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    SYSTEMS AND METHODS FOR PERFORMING ACOUSTIC HEMOSTASIS OF DEEP BLEEDING TRAUMA IN LIMBS
    1.
    发明申请
    SYSTEMS AND METHODS FOR PERFORMING ACOUSTIC HEMOSTASIS OF DEEP BLEEDING TRAUMA IN LIMBS 审中-公开
    用于在LIMBS中执行深层血栓形成的声学HEMOSTASIS的系统和方法

    公开(公告)号：US20100204577A1

    公开(公告)日：2010-08-12

    申请号：US12762938

    申请日：2010-04-19

    申请人： K. Michael Sekins ,  John Kook ,  Ed Caldwell

    发明人： K. Michael Sekins ,  John Kook ,  Ed Caldwell

    IPC分类号： A61N7/00 ,  A61B8/00

    CPC分类号： A61B8/4227 ,  A61B5/445 ,  A61B8/06 ,  A61B8/4281 ,  A61B8/4483 ,  A61B17/1325 ,  A61B17/135 ,  A61N7/02 ,  A61N2007/0078

    摘要： An inflatable cuff having integrated ultrasound transducers is used to effect hemostasis of deep bleeding wounds in limbs. The cuff includes a chamber defined by a bladder or a series of dams into which a fluid may be introduced and pressurized. The pressure of the fluid stops or slows bleeding while high intensity focused ultrasound is applied to effect hemostasis. The fluid may also serve as an acoustic couplant between the limb and the ultrasound transducers. The transducers may be electrostrictive transducers. Diodes may be used to reduce parallel capacitive loading in the transducer array. Bypass capacitors using the electrostrictive material may also be used.

    摘要翻译： 具有集成超声波换能器的充气袖带用于四肢深部出血创伤的止血。 袖带包括由膀胱或一系列水坝限定的腔室，流体可以被引入并加压入其中。 流体压力停止或减慢出血，同时应用高强度聚焦超声进行止血。 流体还可以用作肢体和超声换能器之间的声耦合器。 换能器可以是电致伸缩换能器。 二极管可用于减小换能器阵列中的并联电容负载。 也可以使用使用电致伸缩材料的旁路电容器。

    Lung cancer hyperthermia via ultrasound and/or convection with perfiuorochemical liquids
    3.
    发明授权
    Lung cancer hyperthermia via ultrasound and/or convection with perfiuorochemical liquids 失效
    通过超声和​​/或对流与全氟化学液体的肺癌热疗

    公开(公告)号：US5158536A

    公开(公告)日：1992-10-27

    申请号：US495817

    申请日：1990-03-19

    申请人： K. Michael Sekins ,  Thomas H. Shaffer ,  Marla R. Wolfson

    发明人： K. Michael Sekins ,  Thomas H. Shaffer ,  Marla R. Wolfson

    IPC分类号： A61F7/00 ,  A61B17/22 ,  A61B18/00 ,  A61F7/12 ,  A61K9/00 ,  A61M16/04 ,  A61N7/02 ,  B06B1/06

    CPC分类号： A61K9/0026 ,  A61F7/123 ,  A61M16/0404 ,  A61M16/0463 ,  A61M16/0479 ,  A61N7/022 ,  B06B1/0633 ,  A61B2017/22054 ,  A61B2018/00011 ,  A61F2007/0054 ,  A61M2202/0468 ,  A61M2202/0476 ,  A61M2205/3368

    摘要： A hyperthermic treatment of lung cancer, by temporarily filling with a liquid medium preselected pulmonary air passages adjoining pulmonary tissues containing malignant cells, circulating exogenously heated liquid medium at from about 41.degree. to abThis invention was made with government support under Small Business Innovation Research Program Grant No. 1 R43 CA48611-01 awarded by the Public Health Service, Department of Health and Human Services. The government has certain rights in the invention.

    摘要翻译： 通过临时填充液体培养基中邻近含有恶性细胞的肺组织的液体介质预先选定的肺空气通道，通过液体填充的肺空气通道在约41℃至约50℃循环外源加热的液体培养基进行肺癌的热疗治疗， 然后除去液体介质。 液体介质可以是全氟化碳液体或生理盐水溶液。 具有所需物理和热性质的合适的全氟化碳液体的特征在于平均分子量为约350至约560.代表性全氟化碳液体为FC-84，FC-72，RM-82，FC-75，RM- 101和全氟萘烷。 此外，通过临时填充邻近含有恶性细胞的肺组织的液体培养基预选的肺空气通道，使用超声波对肺癌进行热疗治疗，将邻接的肺组织加热至约41℃至约50℃的温度 通过透过液体填充的肺部空气通道发送超声波，然后除去液体介质。 具有该超声处理所需的物理，热和声学特性的全氟化碳液体的特征在于平均分子量在约400至约500的范围内。此外，液体输注和隔离导管，腔内超声应用器和肋间超声应用器 用于所公开的肺癌的对流和/或超声热疗治疗。 此外，本发明提供了通过液体灌洗/通气对生物制剂的肺部给药。

    TIME-OF-FLIGHT TRIANGULATION BASED METHODS OF DEVICE SPATIAL REGISTRATION FOR MULTIPLE-TRANSDUCER THERAPEUTIC ULTRASOUND SYSTEMS
    7.
    发明申请
    TIME-OF-FLIGHT TRIANGULATION BASED METHODS OF DEVICE SPATIAL REGISTRATION FOR MULTIPLE-TRANSDUCER THERAPEUTIC ULTRASOUND SYSTEMS 审中-公开
    基于时空三角法的多传感器治疗超声系统设备空间注册方法

    公开(公告)号：US20080249419A1

    公开(公告)日：2008-10-09

    申请号：US11955310

    申请日：2007-12-12

    申请人： K. Michael Sekins ,  Charles Emery

    发明人： K. Michael Sekins ,  Charles Emery

    IPC分类号： A61B8/00

    CPC分类号： A61N7/02 ,  A61B8/08 ,  A61B8/4227 ,  A61B8/4483 ,  A61B2017/00106 ,  A61B2090/378 ,  A61N2007/0078

    摘要： Embodiments disclosed herein relate to a therapeutic ultrasound device spatial registration method and apparatus. The method enables locating a tissue target and surrounding tissue structures affecting the available acoustic beam paths to the target, relative to each individual therapeutic and diagnostic (e.g., imaging) transducer, in a device comprising a plurality of such transducers. By locating the target and tissue structures relative to each therapeutic transducer and/or array (e.g., in “local” coordinates) assists in transforming the locations relative to any transducers, enabling determination of which therapeutic transducers to use to treat the target, and specification of their respective ultrasound powers or energy, focal locations and beam patterns. The registration method employs a plurality of emitter and receiver acoustic sensors on, respectively, a plurality of imaging and therapeutic transducer device panels.

    摘要翻译： 本文公开的实施例涉及治疗性超声装置空间配准方法和装置。 该方法使得能够在包括多个这种换能器的装置中相对于每个单独的治疗和诊断（例如，成像）换能器定位影响到目标的可用声束路径的组织靶和周围组织结构。 通过相对于每个治疗换能器和/或阵列（例如，在“局部”坐标）中定位目标和组织结构有助于相对于任何换能器转换位置，能够确定用于治疗靶的哪些治疗传感器，以及规范 其各自的超声功率或能量，焦点位置和波束图案。 登记方法分别在多个成像和治疗换能器装置面板上使用多个发射器和接收器声学传感器。