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公开(公告)号：US20140314809A1
公开(公告)日：2014-10-23
申请号：US13866116
申请日：2013-04-19
申请人： Joseph T. Bruder , Imre Kovesdi , Duncan L. McVey , Douglas E. Brough , C. Richter King , Denise Louise Doolan , Joao Carlos Aguair , Daniel John Carucci , Martha Sedegah , Walter R. Weiss , Keith Limbach
发明人： Joseph T. Bruder , Imre Kovesdi , Duncan L. McVey , Douglas E. Brough , C. Richter King , Denise Louise Doolan , Joao Carlos Aguair , Daniel John Carucci , Martha Sedegah , Walter R. Weiss , Keith Limbach
IPC分类号： G01N33/50
CPC分类号： G01N33/505
摘要： The invention provides a method of identifying an antigen from a pathogen or a disease antigen comprising the use of an adenoviral vector array comprising two or more different adenoviral vectors, wherein each adenoviral vector comprises a nucleic acid sequence encoding a different antigen of a pathogen. The adenoviral vectors are administered to antigen presenting cells (APCs) in vitro or to an animal in vivo. The immunogenicity of the antigen is measured by screening for an immune response from effector T lymphocytes in vitro and by screening for the absence of pathogen-induced disease onset in vivo.
摘要翻译： 本发明提供了鉴定来自病原体或疾病抗原的抗原的方法，其包括使用包含两种或多种不同腺病毒载体的腺病毒载体阵列，其中每个腺病毒载体包含编码病原体的不同抗原的核酸序列。 腺病毒载体在体外或动物体内施用于抗原呈递细胞（APC）。 通过体外筛选来自效应T淋巴细胞的免疫应答并通过筛选在体内不存在病原体诱发的疾病来测量抗原的免疫原性。
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公开(公告)号：US20170082607A9
公开(公告)日：2017-03-23
申请号：US13866116
申请日：2013-04-19
申请人： Joseph T. Bruder , Imre Kovesdi , Duncan L. McVey , Douglas E. Brough , C. Richter King , Denise Louise Doolan , Joao Carlos Aguair , Daniel John Carucci , Martha Sedegah , Walter R. Weiss , Keith Limbach
发明人： Joseph T. Bruder , Imre Kovesdi , Duncan L. McVey , Douglas E. Brough , C. Richter King , Denise Louise Doolan , Joao Carlos Aguair , Daniel John Carucci , Martha Sedegah , Walter R. Weiss , Keith Limbach
IPC分类号： G01N33/50
CPC分类号： G01N33/505
摘要： The invention provides a method of identifying an antigen from a pathogen or a disease antigen comprising the use of an adenoviral vector array comprising two or more different adenoviral vectors, wherein each adenoviral vector comprises a nucleic acid sequence encoding a different antigen of a pathogen. The adenoviral vectors are administered to antigen presenting cells (APCs) in vitro or to an animal in vivo. The immunogenicity of the antigen is measured by screening for an immune response from effector T lymphocytes in vitro and by screening for the absence of pathogen-induced disease onset in vivo.
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公开(公告)号：US09651543B2
公开(公告)日：2017-05-16
申请号：US13866116
申请日：2013-04-19
申请人： Joseph T. Bruder , Imre Kovesdi , Duncan L. McVey , Douglas E. Brough , C. Richter King , Denise Louise Doolan , Joao Carlos Aguair , Daniel John Carucci , Martha Sedegah , Walter R. Weiss , Keith Limbach
发明人： Joseph T. Bruder , Imre Kovesdi , Duncan L. McVey , Douglas E. Brough , C. Richter King , Denise Louise Doolan , Joao Carlos Aguair , Daniel John Carucci , Martha Sedegah , Walter R. Weiss , Keith Limbach
IPC分类号： G01N33/50
CPC分类号： G01N33/505
摘要： The invention provides a method of identifying an antigen from a pathogen or a disease antigen comprising the use of an adenoviral vector array comprising two or more different adenoviral vectors, wherein each adenoviral vector comprises a nucleic acid sequence encoding a different antigen of a pathogen. The adenoviral vectors are administered to antigen presenting cells (APCs) in vitro or to an animal in vivo. The immunogenicity of the antigen is measured by screening for an immune response from effector T lymphocytes in vitro and by screening for the absence of pathogen-induced disease onset in vivo.
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公开(公告)号：US08450055B2
公开(公告)日：2013-05-28
申请号：US11513439
申请日：2006-08-25
申请人： Joseph T. Bruder , Imre Kovesdi , Duncan L. McVey , Douglas E. Brough , C. Richter King , Denise Louise Doolan , Joao Carlos Aguair , Daniel John Carucci , Martha Sedegah , Walter R. Weiss , Keith Limbach
发明人： Joseph T. Bruder , Imre Kovesdi , Duncan L. McVey , Douglas E. Brough , C. Richter King , Denise Louise Doolan , Joao Carlos Aguair , Daniel John Carucci , Martha Sedegah , Walter R. Weiss , Keith Limbach
CPC分类号： G01N33/505 , A61K39/015 , A61K48/00 , A61K49/0008 , A61K2039/5254 , A61K2039/5256 , C12N7/00 , C12N15/1082 , C12N2710/10021 , C12N2710/10043 , G01N33/564 , G01N33/56905 , G01N33/574 , G01N2333/445 , Y02A50/412 , Y02A50/58
摘要： The invention provides a method of identifying an antigen from a pathogen or a disease antigen comprising the use of an adenoviral vector array comprising two or more different adenoviral vectors, wherein each adenoviral vector comprises a nucleic acid sequence encoding a different antigen of a pathogen. The adenoviral vectors are administered to antigen presenting cells (APCs) in vitro or to an animal in vivo. The immunogenicity of the antigen is measured by screening for an immune response from effector T lymphocytes in vitro and by screening for the absence of pathogen-induced disease onset in vivo.
摘要翻译： 本发明提供了鉴定来自病原体或疾病抗原的抗原的方法，其包括使用包含两种或多种不同腺病毒载体的腺病毒载体阵列，其中每个腺病毒载体包含编码病原体的不同抗原的核酸序列。 腺病毒载体在体外或动物体内施用于抗原呈递细胞（APC）。 通过体外筛选来自效应T淋巴细胞的免疫应答并通过筛选在体内不存在病原体诱发的疾病来测量抗原的免疫原性。
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公开(公告)号：US20100222234A1
公开(公告)日：2010-09-02
申请号：US11513439
申请日：2006-08-25
申请人： Joseph T. Bruder , Imre Kovesdi , Duncan L. McVey , Douglas E. Brough , C. Richter King , Denise Louise Doolan , Joao Carlos Aguair , Daniel John Carucci , Martha Sedegah , Walter R. Weiss , Keith Limbach
发明人： Joseph T. Bruder , Imre Kovesdi , Duncan L. McVey , Douglas E. Brough , C. Richter King , Denise Louise Doolan , Joao Carlos Aguair , Daniel John Carucci , Martha Sedegah , Walter R. Weiss , Keith Limbach
IPC分类号： C40B30/06 , A61K39/015 , A61P35/00
CPC分类号： G01N33/505 , A61K39/015 , A61K48/00 , A61K49/0008 , A61K2039/5254 , A61K2039/5256 , C12N7/00 , C12N15/1082 , C12N2710/10021 , C12N2710/10043 , G01N33/564 , G01N33/56905 , G01N33/574 , G01N2333/445 , Y02A50/412 , Y02A50/58
摘要： The invention provides a method of identifying an antigen from a pathogen or a disease antigen comprising the use of an adenoviral vector array comprising two or more different adenoviral vectors, wherein each adenoviral vector comprises a nucleic acid sequence encoding a different antigen of a pathogen. The adenoviral vectors are administered to antigen presenting cells (APCs) in vitro or to an animal in vivo. The immunogenicity of the antigen is measured by screening for an immune response from effector T lymphocytes in vitro and by screening for the absence of pathogen-induced disease onset in vivo.
摘要翻译： 本发明提供了鉴定来自病原体或疾病抗原的抗原的方法，其包括使用包含两种或多种不同腺病毒载体的腺病毒载体阵列，其中每个腺病毒载体包含编码病原体的不同抗原的核酸序列。 腺病毒载体在体外或动物体内施用于抗原呈递细胞（APC）。 通过体外筛选来自效应T淋巴细胞的免疫应答并通过筛选在体内不存在病原体诱发的疾病来测量抗原的免疫原性。
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公开(公告)号：US08765146B2
公开(公告)日：2014-07-01
申请号：US12064554
申请日：2006-08-31
申请人： Joseph T. Bruder , Imre Kovesdi , C. Richter King , Duncan L. McVey , Damodar R. Ettyreddy , Denise Louise Doolan , Daniel John Carucci
发明人： Joseph T. Bruder , Imre Kovesdi , C. Richter King , Duncan L. McVey , Damodar R. Ettyreddy , Denise Louise Doolan , Daniel John Carucci
IPC分类号： A61K39/00 , A61K39/002 , A61K39/015 , A61K39/38 , A61K45/00
CPC分类号： C07K14/445 , A61K39/015 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , C12N15/86 , C12N2710/10322 , C12N2710/10343 , C12N2830/00 , C12N2830/002 , C12N2830/008 , Y02A50/412
摘要： The invention provides adenoviral vectors comprising an adenoviral genome comprising heterologous antigen-encoding nucleic acid sequences, such as Plasmodium nucleic acid sequences, operably linked to promoters. The invention further provides a method of inducing an immune response against malaria in a mammal comprising administering the adenoviral vectors to the mammal.
摘要翻译： 本发明提供了包含腺病毒基因组的腺病毒载体，其包含可操作地连接于启动子的异源抗原编码核酸序列，例如疟原虫核酸序列。 本发明进一步提供了一种在哺乳动物中诱导针对疟疾的免疫应答的方法，包括向哺乳动物施用腺病毒载体。
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公开(公告)号：US20090148477A1
公开(公告)日：2009-06-11
申请号：US12064554
申请日：2006-08-31
申请人： Joseph T. Bruder , Imre Kovesdi , C. Richter King , Duncan L. McVey , Damodar R. Ettyreddy , Denise Louis Doolan , Daniel John Carucci , Keith Limbach
发明人： Joseph T. Bruder , Imre Kovesdi , C. Richter King , Duncan L. McVey , Damodar R. Ettyreddy , Denise Louis Doolan , Daniel John Carucci , Keith Limbach
IPC分类号： A61K39/015 , C12N15/861 , C12N15/11 , A61P33/06
CPC分类号： C07K14/445 , A61K39/015 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , C12N15/86 , C12N2710/10322 , C12N2710/10343 , C12N2830/00 , C12N2830/002 , C12N2830/008 , Y02A50/412
摘要： The invention provides adenoviral vectors comprising an adenoviral genome comprising heterologous antigen-encoding nucleic acid sequences, such as Plasmodium nucleic acid sequences, operably linked to promoters. The invention further provides a method of inducing an immune response against malaria in a mammal comprising administering the adenoviral vectors to the mammal.
摘要翻译： 本发明提供了包含腺病毒基因组的腺病毒载体，其包含可操作地连接于启动子的异源抗原编码核酸序列，例如疟原虫核酸序列。 本发明进一步提供了一种在哺乳动物中诱导针对疟疾的免疫应答的方法，包括向哺乳动物施用腺病毒载体。
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公开(公告)号：US09254316B2
公开(公告)日：2016-02-09
申请号：US13890422
申请日：2013-05-09
IPC分类号： A61K39/00 , A61K39/015 , C07H21/04 , C12N7/00
CPC分类号： A61K39/015 , A61K2039/53 , C12N7/00 , C12N2710/10043 , C12N2710/10343 , Y02A50/412
摘要： The invention provides a method of inducing an immune response against malaria in a mammal. The method comprises intramuscularly administering to a mammal a composition comprising a pharmaceutically acceptable carrier and either or both of (a) a first adenoviral vector comprising a nucleic acid sequence encoding a P. falciparum circumsporozoite protein (CSP) operably linked to a human CMV promoter, and/or (b) a second adenoviral vector comprising a nucleic acid sequence encoding a P. falciparum apical membrane antigen 1 (AMA-1) antigen operably linked to a human CMV promoter.
摘要翻译： 本发明提供在哺乳动物中诱导针对疟疾的免疫应答的方法。 该方法包括向哺乳动物施用包含药学上可接受的载体的组合物和（a）第一种腺病毒载体，其包含与人CMV启动子可操作地连接的编码恶性疟原虫环子孢子蛋白（CSP）的核酸序列， 和/或（b）包含编码与人CMV启动子可操作地连接的恶性疟原虫顶端膜抗原1（AMA-1）抗原的核酸序列的第二腺病毒载体。
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公开(公告)号：US20140335128A1
公开(公告)日：2014-11-13
申请号：US13890422
申请日：2013-05-09
IPC分类号： A61K39/015
CPC分类号： A61K39/015 , A61K2039/53 , C12N7/00 , C12N2710/10043 , C12N2710/10343 , Y02A50/412
摘要： The invention provides a method of inducing an immune response against malaria in a mammal. The method comprises intramuscularly administering to a mammal a composition comprising a pharmaceutically acceptable carrier and either or both of (a) a first adenoviral vector comprising a nucleic acid sequence encoding a P. falciparum circumsporozoite protein (CSP) operably linked to a human CMV promoter, and/or (b) a second adenoviral vector comprising a nucleic acid sequence encoding a P. falciparum apical membrane antigen 1 (AMA-1) antigen operably linked to a human CMV promoter.
摘要翻译： 本发明提供在哺乳动物中诱导针对疟疾的免疫应答的方法。 该方法包括向哺乳动物施用包含药学上可接受的载体的组合物和（a）第一种腺病毒载体，其包含与人CMV启动子可操作地连接的编码恶性疟原虫环子孢子蛋白（CSP）的核酸序列， 和/或（b）包含编码与人CMV启动子可操作地连接的恶性疟原虫顶端膜抗原1（AMA-1）抗原的核酸序列的第二腺病毒载体。
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公开(公告)号：US20100278870A1
公开(公告)日：2010-11-04
申请号：US12522335
申请日：2008-01-09
IPC分类号： A61K39/015 , A61P37/04 , A61P33/06
CPC分类号： A61K39/015 , A01K2227/105 , A01K2267/0337 , A61K2039/5256 , A61K2039/53 , C07K14/445 , Y02A50/412
摘要： The invention provides a method of inducing an immune response against malaria in a mammal. The method comprises intramuscularly administering to a mammal a composition comprising a pharmaceutically acceptable carrier and either or both of (a) a first adenoviral vector comprising a nucleic acid sequence encoding a P. falciparum circumsporozoite protein (CSP) operably linked to a human CMV promoter, and/or (b) a second adenoviral vector comprising a nucleic acid sequence encoding a P. falciparum apical membrane antigen 1 (AMA-1) antigen operably linked to a human CMV promoter.
摘要翻译： 本发明提供在哺乳动物中诱导针对疟疾的免疫应答的方法。 该方法包括向哺乳动物施用包含药学上可接受的载体的组合物和（a）第一种腺病毒载体，其包含与人CMV启动子可操作地连接的编码恶性疟原虫环子孢子蛋白（CSP）的核酸序列， 和/或（b）包含编码与人CMV启动子可操作地连接的恶性疟原虫顶端膜抗原1（AMA-1）抗原的核酸序列的第二腺病毒载体。
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