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    Extrathoracic Augmentation of the Respiratory Pump
    1.
    发明申请
    Extrathoracic Augmentation of the Respiratory Pump 有权
    呼吸泵的胸外扩张

    公开(公告)号：US20110313332A1

    公开(公告)日：2011-12-22

    申请号：US13107208

    申请日：2011-05-13

    申请人： Tariq Rahman ,  Thomas H. Schaffer ,  Marla R. Wolfson

    发明人： Tariq Rahman ,  Thomas H. Schaffer ,  Marla R. Wolfson

    IPC分类号： A61H31/00

    CPC分类号： A61H31/00 ,  A61H9/0071 ,  A61H31/02 ,  A61H2201/107 ,  A61H2201/5002 ,  A61H2201/5097 ,  A61H2230/045 ,  A61H2230/207 ,  A61H2230/425

    摘要： Systems and methods for assisting respiration extrathoracically, particularly useful for augmenting respiration in neonatal patients, including providing a positive pressure to a torso area of a patient. The positive pressure may be delivered to the torso area of the patient while the torso area is exposed to an ambient pressure, such as by providing positive pressure with high frequency gas jets that are positioned in proximity to the torso area. The positive pressure may be delivered to different parts of the torso area of the patient at different times, such as by controlling gas jets independently. The positive pressure may also be controlled in coordination with a gas flow and concentration to the patient's airway, such as by increasing the positive pressure as a gas flow pressure delivered to the patient's airway is reduced. The gas flow to the patient's airway may be provided by, for example, a high-flow nasal cannula (HFNC) mechanism or a continuous positive airway pressure (CPAP) mechanism that is controlled in coordination with the positive pressure based upon a desired respiratory function of the patient. The control of the gas flow and the positive pressure may be based on an input of patient monitored parameters and/or calculated values based on the patient monitored parameters.

    摘要翻译： 辅助辅助呼吸的系统和方法，特别用于增加新生儿患者的呼吸，包括向患者的躯干区域提供正压力。 正常压力可以传递到患者的躯干区域，同时躯干区域暴露于环境压力，例如通过提供定位在躯干区域附近的高频气体射流的正压力。 正压力可以在不同时间被传送到患者的躯干区域的不同部分，例如通过独立地控制气体射流。 正压也可以与气流和对患者气道的浓度协调地进行控制，例如通过当输送到患者气道的气体流量压力降低时增加正压力。 可以通过例如高流量鼻插管（HFNC）机构或连续正气道压力（CPAP）机制来提供到患者气道的气流，该机制基于期望的呼吸功能与正压力协调控制 的病人。 气体流量和正压力的控制可以基于患者监测参数的输入和/或基于患者监测参数的计算值。

    Thoracic Stabilizer
    2.
    发明申请
    Thoracic Stabilizer 有权
    胸部稳定剂

    公开(公告)号：US20090020129A1

    公开(公告)日：2009-01-22

    申请号：US12083253

    申请日：2006-10-18

    申请人： Thomas H. Shaffer ,  Marla R. Wolfson

    发明人： Thomas H. Shaffer ,  Marla R. Wolfson

    IPC分类号： A61G15/00 ,  A61B5/08 ,  A61B5/103

    CPC分类号： A61H31/006 ,  A61H31/008 ,  A61H2201/018 ,  A61H2201/5007 ,  A61H2201/5061

    摘要： A thoracic stabilizer for limiting anterior chest wall collapse includes a platform supporting a patient and a pair of lateral supports contacting opposite sides of the patient's chest wall and applying force to limit collapse of the chest wall. The force applied by the lateral supports is varied depending on the force applied to the platform by the patient. The stabilizer includes a retractometer measuring the collapse of the chest wall. According to one embodiment, the stabilizer includes a controller that varies the force applied to the chest wall in closed-loop fashion based on the chest wall collapse measured by the retractometer using an algorithm of the controller. According to one embodiment, the stabilizer includes motors moving the lateral supports. According to another embodiment, the stabilizer includes a hydraulic system and the lateral supports include expandable fluid-filled members.

    摘要翻译： 用于限制前胸壁塌陷的胸部稳定器包括支撑患者的平台和与患者胸壁的相对侧接触并且施加力以限制胸壁塌陷的一对侧向支撑件。 由侧向支撑施加的力根据患者施加到平台的力而变化。 稳定器包括测量胸壁塌陷的收缩计。 根据一个实施例，所述稳定器包括控制器，所述控制器使用所述控制器的算法，以闭环方式改变施加到所述胸壁的力，所述控制器基于由所述收缩计测量的所述胸壁塌陷。 根据一个实施例，稳定器包括移动横向支撑件的马达。 根据另一个实施例，稳定器包括液压系统，并且侧向支撑件包括可膨胀流体填充构件。

    Control, treatment and/or diagnosis of physiological conditions with degassed perfluorocarbon liquid
    5.
    发明授权
    Control, treatment and/or diagnosis of physiological conditions with degassed perfluorocarbon liquid 失效
    用脱气全氟化碳液体进行生理条件的控制，处理和/或诊断

    公开(公告)号：US5350359A

    公开(公告)日：1994-09-27

    申请号：US916332

    申请日：1992-07-16

    申请人： Thomas H. Shaffer ,  Marla R. Wolfson

    发明人： Thomas H. Shaffer ,  Marla R. Wolfson

    IPC分类号： A61M31/00 ,  A61F7/00 ,  A61K31/025 ,  A61M1/00 ,  A61M3/00 ,  A61M5/44

    CPC分类号： A61M1/00 ,  A61M3/00 ,  A61F7/00 ,  A61M2202/02 ,  A61M2202/04 ,  A61M2202/0476 ,  A61M5/44

    摘要： This invention pertains to the use of a degassed perfluorocarbon ("PFC") liquid as a method of removing gas emboli from parts of a patient's internal anatomy. Moreover, the invention can be used as a method of imaging parts of a patient's internal anatomy. Furthermore, the invention can also be used as a way of delivering biological agents to parts of a patient's internal anatomy which contain or are surrounded by gas emboli and/or which are to be imaged. In this invention, a degassed PFC liquid is delivered to a region within the patient's internal anatomy which contains gas emboli and/or which is to be imaged. If gas emboli are present, the degassed liquid is permitted to absorb at least a portion of the emboli. Thereafter, the emboli-containing liquid is removed from the patient or is used as an imaging agent. If gas emboli are not present, the cite is imaged before the degassed liquid reaches atmospheric equilibrium. Thereafter, the liquid is removed from the patient. Moreover, by mixing a biological agent with the degassed PFC liquid, the mixture can be used as a way of topically treating parts within a patient's internal anatomy. Furthermore, by regulating the temperature of the degassed liquid, it can also be used as a way of hypo- or hyperthermically treating the patient.

    摘要翻译： 本发明涉及使用脱气全氟化碳（“PFC”）液体作为从患者内部解剖结构部分去除气体栓塞的方法。 此外，本发明可以用作对患者内部解剖结构的部件进行成像的方法。 此外，本发明还可以用作将生物制剂递送到患有内部解剖结构的包含或被气体栓塞和/或要被成像的内部解剖结构的部分的方式。 在本发明中，脱气的PFC液体被输送到患者的内部解剖结构内的包含气体栓塞和/或要被成像的内部解剖结构中的区域。 如果存在气体栓塞，则允许脱气的液体吸收至少一部分栓塞。 此后，将含栓塞液体从患者中取出或用作显像剂。 如果不存在气体栓塞，则在脱气液体达到大气平衡之前，引用成像。 此后，从患者身上取出液体。 此外，通过将生物剂与脱气的PFC液体混合，该混合物可以用作在患者的内部解剖结构内局部治疗部位的方式。 此外，通过调节脱气液体的温度，也可以将其用作低温或高热处理患者的方法。

    Lung cancer hyperthermia via ultrasound and/or convection with perfiuorochemical liquids
    6.
    发明授权
    Lung cancer hyperthermia via ultrasound and/or convection with perfiuorochemical liquids 失效
    通过超声和​​/或对流与全氟化学液体的肺癌热疗

    公开(公告)号：US5158536A

    公开(公告)日：1992-10-27

    申请号：US495817

    申请日：1990-03-19

    申请人： K. Michael Sekins ,  Thomas H. Shaffer ,  Marla R. Wolfson

    发明人： K. Michael Sekins ,  Thomas H. Shaffer ,  Marla R. Wolfson

    IPC分类号： A61F7/00 ,  A61B17/22 ,  A61B18/00 ,  A61F7/12 ,  A61K9/00 ,  A61M16/04 ,  A61N7/02 ,  B06B1/06

    CPC分类号： A61K9/0026 ,  A61F7/123 ,  A61M16/0404 ,  A61M16/0463 ,  A61M16/0479 ,  A61N7/022 ,  B06B1/0633 ,  A61B2017/22054 ,  A61B2018/00011 ,  A61F2007/0054 ,  A61M2202/0468 ,  A61M2202/0476 ,  A61M2205/3368

    摘要： A hyperthermic treatment of lung cancer, by temporarily filling with a liquid medium preselected pulmonary air passages adjoining pulmonary tissues containing malignant cells, circulating exogenously heated liquid medium at from about 41.degree. to abThis invention was made with government support under Small Business Innovation Research Program Grant No. 1 R43 CA48611-01 awarded by the Public Health Service, Department of Health and Human Services. The government has certain rights in the invention.

    摘要翻译： 通过临时填充液体培养基中邻近含有恶性细胞的肺组织的液体介质预先选定的肺空气通道，通过液体填充的肺空气通道在约41℃至约50℃循环外源加热的液体培养基进行肺癌的热疗治疗， 然后除去液体介质。 液体介质可以是全氟化碳液体或生理盐水溶液。 具有所需物理和热性质的合适的全氟化碳液体的特征在于平均分子量为约350至约560.代表性全氟化碳液体为FC-84，FC-72，RM-82，FC-75，RM- 101和全氟萘烷。 此外，通过临时填充邻近含有恶性细胞的肺组织的液体培养基预选的肺空气通道，使用超声波对肺癌进行热疗治疗，将邻接的肺组织加热至约41℃至约50℃的温度 通过透过液体填充的肺部空气通道发送超声波，然后除去液体介质。 具有该超声处理所需的物理，热和声学特性的全氟化碳液体的特征在于平均分子量在约400至约500的范围内。此外，液体输注和隔离导管，腔内超声应用器和肋间超声应用器 用于所公开的肺癌的对流和/或超声热疗治疗。 此外，本发明提供了通过液体灌洗/通气对生物制剂的肺部给药。

    Extrathoracic augmentation of the respiratory pump
    7.
    发明授权
    Extrathoracic augmentation of the respiratory pump 有权

    公开(公告)号：US09687415B2

    公开(公告)日：2017-06-27

    申请号：US13107208

    申请日：2011-05-13

    申请人： Tariq Rahman ,  Thomas H. Shaffer ,  Marla R. Wolfson

    发明人： Tariq Rahman ,  Thomas H. Shaffer ,  Marla R. Wolfson

    IPC分类号： A61H31/00 ,  A61H9/00 ,  A61H31/02

    CPC分类号： A61H31/00 ,  A61H9/0071 ,  A61H31/02 ,  A61H2201/107 ,  A61H2201/5002 ,  A61H2201/5097 ,  A61H2230/045 ,  A61H2230/207 ,  A61H2230/425

    摘要： Systems and methods for assisting respiration extrathoracically, particularly useful for augmenting respiration in neonatal patients, including providing a positive pressure to a torso area of a patient. The positive pressure may be delivered to the torso area of the patient while the torso area is exposed to an ambient pressure, such as by providing positive pressure with high frequency gas jets that are positioned in proximity to the torso area. The positive pressure may be delivered to different parts of the torso area of the patient at different times, such as by controlling gas jets independently. The positive pressure may also be controlled in coordination with a gas flow and concentration to the patient's airway, such as by increasing the positive pressure as a gas flow pressure delivered to the patient's airway is reduced. The gas flow to the patient's airway may be provided by, for example, a high-flow nasal cannula (HFNC) mechanism or a continuous positive airway pressure (CPAP) mechanism that is controlled in coordination with the positive pressure based upon a desired respiratory function of the patient. The control of the gas flow and the positive pressure may be based on an input of patient monitored parameters and/or calculated values based on the patient monitored parameters.

    Process for transient and steady state delivery of biological agents to the lung via breathable liquids
    8.
    发明授权
    Process for transient and steady state delivery of biological agents to the lung via breathable liquids 有权
    通过透气液体暂时和稳态地将生物制剂递送到肺的过程

    公开(公告)号：US08375943B2

    公开(公告)日：2013-02-19

    申请号：US13050027

    申请日：2011-03-17

    申请人： Thomas H. Shaffer ,  Marla R. Wolfson

    发明人： Thomas H. Shaffer ,  Marla R. Wolfson

    IPC分类号： A61M16/00 ,  A61M16/10 ,  A61M15/00 ,  A61M11/00

    CPC分类号： A61M16/0054 ,  A61M16/22 ,  A61M2202/0476

    摘要： The present invention includes a transient method of delivering a biological agent in a breathable liquid to a lung of a patient. The present invention includes a steady state method of delivering a biological agent in a breathable liquid to a lung of a patient. The steps of both the transient delivery method and the steady state delivery method can be controlled by a servo-control unit. A supplementary biological agent delivery step can be performed in both the transient method of delivering a biological agent and the steady state method of delivering a biological agent.

    摘要翻译： 本发明包括将透气液体中的生物剂递送到患者的肺的瞬时方法。 本发明包括将透气液体中的生物剂递送到患者的肺的稳态方法。 瞬时输送方式和稳态输送方法两者的步骤可以由伺服控制装置控制。 可以在递送生物剂的瞬时方法和递送生物制剂的稳态方法两者中进行补充生物剂递送步骤。

    NEONATAL AIRWAY STENT
    9.
    发明申请
    NEONATAL AIRWAY STENT 审中-公开

    公开(公告)号：US20100122698A1

    公开(公告)日：2010-05-20

    申请号：US12273871

    申请日：2008-11-19

    申请人： Thomas H. SHAFFER ,  Marla R. Wolfson ,  Thomas L. Miller

    发明人： Thomas H. SHAFFER ,  Marla R. Wolfson ,  Thomas L. Miller

    IPC分类号： A61F2/04 ,  A61M16/00

    CPC分类号： A61F2/04 ,  A61F2/848 ,  A61F2/92 ,  A61F2002/046 ,  A61F2220/0016 ,  A61F2250/0067 ,  A61M16/0406

    摘要： An adjustable neonatal airway stent for use in the airways of a neonate is provided. The stent may include a flexible mesh member having a generally cylindrical shape and size that is capable of being delivered to a neonatal airway. The mesh member may include overlapping inner and outer portions, where the inner portion is adjacent to an inner edge of the flexible mesh. Further, the stent may include a plurality of locking projections that extend outwardly from the inner portion and are capable of engaging the mesh of the overlapping outer portion to prevent contraction of the stent, while allowing expansion of the stent to at least one diameter when implanted in a neonatal airway. The projections may include angularly extending tips, and the stent may be expandable to a second diameter greater than the first diameter in situ.

    摘要翻译： 提供了用于新生儿气道的可调节的新生儿气道支架。 支架可以包括柔性网状构件，其具有能够被输送到新生儿气道的大致圆柱形形状和尺寸。 网状构件可以包括重叠的内部和外部部分，其中内部部分与柔性网的内边缘相邻。 此外，支架可以包括多个锁定突起，其从内部部分向外延伸并且能够接合重叠的外部部分的网，以防止支架的收缩，同时允许支架在植入时扩张至少一个直径 在新生儿气道。 突起可以包括角度延伸的尖端，并且支架可以在原位可扩展到大于第一直径的第二直径。