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公开(公告)号：US6116235A
公开(公告)日：2000-09-12
申请号：US884598
申请日：1997-06-27
CPC分类号： A61M16/009 , A61M16/0093 , Y10S128/913
摘要： Methods and apparatus for the conservation of respiratory promoters following their pulmonary introduction are disclosed. In preferred embodiments the present invention provides methods and apparatus for reducing the loss of respiratory promoter, and particularly fluorochemcials, during medical procedures such as liquid ventilation. The disclosed methods comprise the use of vapor retention assemblies, which may be conventional heat and moisture exchangers, to passively retain the respiratory promoter and return it to the lungs in subsequent breaths. Novel vapor retention assemblies comprising fluorophilic exchange elements are also disclosed.
摘要翻译： 公开了在肺部引入后保护呼吸促进剂的方法和装置。 在优选的实施方案中，本发明提供了用于在诸如液体通气的医疗过程期间减少呼吸促进剂，特别是氟化合物的损失的方法和装置。 所公开的方法包括使用可以是常规热和湿交换器的蒸汽保持组件来被动地保持呼吸促进剂并在随后的呼吸中将其返回到肺。 还公开了包含氟亲口交换元件的新型蒸气保留组件。
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公开(公告)号：US5927273A
公开(公告)日：1999-07-27
申请号：US813330
申请日：1997-03-07
CPC分类号： A61M16/0054 , A61M16/042 , A61M2202/0476 , A61M3/0258 , A61M3/0283 , Y10S128/913
摘要： A method and apparatus utilize liquid ventilation to increase the efficacy of cardiopulmonary resuscitation (CPR). The method involves replacing gas in the lungs with an oxygen and carbon dioxide carrying liquid to eliminate the decreased pumping efficiency of the heart seen during conventional or active compression-decompression (ACD) closed-chest CPR. A further advantage during ACD-CPR is the ability to perform liquid ventilation without a mechanical respirator. A further advantage is provided by supplying a continuous flow of liquid (or gaseous) ventilation medium throughout the entire chest compression/re-expansion cycle, dramatically accelerating both gas exchange and cooling or warming of the patient or animal subject.
摘要翻译： 一种方法和装置利用液体通气来提高心肺复苏（CPR）的疗效。 该方法包括用携带氧气和二氧化碳的液体替换肺中的气体，以消除在常规或主动压缩减压（ACD）闭合胸腔CPR期间看到的心脏泵送效率降低。 ACD-CPR中的另一优势是无机械呼吸器进行液体通气的能力。 通过在整个胸部压缩/再膨胀循环中提供液体（或气体）通气介质的连续流动来提供进一步的优点，显着加速患者或动物受试者的气体交换和冷却或变暖。
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公开(公告)号：US5277176A
公开(公告)日：1994-01-11
申请号：US905347
申请日：1992-06-29
CPC分类号： A61M1/1698 , A61M2202/0476 , Y10S128/03 , Y10S128/913
摘要： An extracorporeal lung assistance device having an oxygen-containing gas chamber positioned in such relationship to a gas exchange chamber that transfer of oxygen to blood and the withdrawal of carbon dioxide from blood disposed may be made. The gas exchange chamber has a blood flow channel extending through the gas exchanger defined by a microporous membrane forming a wall separating the blood flow channel from an oxygen, carbon dioxide exchange media. A second membrane supported in spaced-apart relationship from said first membrane. The space between the membranes is filled with the oxygen carbon dioxide exchange media.
摘要翻译： 可以制造体外肺辅助装置，其具有与气体交换室相关联的含氧气体室，所述气体交换室将氧气输送到血液并且从所配置的血液中排出二氧化碳。 气体交换室具有延伸穿过由微孔膜限定的气体交换器的血流通道，所述微孔膜形成将血流通道与氧气二氧化碳交换介质分开的壁。 与所述第一膜以间隔开的关系支撑的第二膜。 膜之间的空间填充有氧二氧化碳交换介质。
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4.发明申请Apparatus for pulmonary delivery of drugs with simultaneous liquid lavage and ventilation 审中-公开用于同时进行液体灌洗和通气的肺部递送药物的装置公开(公告)号：US20020111386A1
公开(公告)日：2002-08-15
申请号：US10116856
申请日：2002-04-05
IPC分类号： A61K031/02 , A61F007/00
CPC分类号： A61K9/0026 , A61B2017/22054 , A61B2018/00011 , A61F7/123 , A61F2007/0054 , A61M16/0404 , A61M16/0454 , A61M16/0459 , A61M16/0463 , A61M16/0479 , A61M16/0486 , A61M2202/0468 , A61M2202/0476 , A61M2205/3368 , A61N7/022 , B06B1/0633 , Y10S128/913 , Y10S514/937 , Y10T137/87652
摘要： A hyperthermic treatment of lung cancer in a patient and delivering therapeutic or diagnostic biological agents to airway surfaces, where preselected pulmonary air passages adjoining pulmonary tissues comprising malignant cells are temporarily filled and then heating adjoining pulmonary tissues comprising the malignant cells to a temperature in a specified range by transmitting ultrasound through the liquid-filled pulmonary passages of a specific frequency. Also disclosed is an apparatus for applying the ultrasound at the appropriate frequency to the interior surfaces of a bodily cavity for diagnostic and therapeutic treatment.
摘要翻译： 在患者中进行肺癌的热疗治疗，并向气道表面递送治疗或诊断生物学试剂，其中邻近包含恶性细胞的肺组织的预先选定的肺空气通道临时填充，然后将包含恶性细胞的相邻肺组织加热到指定的温度 通过超声波通过特定频率的液体填充肺通道进行传播。 还公开了一种用于以适当的频率将超声波应用于用于诊断和治疗治疗的身体腔的内表面的装置。
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公开(公告)号：US6012453A
公开(公告)日：2000-01-11
申请号：US951138
申请日：1997-10-15
CPC分类号： A62B7/06 , A62B7/02 , F17C7/04 , F17C9/02 , B63C2011/2263 , F17C2201/0109 , F17C2201/056 , F17C2203/0391 , F17C2205/013 , F17C2205/0332 , F17C2205/0338 , F17C2205/0385 , F17C2205/0391 , F17C2205/0397 , F17C2221/011 , F17C2221/014 , F17C2223/0161 , F17C2223/033 , F17C2223/047 , F17C2227/0302 , F17C2250/0413 , F17C2270/025 , F17C2270/0509 , Y10S128/913
摘要： An apparatus that provides for withdrawal of the liquid contents from a closed container 14 independent of the spatial orientation thereof, is described. The liquid withdrawal apparatus includes flexible withdrawal conduits 58 disposed inside the container and in fluid flow communication with external heat exchangers 144, 146. The heat exchangers serve to transfer heat to the withdrawn liquid to thereby provide a breathable gas mixture. The upstream end of the withdrawal conduits 58 are provided with a weighted pick-up means comprising a wicking material that draws liquid into the interior thereof to ensure contact of the liquid with the conduits, even when the supply of liquid is nearly depleted. A pressure differential between the inside of the container and the external heat exchangers, normally brought about by an inhalation event of the user, provides the motive force for withdrawing the liquid contents from the container through the conduits.
摘要翻译： 描述了一种提供液体内容物从封闭容器14排出而与其空间取向无关的装置。 液体提取装置包括设置在容器内部并与外部热交换器144,146流体连通的柔性抽出管道58.热交换器用于将热量传送到排出的液体，从而提供可透气的气体混合物。 提取导管58的上游端设置有加重的拾取装置，该拾取装置包括将液体吸入其内部的芯吸材料，以确保液体与导管的接触，即使当液体供应几乎耗尽时。 通常由使用者的吸入事件引起的容器内部和外部热交换器之间的压差提供了通过导管从容器中取出液体内容物的动力。
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公开(公告)号：US5829428A
公开(公告)日：1998-11-03
申请号：US654551
申请日：1996-05-29
CPC分类号： A61M16/009 , A61M16/0093 , Y10S128/913
摘要： Methods and apparatus for the conservation of respiratory promoters following their pulmonary introduction are disclosed. In preferred embodiments the present invention provides methods and apparatus for reducing the loss of respiratory promoter, and particularly fluorochemcials, during medical procedures such as liquid ventilation. The disclosed methods comprise the use of vapor retention assemblies, which may be conventional heat and moisture exchangers, to passively retain the respiratory promoter and return it to the lungs in subsequent breaths. Novel vapor retention assemblies comprising fluorophilic exchange elements are also disclosed.
摘要翻译： 公开了在肺部引入后保护呼吸促进剂的方法和装置。 在优选的实施方案中，本发明提供了用于在诸如液体通气的医疗过程期间减少呼吸促进剂，特别是氟化合物的损失的方法和装置。 所公开的方法包括使用可以是常规热和湿交换器的蒸汽保持组件来被动地保持呼吸促进剂并在随后的呼吸中将其返回到肺。 还公开了包含氟亲口交换元件的新型蒸气保留组件。
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公开(公告)号：US5655521A
公开(公告)日：1997-08-12
申请号：US600407
申请日：1996-02-12
IPC分类号： A61K9/08 , A61K9/107 , A61K31/02 , A61K31/025 , A61K31/035 , A61K31/08 , A61K31/135 , A61K31/34 , A61K31/341 , A61K31/47 , A61K31/472 , A61K45/00 , A61K45/06 , A61P11/00 , A61P11/10 , A61P31/04 , A61P43/00 , C07D207/10 , C07D217/22 , C07D307/18 , A61M15/00
CPC分类号： A61K31/135 , A61K31/02 , A61K31/025 , A61K31/035 , A61K31/08 , A61K45/06 , A61M2202/0476 , Y10S128/913
摘要： The present invention includes a method for treating a patient in need of facilitated oxygen delivery through the lungs, additional lung surfactant, removal of material from inside the lung, or inflation of collapsed portions of the lung, comprising the step of introducing into the lung of the patient an effective therapeutic amount of a fluorocarbon liquid, the amount not exceeding the functional residual capacity of the lung of the patient upon exhalation taking into account any positive and expiratory pressure applied to the patient's lung. The method may also comprise the additional step of providing an oxygen-containing breathing gas to the patient while the fluorocarbon liquid is in the lung.
摘要翻译： 本发明包括一种用于治疗需要通过肺的促进氧输送的患者的方法，另外的肺表面活性剂，从肺内部去除材料或肺部的塌陷部分的膨胀，包括将引入肺的步骤 患者有效治疗量的氟碳液体，其量不超过在呼气时患者的肺的功能残留能力，同时考虑到施用于患者肺部的任何正压和呼气压力。 该方法还可以包括在氟碳液体在肺中时向患者提供含氧呼吸气体的附加步骤。
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公开(公告)号：US5540225A
公开(公告)日：1996-07-30
申请号：US180700
申请日：1994-01-13
申请人： Ernest G. Schutt
发明人： Ernest G. Schutt
CPC分类号： A61K9/0026 , A61M16/00 , A61M16/0054 , A61M16/0463 , A61M2202/0476 , Y10S128/913
摘要： A method and apparatus for performing partial liquid ventilation, in connection with which a liquid such as an oxygen carrying fluorocarbon liquid is introduced into the lung and removed from the lung of a patient while the patient is simultaneously breathing an oxygen-carrying breathing gas.
摘要翻译： 一种用于进行部分液体通气的方法和装置，在患者同时呼吸携氧呼吸气体的同时，将诸如携氧碳氟液体的液体引入肺中并从患者的肺部移除。
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公开(公告)号：US06694977B1
公开(公告)日：2004-02-24
申请号：US09543709
申请日：2000-04-05
IPC分类号： A61M1600
CPC分类号： A61M16/14 , A61F7/12 , A61F2007/006 , A61M16/0054 , A61M16/107 , A61M16/145 , A61M19/00 , A61M2202/0476 , Y10S128/913
摘要： A novel technique for ventilation and heat exchange is disclosed called Mixed-mode Liquid Ventilation (MMLV). This technique uses an endotracheal catheter to add and remove liquid from the lungs continuously and/or cyclically, and deliver gas at a rate independent of the delivery of liquid. This technique produces small-scale mixing of gas and liquid in the airways, allowing for efficient gas and heat exchange. Medical uses for the technique are disclosed. These uses include induction and reversal of hyperthermia, and hypothermia.
摘要翻译： 公开了一种通气和热交换的新型技术，称为混合型液体通气（MMLV）。 该技术使用气管内导管连续地和/或循环地从肺中添加和去除液体，并且以与液体的输送无关的速率输送气体。 这种技术在气道中产生气体和液体的小规模混合，允许有效的气体和热交换。 公开了该技术的医疗用途。 这些用途包括诱导和逆转热疗，低体温。
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公开(公告)号：US20030131844A1
公开(公告)日：2003-07-17
申请号：US10310118
申请日：2002-12-04
发明人： Matthew M. Kumar , Larry D. Johnson
IPC分类号： A61M016/00
CPC分类号： A61K33/00 , A61M16/0054 , A61M16/0075 , A61M16/0081 , A61M16/0833 , A61M16/1075 , A61M16/14 , A61M16/22 , A61M19/00 , A61M2202/0476 , A61M2230/50 , Y10S128/913
摘要： Devices and methods to heat and cool human beings, including inducing and maintaining hypothermia in human patients. Methods include inducing hypothermia to treat ischemic events, including heart attack and stroke, to limit damage caused by the ischemic event. Methods can include: using the lungs for heat exchange; using cooled gases for ventilation; using helium in the ventilation gas mixture, using medications to control reflex heat production; and injecting a perfluorocarbon mist into the gas stream to increase the cooling rate. The high thermal conductivity and diffusivity of helium results in greater inspired gas temperature equalization toward body temperature. Due to the latent heat of vaporization, addition of even small quantity of phase-change perfluorocarbon dramatically increases the heat carrying capacity of the respiratory gases. Hypothermia may be terminated by discontinuing the medications and warming the patient using a warmed helium-oxygen mixture.
摘要翻译： 用于加热和冷却人类的装置和方法，包括诱导和维持人类患者体温过低。 方法包括诱导低温治疗缺血事件，包括心脏病发作和中风，以限制由缺血事件引起的损伤。 方法可以包括：使用肺进行热交换; 使用冷却气体进行通风; 在通风气体混合物中使用氦气，使用药物来控制反射热产生; 并将全氟化碳雾注入气流中以提高冷却速率。 氦气的高导热性和扩散性导致更大的启发气体温度均衡到体温。 由于蒸发潜热，加入少量相变全氟化碳会大大增加呼吸气体的承载能力。 可以通过中断药物并使用加热的氦 - 氧混合物使患者变暖来终止低体温。
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