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公开(公告)号：US20060222647A1
公开(公告)日：2006-10-05
申请号：US10352534
申请日：2003-01-28
申请人： Joseph Beavo , Jackie Corbin , Kenneth Ferguson , Sharron Francis , Ann Kadlecek , Linda McAllister-Lucas , Kate Loughney , William Sonnenburg , Melissa Thomas , Sergei Rybalkin
发明人： Joseph Beavo , Jackie Corbin , Kenneth Ferguson , Sharron Francis , Ann Kadlecek , Linda McAllister-Lucas , Kate Loughney , William Sonnenburg , Melissa Thomas , Sergei Rybalkin
IPC分类号： A61K48/00 , A61K38/54 , A61K39/395
CPC分类号： C12N9/16
摘要： The present invention provides agents such as agonists, antibodies, antagonists or inhibitors to modulate the activity of PDE5 proteins. These compositions and methods are useful for the diagnosis or treatment of conditions associated with the presence, the deficiency, altered levels, or altered activity of PDE5 proteins.
摘要翻译： 本发明提供了诸如激动剂，抗体，拮抗剂或调节PDE5蛋白活性的抑制剂的药剂。 这些组合物和方法可用于诊断或治疗与PDE5蛋白的存在，缺乏，改变的水平或改变的活性相关的病症。
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2.发明申请公开(公告)号：US20060216809A1
公开(公告)日：2006-09-28
申请号：US11315036
申请日：2005-12-21
申请人： Joseph Beavo , Jackie Corbin , Kenneth Ferguson , Sharron Francis , Ann Kadlecek , Kate Loughney , Linda McAllister-Lucas , William Sonnenburg , Melissa Thomas
发明人： Joseph Beavo , Jackie Corbin , Kenneth Ferguson , Sharron Francis , Ann Kadlecek , Kate Loughney , Linda McAllister-Lucas , William Sonnenburg , Melissa Thomas
CPC分类号： C12N9/16
摘要： The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding, cGMP-specific phosphodiesterase designated cGB-PDE. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and methods for identifying compounds which modulate the enzymatic activity of cGB-PDE polypeptides.
摘要翻译： 本发明提供编码cGMP结合，命名为cGB-PDE的cGMP特异性磷酸二酯酶的新型纯化和分离的核苷酸序列。 本发明还提供了用于重组生产cGB-PDE多肽产物的方法和材料以及用于鉴定调节cGB-PDE多肽的酶活性的化合物的方法。
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3.发明申请Cyclic GMP-binding, cyclic GMP-specific phosphodiesterase materials and methods 审中-公开循环GMP结合，循环GMP特异性磷酸二酯酶材料和方法公开(公告)号：US20050196833A1
公开(公告)日：2005-09-08
申请号：US10353575
申请日：2003-01-28
申请人： Joseph Beavo , Jackie Corbin , Kenneth Ferguson , Sharron Francis , Ann Kadlecek , Linda McAllister-Lucas , Kate Loughney , William Sonnenburg , Melissa Thomas
发明人： Joseph Beavo , Jackie Corbin , Kenneth Ferguson , Sharron Francis , Ann Kadlecek , Linda McAllister-Lucas , Kate Loughney , William Sonnenburg , Melissa Thomas
IPC分类号： C12N15/02 , C07H21/04 , C07K16/40 , C12N1/21 , C12N5/10 , C12N5/12 , C12N9/16 , C12N15/09 , C12N15/55 , C12P21/08 , C12Q1/02 , C12Q1/44 , C12Q1/68 , C12R1/645 , A61K31/519
CPC分类号： C12N9/16
摘要： The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding. cGMP-specific phosphodiesterase designated cGB-PDE. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and methods for identifying compounds which modulate the enzymatic activity of cGB-PDE polypeptides.
摘要翻译： 本发明提供了编码cGMP结合的新型纯化和分离的核苷酸序列。 cGMP特异性磷酸二酯酶命名为cGB-PDE。 本发明还提供了用于重组生产cGB-PDE多肽产物的方法和材料以及用于鉴定调节cGB-PDE多肽的酶活性的化合物的方法。
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公开(公告)号：US20060275871A1
公开(公告)日：2006-12-07
申请号：US11501327
申请日：2006-08-09
CPC分类号： G01N33/5091 , C07H21/04 , C07K16/40 , C12N9/16 , C12Q1/025 , C12Q1/44 , G01N33/5008 , G01N33/502 , G01N33/5041 , G01N2333/39
摘要： The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca2+/calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
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