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1.发明申请Methods, Systems and Devices for Treatment of Cerebrospinal Venous Insufficiency and Multiple Sclerosis 审中-公开用于治疗脑脊液静脉功能不全和多发性硬化的方法，系统和装置公开(公告)号：US20130211489A1
公开(公告)日：2013-08-15
申请号：US13578555
申请日：2011-02-08
申请人： Joshua Makower , Earl A. Bright, II , Theodore M. Bender , Joseph Cantanese, III , John Y. Chang , Thomas King , Clinton Slone , Theodore C. Lamson , Aziz Imraan
发明人： Joshua Makower , Earl A. Bright, II , Theodore M. Bender , Joseph Cantanese, III , John Y. Chang , Thomas King , Clinton Slone , Theodore C. Lamson , Aziz Imraan
IPC分类号： A61F2/06
CPC分类号： A61F2/06 , A61F2/885 , A61F2/89 , A61F2/915 , A61F2002/825 , A61F2220/0008 , A61F2220/0016 , A61F2230/0054
摘要： Methods and devices for relieving stenoses in, or otherwise improving blood flow through, body lumens. Although applicable in a variety of different body lumens, the methods and devices of this invention are specifically useable for relieving stenoses in, or otherwise improving blood flow through, veins which drain blood from the brain for treatment of multiple sclerosis or other neurodegenerative disorders that are caused, triggered or exacerbated by venous occlusion or venous insufficiency.
摘要翻译： 用于减轻体液流经或以其他方式改善身体流明的血流的方法和装置。 尽管适用于各种不同的体腔，本发明的方法和装置特别可用于缓解静脉中的狭窄或改善通过静脉的血液，所述静脉排出来自脑的血液用于治疗多发性硬化症或其它神经变性疾病 导致，触发或加重静脉闭塞或静脉功能不全。
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2.发明申请METHOD AND SYSTEM FOR TREATING TARGET TISSUE WITHIN THE EUSTACHIAN TUBE 审中-公开用于治疗目标组织的方法和系统在EUSTACHIAN TUBE公开(公告)号：US20100198191A1
公开(公告)日：2010-08-05
申请号：US12649078
申请日：2009-12-29
申请人： Anton G. Clifford , Joshua Makower , John Y. Chang , John H. Morriss , Earl A. Bright, II , Eric Goldfarb , Julia D. Vrany
发明人： Anton G. Clifford , Joshua Makower , John Y. Chang , John H. Morriss , Earl A. Bright, II , Eric Goldfarb , Julia D. Vrany
CPC分类号： A61M29/02 , A61B1/227 , A61B1/233 , A61B5/036 , A61B5/415 , A61B8/12 , A61B17/24 , A61B18/08 , A61B18/20 , A61F11/002 , A61F11/004 , A61M25/0041 , A61M25/0054 , A61M25/0068 , A61M25/007 , A61M25/008 , A61M25/0662 , A61M25/09 , A61M25/10 , A61M25/1002 , A61M31/002 , A61M2025/0037 , A61M2025/0039 , A61M2025/09008 , A61M2025/09183 , A61M2025/105 , A61M2025/1054 , A61M2025/1086 , A61N7/02
摘要： Methods and systems for accessing a Eustachian tube of a patient are disclosed. The system includes a guide configured for passing into a nasal passage of the patient to position a distal tip of the catheter at or near a Eustachian tube, the guide having a distal tip with a bend having an angle between 30 and 90 degrees; and a guidewire configured to pass through the guide into the Eustachian tube. A device for providing therapy to the Eustachian tube is passed through the guide.
摘要翻译： 公开了用于访问患者的咽鼓管的方法和系统。 该系统包括引导件，其构造成用于进入患者的鼻通道以将导管的远侧末端定位在咽鼓管处或附近，该导管具有具有在30度和90度之间的角度的弯曲部的远端; 以及引导线，其构造成穿过所述引导件进入咽鼓管。 用于向咽鼓管提供治疗的装置通过引导件。
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公开(公告)号：US08435290B2
公开(公告)日：2013-05-07
申请号：US12730492
申请日：2010-03-24
申请人： Anton G. Clifford , Joshua Makower , John Y. Chang , John H. Morriss , Earl A. Bright, II , Eric Goldfarb , Julia D. Vrany , Ketan P. Muni , William E. Bolger , Joseph Roberson
发明人： Anton G. Clifford , Joshua Makower , John Y. Chang , John H. Morriss , Earl A. Bright, II , Eric Goldfarb , Julia D. Vrany , Ketan P. Muni , William E. Bolger , Joseph Roberson
IPC分类号： A61F2/18
CPC分类号： A61F11/002
摘要： Methods and devices for providing a gas pathway between the nasopharynx and the Eustachian tube are provided. One device may include a lumen with a valve. A portion of the valve may be tethered to adjacent muscle. Another portion of the valve may be tethered to adjacent cartilage. When the muscle contracts the valve may open through movement of the tethers, and provide a gas pathway between the nasopharynx and the Eustachian tube.
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4.发明申请System and Method For Treatment of Non-Ventilating Middle Ear by Providing a Gas Pathway Through the Nasopharynx 有权通过提供通过鼻咽的气道来治疗非通气中耳的系统和方法公开(公告)号：US20100305697A1
公开(公告)日：2010-12-02
申请号：US12730492
申请日：2010-03-24
申请人： Anton G. Clifford , Joshua Makower , John Y. Chang , John H. Morriss , Earl A. Bright, II , Eric Goldfarb , Julia D. Vrany , Ketan P. Muni , William E. Bolger , Joseph Roberson
发明人： Anton G. Clifford , Joshua Makower , John Y. Chang , John H. Morriss , Earl A. Bright, II , Eric Goldfarb , Julia D. Vrany , Ketan P. Muni , William E. Bolger , Joseph Roberson
CPC分类号： A61F11/002
摘要： Methods and devices for providing a gas pathway between the nasopharynx and the Eustachian tube are provided. One device may include a lumen with a valve. A portion of the valve may be tethered to adjacent muscle. Another portion of the valve may be tethered to adjacent cartilage. When the muscle contracts the valve may open through movement of the tethers, and provide a gas pathway between the nasopharynx and the Eustachian tube.
摘要翻译： 提供了用于在鼻咽和咽鼓管之间提供气体通路的方法和装置。 一个装置可以包括具有阀的内腔。 阀的一部分可以系在相邻的肌肉上。 阀的另一部分可以连接到相邻的软骨上。 当肌肉收缩时，阀可以通过系绳的移动而打开，并且在鼻咽和咽鼓管之间提供气体通路。
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5.发明申请Method and System for Accessing, Diagnosing and Treating Target Tissue Regions Within the Middle Ear and the Eustachian Tube 审中-公开方法和系统，用于访问，诊断和治疗中耳和咽鼓管内的目标组织区域公开(公告)号：US20090163890A1
公开(公告)日：2009-06-25
申请号：US12340226
申请日：2008-12-19
申请人： Anton Clifford , Joshua Makower , John Y. Chang , John H. Morriss , Earl A. Bright, II , Eric Goldfarb , Julia D. Vrany
发明人： Anton Clifford , Joshua Makower , John Y. Chang , John H. Morriss , Earl A. Bright, II , Eric Goldfarb , Julia D. Vrany
CPC分类号： A61B8/12 , A61B1/227 , A61B1/233 , A61B5/036 , A61B5/411 , A61B5/415 , A61B18/20 , A61F11/004 , A61M25/0026 , A61M25/0041 , A61M25/0068 , A61M25/007 , A61M25/008 , A61M25/09 , A61M25/10 , A61M31/002 , A61M2025/09008 , A61N7/02
摘要： Method and systems for accessing a Eustachian tube of a patient are disclosed. The system includes a guide configured for passing into a nasal passage of the patient to position a distal tip of the catheter at or near a Eustachian tube, the guide having distal tip with a bend having an angle between 30 and 90 degrees; and a guidewire configured to pass through the guide into the Eustachian tube.
摘要翻译： 公开了用于访问患者的咽鼓管的方法和系统。 该系统包括引导件，其构造成用于进入患者的鼻通道，以将导管的远侧末端定位在咽鼓管处或附近，该导管具有远侧尖端，弯曲部具有30度和90度之间的角度; 以及引导线，其构造成穿过所述引导件进入咽鼓管。
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公开(公告)号：US20100076269A1
公开(公告)日：2010-03-25
申请号：US12562828
申请日：2009-09-18
申请人： Joshua Makower , John Y. Chang , William M. Facteau , Eric Goldfarb , Ketan P. Muni , Earl A. Bright, II , Greg Garfield , Greg Liu , Thomas Jenkins , John H. Morriss , Julia D. Vrany , Hung V. Ha , Ronda M. Heiser , Scott M. Smith
发明人： Joshua Makower , John Y. Chang , William M. Facteau , Eric Goldfarb , Ketan P. Muni , Earl A. Bright, II , Greg Garfield , Greg Liu , Thomas Jenkins , John H. Morriss , Julia D. Vrany , Hung V. Ha , Ronda M. Heiser , Scott M. Smith
摘要： Systems and methods for treating paranasal sinuses in a head of a patient include, for example, forming an opening through a canine fossa into a maxillary paranasal sinus and performing a procedure such as a balloon catheter dilation of the maxillary sinus ostium. In some embodiments, one or more procedures other than a balloon dilation procedure may be performed. In some embodiments, a combination of balloon dilation and one or more other procedures may be performed. Various approaches involve employing medical devices to accomplish alternative treatment modalities as well as taking alternative routes to the interventional site.
摘要翻译： 用于治疗患者头部鼻窦的系统和方法包括例如通过犬窝形成通向上颌鼻旁窦的开口，并执行诸如上颌窦口的气囊导管扩张的过程。 在一些实施例中，可以执行除球囊扩张程序之外的一个或多个程序。 在一些实施例中，可以执行球囊扩张和一个或多个其它程序的组合。 各种方法涉及采用医疗设备来完成替代治疗方式，以及采取替代途径到介入部位。
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7.发明授权Devices, systems and methods for treating disorders of the ear, nose and throat 有权用于治疗耳朵，鼻子和喉咙疾病的装置，系统和方法公开(公告)号：US08123722B2
公开(公告)日：2012-02-28
申请号：US11926467
申请日：2007-10-29
IPC分类号： A61M29/00
CPC分类号： A61F11/002 , A61B5/065 , A61B10/06 , A61B17/1204 , A61B17/12045 , A61B17/12104 , A61B17/12136 , A61B17/1604 , A61B17/1608 , A61B17/1679 , A61B17/1688 , A61B17/24 , A61B17/32002 , A61B17/32075 , A61B17/3478 , A61B34/20 , A61B50/13 , A61B50/15 , A61B50/20 , A61B90/16 , A61B90/361 , A61B2017/00247 , A61B2017/003 , A61B2017/320004 , A61B2017/3486 , A61B2017/3488 , A61B2018/00392 , A61B2034/2051 , A61F2/958 , A61F2250/0067 , A61M25/007 , A61M25/10 , A61M2025/105 , A61M2025/1052
摘要： Sinusitis, mucocysts, tumors, infections, hearing disorders, choanal atresia, fractures and other disorders of the paranasal sinuses, Eustachian tubes, Lachrymal ducts and other ear, nose, throat and mouth structures are diagnosed and/or treated using minimally invasive approaches and, in many cases, flexible catheters as opposed to instruments having rigid shafts. Various diagnostic procedures and devices are used to perform imaging studies, mucus flow studies, air/gas flow studies, anatomic dimension studies and endoscopic studies. Access and occluding devices may be used to facilitate insertion of working devices such asendoscopes, wires, probes, needles, catheters, balloon catheters, dilation catheters, dilators, balloons, tissue cutting or remodeling devices, suction or irrigation devices, imaging devices, sizing devices, biopsy devices, image-guided devices containing sensors or transmitters, electrosurgical devices, energy emitting devices, devices for injecting diagnostic or therapeutic agents, devices for implanting devices such as stents, substance eluting or delivering devices and implants, etc.
摘要翻译： 鼻窦炎，粘膜囊肿，肿瘤，感染，听力障碍，胆管闭锁，鼻旁窦的骨折和其他疾病，咽鼓管，泪道和其他耳，鼻，喉和嘴结构被诊断和/或使用微创方法治疗， 在许多情况下，柔性导管与具有刚性轴的仪器相反。 使用各种诊断程序和装置进行成像研究，粘液流动研究，空气/气体流动研究，解剖维度研究和内窥镜研究。 可以使用进入和闭塞装置以便于诸如内窥镜，电线，探针，针，导管，球囊导管，扩张导管，扩张器，球囊，组织切割或重塑装置等工作装置的插入，抽吸或冲洗装置，成像装置，定径装置 ，活检装置，包含传感器或发射器的图像引导装置，电外科装置，能量发射装置，用于注射诊断或治疗剂的装置，用于植入诸如支架的装置，物质洗脱或递送装置和植入物等的装置。
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8.发明授权Devices, systems and methods for treating disorders of the ear, nose and throat 有权用于治疗耳朵，鼻子和喉咙疾病的装置，系统和方法公开(公告)号：US08088101B2
公开(公告)日：2012-01-03
申请号：US11925357
申请日：2007-10-26
IPC分类号： A61M29/00
CPC分类号： A61F11/002 , A61B5/065 , A61B10/06 , A61B17/1204 , A61B17/12045 , A61B17/12104 , A61B17/12136 , A61B17/1604 , A61B17/1608 , A61B17/1679 , A61B17/1688 , A61B17/24 , A61B17/32002 , A61B17/32075 , A61B17/3478 , A61B34/20 , A61B50/13 , A61B50/15 , A61B50/20 , A61B90/16 , A61B90/361 , A61B2017/00247 , A61B2017/003 , A61B2017/320004 , A61B2017/3486 , A61B2017/3488 , A61B2018/00392 , A61B2034/2051 , A61F2/958 , A61F2250/0067 , A61M25/007 , A61M25/10 , A61M2025/105 , A61M2025/1052
摘要： Sinusitis, mucocysts, tumors, infections, hearing disorders, choanal atresia, fractures and other disorders of the paranasal sinuses, Eustachian tubes, Lachrymal ducts and other ear, nose, throat and mouth structures are diagnosed and/or treated using minimally invasive approaches and, in many cases, flexible catheters as opposed to instruments having rigid shafts. Various diagnostic procedures and devices are used to perform imaging studies, mucus flow studies, air/gas flow studies, anatomic dimension studies and endoscopic studies. Access and occluding devices may be used to facilitate insertion of working devices such as endoscopes, wires, probes, needles, catheters, balloon catheters, dilation catheters, dilators, balloons, tissue cutting or remodeling devices, suction or irrigation devices, imaging devices, sizing devices, biopsy devices, image-guided devices containing sensors or transmitters, electrosurgical devices, energy emitting devices, devices for injecting diagnostic or therapeutic agents, devices for implanting devices such as stents, substance eluting or delivering devices and implants, etc.
摘要翻译： 鼻窦炎，粘膜囊肿，肿瘤，感染，听力障碍，胆管闭锁，鼻旁窦的骨折和其他疾病，咽鼓管，泪道和其他耳，鼻，喉和嘴结构被诊断和/或使用微创方法治疗， 在许多情况下，柔性导管与具有刚性轴的仪器相反。 使用各种诊断程序和装置进行成像研究，粘液流动研究，空气/气体流动研究，解剖维度研究和内窥镜研究。 可以使用进入和闭塞装置来促进诸如内窥镜，电线，探针，针，导管，球囊导管，扩张导管，扩张器，球囊，组织切割或重塑装置等工作装置的插入，抽吸或冲洗装置，成像装置，尺寸 装置，活检装置，包含传感器或发射器的图像引导装置，电外科装置，能量发射装置，用于注射诊断或治疗剂的装置，用于植入诸如支架，物质洗脱或递送装置和植入物等装置的装置等。
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9.发明授权Devices, systems and methods for treating disorders of the ear, nose and throat 有权用于治疗耳朵，鼻子和喉咙疾病的装置，系统和方法公开(公告)号：US07645272B2
公开(公告)日：2010-01-12
申请号：US11926326
申请日：2007-10-29
IPC分类号： A61M31/00
CPC分类号： A61F11/002 , A61B5/065 , A61B10/06 , A61B17/1204 , A61B17/12045 , A61B17/12104 , A61B17/12136 , A61B17/1604 , A61B17/1608 , A61B17/1679 , A61B17/1688 , A61B17/24 , A61B17/32002 , A61B17/32075 , A61B17/3478 , A61B34/20 , A61B50/13 , A61B50/15 , A61B50/20 , A61B90/16 , A61B90/361 , A61B2017/00247 , A61B2017/003 , A61B2017/320004 , A61B2017/3486 , A61B2017/3488 , A61B2018/00392 , A61B2034/2051 , A61F2/958 , A61F2250/0067 , A61M25/007 , A61M25/10 , A61M2025/105 , A61M2025/1052
摘要： Sinusitis, mucocysts, tumors, infections, hearing disorders, choanal atresia, fractures and other disorders of the paranasal sinuses, Eustachian tubes, Lachrymal ducts and other ear, nose, throat and mouth structures are diagnosed and/or treated using minimally invasive approaches and, in many cases, flexible catheters as opposed to instruments having rigid shafts. Various diagnostic procedures and devices are used to perform imaging studies, mucus flow studies, air/gas flow studies, anatomic dimension studies and endoscopic studies. Access and occluding devices may be used to facilitate insertion of working devices such asendoscopes, wires, probes, needles, catheters, balloon catheters, dilation catheters, dilators, balloons, tissue cutting or remodeling devices, suction or irrigation devices, imaging devices, sizing devices, biopsy devices, image-guided devices containing sensors or transmitters, electrosurgical devices, energy emitting devices, devices for injecting diagnostic or therapeutic agents, devices for implanting devices such as stents, substance eluting or delivering devices and implants, etc.
摘要翻译： 鼻窦炎，粘膜囊肿，肿瘤，感染，听力障碍，胆管闭锁，鼻旁窦的骨折和其他疾病，咽鼓管，泪道和其他耳，鼻，喉和嘴结构被诊断和/或使用微创方法治疗， 在许多情况下，柔性导管与具有刚性轴的仪器相反。 使用各种诊断程序和装置进行成像研究，粘液流动研究，空气/气体流动研究，解剖维度研究和内窥镜研究。 可以使用进入和闭塞装置以便于诸如内窥镜，电线，探针，针，导管，球囊导管，扩张导管，扩张器，球囊，组织切割或重塑装置等工作装置的插入，抽吸或冲洗装置，成像装置，定径装置 ，活检装置，包含传感器或发射器的图像引导装置，电外科装置，能量发射装置，用于注射诊断或治疗剂的装置，用于植入诸如支架的装置，物质洗脱或递送装置和植入物等的装置。
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公开(公告)号：US08961495B2
公开(公告)日：2015-02-24
申请号：US11926565
申请日：2007-10-29
IPC分类号： A61M31/00 , A61F11/00 , A61B17/12 , A61B17/16 , A61B17/24 , A61B17/32 , A61B17/3207 , A61B19/02 , A61B19/00 , A61M25/10 , A61B5/06 , A61B10/06 , A61B17/34 , A61B17/00 , A61B18/00 , A61F2/958 , A61M25/00
CPC分类号： A61F11/002 , A61B5/065 , A61B10/06 , A61B17/1204 , A61B17/12045 , A61B17/12104 , A61B17/12136 , A61B17/1604 , A61B17/1608 , A61B17/1679 , A61B17/1688 , A61B17/24 , A61B17/32002 , A61B17/32075 , A61B17/3478 , A61B34/20 , A61B50/13 , A61B50/15 , A61B50/20 , A61B90/16 , A61B90/361 , A61B2017/00247 , A61B2017/003 , A61B2017/320004 , A61B2017/3486 , A61B2017/3488 , A61B2018/00392 , A61B2034/2051 , A61F2/958 , A61F2250/0067 , A61M25/007 , A61M25/10 , A61M2025/105 , A61M2025/1052
摘要： Sinusitis, mucocysts, tumors, infections, hearing disorders, choanal atresia, fractures and other disorders of the paranasal sinuses, Eustachian tubes, Lachrymal ducts and other ear, nose, throat and mouth structures are diagnosed and/or treated using minimally invasive approaches and, in many cases, flexible catheters as opposed to instruments having rigid shafts. Various diagnostic procedures and devices are used to perform imaging studies, mucus flow studies, air/gas flow studies, anatomic dimension studies and endoscopic studies. Access and occluding devices may be used to facilitate insertion of working devices such asendoscopes, wires, probes, needles, catheters, balloon catheters, dilation catheters, dilators, balloons, tissue cutting or remodeling devices, suction or irrigation devices, imaging devices, sizing devices, biopsy devices, image-guided devices containing sensors or transmitters, electrosurgical devices, energy emitting devices, devices for injecting diagnostic or therapeutic agents, devices for implanting devices such as stents, substance eluting or delivering devices and implants, etc.
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