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    Polynucleotides and polypeptides associated with the development of rheumatoid arthritis
    1.
    发明授权
    Polynucleotides and polypeptides associated with the development of rheumatoid arthritis 有权
    与类风湿性关节炎发展相关的多核苷酸和多肽

    公开(公告)号：US07670785B2

    公开(公告)日：2010-03-02

    申请号：US11811442

    申请日：2007-06-07

    申请人： Julie Carman ,  Steven G. Nadler ,  Michael A. Bowen ,  Michael G. Neubauer ,  Pin Lu

    发明人： Julie Carman ,  Steven G. Nadler ,  Michael A. Bowen ,  Michael G. Neubauer ,  Pin Lu

    IPC分类号： G01N33/53 ,  G01N33/52 ,  G01N33/554 ,  C07H21/04

    CPC分类号： C12Q1/6883 ,  C12Q2600/158

    摘要： The present invention is directed to polynucleotides encoding polypeptides associated with the development of rheumatoid arthritis and homologs thereof. The invention further relates to diagnostic and therapeutic methods for utilizing these polynucleotides and polypeptides in the diagnosis, treatment, and/or prevention of rheumatoid arthritis and related disease states. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention, and compounds identified thereby.

    摘要翻译： 本发明涉及编码与类风湿性关节炎及其同系物相关的多肽的多核苷酸。 本发明还涉及在诊断，治疗和/或预防类风湿性关节炎和相关疾病状态中利用这些多核苷酸和多肽的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法，以及由此鉴定的化合物。

    Polynucleotides and polypeptides associated with the development of rheumatoid arthritis
    3.
    发明申请
    Polynucleotides and polypeptides associated with the development of rheumatoid arthritis 有权
    与类风湿性关节炎发展相关的多核苷酸和多肽

    公开(公告)号：US20090004184A1

    公开(公告)日：2009-01-01

    申请号：US11811442

    申请日：2007-06-07

    申请人： Julie Carman ,  Steven G. Nadler ,  Michael Bowen ,  Michael G. Neubauer ,  Pin Lu

    发明人： Julie Carman ,  Steven G. Nadler ,  Michael Bowen ,  Michael G. Neubauer ,  Pin Lu

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  A61K39/395 ,  A61P19/02

    CPC分类号： C12Q1/6883 ,  C12Q2600/158

    摘要： The present invention is directed to polynucleotides encoding polypeptides associated with the development of rheumatoid arthritis and homologs thereof. The invention further relates to diagnostic and therapeutic methods for utilizing these polynucleotides and polypeptides in the diagnosis, treatment, and/or prevention of rheumatoid arthritis and related disease states. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention, and compounds identified thereby.

    摘要翻译： 本发明涉及编码与类风湿性关节炎及其同系物相关的多肽的多核苷酸。 本发明还涉及在诊断，治疗和/或预防类风湿性关节炎和相关疾病状态中利用这些多核苷酸和多肽的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法，以及由此鉴定的化合物。

    Polynucleotides and polypeptides associated with the development of rheumatoid arthritis
    4.
    发明授权
    Polynucleotides and polypeptides associated with the development of rheumatoid arthritis 有权
    与类风湿性关节炎发展相关的多核苷酸和多肽

    公开(公告)号：US07244573B2

    公开(公告)日：2007-07-17

    申请号：US10308279

    申请日：2002-12-03

    申请人： Julie Carman ,  Steven G. Nadler ,  Michael Bowen ,  Michael G. Neubauer ,  Pin Lu

    发明人： Julie Carman ,  Steven G. Nadler ,  Michael Bowen ,  Michael G. Neubauer ,  Pin Lu

    IPC分类号： G01N33/53 ,  G01N33/564 ,  C07H21/04

    CPC分类号： C12Q1/6883 ,  C12Q2600/158

    摘要： The present invention is directed to polynucleotides encoding polypeptides associated with the development of rheumatoid arthritis and homologs thereof. The invention further relates to diagnostic and therapeutic methods for utilizing these polynucleotides and polypeptides in the diagnosis, treatment, and/or prevention of rheumatoid arthritis and related disease states. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention, and compounds identified thereby.

    摘要翻译： 本发明涉及编码与类风湿性关节炎及其同系物相关的多肽的多核苷酸。 本发明还涉及在诊断，治疗和/或预防类风湿性关节炎和相关疾病状态中利用这些多核苷酸和多肽的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法，以及由此鉴定的化合物。

    Online classification of memory pages based on activity level using dynamically adjustable scan rates
    6.
    发明授权
    Online classification of memory pages based on activity level using dynamically adjustable scan rates 有权
    使用动态可调的扫描速率，基于活动级别对内存页进行在线分类

    公开(公告)号：US08832390B1

    公开(公告)日：2014-09-09

    申请号：US12834669

    申请日：2010-07-12

    申请人： Irfan Ahmad ,  Kiran Tati ,  Pin Lu

    发明人： Irfan Ahmad ,  Kiran Tati ,  Pin Lu

    IPC分类号： G06F12/00 ,  G06F9/455

    CPC分类号： G06F9/5016 ,  G06F9/4856 ,  G06F2209/485

    摘要： Activity level of memory pages is repeatedly classified in a virtual machine environment, so that live VM migration can be carried out more efficiently. The time intervals upon which the activity level of the memory pages are repeatedly classified can be dynamically adjusted to better align its performance with the live VM migration process.

    摘要翻译： 内存页面的活动级别在虚拟机环境中重复分类，从而可以更有效地执行虚拟机迁移。 可以动态调整内存页面的活动级别重复分类的时间间隔，以便更好地将其性能与实时VM迁移过程保持一致。

    VENDING MACHINE WITH AUTOMATED DETECTION OF PRODUCT POSITION
    7.
    发明申请
    VENDING MACHINE WITH AUTOMATED DETECTION OF PRODUCT POSITION 失效
    自动检测产品位置的自动售货机

    公开(公告)号：US20130134178A1

    公开(公告)日：2013-05-30

    申请号：US13306692

    申请日：2011-11-29

    申请人： Pin Lu

    发明人： Pin Lu

    IPC分类号： B65D83/00 ,  G06K9/00

    CPC分类号： G07F9/026 ,  G06T7/73 ,  G06T2207/30204

    摘要： Embodiments of a vending machine are disclosed that can comprise one or more horizontally oriented shelves for supporting products to be vended, a plurality of vertically oriented dividers coupled to the shelves, a plurality of location markers located on the dividers and/or on the shelves, and an optical recognition module configured to optically recognize the location markers and to determine positions of the location markers and products relative to the shelves. In some embodiments, the optical recognition module can recognize the products by comparing images of the products to stored product images.

    摘要翻译： 公开了一种自动售货机的实施例，其可以包括一个或多个水平定向的货架，用于支撑要销售的产品，耦合到货架的多个垂直定向的分隔件，位于分隔件和/或货架上的多个位置标记， 以及光学识别模块，被配置为光学地识别所述位置标记并且确定所述位置标记和产品相对于所述架子的位置。 在一些实施例中，光学识别模块可以通过将产品的图像与存储的商品图像进行比较来识别产品。

    DYNAMICALLY ALLOCATING INDEX SERVER RESOURCES TO PARTNER ENTITIES
    8.
    发明申请
    DYNAMICALLY ALLOCATING INDEX SERVER RESOURCES TO PARTNER ENTITIES 审中-公开
    向合作伙伴实体分配索引服务器资源

    公开(公告)号：US20120030355A1

    公开(公告)日：2012-02-02

    申请号：US12844823

    申请日：2010-07-27

    申请人： Sridharan Iyer ,  Xun Kang ,  Pin Lu ,  Junhua Wang ,  Jian Cao

    发明人： Sridharan Iyer ,  Xun Kang ,  Pin Lu ,  Junhua Wang ,  Jian Cao

    IPC分类号： G06F15/173

    CPC分类号： G06F16/951

    摘要： A provisioning system is described for dynamically and automatically allocating index server resources to different respective uses. For example, the provisioning system can allocate index server resources among different search-related production uses, different analysis-related uses, different testing-related uses, and so on. In one case, the provisioning system includes an allocation manager module that receives information that has a bearing on the allocation of index server resources. Based on this information, the allocation manager module determines an allocation of index server resources and sends instructions to an indexing system to carry out the allocation. In one case, the indexing system respond to the instructions by allocating rows of index server resources to different partner entities which have requested index server resources. Each row can also implement custom index information and/or custom processing functionality for use by particular partner entities.

    摘要翻译： 描述了供应系统，用于动态地并自动地将索引服务器资源分配给不同的相应用途。 例如，配置系统可以在不同的搜索相关的生产用途，不同的分析相关用途，不同的测试相关用途等之间分配索引服务器资源。 在一种情况下，供应系统包括分配管理器模块，其接收对索引服务器资源的分配有影响的信息。 基于该信息，分配管理器模块确定索引服务器资源的分配，并向索引系统发送指令以执行分配。 在一种情况下，索引系统通过将索引服务器资源的行分配给已请求索引服务器资源的不同伙伴实体来响应指令。 每行还可以实现自定义索引信息和/或定制处理功能，供特定合作伙伴实体使用。

    Online classification of memory pages based on activity level represented by one or more bits
    9.
    发明授权
    Online classification of memory pages based on activity level represented by one or more bits 有权
    基于由一个或多个位表示的活动级别的内存页面的在线分类

    公开(公告)号：US09032398B2

    公开(公告)日：2015-05-12

    申请号：US12834662

    申请日：2010-07-12

    申请人： Irfan Ahmad ,  Carl A. Waldspurger ,  Alexander Thomas Garthwaite ,  Kiran Tati ,  Pin Lu

    发明人： Irfan Ahmad ,  Carl A. Waldspurger ,  Alexander Thomas Garthwaite ,  Kiran Tati ,  Pin Lu

    IPC分类号： G06F21/00 ,  G06F12/00 ,  G06F12/08 ,  G06F12/10

    CPC分类号： G06F12/08 ,  G06F12/10

    摘要： Activity level of memory pages is classified in virtual machine environment, so that processes such as live VM migration and checkpointing, among others, can be carried out more efficiently. The method includes the steps of scanning page table entries of hypervisor-managed page tables continuously over repeating scan periods to determine whether memory pages have been accessed or not, and for each memory page, determining an activity level of the memory page based on whether the memory page has been accessed or not since a prior scan and storing the activity level of the memory page. The activity level of the memory page may be represented by one or more bits of its page table entry and may be classified as having at least two states ranging from hot to cold.

    摘要翻译： 内存页面的活动级别分为虚拟机环境，可以更有效地执行诸如虚拟机迁移和检查点之类的进程。 该方法包括以下步骤：在重复的扫描周期上连续地扫描虚拟机管理程序管理的页表的页表条目，以确定是否已存取存储器页;以及对于每个存储器页，基于是否存储页，确定存储器页的活动级别 存储器页面已被访问或不被访问，因为先前扫描并存储存储器页面的活动级别。 存储器页面的活动级别可以由其页表项的一个或多个位表示，并且可以被分类为具有从热到冷的至少两个状态。

    Vending machine with automated detection of product position
    10.
    发明授权
    Vending machine with automated detection of product position 失效
    自动售货机自动检测产品的位置

    公开(公告)号：US08706293B2

    公开(公告)日：2014-04-22

    申请号：US13306692

    申请日：2011-11-29

    申请人： Pin Lu

    发明人： Pin Lu

    IPC分类号： G06F17/00

    CPC分类号： G07F9/026 ,  G06T7/73 ,  G06T2207/30204

    摘要： Embodiments of a vending machine are disclosed that can comprise one or more horizontally oriented shelves for supporting products to be vended, a plurality of vertically oriented dividers coupled to the shelves, a plurality of location markers located on the dividers and/or on the shelves, and an optical recognition module configured to optically recognize the location markers and to determine positions of the location markers and products relative to the shelves. In some embodiments, the optical recognition module can recognize the products by comparing images of the products to stored product images.

    摘要翻译： 公开了一种自动售货机的实施例，其可以包括一个或多个水平定向的货架，用于支撑要销售的产品，耦合到货架的多个垂直定向的分隔件，位于分隔件和/或货架上的多个位置标记， 以及光学识别模块，被配置为光学地识别所述位置标记并且确定所述位置标记和产品相对于所述架子的位置。 在一些实施例中，光学识别模块可以通过将产品的图像与存储的商品图像进行比较来识别产品。