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公开(公告)号：US08299107B2
公开(公告)日：2012-10-30
申请号：US12526491
申请日：2008-02-08
申请人： Dinesh U. Chimmanamada , Joseph A. Burlison , Weiwen Ying , Lijun Sun , Stefan Michael Schweizer , Shijie Zhang , Zachary Demko , David James , Teresa K. Przewloka
发明人： Dinesh U. Chimmanamada , Joseph A. Burlison , Weiwen Ying , Lijun Sun , Stefan Michael Schweizer , Shijie Zhang , Zachary Demko , David James , Teresa K. Przewloka
IPC分类号： A61K31/41 , C07D249/00
CPC分类号： C07D417/14 , C07D249/08 , C07D249/10 , C07D249/12 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/12
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to the use of a substituted triazole compound of the invention, or a composition comprising such a compound in the preparation of a medicament for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof.
摘要翻译： 本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。 本发明还涉及本发明的取代的三唑化合物或包含这种化合物的组合物在制备用于预防或治疗有需要的受试者中的过度增殖性疾病如癌症的药物中的用途。
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公开(公告)号：US20100113447A1
公开(公告)日：2010-05-06
申请号：US12538751
申请日：2009-08-10
申请人： Joseph A. Burlison , Shijie Zhang , Weiwen Ying , Dinesh U. Chimmanamada , Minghu Song , Junghyun Chae , Stefan M. Schweizer
发明人： Joseph A. Burlison , Shijie Zhang , Weiwen Ying , Dinesh U. Chimmanamada , Minghu Song , Junghyun Chae , Stefan M. Schweizer
IPC分类号： A61K31/4196 , C07D403/10 , C07D413/10 , C07D403/14 , C07D249/10 , C12N5/00 , A61P35/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/00 , A61P29/00 , A61P37/00 , A61K31/496 , A61K31/5377
CPC分类号： A61K31/4196 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/635 , A61K45/06 , C07D249/08 , C07D249/10 , C07D249/12 , C07D249/14 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/08 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/10 , C07D409/04 , C07D409/12
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a pharmaceutical composition comprising such a compound.
摘要翻译： 本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物或 包含这种化合物的药物组合物。
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公开(公告)号：US09156836B2
公开(公告)日：2015-10-13
申请号：US12992448
申请日：2009-05-15
申请人： Joseph A. Burlison , Weiwen Ying
发明人： Joseph A. Burlison , Weiwen Ying
IPC分类号： C07D471/04 , C07D487/04
CPC分类号： C07D487/04 , C07D471/04
摘要： The present invention relates to substituted tricyclic triazole compounds and compositions comprising substituted tricyclic triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a compound of the invention, or a composition comprising such a compound.
摘要翻译： 本发明涉及取代的三环三唑化合物和包含取代的三环三唑化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法以及在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明化合物或 包含这种化合物的组合物。
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公开(公告)号：US20120046288A1
公开(公告)日：2012-02-23
申请号：US13001255
申请日：2009-06-26
IPC分类号： A61K31/5377 , C07D295/155 , C07D317/66 , A61P35/00 , C07D405/12 , A61K31/535 , A61K31/36 , A61K31/4525 , C07D413/04 , C07D317/58
CPC分类号： C07C257/22 , C07D213/74 , C07D317/58 , C07D317/66
摘要： The present invention relates to substituted hydrazonamide compounds. The invention further relates to methods of inhibiting the activity of Hsρ90 in a subject in need thereof and methods for treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted hydrazonamide compound of the invention, or a pharmaceutical composition comprising such a compound.
摘要翻译： 本发明涉及取代的酰胺化合物。 本发明还涉及在有需要的受试者中抑制Hs＆gt; 90的活性的方法以及在有需要的受试者中治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的酰胺化合物， 或包含这种化合物的药物组合物。
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公开(公告)号：US08106083B2
公开(公告)日：2012-01-31
申请号：US12538751
申请日：2009-08-10
申请人： Joseph A. Burlison , Shijie Zhang , Weiwen Ying , Dinesh U. Chimmanamada , Minghu Song , Junghyun Chae , Stefan M. Schweizer
发明人： Joseph A. Burlison , Shijie Zhang , Weiwen Ying , Dinesh U. Chimmanamada , Minghu Song , Junghyun Chae , Stefan M. Schweizer
IPC分类号： A61K31/41 , C07D249/00
CPC分类号： A61K31/4196 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/635 , A61K45/06 , C07D249/08 , C07D249/10 , C07D249/12 , C07D249/14 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/08 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/10 , C07D409/04 , C07D409/12
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a pharmaceutical composition comprising such a compound.
摘要翻译： 本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物或 包含这种化合物的药物组合物。
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公开(公告)号：US20110224206A1
公开(公告)日：2011-09-15
申请号：US13057962
申请日：2009-08-07
申请人： Weiwen Ying , Dinesh U. Chimmanamada , Joseph A. Burlison , Shijie Zhang , Minghu Song , Junghyun Chae
发明人： Weiwen Ying , Dinesh U. Chimmanamada , Joseph A. Burlison , Shijie Zhang , Minghu Song , Junghyun Chae
IPC分类号： A61K31/5377 , C07D249/10 , C07D413/14 , C07D401/10 , C12N5/071 , A61K31/4196 , A61K31/4709 , A61P35/00 , A61P31/00 , A61P29/00 , A61P35/02
CPC分类号： C07D249/10 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14
摘要： The present invention relates to substituted pyrrole compounds of formula I and compositions comprising substituted tri-substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a tri-substituted’ triazole compound of the invention, or a pharmaceutical composition comprising such a compound.
摘要翻译： 本发明涉及式I的取代吡咯化合物和包含取代的三取代三唑化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中治疗过度增殖性疾病例如癌症的方法，其包括向受试者施用本发明的三取代的“三唑化合物 ，或包含这种化合物的药物组合物。
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公开(公告)号：US08486932B2
公开(公告)日：2013-07-16
申请号：US13333191
申请日：2011-12-21
申请人： Joseph A. Burlison , Shijie Zhang , Weiwen Ying , Dinesh U. Chimmanamada , Minghu Song , Junghyun Chae , Stefan Schweizer
发明人： Joseph A. Burlison , Shijie Zhang , Weiwen Ying , Dinesh U. Chimmanamada , Minghu Song , Junghyun Chae , Stefan Schweizer
IPC分类号： A61K31/41 , C07D249/00
CPC分类号： A61K31/4196 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/635 , A61K45/06 , C07D249/08 , C07D249/10 , C07D249/12 , C07D249/14 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/08 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/10 , C07D409/04 , C07D409/12
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a pharmaceutical composition comprising such a compound.
摘要翻译： 本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物或 包含这种化合物的药物组合物。
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公开(公告)号：US20120101072A1
公开(公告)日：2012-04-26
申请号：US13333191
申请日：2011-12-21
申请人： Joseph A. Burlison , Shijie Zhang , Weiwen Ying , Dinesh U. Chimmanamada , Minghu Song , Junghyun Chae , Stefan M. Schweizer
发明人： Joseph A. Burlison , Shijie Zhang , Weiwen Ying , Dinesh U. Chimmanamada , Minghu Song , Junghyun Chae , Stefan M. Schweizer
IPC分类号： A61K31/4196 , C07D413/14 , C07D417/14 , C07D405/10 , A61P35/00 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/454 , A61K31/635 , C07D403/10 , C07D413/10
CPC分类号： A61K31/4196 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/635 , A61K45/06 , C07D249/08 , C07D249/10 , C07D249/12 , C07D249/14 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/08 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/10 , C07D409/04 , C07D409/12
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a pharmaceutical composition comprising such a compound.
摘要翻译： 本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物或 包含这种化合物的药物组合物。
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9.发明申请公开(公告)号：US20110152310A1
公开(公告)日：2011-06-23
申请号：US12992448
申请日：2009-05-15
申请人： Joseph A. Burlison , Weiwen Ying
发明人： Joseph A. Burlison , Weiwen Ying
IPC分类号： A61K31/4745 , C07D487/04 , C07D471/04 , A61K31/4196 , A61P35/00
CPC分类号： C07D487/04 , C07D471/04
摘要： The present invention relates to substituted tricyclic triazole compounds and compositions comprising substituted tricyclic triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a compound of the invention, or a composition comprising such a compound.
摘要翻译： 本发明涉及取代的三环三唑化合物和包含取代的三环三唑化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法以及在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明化合物或 包含这种化合物的组合物。
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公开(公告)号：US20110105483A1
公开(公告)日：2011-05-05
申请号：US12526491
申请日：2008-02-08
申请人： Dinesh U. Chimmanamada , Joseph A. Burlison , Weiwen Ying , Lijun Sun , Stefan Michael Schweizer , Shijie Zhang , Zachary Demko , David James , Teresa Przewloka
发明人： Dinesh U. Chimmanamada , Joseph A. Burlison , Weiwen Ying , Lijun Sun , Stefan Michael Schweizer , Shijie Zhang , Zachary Demko , David James , Teresa Przewloka
IPC分类号： A61K31/4196 , C07D403/10 , C07D403/14 , C07D413/10 , C07D413/14 , C07D417/10 , A61K31/506 , A61K31/5377 , A61K31/541 , A61P37/00 , A61P31/10 , A61P7/00
CPC分类号： C07D417/14 , C07D249/08 , C07D249/10 , C07D249/12 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/12
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to the use of a substituted triazole compound of the invention, or a composition comprising such a compound in the preparation of a medicament for preventing or treating hyperprolif erative disorders, such as cancer, in a subject in need thereof.
摘要翻译： 本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。 本发明还涉及本发明的取代的三唑化合物或包含这种化合物的组合物在制备用于预防或治疗有需要的受试者中的多药耐药性疾病如癌症的药物中的用途。
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