Use of bioactive silicious glass and new compositions containing
bioactive silicious glass
    1.
    发明授权
    Use of bioactive silicious glass and new compositions containing bioactive silicious glass 失效
    使用生物活性硅玻璃和含有生物活性硅玻璃的新组合物

    公开(公告)号:US5891233A

    公开(公告)日:1999-04-06

    申请号:US809867

    申请日:1997-04-02

    摘要: A pharmaceutical preparation, including a glass phase which is bioactive silica containing glass in the form of a paste, suspension or solution mixed in a physiologically suitable liquid or bound to a physiologically suitable vehicle, and which preparation reduces the pulpal irritation or a tooth and/or strengthens the structure of a tooth. Bioactive silica containing glass may be a material which contains only Si-oxide or Si-hydroxide and which allows the formation and movement of Si--OH-groups. Preferably, the preparation also contains calcium and phosphate sources.

    摘要翻译: PCT No.PCT / FI95 / 00539 Sec。 371日期1997年4月2日 102(e)日期1997年4月2日PCT提交1995年10月2日PCT公布。 公开号WO96 / 10985 PCT 日期1996年04月18日一种药物制剂,包括玻璃相,其是生物活性二氧化硅的玻璃形式的糊状物,悬浮液或溶液,混合在生理学上合适的液体中或与生理学合适的载体结合,并且该制剂减少了纸浆刺激 或牙齿和/或加强牙齿的结构。 含有生物活性二氧化硅的玻璃可以是仅含有Si氧化物或Si-氢氧化物并且允许Si-OH基团的形成和移动的材料。 优选地,制剂还含有钙和磷酸盐源。

    Compositions for controlled release of a biologically active agent, and the preparation thereof
    3.
    发明授权
    Compositions for controlled release of a biologically active agent, and the preparation thereof 有权
    用于控制释放生物活性剂的组合物及其制备

    公开(公告)号:US07112339B1

    公开(公告)日:2006-09-26

    申请号:US10069145

    申请日:2000-08-22

    IPC分类号: A61K9/14

    摘要: A composition for controlled release of a biologically active agent from a carrier. The biologically active agent is heparin or a related biologically active acidic polysaccharide and the carrier is a sol-gel derived silica xerogel. The xerogel is derived from a tetraalkoxysilane such as tetrethoxysilane (TEOS) and part of the tetraalkoxysilane is replaced by an organomodified alkoxysilane, preferably an akylsubsitituted alkoxysilane. The invention also includes a method for the preparation of this composition.

    摘要翻译: 用于从载体中控制释放生物活性剂的组合物。 生物活性剂是肝素或相关的生物活性酸性多糖,载体是溶胶 - 凝胶衍生的二氧化硅干凝胶。 干凝胶衍生自四烷氧基硅烷如四氧杂硼烷(TEOS),部分四烷氧基硅烷被有机改性的烷氧基硅烷代替,优选烷基取代的烷氧基硅烷。 本发明还包括制备该组合物的方法。

    Method for improvement of soft tissue attachment and implants making use of said method
    5.
    发明授权
    Method for improvement of soft tissue attachment and implants making use of said method 有权
    利用所述方法改善软组织附着和植入物的方法

    公开(公告)号:US07527804B2

    公开(公告)日:2009-05-05

    申请号:US10476157

    申请日:2002-04-25

    IPC分类号: A61F2/00

    CPC分类号: A61L27/306

    摘要: A method for improving soft tissue attachment which includes the steps of coating a surface of a material, to which surface soft tissue is to be attached, with a coating rich in TiO2 and/or SiO2, and applying the coating where soft tissue attachment is desired. An implant in which a surface or surfaces of the implant intended to be attached to soft tissue are coated with a porous coating rich in TiO2 and/or SiO2, and the use of a porous surface coating rich in TiO2, SiO2, or TiO2 and SiO2, for the manufacture of an implant for soft tissue attachment are also disclosed.

    摘要翻译: 一种用于改善软组织附着的方法,其包括以下步骤:用富含TiO 2和/或SiO 2的涂层涂覆表面软组织附着的材料的表面,并涂覆需要软组织附着的涂层 。 植入物,其中旨在附着到软组织的植入物的表面或表面涂覆有富含TiO 2和/或SiO 2的多孔涂层,并且使用富含TiO 2,SiO 2或TiO 2和SiO 2的多孔表面涂层 ,用于制造用于软组织附着的植入物。

    Multilayered material bearing a biologically active agent and the preparation thereof
    6.
    发明授权
    Multilayered material bearing a biologically active agent and the preparation thereof 有权
    具有生物活性剂的多层材料及其制备方法

    公开(公告)号:US06991802B1

    公开(公告)日:2006-01-31

    申请号:US10069785

    申请日:2000-08-29

    IPC分类号: A61F2/02 A61K9/14

    摘要: A material for medical use in humans and/or animals bearing a biologically active agent, the material being multilayered, as well as a device of this material and a method to produce it. The material includes a core material, where the core material is formed into a body, optionally having the shape of a finished device; two or more layers of coating material of which the first layer has been applied onto the core material and additional layers have been applied onto the coating material of a preceding layer; and where at least one of the layers includes the biologically active agent. A feature of this invention is that the coating material is a biopolymer, a sol-gel produced silica gel or a biologically active molecule.

    摘要翻译: 用于患有生物活性剂的人类和/或动物的材料,该多层材料,以及该材料的装置及其制造方法。 所述材料包括芯材料,其中芯材料形成为主体,任选地具有成品装置的形状; 将第一层施加到芯材上的两层或更多层涂层材料和附加层已经施加到前一层的涂层材料上; 并且其中至少一层包括生物活性剂。 本发明的一个特征是涂层材料是生物聚合物,溶胶 - 凝胶产生的硅胶或生物活性分子。

    Bioceramic system for delivery of bioactive compounds
    8.
    发明授权
    Bioceramic system for delivery of bioactive compounds 失效
    用于生物活性化合物递送的生物陶瓷系统

    公开(公告)号:US5762950A

    公开(公告)日:1998-06-09

    申请号:US438557

    申请日:1995-05-10

    摘要: A bioceramic system for delivery of a bioactive compound, which comprises a combination of bioactive glass, bioactive glass ceramic or bioactive ceramic, hydroxyapatite, optionally one or more other calcium phosphate compound and optionally a matrix, and which may incorporate into the bioceramic system a bioactive compound. The timing of the release of the bioactive compound can be regulated as desired and depends on the conditions of the surrounding, the composition of the bioceramic system and its method preparation.

    摘要翻译: 用于递送生物活性化合物的生物陶瓷系统,其包括生物活性玻璃,生物活性玻璃陶瓷或生物活性陶瓷,羟基磷灰石,任选的一种或多种其它磷酸钙化合物和任选的基质的组合,并且其可以并入生物陶瓷体系中的生物活性 复合。 可以根据需要调节生物活性化合物的释放时间,并且取决于周围的条件,生物陶瓷系统的组成及其方法制备。

    Prepreg and its use
    9.
    发明授权
    Prepreg and its use 有权
    预浸料及其用途

    公开(公告)号:US07435764B2

    公开(公告)日:2008-10-14

    申请号:US10558274

    申请日:2004-05-21

    IPC分类号: A61K6/083 A61C5/00

    摘要: The invention relates to a prepreg comprising a base part, said base part comprising fibers and a matrix, said matrix being at least partially uncured. The prepreg is characterized in that it further comprises a surface part consisting essentially of bioactive filler material, said bioactive filler material being in particle form and at least partially and at most partially embedded in said base part. The invention also relates to a composite obtainable by curing said prepreg. The invention further relates to a mineralizing sheet for treatment of hypersensitive teeth and to the use of said prepreg and composite.

    摘要翻译: 本发明涉及一种预浸料,其包含基体部分,所述基体部分包含纤维和基体,所述基体至少部分未固化。 预浸料的特征在于,其还包括基本上由生物活性填料材料组成的表面部分,所述生物活性填料材料为颗粒形式,并且至少部分且最多部分地嵌入所述基底部分。 本发明还涉及通过固化所述预浸料获得的复合物。 本发明还涉及一种用于治疗过敏牙齿的矿化片以及所述预浸料和复合材料的使用。