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公开(公告)号:US20110077237A1
公开(公告)日:2011-03-31
申请号:US12752283
申请日:2010-04-01
申请人: Juan-Miguel Jimenez , Guy W. Bemis , Francois Maltais , Tiansheng Wang , Ronald Knegtel , Chris Davis , Damien Fraysse , Dean Boyall , Luca Settimo , Stephen Young , Michael Mortimore
发明人: Juan-Miguel Jimenez , Guy W. Bemis , Francois Maltais , Tiansheng Wang , Ronald Knegtel , Chris Davis , Damien Fraysse , Dean Boyall , Luca Settimo , Stephen Young , Michael Mortimore
IPC分类号: A61K31/5513 , C07D401/06 , C07D401/14 , C07D417/14 , C07D409/06 , A61K31/444 , A61K31/496 , A61K31/4436 , A61K31/4439 , A61P25/28 , A61P25/16 , A61P25/18 , A61P25/00 , A61P29/00 , A61P35/00 , A61P35/02 , A61P1/00
CPC分类号: C07D213/73 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/06 , C07D409/14 , C07D417/06 , C07D417/14 , C07D487/04 , C07D487/08
摘要: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病,病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号:US20120214799A1
公开(公告)日:2012-08-23
申请号:US13442244
申请日:2012-04-09
申请人: Juan-Miguel Jimenez , Guy Bemis , Francois Maltais , Tiansheng Wang , Ronald Knegtel , Chris Davis , Damien Fraysse , Dean Boyall , Luca Settimo , Stephen Young , Michael Mortimore
发明人: Juan-Miguel Jimenez , Guy Bemis , Francois Maltais , Tiansheng Wang , Ronald Knegtel , Chris Davis , Damien Fraysse , Dean Boyall , Luca Settimo , Stephen Young , Michael Mortimore
IPC分类号: A61K31/551 , A61P25/28 , A61P25/14 , A61P25/16 , A61P25/00 , A61P25/18 , A61P7/00 , A61P9/00 , A61P9/10 , A61P29/00 , A61P1/00 , A61P35/00 , C07D401/06 , A61K31/444 , C07D401/14 , C07D417/14 , A61K31/496 , C07D409/06 , A61K31/4436 , A61K31/4439 , A61K31/506 , A61K31/497 , A61P3/10
CPC分类号: C07D213/73 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/06 , C07D409/14 , C07D417/06 , C07D417/14 , C07D487/04 , C07D487/08
摘要: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
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公开(公告)号:US08188071B2
公开(公告)日:2012-05-29
申请号:US12187909
申请日:2008-08-07
申请人: Juan-Miguel Jimenez , Guy Bemis , Francois Maltais , Tiansheng Wang , Ronald Knegtel , Chris Davis , Damien Fraysse , Dean Boyall , Luca Settimo , Stephen Young , Michael Mortimore
发明人: Juan-Miguel Jimenez , Guy Bemis , Francois Maltais , Tiansheng Wang , Ronald Knegtel , Chris Davis , Damien Fraysse , Dean Boyall , Luca Settimo , Stephen Young , Michael Mortimore
IPC分类号: A61K31/551
CPC分类号: C07D213/73 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/06 , C07D409/14 , C07D417/06 , C07D417/14 , C07D487/04 , C07D487/08
摘要: The present invention relates to compounds useful as inhibitors of protein kinase of the following structural formula: The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译: 本发明涉及可用作以下结构式的蛋白激酶抑制剂的化合物:本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病,病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号:US09067932B2
公开(公告)日:2015-06-30
申请号:US13014505
申请日:2011-01-26
申请人: Dean Boyall , Guy Brenchley , Chris Davis , Damien Fraysse , Julian Golec , Juan-Miguel Jimenez , Andrew Miller , Luca Settimo , Heather Twin , Stephen Young
发明人: Dean Boyall , Guy Brenchley , Chris Davis , Damien Fraysse , Julian Golec , Juan-Miguel Jimenez , Andrew Miller , Luca Settimo , Heather Twin , Stephen Young
IPC分类号: C07D471/04 , A61K31/496 , A61K31/437
CPC分类号: C07D471/04 , A61K31/437 , A61K31/496
摘要: The present invention relates to compounds of pyrazolopyridine derivatives useful as inhibitors of protein kinase. In one embodiment the compounds of the present invention are represented by the following structural formula: or a pharmaceutically acceptable salt thereof.
摘要翻译: 本发明涉及可用作蛋白激酶抑制剂的吡唑并吡啶衍生物的化合物。 在一个实施方案中,本发明的化合物由以下结构式表示:或其药学上可接受的盐。
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公开(公告)号:US20120071494A1
公开(公告)日:2012-03-22
申请号:US13014505
申请日:2011-01-26
申请人: Dean Boyall , Guy Brenchley , Chris Davis , Damien Fraysse , Julian Golec , Juan-Miguel Jimenez , Andrew Miller , Luca Settimo , Heather Twin , Stephen Young
发明人: Dean Boyall , Guy Brenchley , Chris Davis , Damien Fraysse , Julian Golec , Juan-Miguel Jimenez , Andrew Miller , Luca Settimo , Heather Twin , Stephen Young
IPC分类号: A61K31/496 , A61K31/437 , A61P11/06 , A61P1/00 , A61P3/10 , A61P35/00 , A61P25/28 , A61P29/00 , A61P37/06 , C07D471/04 , A61P17/06
CPC分类号: C07D471/04 , A61K31/437 , A61K31/496
摘要: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病,病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号:US20120149680A1
公开(公告)日:2012-06-14
申请号:US13275551
申请日:2011-10-18
申请人: Juan-Miguel Jimenez , Michael Mortimore , Andrew Miller , Philip Collier , Stephen Young , Guy Brenchley , Chris Davis , Heather Twin , Chau Mak , Dean Boyall , Shazia Keily , Luca Settimo
发明人: Juan-Miguel Jimenez , Michael Mortimore , Andrew Miller , Philip Collier , Stephen Young , Guy Brenchley , Chris Davis , Heather Twin , Chau Mak , Dean Boyall , Shazia Keily , Luca Settimo
IPC分类号: A61K31/437 , A61P37/00 , A61P29/00 , A61P35/00 , A61P11/06 , A61P17/06 , A61P19/02 , A61P25/00 , A61P3/10 , A61P1/00 , A61P37/06 , A61P35/02 , A61P19/04 , A61K31/496 , C07D471/04
CPC分类号: C07D471/04
摘要: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病,病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号:US20090291937A1
公开(公告)日:2009-11-26
申请号:US12262459
申请日:2008-10-31
申请人: Juan-Miguel Jimenez , Michael Mortimore , Andrew Miller , Philip Collier , Stephen Young , Guy Brenchley , Chris Davis , Heather Twin , Chau Mak , Dean Boyall , Shazia Keily , Luca Settimo
发明人: Juan-Miguel Jimenez , Michael Mortimore , Andrew Miller , Philip Collier , Stephen Young , Guy Brenchley , Chris Davis , Heather Twin , Chau Mak , Dean Boyall , Shazia Keily , Luca Settimo
IPC分类号: A61K31/496 , C07D471/04 , A61K31/5377 , A61K31/437
CPC分类号: C07D471/04
摘要: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病,病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号:US08367697B2
公开(公告)日:2013-02-05
申请号:US13275551
申请日:2011-10-18
申请人: Juan-Miguel Jimenez , Michael Mortimore , Andrew Miller , Philip Collier , Stephen Young , Guy Brenchley , Chris Davis , Heather Twin , Chau Mak , Dean Boyall , Shazia Keily , Luca Settimo
发明人: Juan-Miguel Jimenez , Michael Mortimore , Andrew Miller , Philip Collier , Stephen Young , Guy Brenchley , Chris Davis , Heather Twin , Chau Mak , Dean Boyall , Shazia Keily , Luca Settimo
IPC分类号: C07D513/02 , C07D515/02 , A01N43/42 , A01K31/44
CPC分类号: C07D471/04
摘要: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病,病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号:US08173635B2
公开(公告)日:2012-05-08
申请号:US12262459
申请日:2008-10-31
申请人: Juan-Miguel Jimenez , Michael Mortimore , Andrew Miller , Philip Collier , Stephen Young , Guy Brenchley , Chris Davis , Heather Twin , Chau Mak , Dean Boyall , Shazia Keily , Luca Settimo
发明人: Juan-Miguel Jimenez , Michael Mortimore , Andrew Miller , Philip Collier , Stephen Young , Guy Brenchley , Chris Davis , Heather Twin , Chau Mak , Dean Boyall , Shazia Keily , Luca Settimo
IPC分类号: A61K31/496 , C07D471/04 , A61K31/5377 , A61K31/437
CPC分类号: C07D471/04
摘要: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病,病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号:US08637511B2
公开(公告)日:2014-01-28
申请号:US12796297
申请日:2010-06-08
申请人: Hayley Binch , Michael Mortimore , Chris Davis , Dean Boyall , Simon Everitt , Daniel Robinson , Sham Ramaya , Damien Fraysse , John Studley , Andrew Miller , Michael O'Donnell , Alistair Rutherford , Joanne Pinder
发明人: Hayley Binch , Michael Mortimore , Chris Davis , Dean Boyall , Simon Everitt , Daniel Robinson , Sham Ramaya , Damien Fraysse , John Studley , Andrew Miller , Michael O'Donnell , Alistair Rutherford , Joanne Pinder
IPC分类号: A61K31/506 , A61K31/5355 , A61P29/00 , A61P19/08 , A61P3/00 , A61P25/28 , A61P35/00 , A61P9/00 , A61P37/08
CPC分类号: C07D403/12 , C07D239/38 , C07D401/14 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
摘要翻译: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含这些化合物的药学上可接受的组合物和使用该化合物和组合物治疗各种疾病,病症和障碍的方法。 本发明还提供了制备本发明化合物的方法。
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