公开(公告)号：US20060052739A1

公开(公告)日：2006-03-09

申请号：US11265383

申请日：2005-11-03

申请人： Julian Henley ,  Kuo Chang ,  Joseph Potter ,  Dennis Goldberg ,  Christopher Porter ,  V. Porcelli

发明人： Julian Henley ,  Kuo Chang ,  Joseph Potter ,  Dennis Goldberg ,  Christopher Porter ,  V. Porcelli

IPC分类号： A61N1/30

CPC分类号： A61N1/0428 ,  A61N1/0436 ,  A61N1/044 ,  A61N1/0448 ,  A61N1/30

摘要： An electrokinetic delivery or diagnostic device for personal use and self-administration of a medicament to a treatment site is provided. The device includes a housing containing a power supply, a first active electrode and a ground tactile electrode. An applicator includes a pad for containing medicament for overlying the first electrode of the device. The medicament may be applied by the user to the pad, contained within the pad or contained in rupturable capsules within the pad, together with a hydrogel if necessary for imparting electrical conductivity whereby, upon application of the applicator to the treatment site, the medicament is electrokinetically transported into the treatment site. In another form, the applicator is self-contained, having a power supply, a first electrode overlying a pad and a ground electrode from the opposite side from the pad whereby the individual presses the pad against the treatment site to complete the electrical circuit and electrokinetically drive the medicament into the treatment site.

公开(公告)号：US20060025715A1

公开(公告)日：2006-02-02

申请号：US11236748

申请日：2005-09-28

申请人： Julian Henley ,  Kuo Chang ,  Joseph Potter ,  Dennis Goldberg ,  James Derouin

发明人： Julian Henley ,  Kuo Chang ,  Joseph Potter ,  Dennis Goldberg ,  James Derouin

IPC分类号： A61N1/30

CPC分类号： A61N1/044 ,  A61N1/30 ,  A61N1/325

摘要： A system for delivering a substance into a body at a treatment site that includes an alternating current source and a plurality of electrodes. Circuitry is connected between the alternating current source and the electrodes for supplying current to the electrodes when the electrodes are in electrical contact with said body so that a uni-directional current flow for delivering the substance into the body is maintained at the treatment site and a bi-directional current flow is maintained throughout the body. At least one of the electrodes is divided into sub-electrodes to, for example, reduce hazards associated with current concentration. These and other systems and methods are adaptable for large treatment areas and/or use a convenient and low-cost arrangement of electronics.

公开(公告)号：US20060167403A1

公开(公告)日：2006-07-27

申请号：US11373301

申请日：2006-03-13

申请人： Julian Henley ,  Kuo Chang ,  Joseph Potter ,  Dennis Goldberg ,  James Derquin

发明人： Julian Henley ,  Kuo Chang ,  Joseph Potter ,  Dennis Goldberg ,  James Derquin

IPC分类号： A61N1/30

CPC分类号： A61N1/325 ,  A61N1/044 ,  A61N1/0448 ,  A61N1/30

摘要： An electrokinetic delivery system for personal use in self-administration of a medicament to a treatment site on an individual includes a device shaped to conform with the shape of a portion of an individual's finger from a tip thereof to a location past the first finger joint. A self-contained power source is carried by the device and a first electrode is carried by the device adjacent a distal end portion thereof and the tip of the individual's finger. The first electrode is in electrical contact with the power source. A second electrode is carried by the device for contact with the individual's finger. The second electrode is in electrical contact with the power source. Upon application of the first electrode over a treatment site with the medicament disposed between the first electrode and the treatment site and completion of an electrical circuit through the individual's body and said electrode, the device applies current for electrokinetically driving the medicament into the treatment site.

公开(公告)号：US20050182351A1

公开(公告)日：2005-08-18

申请号：US11104568

申请日：2005-04-13

申请人： Julian Henley ,  Kuo Chang ,  Joseph Potter ,  Dennis Goldberg

发明人： Julian Henley ,  Kuo Chang ,  Joseph Potter ,  Dennis Goldberg

IPC分类号： A61M37/00 ,  A61N1/30

CPC分类号： A61N1/0428 ,  A61N1/0436 ,  A61N1/044 ,  A61N1/0448 ,  A61N1/30

摘要： An electrokinetic delivery or diagnostic device for personal use and self-administration of a medicament to a treatment site is provided. The device includes a housing containing a power supply, a first active electrode and a ground tactile electrode. An applicator includes a pad for containing medicament for overlying the first electrode of the device. The medicament may be applied by the user to the pad, contained within the pad or contained in rupturable capsules within the pad, together with a hydrogel if necessary for imparting electrical conductivity whereby, upon application of the applicator to the treatment site, the medicament is electrokinetically transported into the treatment site. In another form, the applicator is self-contained, having a power supply, a first electrode overlying a pad and a ground electrode from the opposite side from the pad whereby the individual presses the pad against the treatment site to complete the electrical circuit and electrokinetically drive the medicament into the treatment site.

摘要翻译： 提供了一种用于个人使用的电动输送或诊断装置以及药物自动施用于治疗部位。 该装置包括容纳电源，第一有源电极和接地触觉电极的壳体。 涂抹器包括用于容纳用于覆盖装置的第一电极的药物的垫。 使用者可以将药物施用于包含在垫内的垫或包含在垫内的可破裂胶囊中，以及如果需要赋予导电性的水凝胶，由此当将施用器施加到治疗部位时，药物是 电动运输到治疗部位。 在另一种形式中，施用器是独立的，具有电源，与衬垫相重叠的第一电极和接地电极，其中个体将衬垫压在治疗部位上以完成电路和电动 驱使药物进入治疗部位。

公开(公告)号：US20080051692A1

公开(公告)日：2008-02-28

申请号：US11565335

申请日：2006-11-30

申请人： John Petersen ,  Dennis Goldberg ,  James Kelland ,  Robert Ehteredge ,  Michael Barsness ,  Kuowei Chang

发明人： John Petersen ,  Dennis Goldberg ,  James Kelland ,  Robert Ehteredge ,  Michael Barsness ,  Kuowei Chang

IPC分类号： A61N1/30

CPC分类号： A61N1/303

摘要： An applicator for a device for electrokinetic delivery of medicament to a treatment site includes an applicator head having an active electrode, a matrix, and a medicament or a medicament and an electrically conductive carrier, carried by the matrix in electrical contact with the electrode. The cartridge includes a plurality of raised projections allowing the matrix and head to be ultrasonically welded one to the other. The electrode opens through a face of the head remote from the matrix for connection with an electrical connector carried by the device. A lid overlies the matrix and is releasably attached to a margin of the head. The lid includes layers of different materials with one of the layers formed of a metallic material having a discontinued interface with the lid and a tab carried by the lid.

摘要翻译： 用于将药物电动递送到治疗部位的装置的施加器包括具有活性电极，基质以及由电极与电极电接触的基质携带的药物或药物和导电载体的施用器头。 盒包括多个凸起突起，允许矩阵和头被彼此超声波焊接。 电极通过远离矩阵的头部的面打开，以与由该装置承载的电连接器连接。 盖子覆盖在基体上并且可释放地附接到头部的边缘。 盖子包括不同材料的层，其中一个层由金属材料形成，该金属材料具有与盖子不连续的界面和由盖子承载的翼片。

公开(公告)号：US20070233048A1

公开(公告)日：2007-10-04

申请号：US11565360

申请日：2006-11-30

申请人： John Petersen ,  Dennis Goldberg ,  James Kelland ,  Paul Rand ,  Anthony Jones ,  Robert Etheredge

发明人： John Petersen ,  Dennis Goldberg ,  James Kelland ,  Paul Rand ,  Anthony Jones ,  Robert Etheredge

IPC分类号： A61N1/30 ,  A61M5/00 ,  A61K9/22

CPC分类号： A61N1/30 ,  A61K9/0009

摘要： A device for electrokinetic delivery of medicament to a treatment site includes a cartridge having an active electrode and a membrane overlying the active electrode and a medicament or a medicament and an electrically conductive carrier therefor, carried by the membrane in electrical contact with the electrode. The electrode opens through a surface of the cartridge remote from the membrane for connection with an electrical connector carried by the device. An locking element releasably couples the cartridge to the housing.

摘要翻译： 用于将药物电动递送到治疗部位的装置包括具有活性电极和覆盖有源电极的膜的药筒以及与电极电接触的膜携带的药物或药物及其导电载体。 电极通过远离膜的盒的表面打开，以与由装置承载的电连接器连接。 锁定元件可释放地将盒连接到壳体。

公开(公告)号：US20070066934A1

公开(公告)日：2007-03-22

申请号：US11228461

申请日：2005-09-19

申请人： Robert Etheredge ,  Dennis Goldberg ,  Phillip Friden ,  John Peterson

发明人： Robert Etheredge ,  Dennis Goldberg ,  Phillip Friden ,  John Peterson

IPC分类号： A61B17/20

CPC分类号： A61B17/205 ,  A61M37/0015

摘要： The electrokinetic medicament delivery system includes at least one applicator having a multiplicity of non-conductive micro-needles carried on a non-conductive surface of the applicator. The opposite surface is formed of electrically conductive material for contact with an active electrode. The applicator includes a matrix containing a medicament or a carrier therefor between the opposite surfaces. When the applicator is applied to the individual's skin with the micro-needles penetrating the skin, an electrical current is completed through the power source, the active electrode, medicament, or electrically conductive carrier therefor, the targeted treatment site, the individual's body, a ground electrode and the power supply, thereby electokinetically driving the medicament through the non-conductive micro-needles into the targeted treatment site.

摘要翻译： 电动药物递送系统包括至少一个施用器，其具有承载在施用器的非导电表面上的多个非导电微针。 相对表面由用于与有源电极接触的导电材料形成。 施用器包括在相对表面之间包含药物或载体的基质。 当施用器被微针穿透皮肤施加到个体的皮肤上时，通过动力源，有效电极，药物或导电载体，目标治疗部位，个体的身体， 接地电极和电源，从而通过非导电微针将药物电动驱动到目标治疗部位。

公开(公告)号：US20060239959A1

公开(公告)日：2006-10-26

申请号：US11344862

申请日：2006-02-01

申请人： Stephen Holmes-Farley ,  W. Mandeville ,  Steven Burke ,  Dennis Goldberg

发明人： Stephen Holmes-Farley ,  W. Mandeville ,  Steven Burke ,  Dennis Goldberg

IPC分类号： A61K31/785

CPC分类号： A61K31/785

摘要： A method for removing bile salts from a patient that includes administering to the patient a therapeutically effective amount of a non-absorbable amine polymers characterized by a repeat unit having the formula: and salts thereof, where n is a positive integer and x is zero or an integer between 1 and about 4.

公开(公告)号：US20070185432A1

公开(公告)日：2007-08-09

申请号：US11538249

申请日：2006-10-03

申请人： Robert Etheredge ,  Dennis Goldberg ,  Phillip Friden ,  John Petersen

发明人： Robert Etheredge ,  Dennis Goldberg ,  Phillip Friden ,  John Petersen

IPC分类号： A61N1/30

CPC分类号： A61B17/205 ,  A61M37/0015 ,  A61M2037/0061

摘要： The electrokinetic methotrexate delivery system includes at least one applicator having a multiplicity of non-conductive micro-needles carried on a non-conductive surface of the applicator. The opposite surface is formed of electrically conductive material for contact with an active electrode. The applicator includes a matrix containing a medicament, e.g., methotrexate, or a carrier therefor between the opposite surfaces. When the applicator is applied to the individual's skin with the micro-needles penetrating the skin, an electrical current is completed through the power source, the active electrode, methotrexate, or electrically conductive carrier therefor, the targeted treatment site, the individual's body, a ground electrode and the power supply, thereby electokinetically driving the medicament through the non-conductive micro-needles into the targeted treatment site.

摘要翻译： 电动氨甲蝶呤递送系统包括至少一个施用器，其具有承载在施用器的非导电表面上的多个非导电微针。 相对表面由用于与有源电极接触的导电材料形成。 施用器包括在相对表面之间包含药物，例如甲氨蝶呤或其载体的基质。 当施用器被微针穿透皮肤施加到个体的皮肤上时，通过电源，有效电极，甲氨蝶呤或导电载体，目标治疗部位，个体的身体， 接地电极和电源，从而通过非导电微针将药物电动驱动到目标治疗部位。