公开(公告)号：US4789401A

公开(公告)日：1988-12-06

申请号：US876824

申请日：1986-06-20

申请人： Jurgen Ebinger ,  Rolf-Dieter Beutler ,  Helmut Lindner

发明人： Jurgen Ebinger ,  Rolf-Dieter Beutler ,  Helmut Lindner

IPC分类号： A61K9/00 ,  A61K47/42 ,  A61L15/22 ,  A61L15/32 ,  C08L89/06 ,  A61F13/16

CPC分类号： C08L89/06 ,  A61K47/42 ,  A61K9/0034 ,  A61L15/225 ,  A61L15/325 ,  A61L15/425 ,  Y10S514/947 ,  Y10S514/95

摘要： The invention concerns a collagen sponge which has a denaturation temperature of at least 37.degree. C., is not cross-linked and in one of its two embodiments forms an optically clear solution in aqueous medium. As compared with the collagen sponges previously known, it is particularly suitable as support material for pharmaceutical and cosmetic active substances since it has a higher denaturation temperature than the latter and dissolves again in contact with body fluid. The collagen sponge of the invention is prepared from an optically clear collagen solution by precipitation with neutral salts, dissolving and reprecipitation and then subjecting the collagen to freeze-drying without removal of the precipitation salt. Acid-swollen collagens and/or cellulose or cellulose derivatives can also be added to the solution, whereby the physical properties of the collagen sponge can be affected.

摘要翻译： 本发明涉及一种胶原海绵，其具有至少37℃的变性温度，不是交联的，并且在其两个实施方案之一中在水性介质中形成光学透明的溶液。 与以前已知的胶原海绵相比，它特别适合用作药物和化妆品活性物质的载体材料，因为它具有比后者更高的变性温度，并再次溶解于体液接触。 本发明的胶原海绵由光学透明的胶原溶液通过用中性盐沉淀制备，溶解和再沉淀，然后使胶原蛋白冷冻干燥而不除去沉淀盐。 也可以将酸膨胀的胶原和/或纤维素或纤维素衍生物加入到溶液中，由此可以影响胶原海绵的物理性质。