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公开(公告)号：US08765146B2
公开(公告)日：2014-07-01
申请号：US12064554
申请日：2006-08-31
申请人： Joseph T. Bruder , Imre Kovesdi , C. Richter King , Duncan L. McVey , Damodar R. Ettyreddy , Denise Louise Doolan , Daniel John Carucci
发明人： Joseph T. Bruder , Imre Kovesdi , C. Richter King , Duncan L. McVey , Damodar R. Ettyreddy , Denise Louise Doolan , Daniel John Carucci
IPC分类号： A61K39/00 , A61K39/002 , A61K39/015 , A61K39/38 , A61K45/00
CPC分类号： C07K14/445 , A61K39/015 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , C12N15/86 , C12N2710/10322 , C12N2710/10343 , C12N2830/00 , C12N2830/002 , C12N2830/008 , Y02A50/412
摘要： The invention provides adenoviral vectors comprising an adenoviral genome comprising heterologous antigen-encoding nucleic acid sequences, such as Plasmodium nucleic acid sequences, operably linked to promoters. The invention further provides a method of inducing an immune response against malaria in a mammal comprising administering the adenoviral vectors to the mammal.
摘要翻译： 本发明提供了包含腺病毒基因组的腺病毒载体，其包含可操作地连接于启动子的异源抗原编码核酸序列，例如疟原虫核酸序列。 本发明进一步提供了一种在哺乳动物中诱导针对疟疾的免疫应答的方法，包括向哺乳动物施用腺病毒载体。
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公开(公告)号：US20140314809A1
公开(公告)日：2014-10-23
申请号：US13866116
申请日：2013-04-19
申请人： Joseph T. Bruder , Imre Kovesdi , Duncan L. McVey , Douglas E. Brough , C. Richter King , Denise Louise Doolan , Joao Carlos Aguair , Daniel John Carucci , Martha Sedegah , Walter R. Weiss , Keith Limbach
发明人： Joseph T. Bruder , Imre Kovesdi , Duncan L. McVey , Douglas E. Brough , C. Richter King , Denise Louise Doolan , Joao Carlos Aguair , Daniel John Carucci , Martha Sedegah , Walter R. Weiss , Keith Limbach
IPC分类号： G01N33/50
CPC分类号： G01N33/505
摘要： The invention provides a method of identifying an antigen from a pathogen or a disease antigen comprising the use of an adenoviral vector array comprising two or more different adenoviral vectors, wherein each adenoviral vector comprises a nucleic acid sequence encoding a different antigen of a pathogen. The adenoviral vectors are administered to antigen presenting cells (APCs) in vitro or to an animal in vivo. The immunogenicity of the antigen is measured by screening for an immune response from effector T lymphocytes in vitro and by screening for the absence of pathogen-induced disease onset in vivo.
摘要翻译： 本发明提供了鉴定来自病原体或疾病抗原的抗原的方法，其包括使用包含两种或多种不同腺病毒载体的腺病毒载体阵列，其中每个腺病毒载体包含编码病原体的不同抗原的核酸序列。 腺病毒载体在体外或动物体内施用于抗原呈递细胞（APC）。 通过体外筛选来自效应T淋巴细胞的免疫应答并通过筛选在体内不存在病原体诱发的疾病来测量抗原的免疫原性。
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公开(公告)号：US20170082607A9
公开(公告)日：2017-03-23
申请号：US13866116
申请日：2013-04-19
申请人： Joseph T. Bruder , Imre Kovesdi , Duncan L. McVey , Douglas E. Brough , C. Richter King , Denise Louise Doolan , Joao Carlos Aguair , Daniel John Carucci , Martha Sedegah , Walter R. Weiss , Keith Limbach
发明人： Joseph T. Bruder , Imre Kovesdi , Duncan L. McVey , Douglas E. Brough , C. Richter King , Denise Louise Doolan , Joao Carlos Aguair , Daniel John Carucci , Martha Sedegah , Walter R. Weiss , Keith Limbach
IPC分类号： G01N33/50
CPC分类号： G01N33/505
摘要： The invention provides a method of identifying an antigen from a pathogen or a disease antigen comprising the use of an adenoviral vector array comprising two or more different adenoviral vectors, wherein each adenoviral vector comprises a nucleic acid sequence encoding a different antigen of a pathogen. The adenoviral vectors are administered to antigen presenting cells (APCs) in vitro or to an animal in vivo. The immunogenicity of the antigen is measured by screening for an immune response from effector T lymphocytes in vitro and by screening for the absence of pathogen-induced disease onset in vivo.
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公开(公告)号：US20090148477A1
公开(公告)日：2009-06-11
申请号：US12064554
申请日：2006-08-31
申请人： Joseph T. Bruder , Imre Kovesdi , C. Richter King , Duncan L. McVey , Damodar R. Ettyreddy , Denise Louis Doolan , Daniel John Carucci , Keith Limbach
发明人： Joseph T. Bruder , Imre Kovesdi , C. Richter King , Duncan L. McVey , Damodar R. Ettyreddy , Denise Louis Doolan , Daniel John Carucci , Keith Limbach
IPC分类号： A61K39/015 , C12N15/861 , C12N15/11 , A61P33/06
CPC分类号： C07K14/445 , A61K39/015 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , C12N15/86 , C12N2710/10322 , C12N2710/10343 , C12N2830/00 , C12N2830/002 , C12N2830/008 , Y02A50/412
摘要： The invention provides adenoviral vectors comprising an adenoviral genome comprising heterologous antigen-encoding nucleic acid sequences, such as Plasmodium nucleic acid sequences, operably linked to promoters. The invention further provides a method of inducing an immune response against malaria in a mammal comprising administering the adenoviral vectors to the mammal.
摘要翻译： 本发明提供了包含腺病毒基因组的腺病毒载体，其包含可操作地连接于启动子的异源抗原编码核酸序列，例如疟原虫核酸序列。 本发明进一步提供了一种在哺乳动物中诱导针对疟疾的免疫应答的方法，包括向哺乳动物施用腺病毒载体。
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公开(公告)号：US09651543B2
公开(公告)日：2017-05-16
申请号：US13866116
申请日：2013-04-19
申请人： Joseph T. Bruder , Imre Kovesdi , Duncan L. McVey , Douglas E. Brough , C. Richter King , Denise Louise Doolan , Joao Carlos Aguair , Daniel John Carucci , Martha Sedegah , Walter R. Weiss , Keith Limbach
发明人： Joseph T. Bruder , Imre Kovesdi , Duncan L. McVey , Douglas E. Brough , C. Richter King , Denise Louise Doolan , Joao Carlos Aguair , Daniel John Carucci , Martha Sedegah , Walter R. Weiss , Keith Limbach
IPC分类号： G01N33/50
CPC分类号： G01N33/505
摘要： The invention provides a method of identifying an antigen from a pathogen or a disease antigen comprising the use of an adenoviral vector array comprising two or more different adenoviral vectors, wherein each adenoviral vector comprises a nucleic acid sequence encoding a different antigen of a pathogen. The adenoviral vectors are administered to antigen presenting cells (APCs) in vitro or to an animal in vivo. The immunogenicity of the antigen is measured by screening for an immune response from effector T lymphocytes in vitro and by screening for the absence of pathogen-induced disease onset in vivo.
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公开(公告)号：US08450055B2
公开(公告)日：2013-05-28
申请号：US11513439
申请日：2006-08-25
申请人： Joseph T. Bruder , Imre Kovesdi , Duncan L. McVey , Douglas E. Brough , C. Richter King , Denise Louise Doolan , Joao Carlos Aguair , Daniel John Carucci , Martha Sedegah , Walter R. Weiss , Keith Limbach
发明人： Joseph T. Bruder , Imre Kovesdi , Duncan L. McVey , Douglas E. Brough , C. Richter King , Denise Louise Doolan , Joao Carlos Aguair , Daniel John Carucci , Martha Sedegah , Walter R. Weiss , Keith Limbach
CPC分类号： G01N33/505 , A61K39/015 , A61K48/00 , A61K49/0008 , A61K2039/5254 , A61K2039/5256 , C12N7/00 , C12N15/1082 , C12N2710/10021 , C12N2710/10043 , G01N33/564 , G01N33/56905 , G01N33/574 , G01N2333/445 , Y02A50/412 , Y02A50/58
摘要： The invention provides a method of identifying an antigen from a pathogen or a disease antigen comprising the use of an adenoviral vector array comprising two or more different adenoviral vectors, wherein each adenoviral vector comprises a nucleic acid sequence encoding a different antigen of a pathogen. The adenoviral vectors are administered to antigen presenting cells (APCs) in vitro or to an animal in vivo. The immunogenicity of the antigen is measured by screening for an immune response from effector T lymphocytes in vitro and by screening for the absence of pathogen-induced disease onset in vivo.
摘要翻译： 本发明提供了鉴定来自病原体或疾病抗原的抗原的方法，其包括使用包含两种或多种不同腺病毒载体的腺病毒载体阵列，其中每个腺病毒载体包含编码病原体的不同抗原的核酸序列。 腺病毒载体在体外或动物体内施用于抗原呈递细胞（APC）。 通过体外筛选来自效应T淋巴细胞的免疫应答并通过筛选在体内不存在病原体诱发的疾病来测量抗原的免疫原性。
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公开(公告)号：US20100222234A1
公开(公告)日：2010-09-02
申请号：US11513439
申请日：2006-08-25
申请人： Joseph T. Bruder , Imre Kovesdi , Duncan L. McVey , Douglas E. Brough , C. Richter King , Denise Louise Doolan , Joao Carlos Aguair , Daniel John Carucci , Martha Sedegah , Walter R. Weiss , Keith Limbach
发明人： Joseph T. Bruder , Imre Kovesdi , Duncan L. McVey , Douglas E. Brough , C. Richter King , Denise Louise Doolan , Joao Carlos Aguair , Daniel John Carucci , Martha Sedegah , Walter R. Weiss , Keith Limbach
IPC分类号： C40B30/06 , A61K39/015 , A61P35/00
CPC分类号： G01N33/505 , A61K39/015 , A61K48/00 , A61K49/0008 , A61K2039/5254 , A61K2039/5256 , C12N7/00 , C12N15/1082 , C12N2710/10021 , C12N2710/10043 , G01N33/564 , G01N33/56905 , G01N33/574 , G01N2333/445 , Y02A50/412 , Y02A50/58
摘要： The invention provides a method of identifying an antigen from a pathogen or a disease antigen comprising the use of an adenoviral vector array comprising two or more different adenoviral vectors, wherein each adenoviral vector comprises a nucleic acid sequence encoding a different antigen of a pathogen. The adenoviral vectors are administered to antigen presenting cells (APCs) in vitro or to an animal in vivo. The immunogenicity of the antigen is measured by screening for an immune response from effector T lymphocytes in vitro and by screening for the absence of pathogen-induced disease onset in vivo.
摘要翻译： 本发明提供了鉴定来自病原体或疾病抗原的抗原的方法，其包括使用包含两种或多种不同腺病毒载体的腺病毒载体阵列，其中每个腺病毒载体包含编码病原体的不同抗原的核酸序列。 腺病毒载体在体外或动物体内施用于抗原呈递细胞（APC）。 通过体外筛选来自效应T淋巴细胞的免疫应答并通过筛选在体内不存在病原体诱发的疾病来测量抗原的免疫原性。
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8.发明授权Stocks of recombinant, replication-deficient adenovirus free of replication-competent adenovirus 失效具有无复制能力的腺病毒的重组，复制缺陷型腺病毒的库存
公开(公告)号：US5994106A
公开(公告)日：1999-11-30
申请号：US757023
申请日：1996-11-26
IPC分类号： C12N15/09 , A61K35/76 , A61K38/00 , A61K48/00 , A61P43/00 , C07K14/075 , C07K14/47 , C12N5/10 , C12N15/00 , C12N15/12 , C12N15/34 , C12N15/86 , C12N15/861 , C12Q1/68 , C12R1/92 , C12N15/64
CPC分类号： C12N7/00 , C07K14/005 , C07K14/4712 , C12N15/86 , A61K2039/5256 , A61K38/00 , A61K48/00 , C12N2710/10322 , C12N2710/10343 , C12N2710/10352 , C12N2810/60 , C12N2810/6081 , C12N2830/002 , C12N2830/85 , C12N2840/20 , C12N2840/203 , C12N2840/44 , Y10S977/799
摘要： The present invention provides multiply deficient adenoviral vectors and complementing cell lines. Also provided are recombinants of the multiply deficient adenoviral vectors and a therapeutic method, particularly relating to gene therapy, vaccination, and the like, involving the use of such recombinants.
摘要翻译： 本发明提供多重缺陷型腺病毒载体和补体细胞系。 还提供了多重缺陷型腺病毒载体的重组体和涉及使用这种重组体的基因治疗，疫苗接种等的治疗方法。
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公开(公告)号：US06998263B2
公开(公告)日：2006-02-14
申请号：US09780526
申请日：2001-02-09
CPC分类号： C12N15/1093 , A61K48/00 , C12N15/86 , C12N2710/10343 , C12N2710/10345 , C12N2810/40
摘要： The present invention provides a library of viral vectors, wherein each member comprises a first heterologous DNA encoding a first gene product and a second heterologous DNA encoding a second gene product. The first heterologous DNA is common to each member of the library, while the second heterologous DNA varies between members of the library. The present invention additionally provides a method of constructing a library of viral vectors. The method comprises carrying out homologous recombination between a first DNA molecule and a second DNA molecule to form a pool of intermediate viral vector genomes. One or more linear third DNA molecules are ligated into the pool of intermediate viral genomes to produce a library of viral vector genomes. Alternatively, homologous recombination between linear DNA molecules and recipient DNA molecules produces a library of viral vector genomes. The library of viral vector genomes is converted into a library of viral vectors.
摘要翻译： 本发明提供病毒载体文库，其中每个成员包含编码第一基因产物的第一异源DNA和编码第二基因产物的第二异源DNA。 第一个异源DNA对于文库的每个成员是共同的，而第二异源DNA在文库的成员之间是不同的。 本发明另外提供构建病毒载体文库的方法。 该方法包括在第一DNA分子和第二DNA分子之间进行同源重组以形成中间病毒载体基因组池。 将一个或多个线性第三DNA分子连接到中间病毒基因组池中以产生病毒载体基因组文库。 或者，线性DNA分子和受体DNA分子之间的同源重组产生病毒载体基因组文库。 将病毒载体基因组文库转化为病毒载体文库。
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公开(公告)号：US5851806A
公开(公告)日：1998-12-22
申请号：US572126
申请日：1995-12-14
IPC分类号： C12N15/09 , A61K31/70 , A61K35/76 , A61K38/00 , A61K39/00 , A61K48/00 , A61P37/04 , A61P43/00 , C07K14/075 , C07K14/47 , C12N5/10 , C12N7/00 , C12N15/00 , C12N15/12 , C12N15/34 , C12N15/86 , C12N15/861 , C12Q1/02 , C12Q1/68 , C12R1/92 , G01N33/15 , C12P19/34 , C12N15/11 , C12N5/16 , C12N5/22
CPC分类号： C12N15/86 , C07K14/005 , C07K14/4712 , C12N7/00 , A61K2039/5256 , A61K38/00 , A61K48/00 , C12N2710/10322 , C12N2710/10343 , C12N2710/10352 , C12N2800/108 , C12N2810/60 , C12N2810/6081 , C12N2830/002 , C12N2830/85 , C12N2840/20 , C12N2840/203 , C12N2840/44
摘要： The present invention provides multiply replication deficient adenoviral vectors having a spacer in at least one replication deficient adenoviral region, as well as complementing cell lines therefor. Also provided are means of constructing the multiply replication deficient adenoviral vectors and methods of use thereof, e.g., in gene therapy.
摘要翻译： 本发明提供在至少一个复制缺陷型腺病毒区域中具有间隔基的多重复制缺陷型腺病毒载体，以及补体细胞系。 还提供构建多重复制缺陷型腺病毒载体的方法及其使用方法，例如在基因治疗中。
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