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1.发明授权4-(1,2,5,6-tetrahydro-1-alkyl-3-pyridinyl)-2-thiazolamines and 4-(hexahydro-1-alkyl-3-pyridinyl)-2-thiazolamines 失效4-（1,2,5,6-四氢-1-烷基-3-吡啶基）-2-噻唑胺和4-（六氢-1-烷基-3-吡啶基）-2-噻唑胺
公开(公告)号：US4739067A
公开(公告)日：1988-04-19
申请号：US925760
申请日：1986-10-31
IPC分类号： A61K31/425 , A61K31/435 , A61K31/44 , A61K31/445 , A61P9/12 , A61P25/18 , C07D417/04
CPC分类号： C07D417/04
摘要： A unique series of 4-(1,2,5,6-tetrahydro-1-alkyl-3-pyridinyl)-2-thiazolamines and 4-(hexahydro-1-alkylpyridinyl)-2-thiazolamines are disclosed. These compounds are useful as dopaminergic agents. Intermediates for preparing the compounds, pharmaceutical compositions containing them, and methods for using the pharmaceutical compositions for treating human psychosis, elevated blood pressure, Parkinson's disease, hyperprolactinaemia, sexual disorders, and acromegaly are described.
摘要翻译： 公开了4-（1,2,5,6-四氢-1-烷基-3-吡啶基）-2-噻唑胺和4-（六氢-1-烷基吡啶基）-2-噻唑胺的独特系列。 这些化合物可用作多巴胺能药剂。 描述了用于制备化合物的中间体，含有它们的药物组合物和用于治疗人类精神病，血压升高，帕金森病，高泌乳素血症，性功能障碍和肢端肥大症的药物组合物的方法。
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2.发明授权4-(1,2,5,6-Tetrahydro-1-alkyl-3-pyridinyl)-2-thiazolamines and 4-(hexahydro-1-alkyl-3-pyridinyl)-2-thiazolamines having anti-psychotic activity 失效4-（1,2,5,6-四氢-1-烷基-3-吡啶基）-2-噻唑胺和具有抗精神病活性的4-（六氢-1-烷基-3-吡啶基）-2-噻唑胺
公开(公告)号：US4650805A
公开(公告)日：1987-03-17
申请号：US803697
申请日：1985-12-02
IPC分类号： A61K31/425 , A61K31/435 , A61K31/44 , A61K31/445 , A61P9/12 , A61P25/18 , C07D417/04
CPC分类号： C07D417/04
摘要： A unique series of 4-(1,2,5,6-tetrahydro-1-alkyl-3-pyridinyl)-2-thiazolamines and 4-(hexahydro-1-alkyl-pyridinyl)-2-thiazolamines are disclosed. These compounds are useful as dopaminergic agents. Intermediates for preparing the compounds, pharmaceutical compositions containing them, and methods for using the pharmaceutical compositions for treating human psychosis, elevated blood pressure, Parkinson's disease, hyperprolactinaemia, sexual disorders, and acromegaly are described.
摘要翻译： 公开了一系列独特的4-（1,2,5,6-四氢-1-烷基-3-吡啶基）-2-噻唑胺和4-（六氢-1-烷基 - 吡啶基）-2-噻唑胺。 这些化合物可用作多巴胺能药剂。 描述了用于制备化合物的中间体，含有它们的药物组合物和用于治疗人类精神病，血压升高，帕金森病，高泌乳素血症，性功能障碍和肢端肥大症的药物组合物的方法。
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公开(公告)号：US5270312A
公开(公告)日：1993-12-14
申请号：US778247
申请日：1991-10-24
申请人： Shelly Glase , Juan C. Jaen , Sarah J. Smith , Lawrence D. Wise
发明人： Shelly Glase , Juan C. Jaen , Sarah J. Smith , Lawrence D. Wise
IPC分类号： A61K31/495 , A61K31/496 , A61K31/505 , A61P9/12 , A61P25/18 , A61P25/24 , A61P25/26 , A61P43/00 , C07D213/38 , C07D213/74 , C07D401/12 , C07D417/12 , A61K31/50 , C07D401/02 , C07D403/02
CPC分类号： C07D213/74 , C07D213/38 , C07D401/12 , C07D417/12
摘要： Substituted piperazines and derivatives of Formula I ##STR1## are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
摘要翻译： 描述了取代的哌嗪和式I的衍生物
，以及其制备方法及其药物组合物，其可用作中枢神经系统试剂，并且特别可用作多巴胺能抗精神病药和抗高血压药物，以及 用于治疗高泌乳素血症相关病症和中枢神经系统疾病。 -
4.发明授权Substituted tetrahydropyridines and hydroxypiperidines as central nervous system agents 失效取代的四氢吡啶和羟基哌啶作为中枢神经系统药剂
公开(公告)号：US5620988A
公开(公告)日：1997-04-15
申请号：US469127
申请日：1995-06-06
申请人： Shelly Glase , Juan C. Jaen , Sarah J. Smith , Lawrence D. Wise
发明人： Shelly Glase , Juan C. Jaen , Sarah J. Smith , Lawrence D. Wise
IPC分类号： A61K31/44 , A61K31/4418 , A61K31/4427 , A61K31/4433 , A61K31/444 , A61K31/445 , A61K31/451 , A61K31/47 , A61K31/4725 , A61P5/06 , A61P9/12 , A61P25/00 , A61P25/18 , A61P25/24 , A61P25/26 , A61P43/00 , C07D211/70 , C07D211/74 , C07D277/22 , C07D401/06 , C07D409/14 , C07D417/06 , C07D215/38 , C07D217/24 , C07D403/06
CPC分类号： C07D401/06 , C07D211/70 , C07D409/14
摘要： Substituted tetrahydropyridines and hydroxypiperidines and derivatives thereof are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
摘要翻译： 本发明描述了取代的四氢吡啶类和羟基哌啶及其衍生物，以及其制备方法及其药物组合物，其可用作中枢神经系统试剂，并且特别可用作多巴胺能抗精神病药和抗高血压药物以及用于治疗高泌乳素血症 相关病症和中枢神经系统疾病。
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公开(公告)号：US5047406A
公开(公告)日：1991-09-10
申请号：US517913
申请日：1990-05-02
IPC分类号： C07D295/08 , A61K31/00 , A61K31/42 , A61K31/435 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61P9/12 , A61P13/02 , A61P15/00 , A61P15/10 , A61P15/14 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/26 , C07D211/00 , C07D211/82 , C07D213/74 , C07D213/75 , C07D213/82 , C07D261/02 , C07D265/02 , C07D401/08 , C07D401/12 , C07D405/12 , C07D409/00 , C07D409/08 , C07D409/12 , C07D417/12 , C07D521/00
CPC分类号： C07D211/82 , C07D213/74 , C07D213/82 , C07D401/08 , C07D401/12 , C07D405/12 , C07D409/08 , C07D409/12 , C07D417/12
摘要： Substituted cyclohexanols and cyclohexylamines and derivatives thereof are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
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6.发明授权4 or 5-(substituted piperazinylalkyl)-2-aminothiazoles as antipsychotic agents 失效4或5-（取代的哌嗪基烷基）-2-氨基噻唑作为抗精神病药
公开(公告)号：US4935424A
公开(公告)日：1990-06-19
申请号：US199898
申请日：1988-05-27
IPC分类号： C07D277/40 , C07D417/12
CPC分类号： C07D417/12 , C07D277/40
摘要： Substituted 2-aminothiazoles are described, as well as methods for the preparation and pharmaceutical compositions of same, which are useful as dopamine agonists with selectivity for the presynaptic dopamine receptor and are useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
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7.发明授权Substituted tetrahydropyridines and their use as central nervous system agents 失效取代的四氢吡啶并用作中枢神经系统药剂
公开(公告)号：US5187280A
公开(公告)日：1993-02-16
申请号：US746434
申请日：1991-08-16
申请人： Juan C. Jaen , David G. Nickell , Donna M. Reynolds , Sarah J. Smith , Lawrence D. Wise , David J. Wustrow
发明人： Juan C. Jaen , David G. Nickell , Donna M. Reynolds , Sarah J. Smith , Lawrence D. Wise , David J. Wustrow
IPC分类号： C07D401/06 , C07D401/14 , C07D409/14
CPC分类号： C07D401/06 , C07D401/14 , C07D409/14
摘要： Substituted tetrahydropyridines and derivatives thereof are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
摘要翻译： 本发明描述了取代的四氢吡啶类及其衍生物，以及其制备方法及其药物组合物，其可用作中枢神经系统药剂，特别可用作多巴胺能抗精神病药和抗高血压药，以及用于治疗高泌乳素血症相关病症 和中枢神经系统疾病。
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公开(公告)号：US5118691A
公开(公告)日：1992-06-02
申请号：US716048
申请日：1991-06-17
申请人： Juan C. Jaen , David G. Nickell , Donna M. Reynolds , Sarah J. Smith , Lawrence D. Wise , David J. Wustrow
发明人： Juan C. Jaen , David G. Nickell , Donna M. Reynolds , Sarah J. Smith , Lawrence D. Wise , David J. Wustrow
IPC分类号： C07D401/06 , C07D401/14 , C07D409/14
CPC分类号： C07D401/06 , C07D401/14 , C07D409/14
摘要： Substituted tetrahydropyridines and derivatives thereof are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
摘要翻译： 本发明描述了取代的四氢吡啶类及其衍生物，以及其制备方法及其药物组合物，其可用作中枢神经系统药剂，特别可用作多巴胺能抗精神病药和抗高血压药，以及用于治疗高泌乳素血症相关病症 和中枢神经系统疾病。
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公开(公告)号：US5089497A
公开(公告)日：1992-02-18
申请号：US585742
申请日：1990-09-20
申请人： Juan C. Jaen , David G. Nickell , Donna M. Reynolds , Sarah J. Smith , Lawrence D. Wise , David J. Wustrow
发明人： Juan C. Jaen , David G. Nickell , Donna M. Reynolds , Sarah J. Smith , Lawrence D. Wise , David J. Wustrow
IPC分类号： C07D213/74 , C07D401/12
CPC分类号： C07D213/74 , C07D401/12
摘要： Substituted piperazines and derivatives thereof are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
摘要翻译： 描述了取代的哌嗪及其衍生物，以及其制备方法及其药物组合物，其可用作中枢神经系统试剂，并且特别可用作多巴胺能抗精神病药和抗高血压药，以及用于治疗高泌乳素血症相关病症 和中枢神经系统疾病。
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公开(公告)号：US4975445A
公开(公告)日：1990-12-04
申请号：US446950
申请日：1989-12-06
IPC分类号： C07D295/12 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4418 , A61K31/4427 , A61K31/4433 , A61K31/495 , A61P9/12 , A61P15/00 , A61P25/00 , A61P25/14 , A61P25/18 , A61P25/24 , A61P25/26 , A61P43/00 , C07D211/00 , C07D213/74 , C07D277/20 , C07D277/42 , C07D307/33 , C07D307/56 , C07D307/66 , C07D401/00 , C07D401/08 , C07D409/00 , C07D409/08 , C07D409/12 , C07D417/00 , C07D417/08 , C07D417/12
CPC分类号： C07D213/74 , C07D401/08 , C07D409/08 , C07D409/12 , C07D417/12
摘要： Substituted cyclohexenes are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
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