公开(公告)号：US20050119450A1

公开(公告)日：2005-06-02

申请号：US10500565

申请日：2002-05-14

申请人： Jun Wang ,  Hai-Quan Mao ,  Kam Leong

发明人： Jun Wang ,  Hai-Quan Mao ,  Kam Leong

IPC分类号： A61K47/48 ,  A61P1/08 ,  A61P1/10 ,  A61P1/12 ,  A61P9/10 ,  A61P11/02 ,  A61P11/06 ,  A61P21/06 ,  A61P35/00 ,  C08G79/02 ,  C08G79/04 ,  C08L85/02 ,  C12N15/11

CPC分类号： C08G79/02 ,  A61K9/146 ,  A61K31/7088 ,  A61K47/34 ,  A61K47/605 ,  C08G79/04 ,  C08L85/02 ,  C08L2203/02 ,  C12N15/111 ,  C12N2320/32

摘要： The present invention is directed to a series of new polycationic biodegradable polyphosphoramidates. Process for making the polymers, compositions containing these polymers and bioactive ligands to enhance the cellular uptake ad intracellular trafficking, articles and methods for delivery of drugs and genes using these polymers are described. A gene delivery system based on these polymers is prepared by complex coacervation of nucleic acid (DNA or RNA) with polymers. Targeting ligands and molecules that could facilitate gene transfer can be conjugated to polymers to achieve selective and enhanced gene delivery. The current invention also provides a complex composition with buffering capacity.

摘要翻译： 本发明涉及一系列新的聚阳离子可生物降解的聚磷酸酰胺酯。 描述了制备聚合物的方法，含有这些聚合物的组合物和生物活性配体以增强细胞摄取和细胞内运输，用于递送药物和使用这些聚合物的基因的方法。 基于这些聚合物的基因递送系统通过核酸（DNA或RNA）与聚合物的复合凝聚来制备。 可以促进基因转移的靶向配体和分子可以与聚合物缀合以实现选择性和增强的基因递送。 本发明还提供具有缓冲能力的复合组合物。

公开(公告)号：US20050131200A1

公开(公告)日：2005-06-16

申请号：US10499898

申请日：2002-05-14

申请人： Jun Wang ,  Hai-Quan Mao ,  Kam Leong

发明人： Jun Wang ,  Hai-Quan Mao ,  Kam Leong

IPC分类号： A61K9/16 ,  A61K9/20 ,  A61K47/34 ,  A61K47/48 ,  A61K48/00 ,  A61P1/08 ,  A61P1/10 ,  A61P1/12 ,  A61P9/10 ,  A61P11/02 ,  A61P11/06 ,  A61P21/06 ,  A61P35/00 ,  C08G79/04 ,  C08L85/02 ,  C12N15/87 ,  C08G63/02

CPC分类号： C08L85/02 ,  A61K9/1647 ,  A61K9/204 ,  A61K47/34 ,  A61K47/605 ,  A61K47/645 ,  A61K48/0041 ,  C08G79/04 ,  C12N15/87

摘要： The present invention is directed to a biodegradable system for the controlled release of bioactive substances. This system comprises novel biodegradable and biocompatible polyphosphoesters that carry positive charges. Process for making these polyphosphoesters, compositions containing these polyphosphoesters and biologically active substances, articles and methods for delivery of drugs and genes using this system are described. A controlled gene delivery system based on these polyphosphoesters is prepared by complex coacervation of nucleic acid (DNA or RNA) with polymers. The release rates can be manipulated by adjusting the charge ratios of polyphosphoesters to nucleic acids. This gene delivery system yields a higher gene expression in muscle when injected intramuscularly.

摘要翻译： 本发明涉及用于控制释放生物活性物质的可生物降解的系统。 该系统包含携带正电荷的新型生物可降解和生物相容性聚磷酸酯。 描述了制备这些聚磷酸酯的方法，含有这些聚磷酸酯和生物活性物质的组合物，使用该系统递送药物和基因的制品和方法。 通过核酸（DNA或RNA）与聚合物的复合凝聚来制备基于这些多聚磷酸酯的受控基因递送系统。 可以通过调节多聚磷酸酯与核酸的电荷比来操纵释放速率。 当肌内注射时，该基因递送系统在肌肉中产生较高的基因表达。

公开(公告)号：US20090004741A1

公开(公告)日：2009-01-01

申请号：US12137450

申请日：2008-06-11

申请人： Jun Wang ,  Hai-Quan Mao ,  Kam Weng Leong

发明人： Jun Wang ,  Hai-Quan Mao ,  Kam Weng Leong

IPC分类号： C12N15/87

CPC分类号： C08L85/02 ,  A61K47/59 ,  C08G79/02

摘要： The present invention is directed to a series of new polycationic biodegradable polyphosphoramidates. Process for making the polymers, compositions containing these polymers and bioactive ligands to enhance the cellular uptake ad intracellular trafficking, articles and methods for delivery of drugs and genes using these polymers are described. A gene delivery system based on these polymers is prepared by complex coacervation of nucleic acid (DNA or RNA) with polymers. Targeting ligands and molecules that could facilitate gene transfer can be conjugated to polymers to achieve selective and enhanced gene delivery. The current invention also provides a complex composition with buffering capacity.

公开(公告)号：US07345138B2

公开(公告)日：2008-03-18

申请号：US10499898

申请日：2002-05-14

申请人： Jun Wang ,  Hai-Quan Mao ,  Kam Weng Leong

发明人： Jun Wang ,  Hai-Quan Mao ,  Kam Weng Leong

IPC分类号： C08G63/68 ,  C08G79/02

CPC分类号： C08L85/02 ,  A61K9/1647 ,  A61K9/204 ,  A61K47/34 ,  A61K47/605 ,  A61K47/645 ,  A61K48/0041 ,  C08G79/04 ,  C12N15/87

摘要： The present invention is directed to a biodegradable system for the controlled release of bioactive substances. This system comprises novel biodegradable and biocompatible polyphosphoesters that carry positive charges. Process for making these polyphosphoesters, compositions containing these polyphosphoesters and biologically active substances, articles and methods for delivery of drugs and genes using this system are described. A controlled gene delivery system based on these polyphosphoesters is prepared by complex coacervation of nucleic acid (DNA or RNA) with polymers. The release rates can be manipulated by adjusting the charge ratios of polyphosphoesters to nucleic acids. This gene delivery system yields a higher gene expression in muscle when injected intramuscularly.

摘要翻译： 本发明涉及用于控制释放生物活性物质的可生物降解的系统。 该系统包含携带正电荷的新型生物可降解和生物相容性聚磷酸酯。 描述了制备这些聚磷酸酯的方法，含有这些聚磷酸酯和生物活性物质的组合物，使用该系统递送药物和基因的制品和方法。 通过核酸（DNA或RNA）与聚合物的复合凝聚来制备基于这些多聚磷酸酯的受控基因递送系统。 可以通过调节多聚磷酸酯与核酸的电荷比来操纵释放速率。 当肌内注射时，该基因递送系统在肌肉中产生较高的基因表达。

公开(公告)号：US07417110B2

公开(公告)日：2008-08-26

申请号：US10500565

申请日：2002-05-14

申请人： Jun Wang ,  Hai-Quan Mao ,  Kam Weng Leong

发明人： Jun Wang ,  Hai-Quan Mao ,  Kam Weng Leong

IPC分类号： C08G79/02 ,  C08G79/04 ,  C08J3/07

CPC分类号： C08G79/02 ,  A61K9/146 ,  A61K31/7088 ,  A61K47/34 ,  A61K47/605 ,  C08G79/04 ,  C08L85/02 ,  C08L2203/02 ,  C12N15/111 ,  C12N2320/32

摘要： The present invention is directed to a series of new polycationic biodegradable polyphosphoramidates. Process for making the polymers, compositions containing these polymers and bioactive ligands to enhance the cellular uptake ad intracellular trafficking, articles and methods for delivery of drugs and genes using these polymers are described. A gene delivery system based on these polymers is prepared by complex coacervation of nucleic acid (DNA or RNA) with polymers. Targeting ligands and molecules that could facilitate gene transfer can be conjugated to polymers to achieve selective and enhanced gene delivery. The current invention also provides a complex composition with buffering capacity.

摘要翻译： 本发明涉及一系列新的聚阳离子可生物降解的聚磷酸酰胺酯。 描述了制备聚合物的方法，含有这些聚合物的组合物和生物活性配体以增强细胞摄取和细胞内运输，用于递送药物和使用这些聚合物的基因的方法。 基于这些聚合物的基因递送系统通过核酸（DNA或RNA）与聚合物的复合凝聚来制备。 可以促进基因转移的靶向配体和分子可以与聚合物缀合以实现选择性和增强的基因递送。 本发明还提供具有缓冲能力的复合组合物。

公开(公告)号：US20090012027A1

公开(公告)日：2009-01-08

申请号：US12137445

申请日：2008-06-11

申请人： Jun Wang ,  Hai-Quan Mao ,  Kam Weng Leong

发明人： Jun Wang ,  Hai-Quan Mao ,  Kam Weng Leong

IPC分类号： A61K47/48 ,  C08G79/02 ,  C12N5/06 ,  C12N15/11 ,  A61K31/7088

CPC分类号： C08G79/02 ,  A61K9/146 ,  A61K31/7088 ,  A61K47/34 ,  A61K47/605 ,  C08G79/04 ,  C08L85/02 ,  C08L2203/02 ,  C12N15/111 ,  C12N2320/32

摘要： The present invention is directed to a series of new polycationic biodegradable polyphosphoramidates. Process for making the polymers, compositions containing these polymers and bioactive ligands to enhance the cellular uptake ad intracellular trafficking, articles and methods for delivery of drugs and genes using these polymers are described. A gene delivery system based on these polymers is prepared by complex coacervation of nucleic acid (DNA or RNA) with polymers. Targeting ligands and molecules that could facilitate gene transfer can be conjugated to polymers to achieve selective and enhanced gene delivery. The current invention also provides a complex composition with buffering capacity.

摘要翻译： 本发明涉及一系列新的聚阳离子可生物降解的聚磷酸酰胺酯。 描述了制备聚合物的方法，含有这些聚合物的组合物和生物活性配体以增强细胞摄取和细胞内运输，用于递送药物和使用这些聚合物的基因的方法。 基于这些聚合物的基因递送系统通过核酸（DNA或RNA）与聚合物的复合凝聚来制备。 可以促进基因转移的靶向配体和分子可以与聚合物缀合以实现选择性和增强的基因递送。 本发明还提供具有缓冲能力的复合组合物。

公开(公告)号：US20210383637A1

公开(公告)日：2021-12-09

申请号：US17152786

申请日：2021-01-19

申请人： Jun Wang ,  Weijun Zhang

发明人： Jun Wang ,  Weijun Zhang

IPC分类号： G07F13/04 ,  G16H20/60 ,  G06Q30/02 ,  G01G19/414

摘要： A nutrition tracking system comprises a nutrition tracking server, a plurality of weight-based food offering terminals, and one or more nutrition and meal information inquiry terminals. Multiple weight-based food offering terminals may be equipped on a food service cart. Each weight-based food offering terminal may be initialized to offer a type of food. The weight-based food offering terminal automatically measures the weight of food taken by a customer or for a customer, calculates the cost of food, and shows the weight and the cost on the display in real time. When the food is paid, the weight-based food offering terminal automatically reports the vending information to the nutrition tracking server. The nutrition tracking server maintains a database for customer meal information and a database for customer nutrition information. Customers may inquire their meal history and nutrition information using the nutrition and meal information inquiry terminals.

公开(公告)号：US20200153538A1

公开(公告)日：2020-05-14

申请号：US16620129

申请日：2018-06-13

申请人： Xixian CHEN ,  Jung-Fu CHENG ,  James Jianfeng WENG ,  Jun Wang

发明人： Xixian CHEN ,  Jung-Fu CHENG ,  James Jianfeng WENG ,  Jun Wang

IPC分类号： H04L1/00

摘要： There is provided a method performed by a wireless device for handling user data. The method comprises: receiving an index (such as a Transport Block Size (TBS) index) from a network node; determining a TBS based on the received index; determining a modulation order based at least on the determined TBS; and performing one of decoding and encoding the user data based at least on the determined modulation order.

公开(公告)号：US10171998B2

公开(公告)日：2019-01-01

申请号：US12048883

申请日：2008-03-14

申请人： Jun Wang ,  Arungundram C. Mahendran ,  Vidya Narayanan

发明人： Jun Wang ,  Arungundram C. Mahendran ,  Vidya Narayanan

IPC分类号： H04W12/06 ,  H04L29/06 ,  H04W12/02 ,  H04W80/04

摘要： An authentication server may be adapted to (a) authenticate an authentication peer seeking to establish communications via a first network access node; (b) retrieve user profile information associated with the authentication peer; and/or (c) send the user profile information to a network gateway node that facilitates communication services for the authentication peer. A PMIP network node may be adapted to (a) provide wireless network connectivity to an authentication peer via a first network access node; (b) provide a PMIP key to both ends of a PMIP tunnel between the first network access node and a PMIP network node used to provide communications to the authentication peer; (c) provide the PMIP key to a first authenticator associated the first network access node; (d) receive a request at the PMIP network node from a requesting entity to reroute communications for the authentication peer; and/or (e) verify whether the requesting entity knows the PMIP key.

公开(公告)号：US09493821B2

公开(公告)日：2016-11-15

申请号：US13989031

申请日：2011-09-21

申请人： Ye Du ,  Meiru Zhao ,  Ying Chen ,  Jinghua Wu ,  Geng Tian ,  Jun Wang

发明人： Ye Du ,  Meiru Zhao ,  Ying Chen ,  Jinghua Wu ,  Geng Tian ,  Jun Wang

IPC分类号： C12Q1/68 ,  C12N15/10 ,  C40B50/06

CPC分类号： C12Q1/683 ,  C12N15/1093 ,  C12Q1/6869 ,  C12Q1/6883 ,  C12Q2521/313 ,  C12Q2525/191 ,  C40B50/06

摘要： A DNA library, and a preparing method thereof, a method of determining DNA sequence information, an apparatus and a kit for detecting SNPs, and a method for genotyping may be provided. The method for preparing the DNA library may comprise the steps of: digesting a genomic DNA sample using a restriction endonuclease to obtain a digested product, wherein the restriction endonuclease comprises at least one selected from the group consisting of Mbo II and Tsp 45I; separating the digested product to obtain DNA fragments having a length of 100 bp to 1,000 bp; end-repairing the DNA fragments to obtain an end-repaired DNA fragments; adding a base A to the end of the end-repaired DNA fragments to obtain DNA fragments having a terminal base A; and ligating the DNA fragments having the terminal base A with sequencing adaptors to obtain the DNA library.