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公开(公告)号：US5955583A
公开(公告)日：1999-09-21
申请号：US463949
申请日：1995-06-05
申请人： Joseph A. Beavo , Jackie D. Corbin , Kenneth M. Ferguson , Sharron H. Francis , Ann Kadlecek , Kate Loughney , Linda M. McAllister-Lucas , William K. Sonnenburg , Melissa K. Thomas
发明人： Joseph A. Beavo , Jackie D. Corbin , Kenneth M. Ferguson , Sharron H. Francis , Ann Kadlecek , Kate Loughney , Linda M. McAllister-Lucas , William K. Sonnenburg , Melissa K. Thomas
IPC分类号： C12N15/02 , C07H21/04 , C07K16/40 , C12N1/21 , C12N5/10 , C12N5/12 , C12N9/16 , C12N15/09 , C12N15/55 , C12P21/08 , C12Q1/02 , C12Q1/44 , C12Q1/68 , C12R1/645
CPC分类号： C12N9/16
摘要： The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding, cGMP-specific phosphodiesterase designated cGB-PDE. Antibodies to the cGMP-binding, cGMP-stimulated phosphodiesterase are disclosed. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and methods for identifying compounds which modulate the enzymatic activity of cGB-PDE polypeptides.
摘要翻译： 本发明提供编码cGMP结合，命名为cGB-PDE的cGMP特异性磷酸二酯酶的新型纯化和分离的核苷酸序列。 公开了cGMP结合的抗体，cGMP刺激的磷酸二酯酶。 本发明还提供了用于重组生产cGB-PDE多肽产物的方法和材料以及用于鉴定调节cGB-PDE多肽的酶活性的化合物的方法。
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2.发明授权Cyclic GMP-binding, cyclic GMP-specific phosphodiesterase materials and methods 失效循环GMP结合，循环GMP特异性磷酸二酯酶材料和方法
公开(公告)号：US5702936A
公开(公告)日：1997-12-30
申请号：US250847
申请日：1994-05-27
申请人： Joseph A. Beavo , Jackie D. Corbin , Kenneth M. Ferguson , Sharron H. Francis , Ann Kadlecek , Kate Loughney , Linda M. McAllister-Lucas , William K. Sonnenburg , Melissa K. Thomas
发明人： Joseph A. Beavo , Jackie D. Corbin , Kenneth M. Ferguson , Sharron H. Francis , Ann Kadlecek , Kate Loughney , Linda M. McAllister-Lucas , William K. Sonnenburg , Melissa K. Thomas
IPC分类号： C12N15/02 , C07H21/04 , C07K16/40 , C12N1/21 , C12N5/10 , C12N5/12 , C12N9/16 , C12N15/09 , C12N15/55 , C12P21/08 , C12Q1/02 , C12Q1/44 , C12Q1/68 , C12R1/645
CPC分类号： C12N9/16
摘要： The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding, cGMP-specific phosphodiesterase designated cGB-PDE. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and methods for identifying compounds which modulate the enzymatic activity of cGB-PDE polypeptides.
摘要翻译： 本发明提供编码cGMP结合，命名为cGB-PDE的cGMP特异性磷酸二酯酶的新型纯化和分离的核苷酸序列。 本发明还提供了用于重组生产cGB-PDE多肽产物的方法和材料以及用于鉴定调节cGB-PDE多肽的酶活性的化合物的方法。
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公开(公告)号：US5652131A
公开(公告)日：1997-07-29
申请号：US480547
申请日：1995-06-07
申请人： Joseph A. Beavo , Jackie D. Corbin , Kenneth M. Ferguson , Sharron H. Francis , Ann Kadlecek , Kate Loughney , Linda M. McAllister-Lucas , William K. Sonnenburg , Melissa K. Thomas
发明人： Joseph A. Beavo , Jackie D. Corbin , Kenneth M. Ferguson , Sharron H. Francis , Ann Kadlecek , Kate Loughney , Linda M. McAllister-Lucas , William K. Sonnenburg , Melissa K. Thomas
IPC分类号： C12N15/02 , C07H21/04 , C07K16/40 , C12N1/21 , C12N5/10 , C12N5/12 , C12N9/16 , C12N15/09 , C12N15/55 , C12P21/08 , C12Q1/02 , C12Q1/44 , C12Q1/68 , C12R1/645 , C12N15/63
CPC分类号： C12N9/16
摘要： The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding, cGMP-specific phosphodiesterase designated cGB-PDE. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and methods for identifying compounds which modulate the enzymatic activity of cGB-PDE polypeptides.
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公开(公告)号：US6037119A
公开(公告)日：2000-03-14
申请号：US464410
申请日：1995-06-05
申请人： Joseph A. Beavo , Jackie D. Corbin , Kenneth M. Ferguson , Sharron H. Francis , Ann Kadlecek , Kate Loughney , Linda M. McAllister-Lucas , William K. Sonnenburg , Melissa K. Thomas
发明人： Joseph A. Beavo , Jackie D. Corbin , Kenneth M. Ferguson , Sharron H. Francis , Ann Kadlecek , Kate Loughney , Linda M. McAllister-Lucas , William K. Sonnenburg , Melissa K. Thomas
IPC分类号： C12N15/02 , C07H21/04 , C07K16/40 , C12N1/21 , C12N5/10 , C12N5/12 , C12N9/16 , C12N15/09 , C12N15/55 , C12P21/08 , C12Q1/02 , C12Q1/44 , C12Q1/68 , C12R1/645
CPC分类号： C12N9/16
摘要： The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding, cGMP-specific phosphodiesterase designated cGB-PDE. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and methods for identifying compounds which modulate the enzymatic activity of cGB-PDE polypeptides.
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公开(公告)号：US6015677A
公开(公告)日：2000-01-18
申请号：US139491
申请日：1998-08-25
IPC分类号： C07K14/00 , C07K16/00 , C07K16/40 , C12N1/11 , C12N1/19 , C12N9/16 , C12N15/09 , C12N15/55 , C12Q1/02 , C12Q1/44 , C12R1/865 , G01N33/15 , G01N33/50 , G01N33/53 , C12Q1/68
CPC分类号： G01N33/5091 , C07H21/04 , C07K16/40 , C12N9/16 , C12Q1/025 , C12Q1/44 , G01N33/5008 , G01N33/502 , G01N33/5041 , G01N2333/39
摘要： The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca.sup.2+ /calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
摘要翻译： 本发明涉及编码哺乳动物Ca2 + /钙调素刺激的磷酸二酯酶（CaM-PDEs）和环状GMP刺激的磷酸二酯酶（cGS-PDEs）的新型纯化和分离的核苷酸序列。 还提供了所述核苷酸序列的相应重组表达产物，与其特异性反应的免疫试剂，以及用于鉴定调节这些表达产物的酶活性的化合物的方法。
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6.发明授权Isolated and purified calcium/calmodulin stimulated cyclic nucleotide phosphodiesterases 失效分离和纯化的钙/钙调蛋白刺激的环核苷酸磷酸二酯酶
公开(公告)号：US5776752A
公开(公告)日：1998-07-07
申请号：US479532
申请日：1995-06-07
IPC分类号： C07K14/00 , C07K16/00 , C07K16/40 , C12N1/11 , C12N1/19 , C12N9/16 , C12N15/09 , C12N15/55 , C12Q1/02 , C12Q1/44 , C12R1/865 , G01N33/15 , G01N33/50 , G01N33/53
CPC分类号： G01N33/5091 , C07H21/04 , C07K16/40 , C12N9/16 , C12Q1/025 , C12Q1/44 , G01N33/5008 , G01N33/502 , G01N33/5041 , G01N2333/39
摘要： The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca.sup.2+ /calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
摘要翻译： 本发明涉及编码哺乳动物Ca2 + /钙调素刺激的磷酸二酯酶（CaM-PDEs）和环状GMP刺激的磷酸二酯酶（cGS-PDEs）的新型纯化和分离的核苷酸序列。 还提供了所述核苷酸序列的相应重组表达产物，与其特异性反应的免疫试剂，以及用于鉴定调节这些表达产物的酶活性的化合物的方法。
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公开(公告)号：US07842478B2
公开(公告)日：2010-11-30
申请号：US11501327
申请日：2006-08-09
IPC分类号： C12P21/06
CPC分类号： G01N33/5091 , C07H21/04 , C07K16/40 , C12N9/16 , C12Q1/025 , C12Q1/44 , G01N33/5008 , G01N33/502 , G01N33/5041 , G01N2333/39
摘要： The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca2+/calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
摘要翻译： 本发明涉及编码哺乳动物Ca2 + /钙调素刺激的磷酸二酯酶（CaM-PDEs）和环状GMP刺激的磷酸二酯酶（cGS-PDEs）的新型纯化和分离的核苷酸序列。 还提供了所述核苷酸序列的相应重组表达产物，与其特异性反应的免疫试剂，以及用于鉴定调节这些表达产物的酶活性的化合物的方法。
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公开(公告)号：US5800987A
公开(公告)日：1998-09-01
申请号：US455525
申请日：1995-05-31
IPC分类号： C07K14/00 , C07K16/00 , C07K16/40 , C12N1/11 , C12N1/19 , C12N9/16 , C12N15/09 , C12N15/55 , C12Q1/02 , C12Q1/44 , C12R1/865 , G01N33/15 , G01N33/50 , G01N33/53 , C12Q1/68
CPC分类号： G01N33/5091 , C07H21/04 , C07K16/40 , C12N9/16 , C12Q1/025 , C12Q1/44 , G01N33/5008 , G01N33/502 , G01N33/5041 , G01N2333/39
摘要： The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca.sup.2+ /calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
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公开(公告)号：US5602019A
公开(公告)日：1997-02-11
申请号：US297510
申请日：1994-08-29
IPC分类号： C07K14/00 , C07K16/00 , C07K16/40 , C12N1/11 , C12N1/19 , C12N9/16 , C12N15/09 , C12N15/55 , C12Q1/02 , C12Q1/44 , C12R1/865 , G01N33/15 , G01N33/50 , G01N33/53 , C12N1/16 , C12N15/63
CPC分类号： G01N33/5091 , C07H21/04 , C07K16/40 , C12N9/16 , C12Q1/025 , C12Q1/44 , G01N33/5008 , G01N33/502 , G01N33/5041 , G01N2333/39
摘要： The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca.sup.2+ /calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
摘要翻译： 本发明涉及编码哺乳动物Ca2 + /钙调素刺激的磷酸二酯酶（CaM-PDEs）和环状GMP刺激的磷酸二酯酶（cGS-PDEs）的新型纯化和分离的核苷酸序列。 还提供了所述核苷酸序列的相应重组表达产物，与其特异性反应的免疫试剂，以及用于鉴定调节这些表达产物的酶活性的化合物的方法。
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公开(公告)号：US07122363B2
公开(公告)日：2006-10-17
申请号：US10697894
申请日：2003-10-30
CPC分类号： G01N33/5091 , C07H21/04 , C07K16/40 , C12N9/16 , C12Q1/025 , C12Q1/44 , G01N33/5008 , G01N33/502 , G01N33/5041 , G01N2333/39
摘要： The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca2+/calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
摘要翻译： 本发明涉及编码哺乳动物Ca 2+ /钙调素刺激的磷酸二酯酶（CaM-PDEs）和环状GMP刺激的磷酸二酯酶（cGS-PDEs）的新型纯化和分离的核苷酸序列。 还提供了所述核苷酸序列的相应重组表达产物，与其特异性反应的免疫试剂，以及用于鉴定调节这些表达产物的酶活性的化合物的方法。
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