公开(公告)号：US08598320B2

公开(公告)日：2013-12-03

申请号：US12739761

申请日：2008-10-27

申请人： Joseph A. Hedrick ,  Frederick James Monsma, Jr. ,  Tatyana Churakova ,  Diane Hollenbaugh

发明人： Joseph A. Hedrick ,  Frederick James Monsma, Jr. ,  Tatyana Churakova ,  Diane Hollenbaugh

IPC分类号： C12P21/08

CPC分类号： C07K16/40 ,  A61K31/397 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76

摘要： The present invention provides compositions and methods for treating disorders of cholesterol and lipid metabolism by administration of an anti-PCSK9 antibody or a peptide inhibitor of PCSK9.

摘要翻译： 本发明提供了通过施用PCSK9的抗PCSK9抗体或肽抑制剂来治疗胆固醇和脂质代谢紊乱的组合物和方法。

公开(公告)号：US07547523B2

公开(公告)日：2009-06-16

申请号：US11620337

申请日：2007-01-05

申请人： Jiang X. Behan ,  Joseph A. Hedrick ,  Thomas M. Laz ,  Frederick James Monsma, Jr. ,  Kelley L. Morse ,  Shelby P. Umland ,  Suke Wang

发明人： Jiang X. Behan ,  Joseph A. Hedrick ,  Thomas M. Laz ,  Frederick James Monsma, Jr. ,  Kelley L. Morse ,  Shelby P. Umland ,  Suke Wang

IPC分类号： G01N33/567 ,  C07K14/705

CPC分类号： G01N33/566 ,  C07K14/723 ,  G01N2333/4719

摘要： The present invention provides an isolated mammalian histamine receptor, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods of making the receptor using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the receptor and are useful for treating medical conditions caused or mediated by histamine. Also provided are screening methods for identifying specific agonists and antagonists of the mammalian histamine receptor.

公开(公告)号：US07872101B1

公开(公告)日：2011-01-18

申请号：US11949306

申请日：2007-12-03

申请人： Suke Wang ,  Frederick James Monsma, Jr. ,  Xiaoxin Yang ,  Eric L. Gustafson ,  Maureen Laverty ,  Elizabeth B. Smith

发明人： Suke Wang ,  Frederick James Monsma, Jr. ,  Xiaoxin Yang ,  Eric L. Gustafson ,  Maureen Laverty ,  Elizabeth B. Smith

IPC分类号： C07K14/00

CPC分类号： C07K14/723

摘要： The invention relates to the use of the interaction between the GPR78 polypeptide or the GPR26 polypeptide and their identified ligands and antagonists as the basis for screening methods for the identification of agents that modulate the activity of these receptors, and for diagnostic and therapeutic purposes. The agents identified by the screening methods of the invention have use in the treatment of GPR78- and/or GPR26-mediated disorders, including, but not limited to, neurological disorders (such as anxiety disorders), metabolic disorders, cardiovascular disorders, hormone-related disorders, vascular disorders and hyperproliferative disorders (such as cancer).

摘要翻译： 本发明涉及GPR78多肽或GPR26多肽及其鉴定的配体和拮抗剂之间的相互作用的用途，作为筛选调节这些受体活性的试剂的筛选方法以及用于诊断和治疗目的的基础。 通过本发明的筛选方法鉴定的药物可用于治疗GPR78和/或GPR26介导的病症，包括但不限于神经系统疾病（例如焦虑症），代谢障碍，心血管疾病，激素 - 相关疾病，血管疾病和过度增殖性疾病（例如癌症）。