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1.发明授权Amphiphilic networks, implantable immunoisolatory devices and methods of preparation 有权两亲网络，可植入免疫隔离装置及其制备方法公开(公告)号：US06365171B1
公开(公告)日：2002-04-02
申请号：US09433660
申请日：1999-11-04
IPC分类号： A61F1300
CPC分类号： A61K9/0024 , C08F8/00 , C08F220/56 , C08F222/1006 , C08F255/10 , C08F283/00 , C08F290/12 , Y10S514/866 , C08F10/10
摘要： The present invention provides high mechanical strength amphiphilic polymer networks and implantable biological devices that are capable of encasing and, thus, immunoisolating biological material from the immunological response of a host individual. The present invention also provides methods for the formation of the amphiphilic networks and implantable biological devices. The present invention also provides a method for the treatment of type I diabetes mellitus comprising the steps of encasing a sufficient amount of islet of Langerhans cells within said biological device, wherein said biological device is capable of immunoisolating said encased islet cells upon implantation into an individual; implanting said biological device into a diabetic host individual; allowing said implanted biological device to remain implanted said diabetic individual for a time sufficient to normalize the blood glucose level in said diabetic individual.
摘要翻译： 本发明提供了高机械强度的两亲性聚合物网络和可植入的生物学装置，其能够将生物材料免于宿主个体的免疫反应。 本发明还提供了形成两亲网络和可植入生物装置的方法。 本发明还提供了一种治疗I型糖尿病的方法，包括以下步骤：在所述生物装置内包含足够量的朗格汉斯细胞胰岛，其中所述生物装置能够在植入个体时对所述包封的胰岛细胞进行免疫隔离 ; 将所述生物学装置植入糖尿病宿主个体中; 允许所述植入的生物装置保持植入所述糖尿病个体足够的时间以使所述糖尿病个体中的血糖水平归一化。
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2.发明授权Three arm star compositions of matter having diblock arms based on polyisobutylene and methods of preparation 有权具有基于聚异丁烯的二嵌段的物质的三臂星形组成及其制备方法公开(公告)号：US06228945B1
公开(公告)日：2001-05-08
申请号：US09467576
申请日：1999-12-20
IPC分类号： C08L2510
CPC分类号： C09D153/00 , C08F290/06 , C08F293/005 , C08F2438/01 , C08L53/00 , C09J153/00
摘要： The present invention relates to compositions of matter comprising a trifunctional aromatic core, said core having three arms radiating therefrom, wherein each of said arms is a diblock copolymer comprising an inner segment of polyisobutylene connected to a outer polymer segment obtained by a living radical polymerization process. The present invention also provides a process of preparing a composition of matter comprising the steps of: providing a trifunctional aromatic initiator core; reacting the trifunctional aromatic core with isobutylene to form a macroinitiator, said macroinitiator comprising polyisobutylene functionalized at the terminus of each said arm; conducting site transformation at the terminus of each arm to introduce a group capable of initiating living radical polymerization of outer segments at the terminus of each arm; performing living radical polymerization to form the outer polymer segments to produce a three arm star composition of matter having three diblock copolymer arms.
摘要翻译： 本发明涉及包含三官能芳族核心的物质组合物，所述核心具有从其辐射的三个臂，其中每个所述臂是二嵌段共聚物，其包含连接到通过活性自由基聚合方法获得的外部聚合物链段的聚异丁烯内部段 。 本发明还提供了一种制备物质组合物的方法，包括以下步骤：提供三官能芳族起始物核心; 使三官能芳族核与异丁烯反应以形成大分子引发剂，所述大分子引发剂包括在每个所述臂的末端官能化的聚异丁烯; 在每个臂的末端进行位点转化，以引入能够在每个臂的末端引发外部段的活性自由基聚合的基团; 进行活性自由基聚合以形成外部聚合物链段以产生具有三个二嵌段共聚物臂的物质的三臂星形组合物。
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