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1.发明授权公开(公告)号：US08530459B2
公开(公告)日：2013-09-10
申请号：US13316009
申请日：2011-12-09
IPC分类号： C07B47/00 , C07D487/22 , A01N43/36
CPC分类号： G01N33/582 , C07D487/22 , C07F9/572 , C07F9/6524
摘要： Porphyrinic compounds that contain solubilizing groups are described, along with methods of making and using the same and compositions comprising such compounds. Examples of such compounds include compounds compounds of Formula I: wherein: Z is a porphyrinic macrocycle, Alk1 and Alk2 are each independently an alkylidene chain; L is a linking group or is absent; R1 is preferably an ionic group or polar group; R2 is an ionic group, polar group, bioconjugatable group, or targeting group; R3 is present or absent and when present is a halo group, bioconjugatable group, or targeting group, n is O or 1 (that is, the CH group is present, or Alk1 and Alk2 are bonded directly to a carbon of the porphyrinic macrocycle Z); or a salt thereof.
摘要翻译： 描述含有增溶基团的卟啉化合物及其制备和使用方法以及包含这些化合物的组合物。 这些化合物的实例包括式I化合物：其中：Z是卟啉大环，Alk1和Alk2各自独立地是亚烷基链; L是连接基团或不存在; R1优选为离子基团或极性基团; R2是离子基团，极性基团，生物共轭基团或靶向基团; R3存在或不存在，并且当存在卤素基团，生物共轭基团或靶向基团时，n为0或1（即，存在CH基团，或Alk1和Alk2直接键合到卟啉化大环Z的碳上 ）; 或其盐。
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2.发明申请公开(公告)号：US20120082621A1
公开(公告)日：2012-04-05
申请号：US13316009
申请日：2011-12-09
IPC分类号： A61K49/00 , C07D403/06 , C07F9/6558 , A61M37/00 , C07F9/6561 , A61K31/675 , C12Q1/04 , A61P35/00 , C07F7/18 , C07F19/00
CPC分类号： G01N33/582 , C07D487/22 , C07F9/572 , C07F9/6524
摘要： Porphyrinic compounds that contain solubilizing groups are described, along with methods of making and using the same and compositions comprising such compounds. Examples of such compounds include compounds compounds of Formula I: wherein: Z is a porphyrinic macrocycle, Alk1 and Alk2 are each independently an alkylidene chain; L is a linking group or is absent; R1 is preferably an ionic group or polar group; R2 is an ionic group, polar group, bioconjugatable group, or targeting group; R3 is present or absent and when present is a halo group, bioconjugatable group, or targeting group, n is O or 1 (that is, the CH group is present, or Alk1 and Alk2 are bonded directly to a carbon of the porphyrinic macrocycle Z); or a salt thereof.
摘要翻译： 描述含有增溶基团的卟啉化合物及其制备和使用方法以及包含这些化合物的组合物。 这些化合物的实例包括式I化合物：其中：Z是卟啉大环，Alk1和Alk2各自独立地是亚烷基链; L是连接基团或不存在; R1优选为离子基团或极性基团; R2是离子基团，极性基团，生物共轭基团或靶向基团; R3存在或不存在，并且当存在卤素基团，生物共轭基团或靶向基团时，n为0或1（即，存在CH基团，或Alk1和Alk2直接键合到卟啉化大环Z的碳上 ）; 或其盐。
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3.发明授权公开(公告)号：US08097609B2
公开(公告)日：2012-01-17
申请号：US12064656
申请日：2006-10-19
IPC分类号： A01N43/36 , A01N55/02 , C07B47/00 , C07D487/22
CPC分类号： G01N33/582 , C07D487/22 , C07F9/572 , C07F9/6524
摘要： Porphyrinic compounds that contain solubilizing groups are described, along with methods of making and using the same and compositions comprising such compounds. Examples of such compounds include compounds of Formula (I) wherein: Z is a porphyrinic macrocyclic, Alk1 and Alk2 are each independently an alkylidene chain; L is a linking group or is absent; R1 is preferably an ionic group or polar group; R2 is an ionic group, polar group, bioconjugatable group, or targeting group: R3 is present or absent and when present is a halo group, bioconjugatable group, or targeting group, n is O or 1 (that is, the CH group is present, or Alk1 and Alk2 are bonded directly to a carbon of the porphyrinic macrocycle Z); or a salt thereof.
摘要翻译： 描述含有增溶基团的卟啉化合物及其制备和使用方法以及包含这些化合物的组合物。 这些化合物的实例包括式（I）的化合物，其中：Z是卟啉大环，Alk1和Alk2各自独立地是亚烷基链; L是连接基团或不存在; R1优选为离子基团或极性基团; R2是离子基团，极性基团，生物共轭基团或靶向基团：R 3存在或不存在，并且当存在卤素基团，生物共轭基团或靶向基团时，n为0或1（即，CH基团存在 ，或Alk1和Alk2直接键合到卟啉大环Z的碳上）; 或其盐。
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4.发明申请公开(公告)号：US20090297456A1
公开(公告)日：2009-12-03
申请号：US12064656
申请日：2006-10-19
IPC分类号： A61K49/00 , C07F9/06 , A61K31/675 , C12Q1/02 , A61P35/00
CPC分类号： G01N33/582 , C07D487/22 , C07F9/572 , C07F9/6524
摘要： Porphyrinic compounds that contain solubilizing groups are described, along with methods of making and using the same and compositions comprising such compounds. Examples of such compounds include compounds of Formula (I) wherein: Z is a porphyrinic macrocyclic, Alk1 and Alk2 are each independently an alkylidene chain; L is a linking group or is absent; R1 is preferably an ionic group or polar group; R2 is an ionic group, polar group, bioconjugatable group, or targeting group: R3 is present or absent and when present is a halo group, bioconjugatable group, or targeting group, n is O or 1 (that is, the CH group is present, or Alk1 and Alk2 are bonded directly to a carbon of the porphyrinic macrocycle Z); or a salt thereof.
摘要翻译： 描述含有增溶基团的卟啉化合物及其制备和使用方法以及包含这些化合物的组合物。 这些化合物的实例包括式（I）的化合物，其中：Z是卟啉大环，Alk1和Alk2各自独立地是亚烷基链; L是连接基团或不存在; R1优选为离子基团或极性基团; R2是离子基团，极性基团，生物共轭基团或靶向基团：R 3存在或不存在，并且当存在卤素基团，生物共轭基团或靶向基团时，n为0或1（即，CH基团存在 ，或Alk1和Alk2直接键合到卟啉大环Z的碳上）; 或其盐。
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5.发明申请SYNTHESIS OF CHLORINS AND PHORBINES WITH ENHANCED RED SPECTRAL FEATURES 审中-公开具有增强的红色光谱特征的氯离子和磷酸盐的合成公开(公告)号：US20120245508A1
公开(公告)日：2012-09-27
申请号：US13480796
申请日：2012-05-25
IPC分类号： C07D487/22 , A61M37/00 , A61K31/409
CPC分类号： C07D487/22
摘要： The present invention provides compounds of the general Formula DI: along with methods of making such compounds, formulations containing the same, and methods of using the same (e.g., in photodynamic therapy, for the production of solar cells, etc.).
摘要翻译： 本发明提供了通式DI的化合物，以及制备此类化合物的方法，含有该化合物的制剂及其使用方法（例如，在光动力疗法中，用于生产太阳能电池等）。
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6.发明授权公开(公告)号：US08207329B2
公开(公告)日：2012-06-26
申请号：US12095435
申请日：2006-11-30
IPC分类号： C07D487/00 , C07B47/00
CPC分类号： C07D487/22
摘要： The present invention provides compounds of the general Formula DI: along with methods of making such compounds, formulations containing the same, and methods of using the same (e.g., in photodynamic therapy, for the production of solar cells, etc.).
摘要翻译： 本发明提供了通式DI的化合物，以及制备此类化合物的方法，含有该化合物的制剂及其使用方法（例如，在光动力疗法中，用于生产太阳能电池等）。
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7.发明申请公开(公告)号：US20090227553A1
公开(公告)日：2009-09-10
申请号：US12095435
申请日：2006-11-30
IPC分类号： A61K31/555 , C07F3/06 , A61K31/409
CPC分类号： C07D487/22
摘要： The present invention provides compounds of the general Formula DI: along with methods of making such compounds, formulations containing the same, and methods of using the same (e.g., in photodynamic therapy, for the production of solar cells, etc.)
摘要翻译： 本发明提供了通式DI的化合物，以及制备此类化合物的方法，含有该化合物的制剂及其使用方法（例如，在光动力疗法中，用于生产太阳能电池等）
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公开(公告)号：US08546088B2
公开(公告)日：2013-10-01
申请号：US13459464
申请日：2012-04-30
申请人： Jonathan S. Lindsey
发明人： Jonathan S. Lindsey
IPC分类号： G01N33/533 , G01N21/64
CPC分类号： G01N33/582 , G01N21/643 , G01N21/6486 , G01N33/533 , G01N2021/6439 , Y02A50/53 , Y02A50/55 , Y02A50/57 , Y02A50/58 , Y10T436/145555
摘要： The present invention provides a method of detecting (e.g., by flow cytometry) a target compound, cell or particle, wherein the target is labelled with a detectable luminescent compound. The method comprises utilizing as the detectable luminescent compound a compound comprising a porphyrinic macrocycle such as a porphyrin, chlorin, bacteriochlorin, or isobacteriochlorin. In particular embodiments, the detectable luminescent compound comprises a compound of the formula A-A′-Z-B′-B, wherein: A is a targeting group or member of a specific binding pair that specifically binds the detectable luminescent compound to the target compound, cell or particle; A′ is a linker group or covalent bond; B′ is a linker group or covalent bond; B is a water-soluble group; and Z is the porphyrinic macrocycle.
摘要翻译： 本发明提供了检测（例如，通过流式细胞术）目标化合物，细胞或颗粒的方法，其中靶标用可检测的发光化合物标记。 所述方法包括使用包含卟啉大环化合物如卟啉，二氢卟酚，细菌二氢卟酚或异细菌素的化合物作为可检测的发光化合物。 在具体实施方案中，可检测的发光化合物包含式A-A'-Z-B'-B的化合物，其中：A是特异性结合对的靶向基团或特异性结合对的成员，其将可检测的发光化合物特异性结合到靶 化合物，细胞或颗粒; A'是连接基团或共价键; B'是连接基团或共价键; B是水溶性基团; Z是卟啉大环。
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公开(公告)号：US20130079528A1
公开(公告)日：2013-03-28
申请号：US13600808
申请日：2012-08-31
IPC分类号： C07D403/06
CPC分类号： C07D403/06 , C07D487/22
摘要： A method of making a compound of Formula I′ comprises reacting a compound of the formula DLCHO, with a compound of the formula to produce the compound of Formula I′. Methods of using the compounds are also described, particularly as intermediates for the synthesis of porphyrin rods, which porphyrin rods are in turn useful for (among other things) the production of molecular memory devices.
摘要翻译： 制备式I'化合物的方法包括使式DLCHO的化合物与下式的化合物反应以制备式I'的化合物。 还描述了使用化合物的方法，特别是作为合成卟啉棒的中间体，其中卟啉棒又可用于（尤其）分子存储装置的生产。
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公开(公告)号：US20120244551A1
公开(公告)日：2012-09-27
申请号：US13459464
申请日：2012-04-30
申请人： Jonathan S. Lindsey
发明人： Jonathan S. Lindsey
IPC分类号： G01N21/64
CPC分类号： G01N33/582 , G01N21/643 , G01N21/6486 , G01N33/533 , G01N2021/6439 , Y02A50/53 , Y02A50/55 , Y02A50/57 , Y02A50/58 , Y10T436/145555
摘要： The present invention provides a method of detecting (e.g., by flow cytometry) a target compound, cell or particle, wherein the target is labelled with a detectable luminescent compound. The method comprises utilizing as the detectable luminescent compound a compound comprising a porphyrinic macrocycle such as a porphyrin, chlorin, bacteriochlorin, or isobacteriochlorin. In particular embodiments, the detectable luminescent compound comprises a compound of the formula A-A′-Z-B′-B, wherein: A is a targeting group or member of a specific binding pair that specifically binds the detectable luminescent compound to the target compound, cell or particle; A′ is a linker group or covalent bond; B′ is a linker group or covalent bond; B is a water-soluble group; and Z is the porphyrinic macrocycle.
摘要翻译： 本发明提供了检测（例如，通过流式细胞术）目标化合物，细胞或颗粒的方法，其中靶标用可检测的发光化合物标记。 所述方法包括使用包含卟啉大环化合物如卟啉，二氢卟酚，细菌二氢卟酚或异细菌素的化合物作为可检测的发光化合物。 在具体实施方案中，可检测的发光化合物包含式AA'-ZB'-B的化合物，其中：A是靶向基团或特异性结合对的成员，其特异性结合可检测的发光化合物与目标化合物，细胞或 粒子; A'是连接基团或共价键; B'是连接基团或共价键; B是水溶性基团; Z是卟啉大环。
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