-
公开(公告)号：US20130245305A1
公开(公告)日：2013-09-19
申请号：US13990312
申请日：2010-11-29
申请人： Junko Takada , Shunsuke Iwamoto , Satoshi Nakano
发明人： Junko Takada , Shunsuke Iwamoto , Satoshi Nakano
IPC分类号： C07C331/28
CPC分类号： C07C331/28
摘要： The object of the present invention is to provide a novel method for producing an isothiocyanate compound having a carboxyl group(s) by a reaction of the corresponding amino compound having a carboxyl group(s), thiocarbonyldiimidazole and a base, in one step with high purity.An amino compound having a carboxyl group(s) is reacted with thiocarbonyldiimidazole in a solvent in the presence of a base to obtain an isothiocyanate compound having a carboxyl group(s).
摘要翻译： 本发明的目的是提供一种具有羧基的具有羧基的相应氨基化合物，硫代羰基二咪唑和碱的具有羧基的异硫氰酸酯化合物的新方法，其中一步具有高的 纯度。 具有羧基的氨基化合物与硫代羰基二咪唑在溶剂中在碱存在下反应，得到具有羧基的异硫氰酸酯化合物。
-
公开(公告)号：US09102602B2
公开(公告)日：2015-08-11
申请号：US13990312
申请日：2010-11-29
申请人： Junko Takada , Shunsuke Iwamoto , Satoshi Nakano
发明人： Junko Takada , Shunsuke Iwamoto , Satoshi Nakano
IPC分类号： C07C331/28
CPC分类号： C07C331/28
摘要： The object of the present invention is to provide a novel method for producing an isothiocyanate compound having a carboxyl group(s) by a reaction of the corresponding amino compound having a carboxyl group(s), thiocarbonyldiimidazole and a base, in one step with high purity. An amino compound having a carboxyl group(s) is reacted with thiocarbonyldiimidazole in a solvent in the presence of a base to obtain an isothiocyanate compound having a carboxyl group(s).
摘要翻译： 本发明的目的是提供一种具有羧基的具有羧基的相应氨基化合物，硫代羰基二咪唑和碱的具有羧基的异硫氰酸酯化合物的新方法，其中一步具有高的 纯度。 具有羧基的氨基化合物与硫代羰基二咪唑在溶剂中在碱存在下反应，得到具有羧基的异硫氰酸酯化合物。
-
3.发明申请ORGANIC AMINE SALTS OF AMINOBENZOIC ACID DERIVATIVES AND METHOD FOR PRODUCING SAME 有权氨基苯甲酸衍生物的有机胺盐及其生产方法公开(公告)号：US20130217894A1
公开(公告)日：2013-08-22
申请号：US13883171
申请日：2011-11-01
IPC分类号： C07D333/32
CPC分类号： C07D333/32 , A61K9/0019 , A61K9/1623 , A61K9/1652 , A61K9/2018 , A61K9/2059 , A61K9/4866 , A61K47/14
摘要： A novel organic amine salt or salt with quaternary ammonium ion of 3-{[((2E)-2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid having useful properties as a drug is provided.A novel organic amine or salt with quaternary ammonium ion of 3-{[((2E)-2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid, a method for producing the organic amine salt or the salt with quaternary ammonium ion and a platelet increasing agent.
摘要翻译： 具有3 - {[（（2E）-2- {1- [5-（4-叔丁基苯基）-4-羟基-3-噻吩基]亚乙基}肼基）碳硫基的季铵离子的新型有机胺盐或盐 ]氨基}苯甲酸作为药物具有有用的性质。 具有季铵离子的3 - {[（（2E）-2- {1- [5-（4-叔丁基苯基）-4-羟基-3-噻吩基]亚乙基}肼基）碳硫基] 氨基}苯甲酸，有机胺盐或其盐与季铵离子的制备方法和增白剂。
-
公开(公告)号：US08134013B2
公开(公告)日：2012-03-13
申请号：US11721786
申请日：2005-12-14
申请人： Katsuaki Myaji , Shunsuke Iwamoto , Satoshi Nakano , Hirofumi Ota , Yukihiro Shigeta , Yutaka Hirokawa , Kazufumi Yanagihara , Koji Toyama , Shingo Owada , Masato Horikawa , Norihisa Ishiwata
发明人： Katsuaki Myaji , Shunsuke Iwamoto , Satoshi Nakano , Hirofumi Ota , Yukihiro Shigeta , Yutaka Hirokawa , Kazufumi Yanagihara , Koji Toyama , Shingo Owada , Masato Horikawa , Norihisa Ishiwata
IPC分类号： C07D409/02 , A61K31/40
CPC分类号： C07D231/18
摘要： The present invention provides compounds useful for prevention, treatment or alleviation of diseases against which activation of the thrombopoietin receptor is effective.A compound represented by the formula (1): wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are the same as defined in the description, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
摘要翻译： 本发明提供了可用于预防，治疗或缓解血小板生成素受体活化有效的疾病的化合物。 由式（1）表示的化合物：其中A，B，R1，L1，R2，L2，L3，Y，L4，R3和X与说明书中定义的相同，互变异构体，前药或药学上可接受的盐 化合物或其溶剂合物。
-
公开(公告)号：US07968542B2
公开(公告)日：2011-06-28
申请号：US11994502
申请日：2006-07-13
申请人： Katsuaki Miyaji , Kazufumi Yanagihara , Yukihiro Shigeta , Shunsuke Iwamoto , Masato Horikawa , Yutaka Hirokawa , Shingo Owada , Satoshi Nakano , Hirofumi Ota , Norihisa Ishiwata
发明人： Katsuaki Miyaji , Kazufumi Yanagihara , Yukihiro Shigeta , Shunsuke Iwamoto , Masato Horikawa , Yutaka Hirokawa , Shingo Owada , Satoshi Nakano , Hirofumi Ota , Norihisa Ishiwata
IPC分类号： C07D401/14 , C07D409/14 , C07D413/14 , A61K31/381 , A61P7/00
CPC分类号： C07D409/14 , C07D333/32 , C07D333/38 , C07D413/14
摘要： A compound represented by the formula (I) (wherein R1, R2, R3 and R4 are as defined in the description), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
摘要翻译： 由式（I）表示的化合物或其溶剂化物，其中R1，R2，R3和R4如说明书中所定义），互变异构体，前药或药学上可接受的盐。
-
6.发明授权Organic amine salts of aminobenzoic acid derivatives and method for producing same 有权氨基苯甲酸衍生物的有机胺盐及其制备方法公开(公告)号：US08946286B2
公开(公告)日：2015-02-03
申请号：US13883171
申请日：2011-11-01
CPC分类号： C07D333/32 , A61K9/0019 , A61K9/1623 , A61K9/1652 , A61K9/2018 , A61K9/2059 , A61K9/4866 , A61K47/14
摘要： A novel organic amine salt or salt with quaternary ammonium ion of 3-{[((2E)-2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid having useful properties as a drug is provided.A novel organic amine or salt with quaternary ammonium ion of 3-{[((2E)-2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid, a method for producing the organic amine salt or the salt with quaternary ammonium ion and a platelet increasing agent.
摘要翻译： 具有3 - {[（（2E）-2- {1- [5-（4-叔丁基苯基）-4-羟基-3-噻吩基]亚乙基}肼基）碳硫基的季铵离子的新型有机胺盐或盐 ]氨基}苯甲酸作为药物具有有用的性质。 具有季铵离子的3 - {[（（2E）-2- {1- [5-（4-叔丁基苯基）-4-羟基-3-噻吩基]亚乙基}肼基）碳硫基] 氨基}苯甲酸，有机胺盐或其盐与季铵离子的制备方法和增白剂。
-
公开(公告)号：US20110092496A1
公开(公告)日：2011-04-21
申请号：US12955477
申请日：2010-11-29
申请人： Katsuaki MIYAJI , Kazufumi Yanagihara , Yukihiro Shigeta , Shunsuke Iwamoto , Masato Horikawa , Yutaka Hirokawa , Shingo Owada , Satoshi Nakano , Hirofumi Ota , Norihisa Ishiwata
发明人： Katsuaki MIYAJI , Kazufumi Yanagihara , Yukihiro Shigeta , Shunsuke Iwamoto , Masato Horikawa , Yutaka Hirokawa , Shingo Owada , Satoshi Nakano , Hirofumi Ota , Norihisa Ishiwata
IPC分类号： A61K31/5377 , C07D405/12 , C07D409/12 , C07D233/96 , C07D231/10 , C07D333/22 , C07D261/08 , C07D411/12 , A61K31/497 , A61K31/4436 , A61K31/4178 , A61K31/4155 , A61K31/422 , A61K31/4025 , A61K31/381 , A61P7/00
CPC分类号： C07D409/14 , C07D333/32 , C07D333/38 , C07D413/14
摘要： A compound represented by the formula (I) (wherein R1, R2, R3 and R4 are as defined in the description), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
摘要翻译： 由式（I）表示的化合物或其溶剂化物，其中R1，R2，R3和R4如说明书中所定义），互变异构体，前药或药学上可接受的盐。
-
公开(公告)号：US20090131659A1
公开(公告)日：2009-05-21
申请号：US11721786
申请日：2005-12-14
申请人： Katsuaki Miyaji , Shunsuke Iwamoto , Satoshi Nakano , Hirofumi Ota , Yukihiro Shigeta , Yutaka Hirokawa , Kazufumi Yanagihara , Koji Toyama , Shingo Owada , Masato Horikawa , Norihisa Ishiwata
发明人： Katsuaki Miyaji , Shunsuke Iwamoto , Satoshi Nakano , Hirofumi Ota , Yukihiro Shigeta , Yutaka Hirokawa , Kazufumi Yanagihara , Koji Toyama , Shingo Owada , Masato Horikawa , Norihisa Ishiwata
IPC分类号： C07D413/12 , C07D409/14
CPC分类号： C07D231/18
摘要： The present invention provides compounds useful for prevention, treatment or alleviation of diseases against which activation of the thrombopoietin receptor is effective.A compound represented by the formula (1): wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are the same as defined in the description, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
摘要翻译： 本发明提供了可用于预防，治疗或缓解血小板生成素受体活化有效的疾病的化合物。 由式（1）表示的化合物：其中A，B，R1，L1，R2，L2，L3，Y，L4，R3和X与说明书中定义的相同，互变异构体，前药或药学上可接受的盐 化合物或其溶剂合物。
-
公开(公告)号：US20090118500A1
公开(公告)日：2009-05-07
申请号：US11994502
申请日：2006-07-13
申请人： Katsuaki Miyaji , Kazufumi Yanagihara , Yukihiro Shigeta , Shunsuke Iwamoto , Masato Horikawa , Yutaka Hirokawa , Shingo Owada , Satoshi Nakano , Hirofumi Ota , Norihisa Ishiwata
发明人： Katsuaki Miyaji , Kazufumi Yanagihara , Yukihiro Shigeta , Shunsuke Iwamoto , Masato Horikawa , Yutaka Hirokawa , Shingo Owada , Satoshi Nakano , Hirofumi Ota , Norihisa Ishiwata
IPC分类号： C07D495/04 , C07D409/12 , C07D409/02
CPC分类号： C07D409/14 , C07D333/32 , C07D333/38 , C07D413/14
摘要： A compound represented by the formula (I) (wherein R1, R2, R3 and R4 are as defined in the description), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
摘要翻译： 由式（I）表示的化合物或其溶剂化物，其中R1，R2，R3和R4如说明书中所定义），互变异构体，前药或药学上可接受的盐。
-
公开(公告)号：US08889732B2
公开(公告)日：2014-11-18
申请号：US13503560
申请日：2010-10-22
IPC分类号： A61K31/38 , C07D333/32 , C07D231/18 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14 , C07D409/04 , C07D333/40
CPC分类号： C07D409/14 , C07D231/18 , C07D333/32 , C07D333/38 , C07D333/40 , C07D401/12 , C07D409/04 , C07D409/12
摘要： Fused heterocyclic compounds useful for prevention, treatment or improvement of diseases against which activation of the thrombopoietin receptor is effective are provided.A compound represented by the formula (I) (wherein R1 is an aryl group fused to a saturated ring or the like, A, B, L1, R2, L2, L3, Y, L4, R3 and X are defined in the description), a tautomer, prodrug or a pharmaceutically acceptable salt of the compound or a solvate thereof.
摘要翻译： 提供了可用于预防，治疗或改善血小板生成素受体活化有效的疾病的融合杂环化合物。 式（I）表示的化合物（其中R 1是与饱和环等稠合的芳基A，B，L1，R2，L2，L3，Y，L4，R3和X在说明书中定义） ，该化合物或其溶剂化物的互变异构体，前药或药学上可接受的盐。
-
-
-
-
-
-
-
-
-
搜索结果
24 条记录 (耗时 0.025 秒)
