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    METHOD FOR THE PRODUCTION OF POLY(2-OCTYL CYANOACRYLATE)-POLYISOBUTYLENE CO-NETWORK, AND SUPER INITIATORS THEREFOR
    2.
    发明申请
    METHOD FOR THE PRODUCTION OF POLY(2-OCTYL CYANOACRYLATE)-POLYISOBUTYLENE CO-NETWORK, AND SUPER INITIATORS THEREFOR 有权
    生产聚（2-十八烷基氰基丙烯酸酯） - 聚异丁烯共聚物的方法及其超级发动机

    公开(公告)号：US20170028099A1

    公开(公告)日：2017-02-02

    申请号：US15302744

    申请日：2014-10-21

    申请人： Joseph Kennedy ,  Istvan Szanka ,  Amalia Szanka

    发明人： Joseph Kennedy ,  Istvan Szanka ,  Amalia Szanka

    IPC分类号： A61L24/06 ,  C08G83/00 ,  C08F279/02 ,  C08F22/32

    CPC分类号： A61L24/06 ,  A61L2430/34 ,  C08F22/32 ,  C08F265/08 ,  C08F279/02 ,  C08G83/003

    摘要： A method for increasing the rate of polymerization of 2-octyl cyanoacrylate, or the rate of copolymerization of 2-octyl cyanoacrylate and a tri-telechelic star polymer comprising polyisobutylene terminated with cyanoacrylate groups (Ø(PIB-CA)3) to form a co-network, is provided. The method comprise initiating the polymerization of 2-octyl cyanoacrylate, or the copolymerization of 2-octyl cyanoacrylate and a tri-telechelic star polymer comprising polyisobutylene terminated with cyanoacrylate groups (Ø(PIB-CA)3) to form the co-network, with an initiator selected from the group consisting of cyclic tertiary aliphatic amines optionally dissolved in a non-aqueous solvent. The cyclic tertiary aliphatic amines are selected from the group consisting of azabicyclo[2.2.2]-octane (ABCO), and 1,4-diazabicyclo[2.2.2]-octane (DABCO).

    摘要翻译： 提高氰基丙烯酸2-辛基酯的聚合速率的方法，或氰基丙烯酸2-辛基酯和包含用氰基丙烯酸酯基团（Ø（PIB-CA）3封端的聚异丁烯）的三 - 遥爪星形聚合物的共聚速率，以形成共 - 网络，被提供。 该方法包括引发氰基丙烯酸2-辛酯的聚合，或氰基丙烯酸2-辛基酯和包含用氰基丙烯酸酯基（Ø（PIB-CA）3封端的聚异丁烯）的三脱氧星形聚合物的共聚以形成共网络， 选自任选溶解在非水溶剂中的环状叔脂族胺的引发剂。 环状叔脂族胺选自氮杂双环[2.2.2] - 辛烷（ABCO）和1,4-二氮杂双环[2.2.2] - 辛烷（DABCO）。

    CO-NETWORK OF HIGH AND LOW MOLECULAR WEIGHT 3-ARM STAR CYANOACRYLATE-TELECHELIC POLYISOBUTYLENE AND 2-OCTYL CYANOACRYLATE
    4.
    发明申请
    CO-NETWORK OF HIGH AND LOW MOLECULAR WEIGHT 3-ARM STAR CYANOACRYLATE-TELECHELIC POLYISOBUTYLENE AND 2-OCTYL CYANOACRYLATE 有权

    公开(公告)号：US20170136058A1

    公开(公告)日：2017-05-18

    申请号：US14940735

    申请日：2015-11-13

    申请人： Joseph Kennedy ,  Istvan Szanka ,  Amalia Szanka

    发明人： Joseph Kennedy ,  Istvan Szanka ,  Amalia Szanka

    IPC分类号： A61K31/785 ,  A61K31/275

    CPC分类号： A61K31/785 ,  A61K31/275 ,  A61K2300/00

    摘要： In one or more embodiments, the present invention relates to a substantially homogeneous miscible liquid adhesive composition comprising a relatively high number average molecular weight (Mn=6,000-10,000 g/mole) cyanoacrylate tri-telechelic star polymer having polyisobutylene chains terminated with cyanoacrylate groups (High-Ø(PIB-CA)3); 2-octyl cyanoacrylate (Oct-CA); and a relatively low molecular weight (Mn=1,000-4,000 g/mole) cyanoacrylate tri-telechelic star polymer having polyisobutylene chains terminated with cyanoacrylate groups (Low-Ø(PIB-CA)3). The Low-Ø(PIB-CA)3 compatibilizes the High-Ø(PIB-CA)3 and Oct-CA removing the need for a solvent. When the substantially homogeneous miscible liquid adhesive compositions of various embodiments are reacted with a nucleophile, such as water or an initiator, they form a polymer co-network suitable for any of a number of biomedical applications, from wound closure and healing of skin tissue, to sealant for surgical cuts.

    RUBBERY POLYSILOXANES CARRYING CYANOACRYLATE FUNCTIONS AND RELATED METHODS FOR THEIR PREPARATION AND USES THEREFOR
    7.
    发明申请
    RUBBERY POLYSILOXANES CARRYING CYANOACRYLATE FUNCTIONS AND RELATED METHODS FOR THEIR PREPARATION AND USES THEREFOR 有权
    携带氰基丙烯酸酯官能团的橡胶聚硅氧烷及其制备及其用途的相关方法

    公开(公告)号：US20160215098A1

    公开(公告)日：2016-07-28

    申请号：US15026344

    申请日：2014-10-08

    申请人： Joseph KENNEDY ,  Istvan ANKA ,  Amalia SZANKA

    发明人： Joseph Kennedy ,  Istvan Szanka ,  Amalia Szanka

    IPC分类号： C08G77/388 ,  A61L26/00 ,  A61L24/04

    CPC分类号： C08G77/388 ,  A61K31/74 ,  A61L24/001 ,  A61L24/046 ,  A61L26/0019 ,  A61L26/0061 ,  C08G77/20 ,  C08G77/22 ,  C08L83/04

    摘要： A family of silicone rubbers (e.g., polydimethylsiloxane) carrying one or more cyanoacrylate groups and their methods of production are provided. These silicone rubbers endowed with cyanoacrylate groups are useful in a variety of wound care applications, including wound closures, adhesives, sealants and skin protectors. The silicone rubber moiety provides oxygen and moisture permeability (i.e., “breathability”), biocompatibility, optical transparency, and good mechanical properties, while the cyanoacrylate group imparts instantaneous adhesion/attachment to living tissues such as skin on par with that of contemporary cyanoacrylate-based wound care products.

    摘要翻译： 提供携带一个或多个氰基丙烯酸酯基团的硅橡胶（例如聚二甲基硅氧烷）族及其制备方法。 这些具有氰基丙烯酸酯基团的硅橡胶可用于各种伤口护理应用，包括伤口闭合物，粘合剂，密封剂和皮肤保护剂。 硅橡胶部分提供氧和透湿性（即“透气性”），生物相容性，光学透明性和良好的机械性能，而氰基丙烯酸酯基团将活性组织如皮肤的瞬时粘附/附着与当代氰基丙烯酸酯 - 基于伤口护理产品。