公开(公告)号：US08877515B2

公开(公告)日：2014-11-04

申请号：US13177971

申请日：2011-07-07

申请人： Hiroyuki Chiku ,  Junichi Katada ,  Hideyuki Karaki ,  Hiroki Terada

发明人： Hiroyuki Chiku ,  Junichi Katada ,  Hideyuki Karaki ,  Hiroki Terada

IPC分类号： G01N33/558

CPC分类号： G01N33/558 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/96 ,  Y10S435/97 ,  Y10S436/808 ,  Y10S436/81

摘要： It is an object of the present invention to provide a measurement kit for developing a first developing solution and a second developing solution from different directions to suppress background noise, and an immunochromatography kit. The present invention provides a measurement kit, which comprises a first developing member for supplying a first developing solution and a second developing member for supplying a second developing solution, wherein the developing direction of the first developing solution is allowed to intersect with the developing direction of the second developing solution, so that development is carried out by developing the first and second developing solutions in different developing directions, and a water absorbent portion is established on the downstream of each of the developing directions.

摘要翻译： 本发明的目的是提供一种用于从不同方向开发第一显影液和第二显影液以抑制背景噪音的测量组件和免疫色谱仪。 本发明提供了一种测量套件，其包括用于供应第一显影液的第一显影构件和用于供应第二显影液的第二显影构件，其中使第一显影液的显影方向与显影方向相交， 第二显影液，通过在不同的显影方向显影第一和第二显影液进行显影，并且在每个显影方向的下游形成吸水部分。

公开(公告)号：US08663910B2

公开(公告)日：2014-03-04

申请号：US12562885

申请日：2009-09-18

申请人： Mikinaga Mori ,  Junichi Katada ,  Hiroyuki Chiku ,  Takayoshi Oyamada

发明人： Mikinaga Mori ,  Junichi Katada ,  Hiroyuki Chiku ,  Takayoshi Oyamada

IPC分类号： C12Q1/00

CPC分类号： G01N33/54366

摘要： A plurality of kinds of liquids, which are of at least three kinds, containing (a) a test body solution containing at least one kind of an analyte, and (b) at least two kinds of liquids selected from the group consisting of a reagent solution, an amplifying solution, and a detecting solution, are fed to a detection site containing a specific binding substance with respect to the analyte. A qualitative analysis or a quantitative analysis of the analyte contained in the test body solution is thereby performed. Directions of liquid feeding of all of the plurality of the kinds of the liquids vary from one another, and the plurality of the kinds of the liquids are caused to intersect with one another at the detection site.

摘要翻译： 至少三种的多种液体，其含有（a）含有至少一种分析物的测试体溶液，和（b）至少两种选自试剂 溶液，放大溶液和检测溶液相对于分析物进料到含有特异性结合物质的检测部位。 因此，进行了测试体溶液中包含的分析物的定性分析或定量分析。 所有多种液体的液体供给方向彼此不同，并且使多种液体在检测部位彼此相交。

公开(公告)号：US20110269247A1

公开(公告)日：2011-11-03

申请号：US13177971

申请日：2011-07-07

申请人： Hiroyuki CHIKU ,  Junichi Katada ,  Hideyuki Karaki ,  Hiroki Terada

发明人： Hiroyuki CHIKU ,  Junichi Katada ,  Hideyuki Karaki ,  Hiroki Terada

IPC分类号： G01N33/53 ,  G01N33/48

CPC分类号： G01N33/558 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/96 ,  Y10S435/97 ,  Y10S436/808 ,  Y10S436/81

摘要： It is an object of the present invention to provide a measurement kit for developing a first developing solution and a second developing solution from different directions to suppress background noise, and an immunochromatography kit. The present invention provides a measurement kit, which comprises a first developing member for supplying a first developing solution and a second developing member for supplying a second developing solution, wherein the developing direction of the first developing solution is allowed to intersect with the developing direction of the second developing solution, so that development is carried out by developing the first and second developing solutions in different developing directions, and a water absorbent portion is established on the downstream of each of the developing directions.

摘要翻译： 本发明的目的是提供一种用于从不同方向开发第一显影液和第二显影液以抑制背景噪音的测量组件和免疫色谱仪。 本发明提供了一种测量套件，其包括用于供应第一显影液的第一显影构件和用于供应第二显影液的第二显影构件，其中使第一显影液的显影方向与显影方向相交， 第二显影液，通过在不同的显影方向显影第一和第二显影液进行显影，并且在每个显影方向的下游形成吸水部分。

公开(公告)号：US08716032B2

公开(公告)日：2014-05-06

申请号：US13523388

申请日：2012-06-14

申请人： Junichi Katada ,  Hiroyuki Chiku

发明人： Junichi Katada ,  Hiroyuki Chiku

IPC分类号： G01N33/553 ,  G01N33/558 ,  G01N33/563 ,  G01N33/543 ,  G01N33/53

CPC分类号： G01N33/54393 ,  G01N33/5308

摘要： The present invention is to provide an immunochromatography method which is capable of performing a detection with high-sensitivity or reduced false-positives by suppressing the occurrence of false-positive when a signal is amplified. An immunochromatography method includes in a state of where a complex of a test substance and a labeling substance containing a metal coupled with a first binding substance for the test substance is formed, developing the complex on an insoluble carrier in presence of a protease hydrolyzate of protein; capturing the test substance and the labeling substance at a detection site of the insoluble carrier containing a material which has a binding property to the first binding substance for the test substance or a second binding substance for the test substance; and detecting the test substance by amplifying the labeling substance captured.

摘要翻译： 本发明提供一种免疫色谱法，其能够通过抑制信号放大时的假阳性发生而通过高灵敏度或降低的假阳性进行检测。 免疫色谱方法包括在形成测试物质和含有与测试物质的第一结合物质偶联的金属的标记物质的复合物的状态下，在蛋白质蛋白酶水解物的存在下在不溶性载体上形成复合物 ; 在不溶性载体的检测部位捕获被检物质和标记物质，其含有与测试物质的第一结合物质或测试物质的第二结合物质具有结合性的物质; 并通过放大捕获的标记物质来检测被检物质。

公开(公告)号：US07998753B2

公开(公告)日：2011-08-16

申请号：US12325057

申请日：2008-11-28

申请人： Hiroyuki Chiku ,  Junichi Katada ,  Hideyuki Karaki ,  Hiroki Terada

发明人： Hiroyuki Chiku ,  Junichi Katada ,  Hideyuki Karaki ,  Hiroki Terada

IPC分类号： G01N33/53

CPC分类号： G01N33/558 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/96 ,  Y10S435/97 ,  Y10S436/808 ,  Y10S436/81

摘要： It is an object of the present invention to provide a measurement kit for developing a first developing solution and a second developing solution from different directions to suppress background noise, and an immunochromatography kit. The present invention provides a measurement kit, which comprises a first developing member for supplying a first developing solution and a second developing member for supplying a second developing solution, wherein the developing direction of the first developing solution is allowed to intersect with the developing direction of the second developing solution, so that development is carried out by developing the first and second developing solutions in different developing directions, and a water absorbent portion is established on the downstream of the developing directions.

摘要翻译： 本发明的目的是提供一种用于从不同方向开发第一显影液和第二显影液以抑制背景噪音的测量组件和免疫色谱仪。 本发明提供了一种测量套件，其包括用于供应第一显影液的第一显影构件和用于供应第二显影液的第二显影构件，其中使第一显影液的显影方向与显影方向相交， 第二显影液，通过在不同的显影方向显影第一和第二显影液进行显影，并且在显影方向的下游建立吸水部分。

公开(公告)号：US20090181470A1

公开(公告)日：2009-07-16

申请号：US12325057

申请日：2008-11-28

申请人： Hiroyuki CHIKU ,  Junichi Katada ,  Hideyuki Karaki ,  Hiroki Terada

发明人： Hiroyuki CHIKU ,  Junichi Katada ,  Hideyuki Karaki ,  Hiroki Terada

IPC分类号： G01N33/558

CPC分类号： G01N33/558 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/96 ,  Y10S435/97 ,  Y10S436/808 ,  Y10S436/81

摘要： It is an object of the present invention to provide a measurement kit for developing a first developing solution and a second developing solution from different directions to suppress background noise, and an immunochromatography kit. The present invention provides a measurement kit, which comprises a first developing member for supplying a first developing solution and a second developing member for supplying a second developing solution, wherein the developing direction of the first developing solution is allowed to intersect with the developing direction of the second developing solution, so that development is carried out by developing the first and second developing solutions in different developing directions, and a water absorbent portion is established on the downstream of the developing directions.

摘要翻译： 本发明的目的是提供一种用于从不同方向开发第一显影液和第二显影液以抑制背景噪音的测量组件和免疫色谱仪。 本发明提供了一种测量套件，其包括用于供应第一显影液的第一显影构件和用于供应第二显影液的第二显影构件，其中使第一显影液的显影方向与显影方向相交， 第二显影液，通过在不同的显影方向显影第一和第二显影液进行显影，并且在显影方向的下游建立吸水部分。

公开(公告)号：US08474303B2

公开(公告)日：2013-07-02

申请号：US12895003

申请日：2010-09-30

申请人： Katsuya Inana ,  Tomonori Nishio ,  Junichi Katada

发明人： Katsuya Inana ,  Tomonori Nishio ,  Junichi Katada

IPC分类号： G01N30/02

CPC分类号： G01N21/78 ,  G01N21/8483 ,  G01N30/95

摘要： A chromatographic measurement apparatus for measuring a color development state of an insoluble carrier with a sample solution and a label solution developed thereon to test a test article, the insoluble carrier including a test detection area where a material that binds specifically to a test article is immobilized and a control detection area used for determining an end of measurement. The chromatographic measurement apparatus includes: a determining unit for carrying out determination of validity and determination of necessity of amplification of a test result of the test article; and an amplifying unit for amplifying the color development state according to the result of the determination of necessity of amplification by the determining unit. The amplification is carried out only when it is determined that amplification is necessary.

摘要翻译： 一种用于测量不溶性载体的显色状态的色谱测量装置，其中样品溶液和其上形成的标记溶液在其上显影以测试测试制品，所述不溶性载体包括测试检测区域，其中固定有特异性地与测试制品结合的材料 以及用于确定测量结束的控制检测区域。 色谱测量装置包括：确定单元，用于确定测试物品的测试结果的有效性和放大必要性的确定; 以及放大单元，用于根据由确定单元确定放大的必要性的结果来放大显色状态。 只有当确定需要扩增时才进行扩增。

公开(公告)号：US08404621B2

公开(公告)日：2013-03-26

申请号：US12934322

申请日：2009-03-13

申请人： Morihito Ikeda ,  Taisei Nishimi ,  Junichi Katada

发明人： Morihito Ikeda ,  Taisei Nishimi ,  Junichi Katada

IPC分类号： C40B60/00

CPC分类号： C07F7/1804 ,  G01N33/54353 ,  G01N33/54393 ,  Y10T428/2991

摘要： An immobilization method for immobilizing a physiologically active substance on a solid phase carrier, the method including: bringing the solid phase carrier into contact with an acid anhydride functional group-containing silane coupling agent represented by the following Formula (I); and carrying out a process of binding of the physiologically active substance to the acid anhydride functional group while maintaining the solid phase carrier after the contact at a temperature within the range of 0° C. to 60° C.; a physiologically active substance-immobilized carrier, and a carrier for immobilization are provided. Further, a carrier including a porous material treated with an acid anhydride functional group-containing silane coupling agent represented by the following Formula (I), a blocking agent that is immobilized to the porous material; and a method for producing it is provided.

摘要翻译： 一种用于将生理活性物质固定在固相载体上的固定方法，所述方法包括：使固相载体与由下式（I）表示的含酸酐官能团的硅烷偶联剂接触; 并且在0℃至60℃的范围内的温度下，将生理活性物质与酸酐官能团结合，同时保持接触后的固相载体; 提供生理活性物质固定化载体和用于固定的载体。 此外，包括用下述通式（I）表示的含酸酐官能团的硅烷偶联剂处理的多孔材料的载体，固定在多孔材料上的封端剂; 并提供其制造方法。

公开(公告)号：US20080160549A1

公开(公告)日：2008-07-03

申请号：US11979849

申请日：2007-11-08

申请人： Takayoshi Oyamada ,  Junichi Katada

发明人： Takayoshi Oyamada ,  Junichi Katada

IPC分类号： G01N33/00

CPC分类号： G01N33/558

摘要： An immunochromatography kit including an inorganic silver salt or a silver complex, a reducing agent for silver ions, and a metal colloid label or a metal chalcogenide label. The immunochromatography kit uses an immune reaction of an analyte and an antibody or antigen that can specifically bind to the analyte, and analyzes a signal from a label derived from the immobilized immune complex.

摘要翻译： 包括无机银盐或银络合物，银离子还原剂和金属胶体标记或金属硫族化物标签的免疫色谱试剂盒。 免疫色谱试剂盒使用分析物和可以特异性结合分析物的抗体或抗原的免疫反应，并分析来自固定的免疫复合物的标记的信号。

公开(公告)号：US08802426B2

公开(公告)日：2014-08-12

申请号：US13262526

申请日：2010-03-30

申请人： Mikinaga Mori ,  Junichi Katada ,  Takayoshi Oyamada ,  Hideyuki Karaki ,  Masayasu Konishi ,  Hiroki Terada

发明人： Mikinaga Mori ,  Junichi Katada ,  Takayoshi Oyamada ,  Hideyuki Karaki ,  Masayasu Konishi ,  Hiroki Terada

IPC分类号： B01L3/00 ,  G01N33/543

CPC分类号： G01N33/54386

摘要： A device for assay can evenly develop solution, and performs highly accurate and sensitive measurement. A first device part (10) maintains a second insoluble carrier (12) and a third insoluble carrier (13) in such a manner that they overlap with each other at a detection portion (14) of a first insoluble carrier (11). These three carriers (11), (12) and (13) are housed not in contact with each other. A pressing unit (18) having a pressing surface (18a) that is parallel to the detection portion (14) is provided on an inner surface of the second device part (20) facing the detection portion (14). The pressing surface (18a) is displaced by being pressed toward the detection portion (14), and presses, from the upper side of the first insoluble carrier (11), the second insoluble carrier (12) and the third insoluble carrier (13) onto the first insoluble carrier (11). The first device part (10) and the second device part (20) are joined together.

摘要翻译： 用于测定的装置可以均匀地开发溶液，并进行高度精确和灵敏的测量。 第一装置部分（10）以这样的方式保持第二不溶性载体（12）和第三不溶性载体（13），使得它们在第一不溶性载体（11）的检测部分（14）处彼此重叠。 这三个载体（11），（12）和（13）彼此不接触地容纳。 在与检测部（14）相对的第二装置部（20）的内表面上设置有具有与检测部（14）平行的按压面（18a）的按压部（18）。 按压面（18a）通过朝向检测部（14）被按压而移位，从第一不溶性载体（11）的上侧按压第二不溶性载体（12）和第三不溶性载体（13） 到第一不溶性载体（11）上。 第一装置部件（10）和第二装置部件（20）连接在一起。