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    Anti-myostatin antibodies
    4.
    发明申请
    Anti-myostatin antibodies 审中-公开
    抗肌生成抑制素抗体

    公开(公告)号：US20070178095A1

    公开(公告)日：2007-08-02

    申请号：US10593810

    申请日：2005-03-17

    申请人： Rosamund Smith ,  Kristine Kikly ,  Linda Tobias ,  Bomie Han

    发明人： Rosamund Smith ,  Kristine Kikly ,  Linda Tobias ,  Bomie Han

    IPC分类号： A61K39/395 ,  G01N33/53 ,  C12P21/04 ,  C07K16/26

    CPC分类号： C07K16/22 ,  A61K2039/505 ,  C07K2317/55 ,  C07K2317/76 ,  G01N33/6887 ,  G01N2800/10

    摘要： A neutralizing epitope is identified within amino acids 40-64 of the mature form of human myostatin. Antibodies that bind this epitope fall within the scope of the invention and may be murine, chimeric, or humanized antibodies, immunoconjugates of the antibodies or antigen-binding fragments thereof. The antibodies of the invention are useful for increasing muscle mass, increasing bone density, or for the treatment of various disorders in mammals.

    摘要翻译： 在人类肌生成抑制素成熟形式的40-64位氨基酸内鉴定中和表位。 结合该表位的抗体属于本发明的范围，并且可以是鼠，嵌合或人源化抗体，抗体的免疫缀合物或其抗原结合片段。 本发明的抗体可用于增加肌肉质量，增加骨密度，或用于治疗哺乳动物中的各种疾病。

    Anti-Ghrelin Antibodies
    5.
    发明申请
    Anti-Ghrelin Antibodies 审中-公开
    抗Ghrelin抗体

    公开(公告)号：US20070237775A1

    公开(公告)日：2007-10-11

    申请号：US11569769

    申请日：2005-07-06

    申请人： Kristine Kikly ,  Joseph Manetta ,  Derrick Witcher

    发明人： Kristine Kikly ,  Joseph Manetta ,  Derrick Witcher

    IPC分类号： A61K39/395 ,  C07K16/26

    CPC分类号： C07K16/26 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

    摘要： Monoclonal antibodies, including chimeric and humanized antibodies, that bind both acylated and unacylated human ghrelin are disclosed. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Such antibodies and antigen-binding portions thereof are useful for neutralizing ghrelin activity in, for example, a human subject suffering from a disorder in which ghrelin activity is detrimental.

    摘要翻译： 公开了结合酰化和未被结合的人生长素释放肽的单克隆抗体，包括嵌合和人源化抗体。 本发明的抗体可以是全长抗体或其抗原结合部分。 这样的抗体及其抗原结合部分可用于中和例如患有生长素释放肽活性有害的病症的人类受试者的生长素释放肽活性。

    Interleukin-1 beta converting enzyme like apoptotic protease 6
    6.
    发明申请
    Interleukin-1 beta converting enzyme like apoptotic protease 6 失效
    白细胞介素-1β转换酶如凋亡蛋白酶6

    公开(公告)号：US20050089984A1

    公开(公告)日：2005-04-28

    申请号：US10961148

    申请日：2004-10-12

    申请人： Vishva Dixit ,  Wei-Wu He ,  Kristine Kikly ,  Steven Ruben

    发明人： Vishva Dixit ,  Wei-Wu He ,  Kristine Kikly ,  Steven Ruben

    IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K38/55 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P9/10 ,  A61P25/00 ,  A61P25/28 ,  A61P31/04 ,  A61P43/00 ,  C07K14/47 ,  C07K16/40 ,  C12N5/00 ,  C12N5/10 ,  C12N9/64 ,  C12N9/99 ,  C12N15/12 ,  C12Q1/68 ,  C12R1/91 ,  C07H21/04

    CPC分类号： C12N9/6475 ,  A61K38/00 ,  A61K48/00

    摘要： Human ICE LAP-6 polypeptides and DNA (RNA) encoding such ICE LAP-6 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such ICE LAP-6 for the treatment of a susceptibility to viral infection, tumorogenesis and to diseases and defects in the control embryogenesis and tissue homeostasis, and the nucleic acid sequences described above may be employed in an assay for ascertaining such susceptibility. Antagonists against such ICE LAP-6 and their use as a therapeutic to treat Alzheimer's disease, Parkinson's disease, rheumatoid arthritis, septic shock, sepsis, stroke, chronic inflammation, acute inflammation, CNS inflammation, osteoporosis, ischemia reperfusion injury, cell death associated with cardiovascular disease, polycystic kidney disease, apoptosis of endothelial cells in cardiovascular disease, degenerative liver disease, MS, ALS, cererbellar degeneration, ischemic injury, myocardial infarction, AIDS, myelodysplastic syndromes, aplastic anemia, male pattern baldness, and head injury damage are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the interleukin-1 beta converting enzyme apoptosis proteases and for detecting altered levels of the polypeptide in a host.

    摘要翻译： 公开了人ICE LAP-6多肽和编码这种ICE LAP-6的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了利用这种ICE LAP-6用于治疗对病毒感染，肿瘤发生的易感性以及控制胚胎发生和组织稳态中的疾病和缺陷的方法，并且上述核酸序列可用于确定 这种敏感性。 对抗这种ICE LAP-6的拮抗剂及其作为治疗性阿尔茨海默病，帕金森病，类风湿性关节炎，败血性休克，败血症，中风，慢性炎症，急性炎症，CNS炎症，骨质疏松症，缺血再灌注损伤，与 心血管疾病，多囊肾病，心血管疾病中的内皮细胞凋亡，退行性肝病，MS，ALS，小脑变性，缺血性损伤，心肌梗塞，艾滋病，骨髓增生异常综合征，再生障碍性贫血，男性型秃发和头部损伤也是 披露 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码白细胞介素-1β转换酶凋亡蛋白酶的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定法。