公开(公告)号：US08052225B2

公开(公告)日：2011-11-08

申请号：US12968468

申请日：2010-12-15

申请人： Jun Inoue ,  Takanori Kanehisa

发明人： Jun Inoue ,  Takanori Kanehisa

IPC分类号： B60B27/00

CPC分类号： B62K25/02 ,  B62K23/06 ,  B62K2206/00 ,  B62M25/04

摘要： A bicycle wheel securing structure includes a bicycle fork, an adapter and a holding member. The bicycle fork has two axle support portions that are spaced apart for receiving a bicycle hub therebetween. The adapter is disposed in an adapter receiving bore in one of the axle support portions. The adapter includes a threaded axle mounting opening. The holding member is operatively coupled between the adapter and the one of the axle support portions with the adapter. The holding member prevents both rotational movement of the adapter with respect to the bicycle fork and axial movement of the adapter with respect to the bicycle fork along an axis of the axle mounting opening when the holding member is in a retaining position. The adapter is rotatable within the adapter receiving bore without moving axially with respect to the bicycle fork when the holding member is in a releasing position.

摘要翻译： 自行车车轮固定结构包括自行车叉，适配器和保持构件。 自行车叉具有间隔开的用于在其间接纳自行车轮毂的两个轴支撑部分。 适配器设置在一个轴支撑部分中的适配器接收孔中。 适配器包括一个螺纹轴安装孔。 保持构件通过适配器可操作地联接在适配器和轴支撑部分中的一个之间。 当保持构件处于保持位置时，保持构件防止适配器相对于自行车叉的旋转运动和适配器相对于自行车叉沿着轴安装开口的轴线的轴向运动。 当保持构件处于释放位置时，适配器可在适配器容纳孔内旋转，而不相对于自行车叉轴向移动。

公开(公告)号：US08042881B2

公开(公告)日：2011-10-25

申请号：US12268469

申请日：2008-11-11

申请人： Jun Inoue ,  Takanori Kanehisa

发明人： Jun Inoue ,  Takanori Kanehisa

IPC分类号： B60B27/00

CPC分类号： B62K25/02 ,  B62K23/06 ,  B62K2206/00 ,  B62M25/04

摘要： A bicycle wheel securing structure includes a bicycle fork, an adapter and a holding member. The bicycle fork has two axle support portions that are spaced apart for receiving a bicycle hub therebetween. The adapter is disposed in an adapter receiving bore in one of the axle support portions. The adapter includes a threaded axle mounting opening. The holding member is operatively coupled between the adapter and the one of the axle support portions with the adapter. The holding member prevents both rotational movement of the adapter with respect to the bicycle fork and axial movement of the adapter with respect to the bicycle fork along an axis of the axle mounting opening when the holding member is in a retaining position. The adapter is rotatable within the adapter receiving bore without moving axially with respect to the bicycle fork when the holding member is in a releasing position.

公开(公告)号：US08419137B2

公开(公告)日：2013-04-16

申请号：US13290177

申请日：2011-11-07

申请人： Jun Inoue ,  Takanori Kanehisa

发明人： Jun Inoue ,  Takanori Kanehisa

IPC分类号： B60B27/00

CPC分类号： B62K25/02 ,  B62K23/06 ,  B62K2206/00 ,  B62M25/04

摘要： A bicycle wheel securing structure includes a bicycle fork, an adapter and a holding member. The bicycle fork has two axle support portions that are spaced apart for receiving a bicycle hub therebetween. The adapter is disposed in an adapter receiving bore in one of the axle support portions. The adapter includes a threaded axle mounting opening. The holding member is operatively coupled between the adapter and the one of the axle support portions with the adapter. The holding member prevents both rotational movement of the adapter with respect to the bicycle fork and axial movement of the adapter with respect to the bicycle fork along an axis of the axle mounting opening when the holding member is in a retaining position. The adapter is rotatable within the adapter receiving bore without moving axially with respect to the bicycle fork when the holding member is in a releasing position.

摘要翻译： 自行车车轮固定结构包括自行车叉，适配器和保持构件。 自行车叉具有间隔开的用于在其间接纳自行车轮毂的两个轴支撑部分。 适配器设置在一个轴支撑部分中的适配器接收孔中。 适配器包括一个螺纹轴安装孔。 保持构件通过适配器可操作地联接在适配器和轴支撑部分中的一个之间。 当保持构件处于保持位置时，保持构件防止适配器相对于自行车叉的旋转运动和适配器相对于自行车叉沿着轴安装开口的轴线的轴向运动。 当保持构件处于释放位置时，适配器可在适配器容纳孔内旋转，而不相对于自行车叉轴向移动。

公开(公告)号：US08424975B2

公开(公告)日：2013-04-23

申请号：US13290178

申请日：2011-11-07

申请人： Jun Inoue ,  Takanori Kanehisa

发明人： Jun Inoue ,  Takanori Kanehisa

IPC分类号： B60B27/00

CPC分类号： B62K25/02 ,  B62K23/06 ,  B62K2206/00 ,  B62M25/04

摘要： A bicycle wheel securing structure includes a bicycle fork, an adapter and a holding member. The bicycle fork has two axle support portions that are spaced apart for receiving a bicycle hub therebetween. The adapter is disposed in an adapter receiving bore in one of the axle support portions. The adapter includes a threaded axle mounting opening. The holding member is operatively coupled between the adapter and the one of the axle support portions with the adapter. The holding member prevents both rotational movement of the adapter with respect to the bicycle fork and axial movement of the adapter with respect to the bicycle fork along an axis of the axle mounting opening when the holding member is in a retaining position. The adapter is rotatable within the adapter receiving bore without moving axially with respect to the bicycle fork when the holding member is in a releasing position.

公开(公告)号：US08802705B2

公开(公告)日：2014-08-12

申请号：US12451564

申请日：2008-05-20

申请人： Yoshikuni Nakamura ,  Ikuko Hanano ,  Jun Inoue

发明人： Yoshikuni Nakamura ,  Ikuko Hanano ,  Jun Inoue

IPC分类号： A61K31/422 ,  A61K31/427

CPC分类号： A61K31/427 ,  A61K31/421 ,  A61K31/426 ,  C07D263/32 ,  C07D277/24 ,  C07D417/06

摘要： Provision of an agent for promoting proliferation of meibomian gland epithelial cells or corneal epithelial cells, and a therapeutic agent for ocular diseases such as meibomian gland dysfunction, dry eye and the like.A preparation containing [3-[2-[4-isopropyl-2-(4-trifluoromethyl)phenyl-5-thiazolyl]ethyl]-5-methyl-1,2-benzisoxazol-6-yl]oxyacetic acid, [4-[3-[2-(4-trifluoromethyl)phenyl-4-isopropyl-5-thiazolyl]propionyl]-2-methylphenoxy]acetic acid or [4-[3-[2-(2-hydroxy-4-chlorophenyl)-5-isopropyl-4-oxazolyl]propionyl]-2-methylphenoxy]acetic acid, or a pharmacologically acceptable salt thereof as an active ingredient is used as an agent for promoting proliferation of meibomian gland epithelial cells or corneal epithelial cells, as well as a therapeutic agent for ocular diseases such as meibomian gland dysfunction, dry eye and the like.

摘要翻译： 提供用于促进睑板腺上皮细胞或角膜上皮细胞增殖的药剂，以及眼部疾病如睑板腺功能障碍，干眼症等的治疗剂。 含有[3- [2- [4-异丙基-2-（4-三氟甲基）苯基-5-噻唑基]乙基] -5-甲基-1,2-苯并异恶唑-6-基]氧基乙酸[4- [3- [2-（4-三氟甲基）苯基-4-异丙基-5-噻唑基]丙酰] -2-甲基苯氧基]乙酸或[4- [3- [2-（2-羟基-4-氯苯基） 5-异丙基-4-恶唑基]丙酰基] -2-甲基苯氧基]乙酸或其药理学上可接受的盐作为活性成分用作促进睑板腺上皮细胞或角膜上皮细胞增殖的试剂，以及 诸如睑板腺功能障碍，干眼症等眼部疾病的治疗剂。

公开(公告)号：US08216785B2

公开(公告)日：2012-07-10

申请号：US12568569

申请日：2009-09-28

申请人： Johji Inazawa ,  Issei Imoto ,  Jun Inoue

发明人： Johji Inazawa ,  Issei Imoto ,  Jun Inoue

IPC分类号： C12Q1/68 ,  G01N33/53

CPC分类号： G01N33/57407 ,  A61K38/00 ,  C12Q1/6886 ,  C12Q2600/154

摘要： The present invention is intended to provide a means for judging the malignancy of neuroblastoma and the progress of spontaneous regression thereof. The present invention provides a method for detecting cancer which comprises detecting activation or inactivation of the lysosomal-associated protein multispanning transmembrane 5 (LAPTM5) gene and amplification of the MYCN gene in a specimens to evaluate the malignancy of the specimens and the progress of spontaneous regression.

摘要翻译： 本发明旨在提供一种判断神经母细胞瘤的恶性程度及其自发消退的方法。 本发明提供一种检测癌症的方法，其包括检测样品中溶酶体相关蛋白多能跨膜5（LAPTM5）基因的活化或失活以及MYCN基因的扩增，以评估标本的恶性程度和自发回归的进展 。

公开(公告)号：US20110178299A1

公开(公告)日：2011-07-21

申请号：US13120800

申请日：2009-06-10

申请人： Jun Inoue ,  Hiroshi Kawasaki ,  Sohei Asakura

发明人： Jun Inoue ,  Hiroshi Kawasaki ,  Sohei Asakura

IPC分类号： C07D239/52

CPC分类号： C07D239/52 ,  A01N43/54

摘要： The present invention aims at providing an optically active difluoromethanesulfonanilide derivative exhibiting an excellent herbicidal activity at a low dose.An optically active (R)-2′-(4,6-dimethoxy-pyrimidin-2-yl)hydroxymethyl-1,1-difluoromethanesulfonanilide derivative is represented by the formula (I) (in the formula, R1 is a hydrogen atom, a C1-C4 alkyl group or a C1-C4 alkoxy C1-C4 alkyl group). and this difluoromethanesulfonanilide derivative is produced by subjecting to optical resolution a racemate of 2′-(4,6-dimethoxypyrimidin-2-yl)hydroxymethyl-1,1-difluoromethanesul-fonanilide derivative.

摘要翻译： 本发明的目的在于提供一种在低剂量下表现出优异除草活性的光学活性二氟甲磺酰苯胺衍生物。 光学活性（R）-2' - （4,6-二甲氧基 - 嘧啶-2-基）羟甲基-1,1-二氟甲磺酰苯胺衍生物由式（I）表示（式中，R1是氢原子， C1-C4烷基或C1-C4烷氧基C1-C4烷基）。 该二氟甲磺酰苯胺衍生物是通过光学拆分2' - （4,6-二甲氧基嘧啶-2-基）羟甲基-1,1-二氟甲磺酰氟苯胺衍生物的外消旋物制得的。

公开(公告)号：US20090074849A1

公开(公告)日：2009-03-19

申请号：US12153342

申请日：2008-05-16

申请人： Akiko Misawa ,  Jun Inoue ,  Issei Imoto ,  Johji Inazawa

发明人： Akiko Misawa ,  Jun Inoue ,  Issei Imoto ,  Johji Inazawa

IPC分类号： A61K48/00 ,  A61K9/127 ,  A61P35/00

CPC分类号： C07K14/70567 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/154 ,  G01N33/57407

摘要： It is an object of the present invention to provide a cancer-suppressing agent comprising a novel cancer-suppressing gene based on the discovery of such cancer-suppressing gene. The present invention provides a cancer-suppressing agent which comprises NR1I2 gene or a homologous gene thereof; and a cancer-suppressing agent which comprises NR1I2 protein or a homologous protein thereof.

摘要翻译： 本发明的目的是提供一种基于这种癌症抑制基因的发现而含有新型癌抑制基因的癌抑制剂。 本发明提供了包含NR1I2基因或其同源基因的癌抑制剂; 以及包含NR1I2蛋白或其同源蛋白质的癌抑制剂。

公开(公告)号：US20070154915A1

公开(公告)日：2007-07-05

申请号：US11591470

申请日：2006-11-02

申请人： Johji Inazawa ,  Issei Imoto ,  Jun Inoue ,  Akiko Furihata ,  Sana Yokoi ,  Itaru Sonoda ,  Hideaki Tanami ,  Hiroyuki Izumi ,  Kuniyasu Saigusa ,  Shin Hayashi ,  Hisashi Takada ,  Ayako Suzuki

发明人： Johji Inazawa ,  Issei Imoto ,  Jun Inoue ,  Akiko Furihata ,  Sana Yokoi ,  Itaru Sonoda ,  Hideaki Tanami ,  Hiroyuki Izumi ,  Kuniyasu Saigusa ,  Shin Hayashi ,  Hisashi Takada ,  Ayako Suzuki

IPC分类号： C12Q1/68 ,  C12P19/34

CPC分类号： C12Q1/6886 ,  C12Q2600/156 ,  C12Q2600/158

摘要： An object of the invention is to find a cancer-associated gene to be used as an index for detecting canceration of cells and degree of malignancy of cancer, so as to to provide a method for detecting cancer using the cancer-associated gene as an index and provide a method of suppressing/treating cancer using the cancer-associated gene as essential part. According to the present invention, specific genes which are amplified or deleted in large intestine cancer as compared with normal cell have been collectively found, and a method for detecting cancer using amplification or deletion of these cancer-associated genes as an index is provided. Further, cancer can be suppressed by introducing a gene which is deleted in cancer cells amond these cancer-associated genes into cancer and inhibiting the transcription product of the gene amplified.

摘要翻译： 本发明的目的是找到用作检测癌细胞癌变的指标和癌症恶性程度的指标的癌症相关基因，以便提供使用癌症相关基因作为指标检测癌症的方法 并提供使用癌症相关基因作为必需部分抑制/治疗癌症的方法。 根据本发明，已经共同发现在大肠癌中与正常细胞相比扩增或缺失的特定基因，并且提供了使用这些癌症相关基因的扩增或缺失作为指标来检测癌症的方法。 此外，通过将这些与癌症相关的基因的癌细胞中缺失的基因导入癌症并抑制扩增的基因的转录产物，可以抑制癌症。

公开(公告)号：US07228073B2

公开(公告)日：2007-06-05

申请号：US10615394

申请日：2003-07-09

申请人： Jun Inoue ,  Hideyuki Sotobayashi ,  Wataru Chujo ,  Hitoshi Kawaguchi

发明人： Jun Inoue ,  Hideyuki Sotobayashi ,  Wataru Chujo ,  Hitoshi Kawaguchi

IPC分类号： H04J4/00 ,  H04J14/08 ,  H04B10/08

CPC分类号： H04J14/08

摘要： An optical signal transmission device for transmitting phase information of optical signals is provided. The device includes a multiplexing formatted optical signal generator arranged to generate multiplexing formatted optical signals. The device also includes an optical phase generator arranged to receive the multiplexing formatted optical signals. An optical information transmission method for transmitting optical signal information including phase information is also provided. The method includes receiving multiplexing formatted optical signals generated by a multiplexing formatted optical signal generator at an optical phase generator. The method also includes phase conjugating the multiplexing formatted optical signals by means of four wave mixing (FWM).

摘要翻译： 提供一种用于发送光信号的相位信息的光信号传输装置。 该设备包括多路复用格式化的光信号发生器，被布置为产生复用格式化的光信号。 该装置还包括光学相位发生器，其布置成接收复用格式化的光信号。 还提供了一种用于发送包括相位信息的光信号信息的光信息传输方法。 该方法包括在光相位发生器处接收由复用格式化的光信号发生器产生的格式化的光信号复用。 该方法还包括通过四波混频（FWM）将复用格式化的光信号相位共轭。