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1.发明授权Method and apparatus for embedded heater for desorption and ionization of analytes 有权用于分析物解吸和电离的嵌入式加热器的方法和装置公开(公告)号：US08203117B2
公开(公告)日：2012-06-19
申请号：US12568929
申请日：2009-09-29
IPC分类号： H01J49/04
CPC分类号： G01N1/405 , G01N2001/4038 , H01J49/0468 , H01J49/142 , H01J49/165 , Y10T436/25
摘要： A heated DESI spray device provides improved resolution or control of analyte desorption at a target locus on a sample. Heating controls spot size and enhances resolution in an imaging mode without impairing signal level. Additionally or alternatively the heated DESI spray may control desorption kinetics of a target analyte or otherwise control analyte discrimination in detection mode. One embodiment of the DESI spray is heated by heating nebulizing gas that accompanies the electrosprayed solvent. Another embodiment heats a separate gas stream that transports or directs desorbed material to the ion aperture of an analysis instrument. Heating may reduce size of primary droplets, alter the impact dynamics or the energy delivered by the spray to the surface, reduce size of secondary droplets and/or assure desolvation, improve species selectivity or otherwise affect sampling and enhance the ion signal level.
摘要翻译： 加热的DESI喷雾装置提供了在样品上靶标位点处的分析物解吸附的改进的分辨率或控制。 加热控制光斑尺寸，并在成像模式下增强分辨率，而不会损害信号电平。 另外或替代地，加热的DESI喷雾可以控制目标分析物的解吸动力学或以其他方式控制检测模式中的分析物识别。 DESI喷雾的一个实施方案是通过加热伴随电喷雾溶剂的雾化气体来加热。 另一个实施例加热将解吸材料输送或引导到分析仪器的离子孔的单独气流。 加热可以减小初级液滴的尺寸，改变冲击动力学或由喷雾传递到表面的能量，减小二次液滴的尺寸和/或确保去溶剂化，改善物质选择性或以其他方式影响取样并提高离子信号水平。
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2.发明申请Method and apparatus for embedded heater for desorption and ionization of analytes 有权用于分析物解吸和电离的嵌入式加热器的方法和装置公开(公告)号：US20100078550A1
公开(公告)日：2010-04-01
申请号：US12568929
申请日：2009-09-29
CPC分类号： G01N1/405 , G01N2001/4038 , H01J49/0468 , H01J49/142 , H01J49/165 , Y10T436/25
摘要： A heated DESI spray device provides improved resolution or control of analyte desorption at a target locus on a sample. Heating controls spot size and enhances resolution in an imaging mode without impairing signal level. Additionally or alternatively the heated DESI spray may control desorption kinetics of a target analyte or otherwise control analyte discrimination in detection mode. One embodiment of the DESI spray is heated by heating nebulizing gas that accompanies the electrosprayed solvent. Another embodiment heats a separate gas stream that transports or directs desorbed material to the ion aperture of an analysis instrument. Heating may reduce size of primary droplets, alter the impact dynamics or the energy delivered by the spray to the surface, reduce size of secondary droplets and/or assure desolvation, improve species selectivity or otherwise affect sampling and enhance the ion signal level.
摘要翻译： 加热的DESI喷雾装置提供了在样品上靶标位点处的分析物解吸附的改进的分辨率或控制。 加热控制光斑尺寸，并在成像模式下增强分辨率，而不会损害信号电平。 另外或替代地，加热的DESI喷雾可以控制目标分析物的解吸动力学或以其他方式控制检测模式中的分析物识别。 DESI喷雾的一个实施方案是通过加热伴随电喷雾溶剂的雾化气体来加热。 另一个实施例加热将解吸材料输送或引导到分析仪器的离子孔的单独气流。 加热可以减小初级液滴的尺寸，改变冲击动力学或由喷雾传递到表面的能量，减小二次液滴的尺寸和/或确保去溶剂化，改善物质选择性或以其他方式影响取样并提高离子信号水平。
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公开(公告)号：US20090309020A1
公开(公告)日：2009-12-17
申请号：US12481501
申请日：2009-06-09
CPC分类号： H01J49/14
摘要： A desorption atmospheric pressure chemical ionization (DAPCI) system delivers a primary ion beam composed of an inert, high velocity gas and solvent ions to a surface to effect desorption and ionization of both volatile and non-volatile species present on surfaces. A electrode having a tapered tip is connected to a high voltage power supply. The tapered tip projects outward from a capillary carrying a high-speed flow of gas. A vapor of a solvent is mixed into the annular gas flow surrounding the needle. The gaseous solvent vapor is ionized in close proximity to the tapered tip by virtue of the high voltage applied to the electrode. The high-speed flow of gas and solvent vapor ions extending outward from the capillary is directed toward a substrate on which an analyte of interest may have been deposited. The solvent vapor ions can blanket the surface of the analyte causing a static charge build up that facilitates ion desorption and additionally can provide positive ion adducts of the analyte freed from the substrate surface that can be directed toward an atmospheric intake of a mass spectrometer or other instrument capable of studying the analyte.
摘要翻译： 解吸大气压化学电离（DAPCI）系统将由惰性高速气体和溶剂离子组成的初级离子束传送到表面，以实现表面上存在的挥发性和非挥发性物质的解吸和离子化。 具有锥形尖端的电极连接到高压电源。 锥形尖端从携带高速气体流的毛细管向外突出。 将溶剂的蒸气混合到围绕针的环形气流中。 通过施加到电极的高电压，气态溶剂蒸气被离子化，紧邻锥形尖端。 从毛细管向外延伸的气体和溶剂蒸汽离子的高速流动被引导到其上可能沉积感兴趣的分析物的基底。 溶剂蒸汽离子可以覆盖分析物的表面，导致静电荷积聚，促进离子解吸，并且另外可以提供从衬底表面释放的分析物的阳离子加合物，其可以被引导到大气摄入的质谱仪或其它 能够研究分析物的仪器。
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公开(公告)号：US08076639B2
公开(公告)日：2011-12-13
申请号：US12481501
申请日：2009-06-09
IPC分类号： H01J49/26
CPC分类号： H01J49/14
摘要： A desorption atmospheric pressure chemical ionization (DAPCI) system delivers a primary ion beam composed of an inert, high velocity gas and solvent ions to a surface to effect desorption and ionization of both volatile and non-volatile species present on surfaces. A electrode having a tapered tip is connected to a high voltage power supply. The tapered tip projects outward from a capillary carrying a high-speed flow of gas. A vapor of a solvent is mixed into the annular gas flow surrounding the needle. The gaseous solvent vapor is ionized in close proximity to the tapered tip by virtue of the high voltage applied to the electrode. The high-speed flow of gas and solvent vapor ions extending outward from the capillary is directed toward a substrate on which an analyte of interest may have been deposited. The solvent vapor ions can blanket the surface of the analyte causing a static charge build up that facilitates ion desorption and additionally can provide positive ion adducts of the analyte freed from the substrate surface that can be directed toward an atmospheric intake of a mass spectrometer or other instrument capable of studying the analyte.
摘要翻译： 解吸大气压化学电离（DAPCI）系统将由惰性高速气体和溶剂离子组成的初级离子束传送到表面，以实现表面上存在的挥发性和非挥发性物质的解吸和离子化。 具有锥形尖端的电极连接到高压电源。 锥形尖端从携带高速气体流的毛细管向外突出。 将溶剂的蒸气混合到围绕针的环形气流中。 通过施加到电极的高电压，气态溶剂蒸气被离子化，紧邻锥形尖端。 从毛细管向外延伸的气体和溶剂蒸汽离子的高速流动被引导到其上可能沉积感兴趣的分析物的基底。 溶剂蒸汽离子可以覆盖分析物的表面，导致静电荷积聚，促进离子解吸，并且另外可以提供从衬底表面释放的分析物的阳离子加合物，其可以被引导到大气摄入的质谱仪或其它 能够研究分析物的仪器。
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公开(公告)号：US07544933B2
公开(公告)日：2009-06-09
申请号：US11653569
申请日：2007-01-16
IPC分类号： H01J49/00
CPC分类号： H01J49/14
摘要： A desorption atmospheric pressure chemical ionization (DAPCI) system delivers a primary ion beam composed of an inert, high velocity gas and solvent ions to a surface to effect desorption and ionization of both volatile and non-volatile species present on surfaces. A electrode having a tapered tip is connected to a high voltage power supply. The tapered tip projects outward from a capillary carrying a high-speed flow of gas. A vapor of a solvent is mixed into the annular gas flow surrounding the needle. The gaseous solvent vapor is ionized in close proximity to the tapered tip by virtue of the high voltage applied to the electrode. The high-speed flow of gas and solvent vapor ions extending outward from the capillary is directed toward a substrate on which an analyte of interest may have been deposited. The solvent vapor ions can blanket the surface of the analyte causing a static charge build up that facilitates ion desorption and additionally can provide positive ion adducts of the analyte freed from the substrate surface that can be directed toward an atmospheric intake of a mass spectrometer or other instrument capable of studying the analyte.
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