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公开(公告)号：US06596270B2
公开(公告)日：2003-07-22
申请号：US09835683
申请日：2001-04-16
申请人： Joseph T. Bruder , Imre Kovesdi
发明人： Joseph T. Bruder , Imre Kovesdi
IPC分类号： A61K3500
CPC分类号： A61K48/00 , A61K2039/505 , C07K16/081
摘要： The present invention provides methods for administering an adenoviral gene transfer vector comprising an exogenous gene to an animal. One method involves utilizing systemic neutralizing antibodies to neutralize the adenoviral gene transfer vector outside a targeted muscle. Another method involves the repeat administration of an adenoviral gene transfer vector to a skeletal muscle.
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公开(公告)号：US06576456B2
公开(公告)日：2003-06-10
申请号：US09326447
申请日：1999-06-04
申请人： Thomas J. Wickham , Erik Falck-Pedersen , Petrus W. Roelvink , Joseph T. Bruder , Jason Gall , Imre Kovesdi
发明人： Thomas J. Wickham , Erik Falck-Pedersen , Petrus W. Roelvink , Joseph T. Bruder , Jason Gall , Imre Kovesdi
IPC分类号： C12N701
CPC分类号： C12N15/86 , A61K48/00 , C07K14/005 , C07K2319/00 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2810/405 , C12N2810/6018 , C12N2830/00 , C12N2830/60
摘要： The invention provides a chimeric adenovirus fiber protein including a nonnative amino acid sequence, and a chimeric adenovirus fiber protein lacking a native amino acid receptor-binding sequence. The chimeric protein trimerizes when produced in a mammalian cell.
摘要翻译： 本发明提供了包含非氨基酸序列的嵌合腺病毒纤维蛋白和缺乏天然氨基酸受体结合序列的嵌合腺病毒纤维蛋白。 当在哺乳动物细胞中产生时，嵌合蛋白质三聚体。
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公开(公告)号：US06482616B1
公开(公告)日：2002-11-19
申请号：US09321797
申请日：1999-05-27
IPC分类号： C12N510
CPC分类号： C12N7/00 , A61K38/00 , A61K48/00 , A61K2039/5256 , C07K14/005 , C07K14/4712 , C12N15/86 , C12N2710/10322 , C12N2710/10343 , C12N2710/10352 , C12N2810/60 , C12N2810/6081 , C12N2830/002 , C12N2830/85 , C12N2840/20 , C12N2840/203 , C12N2840/44 , Y10S977/799
摘要： The present invention provides multiply deficient adenoviral vectors and complementing cell lines. Also provided are recombinants of the multiply deficient adenoviral vectors and a therapeutic method, particularly relating to gene therapy, vaccination, and the like, involving the use of such recombinants.
摘要翻译： 本发明提供多重缺陷型腺病毒载体和补体细胞系。 还提供了多重缺陷型腺病毒载体的重组体和涉及使用这种重组体的基因治疗，疫苗接种等的治疗方法。
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公开(公告)号：US5731190A
公开(公告)日：1998-03-24
申请号：US709515
申请日：1996-09-06
IPC分类号： C12N15/09 , A61K35/76 , A61K38/00 , A61K48/00 , C07K14/075 , C07K14/705 , C12N7/00 , C12N7/01 , C12N15/861 , C12N15/866 , C12N15/87 , C12P21/04 , C12N15/86 , C12N15/34 , C12N15/62
CPC分类号： C12N15/87 , C07K14/005 , C07K14/70546 , C12N15/86 , C12N7/00 , A61K48/00 , C07K2319/00 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2710/14043 , C12N2710/14143 , C12N2810/40 , C12N2810/405 , C12N2810/60 , C12N2810/6018 , C12N2810/80 , C12N2810/855 , C12N2810/856 , C12N2810/859
摘要： A recombinant adenovirus comprising a chimeric penton base protein, which includes a nonpenton base sequence, and a therapeutic gene, a method of gene therapy involving the use of such adenovirus, and adenoviral transfer vectors for the generation of such recombinant adenovirus are provided.
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公开(公告)号：US20170082607A9
公开(公告)日：2017-03-23
申请号：US13866116
申请日：2013-04-19
申请人： Joseph T. Bruder , Imre Kovesdi , Duncan L. McVey , Douglas E. Brough , C. Richter King , Denise Louise Doolan , Joao Carlos Aguair , Daniel John Carucci , Martha Sedegah , Walter R. Weiss , Keith Limbach
发明人： Joseph T. Bruder , Imre Kovesdi , Duncan L. McVey , Douglas E. Brough , C. Richter King , Denise Louise Doolan , Joao Carlos Aguair , Daniel John Carucci , Martha Sedegah , Walter R. Weiss , Keith Limbach
IPC分类号： G01N33/50
CPC分类号： G01N33/505
摘要： The invention provides a method of identifying an antigen from a pathogen or a disease antigen comprising the use of an adenoviral vector array comprising two or more different adenoviral vectors, wherein each adenoviral vector comprises a nucleic acid sequence encoding a different antigen of a pathogen. The adenoviral vectors are administered to antigen presenting cells (APCs) in vitro or to an animal in vivo. The immunogenicity of the antigen is measured by screening for an immune response from effector T lymphocytes in vitro and by screening for the absence of pathogen-induced disease onset in vivo.
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公开(公告)号：US09254316B2
公开(公告)日：2016-02-09
申请号：US13890422
申请日：2013-05-09
IPC分类号： A61K39/00 , A61K39/015 , C07H21/04 , C12N7/00
CPC分类号： A61K39/015 , A61K2039/53 , C12N7/00 , C12N2710/10043 , C12N2710/10343 , Y02A50/412
摘要： The invention provides a method of inducing an immune response against malaria in a mammal. The method comprises intramuscularly administering to a mammal a composition comprising a pharmaceutically acceptable carrier and either or both of (a) a first adenoviral vector comprising a nucleic acid sequence encoding a P. falciparum circumsporozoite protein (CSP) operably linked to a human CMV promoter, and/or (b) a second adenoviral vector comprising a nucleic acid sequence encoding a P. falciparum apical membrane antigen 1 (AMA-1) antigen operably linked to a human CMV promoter.
摘要翻译： 本发明提供在哺乳动物中诱导针对疟疾的免疫应答的方法。 该方法包括向哺乳动物施用包含药学上可接受的载体的组合物和（a）第一种腺病毒载体，其包含与人CMV启动子可操作地连接的编码恶性疟原虫环子孢子蛋白（CSP）的核酸序列， 和/或（b）包含编码与人CMV启动子可操作地连接的恶性疟原虫顶端膜抗原1（AMA-1）抗原的核酸序列的第二腺病毒载体。
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公开(公告)号：US20140335128A1
公开(公告)日：2014-11-13
申请号：US13890422
申请日：2013-05-09
IPC分类号： A61K39/015
CPC分类号： A61K39/015 , A61K2039/53 , C12N7/00 , C12N2710/10043 , C12N2710/10343 , Y02A50/412
摘要： The invention provides a method of inducing an immune response against malaria in a mammal. The method comprises intramuscularly administering to a mammal a composition comprising a pharmaceutically acceptable carrier and either or both of (a) a first adenoviral vector comprising a nucleic acid sequence encoding a P. falciparum circumsporozoite protein (CSP) operably linked to a human CMV promoter, and/or (b) a second adenoviral vector comprising a nucleic acid sequence encoding a P. falciparum apical membrane antigen 1 (AMA-1) antigen operably linked to a human CMV promoter.
摘要翻译： 本发明提供在哺乳动物中诱导针对疟疾的免疫应答的方法。 该方法包括向哺乳动物施用包含药学上可接受的载体的组合物和（a）第一种腺病毒载体，其包含与人CMV启动子可操作地连接的编码恶性疟原虫环子孢子蛋白（CSP）的核酸序列， 和/或（b）包含编码与人CMV启动子可操作地连接的恶性疟原虫顶端膜抗原1（AMA-1）抗原的核酸序列的第二腺病毒载体。
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公开(公告)号：US20130337008A1
公开(公告)日：2013-12-19
申请号：US13993210
申请日：2011-12-20
IPC分类号： A61K39/12
CPC分类号： A61K39/12 , A61K2039/5256 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N15/86 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2770/24134 , C12N2810/6018 , Y02A50/386
摘要： The invention relates to a replication-deficient adenoviral vector comprising two or more nucleic acid sequences encoding Dengue virus antigens and a chimeric hexon protein. The chimeric hexon protein comprises a first portion and a second portion. The first portion comprises at least 10 contiguous amino acid residues from a first adenovirus serotype (e.g., serotype 5 adenovirus hexon protein), optionally with one amino acid substitution. The second portion comprises (a) at least one hypervariable region (HVR) of a hexon protein of an adenovirus of a second adenovirus serotype, or (b) at least one synthetic hypervariable region (HVR) that is not present in the hexon protein of the wild-type adenovirus of the first adenovirus serotype.
摘要翻译： 本发明涉及包含编码登革热病毒抗原和嵌合六邻体蛋白质的两个或多个核酸序列的复制缺陷型腺病毒载体。 嵌合六邻体蛋白质包含第一部分和第二部分。 第一部分包含来自第一腺病毒血清型（例如血清型5腺病毒六邻体蛋白）的至少10个连续氨基酸残基，任选具有一个氨基酸取代。 第二部分包含（a）第二种腺病毒血清型的腺病毒的六邻体蛋白质的至少一个高变区（HVR），或（b）至少一个不存在于第六腺体蛋白的六邻体蛋白质中的合成高变区（HVR） 第一种腺病毒血清型的野生型腺病毒。
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公开(公告)号：US20100278870A1
公开(公告)日：2010-11-04
申请号：US12522335
申请日：2008-01-09
IPC分类号： A61K39/015 , A61P37/04 , A61P33/06
CPC分类号： A61K39/015 , A01K2227/105 , A01K2267/0337 , A61K2039/5256 , A61K2039/53 , C07K14/445 , Y02A50/412
摘要： The invention provides a method of inducing an immune response against malaria in a mammal. The method comprises intramuscularly administering to a mammal a composition comprising a pharmaceutically acceptable carrier and either or both of (a) a first adenoviral vector comprising a nucleic acid sequence encoding a P. falciparum circumsporozoite protein (CSP) operably linked to a human CMV promoter, and/or (b) a second adenoviral vector comprising a nucleic acid sequence encoding a P. falciparum apical membrane antigen 1 (AMA-1) antigen operably linked to a human CMV promoter.
摘要翻译： 本发明提供在哺乳动物中诱导针对疟疾的免疫应答的方法。 该方法包括向哺乳动物施用包含药学上可接受的载体的组合物和（a）第一种腺病毒载体，其包含与人CMV启动子可操作地连接的编码恶性疟原虫环子孢子蛋白（CSP）的核酸序列， 和/或（b）包含编码与人CMV启动子可操作地连接的恶性疟原虫顶端膜抗原1（AMA-1）抗原的核酸序列的第二腺病毒载体。
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公开(公告)号：US20090264509A1
公开(公告)日：2009-10-22
申请号：US12117513
申请日：2008-05-08
IPC分类号： A61K31/7088 , C12N15/74 , A61P37/04
CPC分类号： A61K39/135 , A61K39/12 , A61K2039/5258 , A61K2039/552 , C12N15/86 , C12N2710/10343 , C12N2770/32134 , C12N2770/32171
摘要： The invention is directed to an adenoviral vector comprising at least one nucleic acid sequence encoding an aphthovirus antigen and/or a cytokine operably linked to a promoter. The adenoviral vector is replication-deficient and requires at most complementation of both the E1 region and the E4 region of the adenoviral genome for propagation. The invention also is directed to a method of inducing an immune response in a mammal comprising administering to the mammal a composition comprising the aforementioned adenoviral vector.
摘要翻译： 本发明涉及一种腺病毒载体，其包含至少一个编码与促进剂可操作地连接的aphthovirus抗原和/或细胞因子的核酸序列。 腺病毒载体是复制缺陷型的，需要对腺病毒基因组的E1区域和E4区域的最多互补进行扩增。 本发明还涉及在哺乳动物中诱导免疫应答的方法，其包括向哺乳动物施用包含上述腺病毒载体的组合物。
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