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    Biosensor with suppressed non-specific adsorption
    2.
    发明授权
    Biosensor with suppressed non-specific adsorption 有权
    抑制非特异性吸附的生物传感器

    公开(公告)号：US07964414B2

    公开(公告)日：2011-06-21

    申请号：US11377554

    申请日：2006-03-17

    申请人： Toshihide Ezoe ,  Taisei Nishimi ,  Yukou Saito

    发明人： Toshihide Ezoe ,  Taisei Nishimi ,  Yukou Saito

    IPC分类号： G01N33/543 ,  C12M1/34

    CPC分类号： C12Q1/002 ,  G01N21/553 ,  G01N21/554 ,  G01N33/5438 ,  Y10S436/805

    摘要： The present invention provides a biosensor, wherein non-specific adsorption on a surface that does not retain a physiologically active substance (reference unit) is suppressed. The biosensor of the invention includes a substrate having at least two types of surfaces on a single plane, wherein at least one of the surfaces does not retain a physiologically active substance, and wherein at least two types of hydrophilic compounds with different molecular weights are bound to the surface that does not retain a physiologically active substance.

    摘要翻译： 本发明提供一种生物传感器，其中抑制了不保留生理活性物质（参考单元）的表面上的非特异性吸附。 本发明的生物传感器包括在单个平面上具有至少两种类型的表面的基底，其中至少一个表面不保留生理活性物质，并且其中至少两种具有不同分子量的亲水性化合物被结合 到没有保留生理活性物质的表面。

    POROUS FILM
    4.
    发明申请
    POROUS FILM 审中-公开
    多孔膜

    公开(公告)号：US20090239381A1

    公开(公告)日：2009-09-24

    申请号：US12405755

    申请日：2009-03-17

    申请人： Taisei Nishimi ,  Kenichi Ishizuka

    发明人： Taisei Nishimi ,  Kenichi Ishizuka

    IPC分类号： H01L21/311 ,  B32B3/26 ,  H01L21/308 ,  B05D5/12

    CPC分类号： H01L21/3086 ,  B01D61/14 ,  B01D69/02 ,  B01D69/141 ,  B01D71/24 ,  B01D71/26 ,  B01D71/28 ,  B01D71/40 ,  B01D71/80 ,  B01D2325/021 ,  B05D3/007 ,  B05D5/00 ,  B81C1/00031 ,  B81C2201/0149 ,  B81C2201/0198 ,  B82Y30/00 ,  Y10T428/249953 ,  Y10T428/249975

    摘要： A porous film which is formed using a block copolymer composed of a water-soluble polymer and a water-insoluble polymer, has nanometer-size pores, and in which a desired functional polymer is present on the pore inner walls is provided. The porous film includes a microphase-separated morphology including a continuous phase which is composed primarily of a water-insoluble polymer A, and a plurality of cylindrical microdomains which are composed primarily of a water-soluble polymer B incompatible with the water-insoluble polymer A, distributed within the continuous phase and oriented perpendicular to a surface of the film. The cylindrical microdomains contain therein pores having a cylindrical shape and an average diameter of between 1 and 200 nm.

    摘要翻译： 使用由水溶性聚合物和水不溶性聚合物构成的嵌段共聚物形成的多孔膜具有纳米尺寸的孔，其中在孔内壁上存在所需的官能聚合物。 多孔膜包括微相分离的形态，其包括主要由水不溶性聚合物A组成的连续相和主要由与水不溶性聚合物A不相容的水溶性聚合物B组成的多个圆筒状微区 分布在连续相中并垂直于膜的表面定向。 圆柱形微畴中包含具有圆柱形和平均直径在1至200nm之间的孔。

    Biosensor
    5.
    发明授权
    Biosensor 有权
    生物传感器

    公开(公告)号：US07563623B2

    公开(公告)日：2009-07-21

    申请号：US11708637

    申请日：2007-02-21

    申请人： Toshihide Ezoe ,  Taisei Nishimi ,  Yukou Saito

    发明人： Toshihide Ezoe ,  Taisei Nishimi ,  Yukou Saito

    IPC分类号： G01N33/551

    CPC分类号： G01N33/54353 ,  Y10S435/808 ,  Y10S436/805

    摘要： It is an object of the present invention to provide a biosensor on which a large amount of protein can be immobilized and nonspecific adsorption is less likely to occur with the use of a SAM compound having high water solubility and good performance in terms of supply. The present invention provides a biosensor comprising a substrate on which a hydrophilic polymer having a reactive group capable of binding to a physiologically active substance is immobilized via a compound represented by the following formula (1), said compound at a concentration of 1 mM being dissolved in water at 25° C.: X-L-Y  (1) wherein X represents a group capable of binding to metal, L represents a linking group, and Y represents a functional group to which the hydrophilic polymer is bound.

    摘要翻译： 本发明的目的是提供一种生物传感器，其中可以固定大量的蛋白质，并且通过使用具有高水溶性的SAM化合物和在供给方面的良好性能，不太可能发生非特异性吸附。 本发明提供了一种生物传感器，其包括通过下式（1）表示的化合物固定具有能够结合生理活性物质的反应性基团的亲水性聚合物的基材，所述化合物浓度为1mM时溶解 在25°C的水中：<？in-line-formula description =“In-line Formulas”end =“lead”？> XLY（1）<？in-line-formula description =“In-line Formulas”end =“尾”→其中X表示能够与金属结合的基团，L表示连接基团，Y表示亲水性聚合物结合的官能团。

    BIOCHEMICAL INSTRUMENT
    6.
    发明申请
    BIOCHEMICAL INSTRUMENT 审中-公开
    生化仪器

    公开(公告)号：US20080081184A1

    公开(公告)日：2008-04-03

    申请号：US11862598

    申请日：2007-09-27

    申请人： Takashi Kubo ,  Taisei Nishimi ,  Satoshi Hoshi

    发明人： Takashi Kubo ,  Taisei Nishimi ,  Satoshi Hoshi

    IPC分类号： B32B27/28

    CPC分类号： C08J7/045 ,  G01N33/54373 ,  G01N33/54393 ,  Y10T428/269 ,  Y10T428/31507 ,  Y10T428/31663 ,  Y10T428/31721 ,  Y10T428/31938

    摘要： It is an object of the present invention to provide a biochemical instrument wherein an adhesive layer that has hydrophilic properties, heat resistance, and satisfactory adhesiveness is provided between a plastic material surface and a hydrophilic polymer layer. The present invention provides a biochemical instrument comprising a plastic material that is coated on its surface with a hydrophilic polymer, which comprises a metal oxide thin film between the plastic material and the hydrophilic polymer layer, wherein the film stress of said metal oxide thin film is less than 5.4×1021 dyn/cm2.

    摘要翻译： 本发明的目的是提供一种生物化学仪器，其中在塑料材料表面和亲水性聚合物层之间提供具有亲水性，耐热性和令人满意的粘合性的粘合剂层。 本发明提供一种生物化学仪器，其包括在其表面上涂覆有亲水性聚合物的塑料材料，该塑料材料在塑料材料和亲水性聚合物层之间包含金属氧化物薄膜，其中所述金属氧化物薄膜的薄膜应力为 小于5.4×10 21 dyn / cm 2。

    Polymer composition containing organic modified layered silicate, film and gas barrier film as well as substrate and image display device using them
    7.
    发明授权
    Polymer composition containing organic modified layered silicate, film and gas barrier film as well as substrate and image display device using them 失效
    含有有机改性层状硅酸盐，膜和阻气膜的聚合物组合物以及使用它们的底物和图像显示装置

    公开(公告)号：US07341782B2

    公开(公告)日：2008-03-11

    申请号：US10665432

    申请日：2003-09-22

    申请人： Hideaki Naruse ,  Taisei Nishimi

    发明人： Hideaki Naruse ,  Taisei Nishimi

    IPC分类号： H01J1/62 ,  C09K9/04 ,  B32B9/04

    CPC分类号： H05B33/04 ,  C08K9/04 ,  C08K2201/008 ,  H01L51/5253 ,  Y10S428/917 ,  Y10T428/31504

    摘要： A polymer composition includes a polymer having a glass transition temperature of 120° C. to 400° C. as a simple substance of the polymer and an organic modified layered silicate having a decomposition starting temperature of 190° C. to 350° C. and contained in the polymer. (1) A film including the polymer composition, (2) a gas barrier film including the film and an organic/inorganic hybrid layer obtained by the sol-gel method and provided on the film, (3) a substrate comprising the film or the gas barrier film, and (4) an image display device comprising at least an anode, a light-emitting organic thin film layer and a cathode on the film or the gas barrier film are also disclosed. A polymer composition having both superior heat resistance and superior gas baffler properties, a film comprising the polymer composition, and a gas baffler film having the film, as well as a substrate and image display device exhibiting superior precision and durability are provided.

    摘要翻译： 聚合物组合物包括作为聚合物的单体的玻璃化转变温度为120℃至400℃的聚合物和分解开始温度为190℃至350℃的有机改性层状硅酸盐，以及 包含在聚合物中。 （1）包含聚合物组合物的膜，（2）包含该膜的阻气膜和通过溶胶 - 凝胶法获得并提供在该膜上的有机/无机混合层，（3）包含该膜或 气体阻隔膜，以及（4）还包括在膜或阻气膜上至少包含阳极，发光有机薄膜层和阴极的图像显示装置。 提供具有优异的耐热性和优异的气体挡板性能的聚合物组合物，包含聚合物组合物的膜和具有该膜的气体挡板膜，以及显示出优异的精度和耐久性的基板和图像显示装置。

    Biosensor
    8.
    发明授权
    Biosensor 有权
    生物传感器

    公开(公告)号：US08585972B2

    公开(公告)日：2013-11-19

    申请号：US12778555

    申请日：2010-05-12

    申请人： Taisei Nishimi ,  Toshihide Ezoe ,  Toshiaki Kubo ,  Hidetoshi Tomita

    发明人： Taisei Nishimi ,  Toshihide Ezoe ,  Toshiaki Kubo ,  Hidetoshi Tomita

    IPC分类号： G01N33/53

    CPC分类号： G01N33/54353 ,  G01N33/54373

    摘要： One object of the present invention is to provide a biosensor and a production method therefor, by which hydrogel that enables immobilization of a physiologically active substance can be conveniently produced using safe raw materials. The present invention provides a biosensor which comprises a substrate having a metal layer on its surface, wherein a hydrophilic polymer having a reactive functional group capable of reacting with a hydroxyl group or an amino group of a physiologically active substance is bound to the metal layer directly or indirectly via an intermediate layer.

    摘要翻译： 本发明的一个目的是提供一种生物传感器及其生产方法，通过该生物传感器及其生产方法，可以使用安全的原料方便地生产能够固定生理活性物质的水凝胶。 本发明提供一种生物传感器，其包括在其表面具有金属层的基材，其中具有能够与生理活性物质的羟基或氨基反应的反应性官能团的亲水性聚合物直接结合到金属层 或间接经由中间层。

    Method for purifying bioactive substances
    9.
    发明授权
    Method for purifying bioactive substances 有权
    生物活性物质的净化方法

    公开(公告)号：US07928191B2

    公开(公告)日：2011-04-19

    申请号：US12201594

    申请日：2008-08-29

    申请人： Koichi Minami ,  Yohsuke Takeuchi ,  Taisei Nishimi

    发明人： Koichi Minami ,  Yohsuke Takeuchi ,  Taisei Nishimi

    IPC分类号： C07K1/16

    CPC分类号： G01N33/54353 ,  C07K1/22 ,  G01N33/54386 ,  G01N33/54393

    摘要： A method for purifying bioactive substances includes the steps of: causing a bioactive substance having histidine units to contact media, each constituted by a substrate, ligands which are physically attached to the surface of the substrate, and Cu(II) or Fe(II) metal ions which are covalently bonded to the ligands; causing the bioactive substance to covalently bond with the metal ions via the histidine units; and washing the media with an amount of 1 nmol/L to 10 mmol/L imidazole derivative solution 60 times the volume of the media or greater. In the case that the metal ions are Cu(II), the bioactive substance which has covalently bonded with the Cu(II) via the histidine units are recovered by one of a 10 mmol/L to 1 mol/L imidazole derivative solution and a 0.5 mmol/L to 5 mol/L EDTA solution.

    摘要翻译： 净化生物活性物质的方法包括以下步骤：使具有组氨酸单元的生物活性物质与底物接触的介质，物理上附着于基材表面的配体和Cu（II）或Fe（II） 与配体共价键合的金属离子; 使生物活性物质通过组氨酸单元与金属离子共价键合; 并用介质的体积为60倍量的1nmol / L至10mmol / L的咪唑衍生物溶液洗涤培养基。 在金属离子为Cu（II）的情况下，通过组氨酸单元与Cu（II）共价键合的生物活性物质由10mmol / L至1mol / L的咪唑衍生物溶液中的一种回收， 0.5 mmol / L至5 mol / L EDTA溶液。

    METHOD OF MANUFACTURING POLYMER FILM
    10.
    发明申请
    METHOD OF MANUFACTURING POLYMER FILM 有权
    制造聚合物膜的方法

    公开(公告)号：US20110052821A1

    公开(公告)日：2011-03-03

    申请号：US12868385

    申请日：2010-08-25

    申请人： Kenichi ISHIZUKA ,  Taisei NISHIMI

    发明人： Kenichi ISHIZUKA ,  Taisei NISHIMI

    IPC分类号： B05D3/02

    CPC分类号： B05D7/24 ,  B82Y10/00 ,  C08J5/18 ,  C08J2353/00 ,  C08J2387/00 ,  G11B5/82

    摘要： A method of manufacturing a polymer film having a microphase-separated morphology includes a film-forming step in which a solution containing a block copolymer having two or more types of polymer chains which are mutually incompatible and are bonded to each other, a first solvent and a second solvent having a higher boiling point by at least 15° C. than the first solvent is applied onto a substrate and the first solvent is removed to form a film; a heating step in which the film is heated at a temperature which is higher than the boiling point of the first solvent but is lower than the boiling point of the second solvent to make the film formed have a microphase-separated morphology; and a solvent removal step in which the second solvent is removed from the film having the microphase-separated morphology to form the polymer film having the microphase-separated morphology.

    摘要翻译： 具有微相分离形态的聚合物膜的制造方法包括成膜步骤，其中含有具有两种或更多种彼此不相容并且彼此结合的聚合物链的嵌段共聚物的溶液，第一溶剂和 将具有比第一溶剂高沸点至少15℃的第二溶剂施加到基材上，并除去第一溶剂以形成膜; 加热步骤，其中所述膜在比所述第一溶剂的沸点高但低于所述第二溶剂的沸点的温度下加热以使所形成的膜具有微相分离的形态; 以及溶剂除去步骤，其中从具有微相分离形态的膜中除去第二溶剂以形成具有微相分离形态的聚合物膜。