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公开(公告)号:US08486932B2
公开(公告)日:2013-07-16
申请号:US13333191
申请日:2011-12-21
申请人: Joseph A. Burlison , Shijie Zhang , Weiwen Ying , Dinesh U. Chimmanamada , Minghu Song , Junghyun Chae , Stefan Schweizer
发明人: Joseph A. Burlison , Shijie Zhang , Weiwen Ying , Dinesh U. Chimmanamada , Minghu Song , Junghyun Chae , Stefan Schweizer
IPC分类号: A61K31/41 , C07D249/00
CPC分类号: A61K31/4196 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/635 , A61K45/06 , C07D249/08 , C07D249/10 , C07D249/12 , C07D249/14 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/08 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/10 , C07D409/04 , C07D409/12
摘要: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a pharmaceutical composition comprising such a compound.
摘要翻译: 本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中治疗过度增殖性疾病如癌症的方法,其包括向受试者施用本发明的取代的三唑化合物或 包含这种化合物的药物组合物。
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公开(公告)号:US06352949B1
公开(公告)日:2002-03-05
申请号:US09594601
申请日:2000-06-15
申请人: Peter Willems , Johann-Martin Spaeth , Stefan Schweizer , Andrew Edgar , Luc Struye , Paul Leblans
发明人: Peter Willems , Johann-Martin Spaeth , Stefan Schweizer , Andrew Edgar , Luc Struye , Paul Leblans
IPC分类号: C03C1400
CPC分类号: C03C3/325 , C03C4/087 , C03C10/16 , C09K11/7792
摘要: A glass ceramic material for storing energy of X-rays and releasing said energy by photo-stimulation comprising a fluoride glass matrix containing micro-crystalline particles, said particles having an average particle size, d, so that d
摘要翻译: 一种用于储存X射线能量并通过光刺激释放所述能量的玻璃陶瓷材料,其包含含有微晶颗粒的氟化物玻璃基质,所述颗粒具有平均粒径d,使得d <2μm和所述玻璃陶瓷 在XRD光谱中显示所述玻璃基质的连续光谱和叠加在所述连续光谱上的离散峰。 所述玻璃基质优选含有选自碱离子和碱土离子的锆离子和离子,至少5摩尔%的氟离子被溴化物和/或氯离子代替,并且至少0.01摩尔%的阳离子选自 存在由过渡金属离子,稀土金属离子,In +,Ga +,Tl +和Pb 2+组成的组。
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公开(公告)号:US20100313940A1
公开(公告)日:2010-12-16
申请号:US12677535
申请日:2008-09-09
CPC分类号: H01L31/055 , Y02E10/52
摘要: A solar cell and a method for producing a solar cell are described, comprising at least one photovoltaic layer region (1) which at least partially absorbs photons (6) incident therein, whose photon energy is greater than a minimum photon energy Emin, and releases electrical charge carriers in the form of electron-hole pairs, which are spatially separable within the photovoltaic layer region (1) and can be tapped via at least two electrodes (2), which are electrically connected to the photovoltaic layer region (1), to implement an electrical voltage, and comprising at least one interaction layer (3 and/or 4), which at least partially overlaps the photovoltaic layer region, in which at least a part of the incident photons (6) are subject to an interaction with emission of photons of higher or lower photon energy than that of the incident photons. The invention is distinguished in that the at least one interaction layer (3 and/or 4) has a matrix structure, in which locally delimited areas having optically active material, which has the structure and size of crystalline nanoparticles, are provided and interact with the incident photons (6).
摘要翻译: 描述了太阳能电池和太阳能电池的制造方法,其包括至少部分地吸收光子能量大于最小光子能量Emin的光子(6)至少部分吸收的至少一个光伏层区域(1) 电子 - 空穴对形式的电荷载体,其在光电转换层区域(1)内可在空间上分离,并可通过电连接到光伏层区域(1)的至少两个电极(2)进行抽头, 以实现电压,并且包括至少部分与光伏层区域重叠的至少一个相互作用层(3和/或4),其中至少一部分入射光子(6)经受与 发射比入射光子更高或更低的光子能量的光子。 本发明的区别在于,至少一个相互作用层(3和/或4)具有矩阵结构,其中具有结晶纳米颗粒的结构和尺寸的具有光学活性材料的局部限定区域被提供并与 事件光子(6)。
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公开(公告)号:US08008642B2
公开(公告)日:2011-08-30
申请号:US12156300
申请日:2008-05-30
IPC分类号: G01N23/02
CPC分类号: G01T1/2014 , G01T1/2012
摘要: A computed radiography system including a stimulating light source such as a laser, a photostimulable glass imaging plate (PGIP) substantially transparent to the stimulating light positioned such that the stimulating light impinges the PGIP perpendicularly thereto producing photostimulated luminescence light (PLL), a light collector having a light reflecting inner surface proximate the PGIP for collecting PLL emitted from the PGIP and having a hole or slot therein for admitting stimulating light into the light collector and onto the PGIP. An optical filter in communication with the light collector for blocking stimulating light waves and passing PLL therethrough. A light detector receives PLL from the optical filter and the light collector, mechanism providing relative movement between the PGIP and the stimulating light source, and mechanism including an analog to digital converter for converting the collected and detected PLL to a diagnostic readout. The system is particularly useful in mammography.
摘要翻译: 一种计算机放射摄影系统,包括诸如激光的刺激光源,对刺激光基本上透明的光激光玻璃成像板(PGIP),其被定位成使得刺激光垂直于其激发PGIP产生光刺激的发光光(PLL),光收集器 具有靠近PGIP的光反射内表面,用于收集从PGIP发射的PLL并且在其中具有孔或狭槽,用于将刺激光引入聚光器和PGIP。 与光收集器连通的滤光器,用于阻挡刺激光波并使PLL通过。 光检测器从滤光器和光收集器接收PLL,其提供PGIP和刺激光源之间的相对运动,以及包括用于将收集和检测到的PLL转换为诊断读数的模数转换器的机构。 该系统在乳房X线照相术中特别有用。
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公开(公告)号:US20090078874A1
公开(公告)日:2009-03-26
申请号:US12156300
申请日:2008-05-30
CPC分类号: G01T1/2014 , G01T1/2012
摘要: A computed radiography system including a stimulating light source such as a laser, a photostimulable glass imaging plate (PGIP) substantially transparent to the stimulating light positioned such that the stimulating light impinges the PGIP perpendicularly thereto producing photostimulated luminescence light (PLL), a light collector having a light reflecting inner surface proximate the PGIP for collecting PLL emitted from the PGIP and having a hole or slot therein for admitting stimulating light into the light collector and onto the PGIP. An optical filter in communication with the light collector for blocking stimulating light waves and passing PLL therethrough. A light detector receives PLL from the optical filter and the light collector, mechanism providing relative movement between the PGIP and the stimulating light source, and mechanism including an analog to digital converter for converting the collected and detected PLL to a diagnostic readout. The system is particularly useful in mammography.
摘要翻译: 一种计算机放射摄影系统,包括诸如激光的刺激光源,对刺激光基本上透明的光激光玻璃成像板(PGIP),其被定位成使得刺激光垂直于其激发PGIP产生光刺激的发光光(PLL),光收集器 具有靠近PGIP的光反射内表面,用于收集从PGIP发射的PLL并且在其中具有孔或狭槽,用于将刺激光引入聚光器和PGIP。 与光收集器连通的滤光器,用于阻挡刺激光波并使PLL通过。 光检测器从滤光器和光收集器接收PLL,其提供PGIP和刺激光源之间的相对运动,以及包括用于将收集和检测到的PLL转换为诊断读数的模数转换器的机构。 该系统在乳房X线照相术中特别有用。
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公开(公告)号:US20070102647A1
公开(公告)日:2007-05-10
申请号:US11267056
申请日:2005-11-04
申请人: Jacqueline Johnson , Richard Weber , Stefan Schweizer , Douglas MacFarlane , Peter Newman , Gang Chen
发明人: Jacqueline Johnson , Richard Weber , Stefan Schweizer , Douglas MacFarlane , Peter Newman , Gang Chen
IPC分类号: G01T3/06
CPC分类号: G01T3/06
摘要: A radiation detector having glass emitting photons by scintillation in response to incident neutrons and/or electromagnetic radiation of at least about 1 keV, and a system associated with the glass for detecting the presence of photons emitted by scintillation. The glass ceramic material is a fluoride glass matrix having nanocrystalline particles distributed therein substantially all of which are in a phase that scintillates with average diameters of less than about 100 nm in a fluorozirconate matrix. Various metals are disclosed for the ceramic particles and methods of manufacture are also disclosed.
摘要翻译: 一种辐射检测器,具有通过响应于至少约1keV的入射中子和/或电磁辐射的闪烁而发射光子的玻璃,以及与玻璃相关的系统,用于检测闪烁发射的光子的存在。 玻璃陶瓷材料是具有分布在其中的纳米晶体颗粒的氟化物玻璃基质,其基本上都处于在氟锆酸盐基质中闪烁平均直径小于约100nm的相。 公开了用于陶瓷颗粒的各种金属,并且还公开了制造方法。
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公开(公告)号:US20050233473A1
公开(公告)日:2005-10-20
申请号:US10980597
申请日:2004-11-02
申请人: Ronald Cicero , Jonathan Forman , Peter Kernen , Hongbo Lu , David Quincy , Stefan Schweizer , Peter Wagner
发明人: Ronald Cicero , Jonathan Forman , Peter Kernen , Hongbo Lu , David Quincy , Stefan Schweizer , Peter Wagner
IPC分类号: G01N33/543
CPC分类号: B82Y30/00 , G01N33/54393
摘要: Reagents and a method for making arrays of affinity agents are disclosed. Methods of using the arrays of affinity agents also are disclosed. The arrays are particularly useful for high throughput drug screening and clinical diagnostics applications.
摘要翻译: 公开了试剂和制备亲和剂阵列的方法。 还公开了使用亲和剂阵列的方法。 阵列对于高通量药物筛选和临床诊断应用特别有用。
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