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公开(公告)号：US4812442A
公开(公告)日：1989-03-14
申请号：US45941
申请日：1987-05-04
申请人： Joshua S. Boger , Ben E. Evans , Mark G. Bock
发明人： Joshua S. Boger , Ben E. Evans , Mark G. Bock
IPC分类号： A61K38/00 , C07D233/54 , C07F9/30 , C07F9/32 , C07F9/40 , C07F9/48 , C07F9/6506 , C07K5/02 , C07K5/065 , C07K7/02 , C07K5/06 , C07K5/08 , C07D241/04 , C07D265/30 , C07D211/30 , C07D211/70 , C07D263/02 , C07D207/04
CPC分类号： C07D233/64 , C07F9/301 , C07F9/303 , C07F9/3211 , C07F9/3217 , C07F9/3223 , C07F9/4006 , C07F9/4816 , C07F9/4833 , C07F9/65067 , C07K5/0227 , C07K5/06078 , C07K7/02 , A61K38/00 , Y10S530/86
摘要： Enzyme tripeptides of the formula: ##STR1## and analogs thereof which inhibit renin and are useful for treating various forms of renin-associated hypertension, hyperaldosteronism and congestive heart failure; compositions containing these renin-inhibitory peptides, optionally with other antihypertensive agents; and methods of treating hypertension, hyperaldosteronism or congestive heart failure or of establishing renin as a causative factor in these problems employing the novel tripeptides.
摘要翻译： 下式的酶三肽及其类似物抑制肾素，可用于治疗各种形式的肾素相关性高血压，醛固酮增多症和充血性心力衰竭; 含有这些肾素抑制肽的组合物，任选与其它抗高血压药物组合; 以及治疗高血压，醛固酮增多症或充血性心力衰竭的方法，或者在使用新型三肽的这些问题中建立肾素作为致病因素。
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公开(公告)号：US4636491A
公开(公告)日：1987-01-13
申请号：US593754
申请日：1984-03-27
CPC分类号： C07K5/0227 , Y10S530/86
摘要： Renin inhibitory peptides of the formula ##STR1## and analogs thereof inhibit renin and are useful for treating various forms of renin-associated hypertension and hyperaldosteronism.
摘要翻译： 式（Ⅰ）及其类似物的肾素抑制肽抑制肾素，可用于治疗各种形式的肾素相关性高血压和醛固酮增多症。
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公开(公告)号：US4479941A
公开(公告)日：1984-10-30
申请号：US438841
申请日：1982-11-04
申请人： Daniel F. Veber , Joshua S. Boger , Mark G. Bock
发明人： Daniel F. Veber , Joshua S. Boger , Mark G. Bock
IPC分类号： C07K5/02 , C07K7/14 , C07C103/52 , A61K37/02
CPC分类号： C07K5/0227 , C07K7/14 , Y10S530/80 , Y10S530/86
摘要： Renin inhibitory peptides of the formula ##STR1## and analogs thereof inhibit renin and are useful for treating various forms of renin-associated hypertension and hyperalaosteronism.
摘要翻译： 式“IMAGE”及其类似物的肾素抑制肽抑制肾素，并且可用于治疗各种形式的肾素相关性高血压和高醛固酮增多症。
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公开(公告)号：US4661473A
公开(公告)日：1987-04-28
申请号：US593758
申请日：1984-03-27
申请人： Joshua S. Boger , Mark G. Bock
发明人： Joshua S. Boger , Mark G. Bock
IPC分类号： C07D233/90 , A61K31/135 , A61K31/165 , A61K31/19 , A61K31/195 , A61K31/215 , A61K31/22 , A61K31/27 , A61K38/00 , A61P9/12 , A61P43/00 , C07C67/00 , C07C239/00 , C07C269/00 , C07D233/64 , C07F9/30 , C07F9/58 , C07K5/02 , C07K5/04 , C07K7/04 , C07K7/06 , C07K14/81 , A61K37/43 , C07K7/02
CPC分类号： C07K7/06 , C07K5/0227 , A61K38/00 , Y10S530/86
摘要： Renin inhibitory peptides of the formula ##STR1## and analogs thereof inhibit renin and are useful for treating various forms of renin-associated hypertension and hyperaldosteronism.
摘要翻译： 式（Ⅰ）及其类似物的肾素抑制肽抑制肾素，可用于治疗各种形式的肾素相关性高血压和醛固酮增多症。
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公开(公告)号：US4663310A
公开(公告)日：1987-05-05
申请号：US596766
申请日：1984-04-04
IPC分类号： C07D205/04 , A61K38/00 , A61K38/55 , A61P9/12 , A61P43/00 , C07D207/16 , C07K5/02 , C07K7/02 , C07K14/81 , C07K7/06
CPC分类号： C07K5/0227 , Y10S530/86
摘要： Renin inhibitory peptides of the formula ##STR1## and analogs thereof inhibit renin and are useful for treating various forms of renin-associated hypertension and hyperaldosteronism.
摘要翻译： 式（Ⅰ）及其类似物的肾素抑制肽抑制肾素，可用于治疗各种形式的肾素相关性高血压和醛固酮增多症。
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公开(公告)号：US5206237A
公开(公告)日：1993-04-27
申请号：US699849
申请日：1991-05-14
申请人： Roger M. Freidinger , Mark G. Bock , Ben E. Evans
发明人： Roger M. Freidinger , Mark G. Bock , Ben E. Evans
IPC分类号： A61K31/55 , A61K31/551 , A61P25/04 , A61P25/20 , A61P25/30 , A61P27/02 , A61P35/00 , C07D243/14 , C07D401/12 , C07D403/04
CPC分类号： A61K31/55
摘要： Pharmaceutical compositions containing benzodiazepines of the formula: ##STR1## are disclosed which are useful in the treatment of panic disorder or anxiety disorder.
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7.发明授权Amide-substituted derivatives of spiroindanylcamphorsulfonyl oxytocin antagonists 失效螺旋体丹参酮氧基氧化物拮抗剂的酰胺取代衍生物
公开(公告)号：US5204349A
公开(公告)日：1993-04-20
申请号：US760284
申请日：1991-09-16
申请人： Mark G. Bock , Ben E. Evans , Roger M. Freidinger , Kevin Gilbert , Doug W. Hobbs , James B. Hoffman , George F. Lundell , Douglas J. Pettibone
发明人： Mark G. Bock , Ben E. Evans , Roger M. Freidinger , Kevin Gilbert , Doug W. Hobbs , James B. Hoffman , George F. Lundell , Douglas J. Pettibone
IPC分类号： A61K31/435 , A61K31/495 , A61P13/02 , A61P15/00 , C07D221/20 , C07D401/12 , C07D401/14
CPC分类号： C07D221/20 , C07D401/12 , C07D401/14
摘要： Compounds of the formula: ##STR1## where R.sup.1 is hydrogen or hydroxy and R.sup.2 is a substituted amino group, a substituted heterocyclic ring or a substituted alkyl. These compounds are oxytocin and vasopressin antagonists useful in the treatment of preterm labor, dysmenorrhea and for the stoppage of labor preparatory to cesarean delivery, timing of parturition, uterine hyperactivity, endometriosis, hypertension, congestive heart failure, hyponatremia and cognitive disorders. Also disclosed are pharmaceutical compositions containing these compounds, methods of their use and methods of their preparation.
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8.发明授权2-Benzazepines with 5- and 6-membered heterocyclic rings, compositions and medical methods of use thereof 失效具有5-和6-元杂环的2-苯并氮杂，其组合物和医用方法
公开(公告)号：US5166151A
公开(公告)日：1992-11-24
申请号：US668353
申请日：1991-03-11
申请人： Roger M. Freidinger , Ben E. Evans , Mark G. Bock
发明人： Roger M. Freidinger , Ben E. Evans , Mark G. Bock
IPC分类号： C07D487/04 , C07D498/04 , C07D513/04
CPC分类号： C07D487/04 , C07D513/04
摘要： Aromatic 2-benzazepines with fused 5- or 6-membered heterocyclic rings which are antagonists of cholecystokinins and/or gastrin, and are useful in the treatment or prevention of CCK-related and/or gastrin-related disorders of the gastrointestinal, central nervous and appetite regulatory systems; compositions comprising these compounds; and methods of treatment of mammals or of increasing food intake of animals employing these compounds.
摘要翻译： 具有作为缩胆囊素和/或胃泌素拮抗剂的稠合的5-或6-元杂环的芳族2-苯并吖庚因，可用于治疗或预防胃肠道，中枢神经和/或胃肠激素的CCK相关和/或胃泌素相关疾病 食欲调节系统; 包含这些化合物的组合物; 哺乳动物的治疗方法或使用这些化合物的动物的食物摄入量增加。
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公开(公告)号：US5004741A
公开(公告)日：1991-04-02
申请号：US269212
申请日：1988-11-09
申请人： Ben E. Evans , Mark G. Bock , Roger M. Freidinger
发明人： Ben E. Evans , Mark G. Bock , Roger M. Freidinger
IPC分类号： A61K31/55 , A61K38/00 , C07C271/22 , C07D209/20 , C07D209/48 , C07D243/16 , C07D243/20 , C07D243/22 , C07D243/24 , C07D243/26 , C07D243/28 , C07D243/36 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07K5/06 , C07K5/065 , C07K5/078 , C07K5/097
CPC分类号： C07C271/22 , C07D209/20 , C07D209/48 , C07D243/16 , C07D243/20 , C07D243/22 , C07D243/24 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07K5/06078 , C07K5/06139 , C07K5/06191 , C07K5/0821 , A61K38/00 , Y10S514/925 , Y10S514/926 , Y10S514/927
摘要： Methods of antagonizing gastrin and/or cholecystokinin (CCK) with benzodiazepine analogs are disclosed, as well as related pharmaceutical compositions, which are useful in treating disorders of the gastrointestinal tract, central nervous system, and of the appetite.
摘要翻译： 公开了用苯并二氮杂类似物拮抗胃泌素和/或胆囊收缩素（CCK）的方法，以及可用于治疗胃肠道疾病，中枢神经系统和食欲的相关药物组合物。
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10.发明授权1,4-Benzodiazepines with 5- and 6-membered heterocyclic rings and their use as cholecystokinins and gastrin antagonists 失效具有5-和6-元杂环的1,4-苯并二氮杂类及其作为缩胆囊素和胃泌素拮抗剂的用途
公开(公告)号：US4847248A
公开(公告)日：1989-07-11
申请号：US141435
申请日：1988-01-06
申请人： Roger M. Freidinger , Ben E. Evans , Mark G. Bock
发明人： Roger M. Freidinger , Ben E. Evans , Mark G. Bock
IPC分类号： C07D471/04 , C07D487/04
CPC分类号： C07D471/04 , C07D487/04
摘要： Aromatic 1,4-benzodiazepines with fused 5- or 6-membered heterocyclic rings which are antagonists of cholecystokinins and/or gastrin, and are useful in the treatment or prevention of CCK-related and/or gastrin-related disorders of the gastrointestinal, central nervous and appetite regulatory systems; compositions comprising these compounds; and methods of treatment employing these compounds.
摘要翻译： 具有稠合的5-或6-元杂环的芳族1,4-苯并二氮杂，其是缩胆囊素和/或胃泌素的拮抗剂，并且可用于治疗或预防胃肠道，中枢的CCK相关和/或胃泌素相关疾病 紧张和食欲调节系统; 包含这些化合物的组合物; 和使用这些化合物的治疗方法。
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