C07K16/28 , C12P21/08

CPC分类号： C07K16/30 , A61K47/6803 , A61K47/6849 , A61K47/6897 , A61K2039/505 , B82Y5/00 , C07K16/2863 , C07K2317/21 , C07K2317/34 , C07K2317/77 , C07K2317/92 , Y10S435/81

摘要： The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.

摘要翻译： 本发明涉及新型抗体，特别是针对表皮生长因子受体的缺失突变体的抗体，特别涉及III型缺失突变体EGFRvIII的抗体。本发明还涉及针对表皮生长因子受体，特别是EGFRvIII的缺失突变体的人单克隆抗体。还提供了这种抗体的诊断和治疗制剂及其免疫偶联物。