Method for purifying aminomethylenephosphonic acids for pharmaceutical
use
    2.
    发明授权
    Method for purifying aminomethylenephosphonic acids for pharmaceutical use 失效
    纯化用于药物用途的氨基亚甲基膦酸的方法

    公开(公告)号:US4937333A

    公开(公告)日:1990-06-26

    申请号:US389441

    申请日:1989-08-04

    摘要: High purity ethylenediaminetetra(methylenephosphonic acid) and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra(methylenephosphonic acid) are prepared by dissolving the aminomethylenephosphonic acid in an aqueous base, acidifying with a mineral acid at an elevated temperature to precipitate the crystals, maintaining the solution at an elevated temperature for a period of time sufficient to assure crystallization, cooling to a lower temperature and maintaining at that temperature for a time sufficient to precipitate the crystals and filtering the resulting crystals at that temperature, washing the crystals with water and recovering the desired high purity aminophosphonic acid. The ethylenediaminetetra(methylenephosphonic acid) is obtained in a purer state during its synthesis if the crystals are filtered hot without prior cooling.