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1.发明申请FORMATION OF HEMATOPOIETIC PROGENITOR CELLS FROM MESENCHYMAL STEM CELLS 审中-公开从细胞干细胞中形成HEMATOPOIETIC PROGENITOR细胞公开(公告)号：US20130309209A1
公开(公告)日：2013-11-21
申请号：US13880677
申请日：2011-10-24
申请人： Juan Carlos Izpisua-Belmonte , Emmanuel Nivet , Ignacio Sancho-Martinez , Leo Kurian , Julian Andres Pulecio Rojas
发明人： Juan Carlos Izpisua-Belmonte , Emmanuel Nivet , Ignacio Sancho-Martinez , Leo Kurian , Julian Andres Pulecio Rojas
IPC分类号： C12N5/0789
CPC分类号： C12N5/0647 , C12N2501/602 , C12N2506/1384 , C12N2510/00
摘要： There are provided, inter alia, methods for forming (e.g. transgeneration of) hematopoietic stem cells from mesenchymal stem cells.
摘要翻译： 特别提供了用于从间充质干细胞形成（例如）造血干细胞的转基因的方法。
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2.发明申请ROBUST AND EFFICIENT DIFFERENTIATION OF HUMAN PLURIPOTENT STEM CELLS TO MULTIPOTENT VASCULAR PROGENITORS 审中-公开人肺细胞干细胞对多种血管造血细胞的稳定和有效的分化公开(公告)号：US20140045265A1
公开(公告)日：2014-02-13
申请号：US13985852
申请日：2012-02-16
CPC分类号： C12N5/0661 , C12N5/0602 , C12N5/0634 , C12N5/0647 , C12N5/0692 , C12N2501/115 , C12N2501/155 , C12N2501/165 , C12N2506/02 , C12N2506/45
摘要： Provided herein are methods and compositions for generating vascular progenitor cells that can in turn be differentiated into endothelial, smooth muscle, and hematopoietic cells. The present methods provide a faster, safer, and more efficient in vitro differentiation program than existing methodologies. The differentiated cells can be used for research and therapeutic applications, such as cell transplantation.
摘要翻译： 本文提供了用于产生血管祖细胞的方法和组合物，所述血管祖细胞又可分化为内皮，平滑肌和造血细胞。 本方法提供比现有方法更快，更安全和更有效的体外分化程序。 分化细胞可用于研究和治疗应用，如细胞移植。
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3.发明申请公开(公告)号：US20120294856A1
公开(公告)日：2012-11-22
申请号：US13509592
申请日：2010-11-15
IPC分类号： A61K39/395 , C07H21/04 , C07K16/18 , C07K19/00 , A61K31/713 , C12Q1/02 , A61P35/00 , G01N33/573 , G01N33/566 , C40B30/04 , C12Q1/68 , C07H21/02 , A61K31/7105
CPC分类号： G01N33/5041 , A61K31/7105 , G01N33/5011 , G01N2333/70578
摘要： The present invention is concerned with compounds inhibiting CD95 signaling in pancreatic cancer cells. Furthermore, contemplated by the current invention are medicaments comprising such a compound for the prevention and/or treatment of pancreatic cancer as well as the use of such a compound for the manufacture of a medicament for the prevention and/or treatment of pancreatic cancer, the prevention of migration of cancer cells, and/or the prevention and/or treatment of an inflammatory reaction. The present invention also refers to a method for the identification of a compound inhibiting CD95 signaling, as we to a method for the manufacture of a medicament comprising the steps of the method for the identification of a compound inhibiting CD95 signaling and the further step of formulating the inhibiting compound as a medicament.
摘要翻译： 本发明涉及抑制胰腺癌细胞中CD95信号传导的化合物。 此外，本发明考虑的是包含用于预防和/或治疗胰腺癌的这种化合物的药物以及这种化合物在制备用于预防和/或治疗胰腺癌的药物中的用途， 预防癌细胞的迁移，和/或预防和/或治疗炎性反应。 本发明还涉及一种用于鉴定抑制CD95信号的化合物的方法，如我们关于制备药物的方法，包括以下步骤：鉴定抑制CD95信号的化合物的方法和进一步的配制步骤 作为药物的抑制化合物。
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4.发明授权Neutralization of CD95 activity blocks invasion of glioblastoma cells in vivo 有权CD95活性中和阻断胶质母细胞瘤细胞侵袭公开(公告)号：US09309320B2
公开(公告)日：2016-04-12
申请号：US12521625
申请日：2007-12-28
申请人： Ana Martin-Villalba , Susanne Kleber , Benedikt Wiestler , Peter G. Krammer , Christel Herold-Mende , Ignacio Sancho-Martinez
发明人： Ana Martin-Villalba , Susanne Kleber , Benedikt Wiestler , Peter G. Krammer , Christel Herold-Mende , Ignacio Sancho-Martinez
IPC分类号： A61K39/00 , A61K38/00 , C07K16/28 , C07K14/705 , G01N33/566 , G01N33/574
CPC分类号： C07K16/2875 , A61K38/00 , A61K2039/505 , C07K14/70575 , C07K14/70578 , C07K16/2878 , C07K2317/76 , C07K2319/00 , C07K2319/30 , G01N33/566 , G01N33/57407 , G01N33/6863 , G01N2333/70578 , G01N2500/00 , G01N2500/04 , G01N2500/10 , G01N2510/00
摘要： The present invention relates to methods for treating an individual with high grade glioblastoma multiforme by preventing or disrupting the binding of CD95 to its ligand, CD95L, in vivo, whereupon that neutralization of CD95 activity reduces undesirable glial cell migration and invasion into body tissue.
摘要翻译： 本发明涉及通过在体内预防或破坏CD95与其配体CD95L的结合来治疗具有高级胶质母细胞瘤多形性的个体的方法，因此中和CD95活性降低了不希望的胶质细胞迁移和侵入体内组织。
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5.发明授权公开(公告)号：US08986687B2
公开(公告)日：2015-03-24
申请号：US13509592
申请日：2010-11-15
IPC分类号： A61K39/395 , G01N33/50 , A61K31/7105
CPC分类号： G01N33/5041 , A61K31/7105 , G01N33/5011 , G01N2333/70578
摘要： The present invention is concerned with compounds inhibiting CD95 signaling in pancreatic cancer cells. Furthermore, contemplated by the current invention are medicaments comprising such a compound for the prevention and/or treatment of pancreatic cancer as well as the use of such a compound for the manufacture of a medicament for the prevention and/or treatment of pancreatic cancer, the prevention of migration of cancer cells, and/or the prevention and/or treatment of an inflammatory reaction. The present invention also refers to a method for the identification of a compound inhibiting CD95 signaling, as we to a method for the manufacture of a medicament comprising the steps of the method for the identification of a compound inhibiting CD95 signaling and the further step of formulating the inhibiting compound as a medicament.
摘要翻译： 本发明涉及抑制胰腺癌细胞中CD95信号传导的化合物。 此外，本发明考虑的是包含这种用于预防和/或治疗胰腺癌的化合物的药物以及这种化合物在制备用于预防和/或治疗胰腺癌的药物中的用途， 预防癌细胞的迁移，和/或预防和/或治疗炎性反应。 本发明还涉及一种用于鉴定抑制CD95信号的化合物的方法，如我们关于制备药物的方法，包括以下步骤：鉴定抑制CD95信号的化合物的方法和进一步的配制步骤 作为药物的抑制化合物。
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公开(公告)号：US20110189194A1
公开(公告)日：2011-08-04
申请号：US13054269
申请日：2009-07-14
IPC分类号： A61K39/395 , A61P29/00 , A61P25/00
CPC分类号： C07K16/2875 , A61K38/00 , A61K2039/505 , C07K14/70575
摘要： The present invention refers to the use of an inhibitor of the CD95/CD95L system for the prevention and/or treatment of an inflammatory disorder or for the prevention and/or treatment of an inflammatory process in a neuronal disorder, particularly in a CNS disorder.
摘要翻译： 本发明涉及CD95 / CD95L系统的抑制剂用于预防和/或治疗炎性病症或预防和/或治疗神经元病症，特别是CNS病症中的炎性过程的用途。
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7.发明申请Neutralization of CD95 Activity Blocks Invasion of glioblastoma Cells In Vivo 有权CD95活性块的中和进入体内胶质母细胞瘤细胞公开(公告)号：US20100322922A1
公开(公告)日：2010-12-23
申请号：US12521625
申请日：2007-12-28
申请人： Ana Martin-Villalba , Susanne Kleber , Benedikt Wiestler , Peter G. Krammer , Christel Herold-Mende , Ignacio Sancho-Martinez
发明人： Ana Martin-Villalba , Susanne Kleber , Benedikt Wiestler , Peter G. Krammer , Christel Herold-Mende , Ignacio Sancho-Martinez
IPC分类号： A61K39/395 , G01N33/574 , A61P35/00
CPC分类号： C07K16/2875 , A61K38/00 , A61K2039/505 , C07K14/70575 , C07K14/70578 , C07K16/2878 , C07K2317/76 , C07K2319/00 , C07K2319/30 , G01N33/566 , G01N33/57407 , G01N33/6863 , G01N2333/70578 , G01N2500/00 , G01N2500/04 , G01N2500/10 , G01N2510/00
摘要： The present invention relates to methods for treating an individual with high grade glioblastoma multiforme by preventing or disrupting the binding of CD95 to its ligand, CD95L, in vivo, whereupon that neutralization of CD95 activity reduces undesirable glial cell migration and invasion into body tissue.
摘要翻译： 本发明涉及通过在体内预防或破坏CD95与其配体CD95L的结合来治疗具有高级胶质母细胞瘤多形性的个体的方法，因此中和CD95活性降低了不希望的胶质细胞迁移和侵入体内组织。
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