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1.发明申请PYRAZOLOANTHRONE AND DERIVATIVES THEREOF FOR TREATMENT OF CANCER AND EXCESS ANDROGEN STATES 有权用于治疗癌症和过敏原状态的吡咯烷酮及其衍生物公开(公告)号：US20120141605A1
公开(公告)日：2012-06-07
申请号：US13328387
申请日：2011-12-16
申请人： Jose Teixeira , Patricia K. Donahoe
发明人： Jose Teixeira , Patricia K. Donahoe
IPC分类号： A61K31/416 , A61P35/00 , A61K38/22 , A61K33/24 , A61K31/704 , A61K31/436
CPC分类号： A61K31/416 , A61K38/22 , C12Q1/6886
摘要： Provided herein are pyrazoloanthrones or functional derivatives or analogues thereof to activate MIS receptor-mediated downstream effects in a cell. In particular, methods are provided to prevent and treat cancer that expresses MIS receptor type II (MISRII) by administering to a subject at least one pyrazoloanthrone or a functional derivative or analogue thereof. Also provided herein are methods to lower plasma androgen levels in a subject, and/or for the treatment of a subject with a disease characterized by excess androgen, whereby the subject is administered at least one pyrazoloanthrone or a functional derivative or analogue thereof. Also provided are methods to decrease the dose of a chemotherapeutic agent by administering the chemotherapeutic agent with a pyrazoloanthrone or a functional derivative or analogue thereof that lowers the effective dose of the chemotherapeutic agent.
摘要翻译： 本文提供吡唑并二酮或其功能衍生物或类似物，以激活细胞中MIS受体介导的下游作用。 特别地，提供了通过向受试者施用至少一种吡唑蓝酮或其功能衍生物或类似物来预防和治疗表达MIS受体II型（MISRII）的癌症的方法。 本文还提供了降低受试者血浆雄激素水平和/或治疗具有以过量雄激素为特征的疾病的受试者的方法，由此给予受试者至少一种吡唑蓝酮或其功能性衍生物或类似物。 还提供了通过使化学治疗剂与降低化疗剂的有效剂量的吡唑蓝酮或其功能衍生物或类似物来降低化学治疗剂的剂量的方法。
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公开(公告)号：US20140194366A1
公开(公告)日：2014-07-10
申请号：US14123551
申请日：2012-06-01
IPC分类号： G01N33/574
CPC分类号： G01N33/57449 , A61K31/416 , G01N33/5073 , G01N2333/70585 , G01N2333/70596 , G01N2800/52
摘要： The present invention generally relates to methods, assays, compositions and kits related to a subpopulation of ovarian cancer stem cells which are selected or enriched by chemotherapeutic agents and inhibited by MIS (Mullerian Inhibiting Substance) and MIS mimetics. In particular, the present invention relates to a population of CD44+/CD24+/EpCam+/ECad− subpopulation of ovarian cancer stem cells. The present invention also provides methods to screen a subject with ovarian cancer to identify if they have an ovarian cancer comprising CD44+/CD24+/EpCam+/ECad− ovarian cancer stem cells, and methods to identify and enrich or isolate for such ovarian cancer cell populations.
摘要翻译： 本发明一般涉及与化学治疗剂选择或富集并被MIS（Mullerian Inhibiting Substance）和MIS模拟物抑制的卵巢癌干细胞亚群相关的方法，测定，组合物和试剂盒。 特别地，本发明涉及卵巢癌干细胞的CD44 + / CD24 + / EpCam + / ECad亚群的群体。 本发明还提供了筛选具有卵巢癌的受试者以鉴定其是否具有包含CD44 + / CD24 + / EpCam + / ECad-卵巢癌干细胞的卵巢癌的方法以及用于鉴定和丰富或分离这些卵巢癌细胞群体的方法。
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3.发明申请PYRAZOLOANTHRONE AND DERIVATIVES THEREOF FOR THE TREATMENT OF CANCER EXPRESSING 'MULLERIAN INHIBITING SUBSTANCE' TYPE II RECEPTOR (MISRII) AND OF EXCESS ANDROGEN STATES 审中-公开用于治疗癌症表现“MULLERIAN抑制物质”II型受体（MISRII）和异常状态的吡哆醇及其衍生物公开(公告)号：US20100233689A1
公开(公告)日：2010-09-16
申请号：US12532533
申请日：2008-03-21
申请人： Jose Teixeira , Patricia K Donahoe
发明人： Jose Teixeira , Patricia K Donahoe
IPC分类号： C12Q1/68
CPC分类号： A61K31/416 , A61K38/22 , C12Q1/6886
摘要： The present invention relates to pyrazoloanthrones or functional derivatives or functional analogues thereof to activate MIS receptor-mediated downstream effects in a cell. In particular, the present invention relates to method to prevent and treat cancer that expresses MIS receptor type II (MISRII) by administering to a subject at least one pyrazoloanthrone or a functional derivative or a functional analogue thereof. Another aspect of the present invention relates to methods to lower plasma androgen levels in a subject, and/or for the treatment of a subject with a disease characterized by excess androgen, whereby the subject is administered at least one pyrazoloanthrone or a functional derivative or a functional analogue thereof. Another aspect provides pharmaceutical compositions comprising at least one pyrazoloanthrone or functional a derivative or a functional analogue thereof, and optionally with one or more additional agents such as chemotherapeutic agents. Another aspect of the present invention relates to methods to decrease the dose of a chemotherapeutic agent by administering the chemotherapeutic agent with a pyrazoloanthrone or a functional derivative or a functional analogue thereof that lowers the effective dose of the chemotherapeutic agent, such as for example, paclitaxel.
摘要翻译： 本发明涉及吡唑并噻唑或其功能衍生物或其功能类似物，以激活细胞中MIS受体介导的下游作用。 特别地，本发明涉及通过向受试者施用至少一种吡唑蓝酮或其功能性衍生物或其功能类似物来预防和治疗表达MIS受体II型（MISRII）的癌症的方法。 本发明的另一方面涉及降低受试者血浆雄激素水平和/或治疗具有以过量雄激素为特征的疾病的受试者的方法，其中受试者施用至少一种吡唑蓝酮或功能性衍生物或 其功能类似物。 另一方面提供药物组合物，其包含至少一种吡唑蓝酮或其功能性衍生物或其功能类似物，以及任选地与一种或多种另外的试剂如化学治疗剂。 本发明的另一方面涉及通过给予化学治疗剂与降低化疗剂的有效剂量的吡唑蓝酮或功能衍生物或其功能类似物来降低化学治疗剂的剂量的方法，所述化学治疗剂例如紫杉醇 。
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4.发明授权Use of Mullerian inhibiting substance for treating excess androgen states 失效使用Mullerian抑制物质治疗过量的雄激素状态公开(公告)号：US06673352B1
公开(公告)日：2004-01-06
申请号：US09662341
申请日：2000-09-14
IPC分类号： A61K3900
摘要： The present invention provides a method of treating a condition or disease characterized by an excess of one or more androgens, the method comprising administering an effective amount of MIS protein or nucleic acid encoding MIS to a patient. The present invention also provides a method of decreasing the level of one or more androgens to a level below the normal level, the method comprising administering an effective amount of MIS protein or nucleic acid encoding MIS to a patient. The methods of the present invention are particularly well-suited for the treatment of prostatic cancer, polycystic ovarian disease, benign prostatic hypertrophy, and precocious puberty.
摘要翻译： 本发明提供一种治疗特征在于过量一种或多种雄激素的病症或疾病的方法，所述方法包括向患者施用有效量的MIS蛋白或编码MIS的核酸。 本发明还提供了将一种或多种雄激素的水平降低到低于正常水平的水平的方法，所述方法包括向患者施用有效量的MIS蛋白或编码MIS的核酸。 本发明的方法特别适用于治疗前列腺癌，多囊卵巢疾病，良性前列腺肥大和早熟性青春期。
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公开(公告)号：US09791449B2
公开(公告)日：2017-10-17
申请号：US14123551
申请日：2012-06-01
IPC分类号： G01N33/574 , A61K31/416 , G01N33/50
CPC分类号： G01N33/57449 , A61K31/416 , G01N33/5073 , G01N2333/70585 , G01N2333/70596 , G01N2800/52
摘要： The present invention generally relates to methods, assays, compositions and kits related to a subpopulation of ovarian cancer stem cells which are selected or enriched by chemotherapeutic agents and inhibited by MIS (Mullerian Inhibiting Substance) and MIS mimetics. In particular, the present invention relates to a population of CD44+/CD24+/EpCam+/ECad− subpopulation of ovarian cancer stem cells. The present invention also provides methods to screen a subject with ovarian cancer to identify if they have an ovarian cancer comprising CD44+/CD24+/EpCam+/ECad− ovarian cancer stem cells, and methods to identify and enrich or isolate for such ovarian cancer cell populations.
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6.发明授权Pyrazoloanthrone and derivatives thereof for the treatment of cancers expressing MISRII 有权吡唑烷酮及其衍生物，用于治疗表达MISRII的癌症公开(公告)号：US09260759B2
公开(公告)日：2016-02-16
申请号：US13328387
申请日：2011-12-16
申请人： Jose Teixeira , Patricia K. Donahoe
发明人： Jose Teixeira , Patricia K. Donahoe
IPC分类号： A61K38/00 , A61K31/415 , A01N59/00 , C12Q1/68
CPC分类号： A61K31/416 , A61K38/22 , C12Q1/6886
摘要： Provided herein are pyrazoloanthrones or functional derivatives or analogs thereof to activate MIS receptor-mediated downstream effects in a cell. In particular, methods are provided to prevent and treat cancer that expresses MIS receptor type II (MISRII) by administering to a subject at least one pyrazoloanthrone or a functional derivative or analog thereof. Also provided herein are methods to lower plasma androgen levels in a subject, and/or for the treatment of a subject with a disease characterized by excess androgen, whereby the subject is administered at least one pyrazoloanthrone or a functional derivative or analog thereof. Also provided are methods to decrease the dose of a chemotherapeutic agent by administering the chemotherapeutic agent with a pyrazoloanthrone or a functional derivative or analog thereof that lowers the effective dose of the chemotherapeutic agent.
摘要翻译： 本文提供吡唑并二酮或其功能衍生物或类似物，以激活细胞中MIS受体介导的下游作用。 特别地，提供了通过向受试者施用至少一种吡唑蓝酮或其功能衍生物或类似物来预防和治疗表达MIS受体II型（MISRII）的癌症的方法。 本文还提供了降低受试者血浆雄激素水平和/或治疗具有以过量雄激素为特征的疾病的受试者的方法，由此给予受试者至少一种吡唑蓝酮或其功能性衍生物或类似物。 还提供了通过使化学治疗剂与降低化学治疗剂的有效剂量的吡唑蓝酮或其功能性衍生物或类似物来降低化学治疗剂的剂量的方法。
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公开(公告)号：US20080257606A1
公开(公告)日：2008-10-23
申请号：US12103480
申请日：2008-04-15
申请人： Jose Teixeira , Dominique Sabina
发明人： Jose Teixeira , Dominique Sabina
IPC分类号： E21B7/08
摘要： A flexible drill shaft for drilling lateral boreholes comprising: a helical outer wire coil spring; and at least one inner helical wire coil spring residing concentrically within the outer coil spring, with the coils of adjacent springs having an opposite pitch; wherein the wire forming each helical spring has a cross section such that when the drill shaft is in a straight alignment there is planar contact between adjacent coils of the spring.
摘要翻译： 一种用于钻出横向钻孔的柔性钻杆轴，包括：螺旋外线螺旋弹簧; 以及至少一个同心地位于外螺旋弹簧内部的内螺旋线螺旋弹簧，相邻弹簧的线圈具有相对的间距; 其中形成每个螺旋弹簧的线具有横截面，使得当钻轴处于直线对准时，在弹簧的相邻线圈之间存在平面接触。
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公开(公告)号：US5361989A
公开(公告)日：1994-11-08
申请号：US134733
申请日：1993-10-12
申请人： Serge Merchat , Jose Teixeira , Gerard Cinquin
发明人： Serge Merchat , Jose Teixeira , Gerard Cinquin
IPC分类号： B05B17/06
CPC分类号： A61M15/0085 , A61M11/005 , B05B17/0615
摘要： A device for generating a mist from a liquid by a vibrating device. The device comprises a chamber which has a bottom wall on which the liquid rests, a side wall and a top wall. The chamber has at least one mist outlet orifice. The device includes a deflector which has a preferably concave or inclined underside at a distance above the bottom of the chamber and at a level lower than that of the top wall of the chamber.
摘要翻译： 一种用于通过振动装置从液体产生雾气的装置。 该装置包括具有液体搁置在其上的底壁的室，侧壁和顶壁。 该腔室具有至少一个雾出口孔。 该装置包括偏转器，该偏转器在腔室底部之上的距离处具有优选地凹入或倾斜的下侧，并且处于比腔室顶壁低的水平面。
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公开(公告)号：US20120041681A1
公开(公告)日：2012-02-16
申请号：US13147617
申请日：2010-02-27
CPC分类号： G01N27/223 , E21B47/102 , G01N33/2823
摘要： A sensor for measuring water fraction in a fluid mixture flowing in a conductive tubing within a borehole. The sensor comprises: an active probe, a reference probe, and an electronic unit. The active probe includes a first electrode and a second electrode isolated from each other by a first insulating layer, the first and second electrodes are preferably in contact with the fluid mixture. The reference probe is formed from an internal wall of the conductive tubing contacting the fluid mixture and isolated from the reference probe by a second insulating layer. The electronic unit is coupled to the first and second electrodes, and to the reference probe, the electronic unit preferably includes a capacitance module for measuring a capacitance between the active probe and the reference probe.
摘要翻译： 用于测量在钻孔内的导电管中流动的流体混合物中的水分的传感器。 该传感器包括：主动探针，参考探针和电子单元。 有源探头包括通过第一绝缘层彼此隔离的第一电极和第二电极，第一和第二电极优选与流体混合物接触。 参考探针由与流体混合物接触的导电管的内壁形成，并通过第二绝缘层与参考探针隔离。 电子单元耦合到第一和第二电极，并且耦合到参考探针，电子单元优选地包括用于测量有源探针和参考探针之间的电容的电容模块。
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公开(公告)号：US07071696B2
公开(公告)日：2006-07-04
申请号：US10480062
申请日：2002-06-12
CPC分类号： E21B17/1035 , E21B47/011 , G01V3/20
摘要： The invention provides a support for measurement means for monitoring and/or studying a fluid reservoir (13) through which at least one well (11) passes, said support comprising: a cylindrical tube (2); and a jacket (3) surrounding said cylindrical tube. According to the invention, said jacket (3) has at least one recess (4, 5) for receiving means (6) for measuring a characteristic representative of said reservoir and/or connection means (7) leading to power supply and measurement-processing means (16). The invention also provides a measurement device for monitoring and/or studying a fluid reservoir (13) through which at least one well (11) passes, said device comprising: power supply and measurement processing means (16); means (6) for measuring a characteristic representative of said reservoir, and connection means (7) connecting said measurement means (6) to said power supply and measurement processing means (16). According to the invention, said device (10) being characterized in that it further comprises at least one support (1) according to any preceding claim, with said measurement means (6) and said connection means (7) being housed in the recesses (4, 5) in the jacket (3) of said support.
摘要翻译： 本发明提供了用于监测和/或研究流体储存器（13）的测量装置的支撑件，至少一个井（11）穿过该储存器，所述支撑件包括：圆柱形管道（2）; 和围绕所述圆柱形管的护套（3）。 根据本发明，所述护套（3）具有用于接收装置（6）的至少一个凹部（4,5），用于测量表示所述储存器和/或连接装置（7）的特征，所述连接装置（7）导致供电和测量处理 手段（16）。 本发明还提供了一种用于监测和/或研究流体储存器（13）的测量装置，至少一个井（11）通过所述测量装置，所述装置包括：电源和测量处理装置; 用于测量所述储存器的特性的装置（6）和将所述测量装置（6）连接到所述电源和测量处理装置（16）的连接装置（7）。 根据本发明，所述装置（10）的特征在于，其还包括至少一个根据前述权利要求中任一项所述的支撑件（1），其中所述测量装置（6）和所述连接装置（7）容纳在所述凹部 4,5）在所述支架的夹套（3）中。
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