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    2-azabicyclo[3.3.1]nonane derivatives
    1.
    再颁专利
    2-azabicyclo[3.3.1]nonane derivatives 失效
    2-氮杂双环[3.3.1]壬烷衍生物

    公开(公告)号：USRE40838E1

    公开(公告)日：2009-07-07

    申请号：US11874253

    申请日：2007-10-18

    申请人： Jotham W. Coe ,  Stanton F. McHardy

    发明人： Jotham W. Coe ,  Stanton F. McHardy

    IPC分类号： A61K31/439 ,  C07D221/22

    CPC分类号： C07D221/22

    摘要： The subject invention relates to 2-azabicyclo[3.3.1]nonane derivatives, pharmaceutical compositions comprising such derivatives and methods of using such derivatives to treat disease states, disorders and conditions mediated by opioid receptors. The subject invention also particularly relates to using such derivatives to treat certain disorders and conditions, for example irritable bowel syndrome, drug addiction, including alcohol addiction, depression, anxiety, schizophrenia and eating disorders, among others, as are more fully described herein.

    摘要翻译： 本发明涉及2-氮杂双环[3.3.1]壬烷衍生物，包含这些衍生物的药物组合物和使用这些衍生物治疗由阿片受体介导的疾病状态，病症和病症的方法。 本发明还特别涉及如本文更充分描述的那样使用这些衍生物来治疗某些疾病和病症，例如肠易激综合征，药物成瘾，包括酒精成瘾，抑郁，焦虑，精神分裂症和进食障碍等。

    Heteroaryl fused azapolycyclic compounds
    3.
    发明授权
    Heteroaryl fused azapolycyclic compounds 失效
    杂芳基稠合的氮杂多环化合物

    公开(公告)号：US07456177B2

    公开(公告)日：2008-11-25

    申请号：US10889395

    申请日：2004-07-12

    申请人： Martin P. Allen ,  Jotham W. Coe ,  Spiros Liras ,  Christopher J. O'Donnell ,  Brian T. O'Neill

    发明人： Martin P. Allen ,  Jotham W. Coe ,  Spiros Liras ,  Christopher J. O'Donnell ,  Brian T. O'Neill

    IPC分类号： A61K31/502 ,  C07D471/02

    CPC分类号： C07D471/08

    摘要： The present invention provides a compound having the structure of formula I: wherein R1 is hydrogen, (C1–C6) alkyl, unconjugated (C3–C6) alkenyl, benzyl, YC(═O)(C1–C6) alkyl or —CH2CH2—O—(C1–C4) alkyl; X is CH2 or CH2CH2; Y is (C2–C6) alkylene; Z is (CH2)m, CF2, or C(═O), where m is 0, 1 or 2; R2 and R3 are selected independently from hydrogen, halogen, —(C1–C6) alkyl optionally substituted with from 1 to 7 halogen atoms, and —O(C1–C6) alkyl optionally substituted with from 1 to 7 halogen atoms, or R2 and R3 each together with the atom to which it is connected independently form C(═O), S→O, S(═O)2, or N→O; and is a 5- to 7-membered monocyclic heteroaryl group selected from pyridinyl, pyridone, pyridazinyl, imidazolyl, pyrimidinyl, pyrazolyl, triazolyl, pyrazinyl, furyl, thienyl, isoxazolyl, thiazolyl, oxazolyl, isothiazolyl, pyrrolyl, cinnolinyl, triazinyl, oxadiazolyl, thiadiazolyl and furazanyl groups.

    摘要翻译： 本发明提供具有式I结构的化合物：其中R 1是氢，（C 1 -C 6 -C 6）烷基，未缀合的 （C 3 -C 6）烯基，苄基，YC（-O）（C 1 -C 6 - ）烷基或-CH 2 CH 2 -O-（C 1 -C 4 - ）烷基; X是CH 2或CH 2 CH 2 CH 2; Y是（C 2 -C 6 -C 6）亚烷基; Z是（CH 2）2，CH 2或C（-O），其中m是0,1或2; R 2和R 3独立地选自氢，卤素， - （C 1 -C 6 -C 6）烷基 或任选被1至7个卤素原子取代的-O（C 1 -C 6 -C 6）烷基，或任选被1至7个卤素原子取代的-O（C 1 -C 6 -C 6）烷基， 2和R 3各自与其连接的原子一起独立地形成C（-O），S-> O，S（-O）2 或N-> O; 吡啶基，吡唑基，三唑基，吡嗪基，呋喃基，噻吩基，异恶唑基，噻唑基，恶唑基，异噻唑基，吡咯基，噌啉基，三嗪基，恶二唑基， 噻二唑基和呋咱基。

    Diazabicyclic compounds useful in the treatment of CNS and other disorders
    4.
    发明授权
    Diazabicyclic compounds useful in the treatment of CNS and other disorders 失效
    可用于治疗CNS和其他疾病的二氮杂双环化合物

    公开(公告)号：US07442694B2

    公开(公告)日：2008-10-28

    申请号：US10657738

    申请日：2003-09-08

    申请人： Jotham W. Coe ,  Christopher J. O'Donnell ,  Brian T. O'Neill ,  Lawrence A. Vincent

    发明人： Jotham W. Coe ,  Christopher J. O'Donnell ,  Brian T. O'Neill ,  Lawrence A. Vincent

    IPC分类号： C07D487/08 ,  A61K31/495

    CPC分类号： C07D487/08

    摘要： The present invention relates to a compounds of formula I: wherein A, B, D, E and F are defined herein; that are useful in treating central nervous system (CNS) diseases, disorders and conditions, such as but not limited to nicotine addiction, schizophrenia, depression, Alzheimer's disease, Parkinson's disease and ADHD. The present invention further comprises pharmaceutical compositions containing such compounds and methods of treatment comprising the use of such compounds.

    摘要翻译： 本发明涉及式I化合物：其中A，B，D，E和F如本文所定义; 可用于治疗中枢神经系统（CNS）疾病，疾病和病症，例如但不限于尼古丁成瘾，精神分裂症，抑郁症，阿尔茨海默病，帕金森病和ADHD。 本发明还包含含有这些化合物的药物组合物和包括使用这些化合物的治疗方法。

    3-azabicyclo[3.2.1]octane derivatives
    5.
    发明授权
    3-azabicyclo[3.2.1]octane derivatives 失效
    3-氮杂双环[3.2.1]辛烷衍生物

    公开(公告)号：US07241887B2

    公开(公告)日：2007-07-10

    申请号：US10824037

    申请日：2004-04-14

    申请人： Jotham W. Coe ,  Stanton McHardy ,  Crystal G. Bashore

    发明人： Jotham W. Coe ,  Stanton McHardy ,  Crystal G. Bashore

    IPC分类号： C07D223/00 ,  A01N43/00 ,  A61K31/55

    CPC分类号： C07D401/06 ,  C07D221/24 ,  C07D405/06 ,  C07D409/06 ,  C07D417/06

    摘要： The subject invention relates to 3-azabicyclo[3.2.1]octane derivatives, pharmaceutical compositions comprising such derivatives and methods of using such derivatives to treat disease states, disorders and conditions mediated by opioid receptors. The subject invention also particularly relates to using such derivatives to treat certain disorders and conditions, for example irritable bowel syndrome, drug addiction, depression, anxiety, schizophrenia and eating disorders, among others.

    摘要翻译： 本发明涉及3-氮杂双环[3.2.1]辛烷衍生物，包含这些衍生物的药物组合物和使用这些衍生物治疗由阿片受体介导的疾病状态，病症和病状的方法。 本发明还特别涉及使用这样的衍生物来治疗某些疾病和病症，例如肠易激综合征，药物成瘾，抑郁，焦虑，精神分裂症和进食障碍等。

    Hood door airfoil
    6.
    发明授权
    Hood door airfoil 失效
    敞篷门翼型

    公开(公告)号：US6080058A

    公开(公告)日：2000-06-27

    申请号：US98314

    申请日：1998-06-16

    申请人： Jotham W. Coe ,  Daniel P. Brannegan

    发明人： Jotham W. Coe ,  Daniel P. Brannegan

    IPC分类号： B08B15/02

    CPC分类号： B08B15/023

    摘要： An apparatus for directing the flow of air in a laboratory-type hood. A laboratory hood is provided with a closure sash and the lower edge of the closure sash has an airfoil that extends into the laboratory hood work space.

    摘要翻译： 用于在实验室型罩中引导空气流的装置。 实验室罩具有闭合窗框，并且封闭窗框的下边缘具有延伸到实验室罩工作空间中的翼型。

    2-Azabicyclo[3.3.1]nonane derivatives
    7.
    发明授权
    2-Azabicyclo[3.3.1]nonane derivatives 有权
    2-氮杂双环[3.3.1]壬烷衍生物

    公开(公告)号：US07056930B2

    公开(公告)日：2006-06-06

    申请号：US10762730

    申请日：2004-01-22

    申请人： Jotham W. Coe ,  Stanton McHardy

    发明人： Jotham W. Coe ,  Stanton McHardy

    IPC分类号： A61K31/439 ,  C07D221/22

    CPC分类号： C07D221/22

    摘要： The subject invention relates to 2-azabicyclo[3.3.1]nonane derivatives, pharmaceutical compositions comprising such derivatives and methods of using such derivatives to treat disease states, disorders and conditions mediated by opioid receptors. The subject invention also particularly relates to using such derivatives to treat certain disorders and conditions, for example irritable bowel syndrome, drug addiction, including alcohol addiction, depression, anxiety, schizophrenia and eating disorders, among others, as are more fully described herein.

    摘要翻译： 本发明涉及2-氮杂双环[3.3.1]壬烷衍生物，包含这些衍生物的药物组合物和使用这些衍生物治疗由阿片受体介导的疾病状态，病症和病症的方法。 本发明还特别涉及如本文更充分描述的那样使用这些衍生物来治疗某些疾病和病症，例如肠易激综合征，药物成瘾，包括酒精成瘾，抑郁，焦虑，精神分裂症和进食障碍等。