公开(公告)号：US20220184081A1

公开(公告)日：2022-06-16

申请号：US17430557

申请日：2020-02-12

Applicant: KAGOSHIMA UNIVERSITY

Inventor： Takashi KURIHARA ,  lchiro TAKASAKl ,  Naoki TOYOOKA ,  Hiroaki GOUDA

IPC: A61K31/519 ,  A61K31/4178 ,  A61P17/04

Abstract: This invention relates to an antipruritic agent of formula (I) or (II), wherein R1 is a hydrogen atom, a C1-6-alkyl group, a C1-6-alkoxy group, a C2-6-alkenyloxy group, a halogen atom, a C1-6-haloalkyl group, a C1-6-haloalkoxy group, or a substituted or unsubstituted phenyl group; R2 is a hydrogen atom, a C1-6-alkyl group, a C1-6-alkoxy group, a C2-6-alkenyloxy group, a halogen atom, a C1-6-haloalkyl group, a C1-6-haloalkoxy group, or a substituted or unsubstituted phenyl group; and R is an indazolyl group substituted with a halogen atom; a substituted or unsubstituted phenyl group; a pyrazolyl group; or a substituted or unsubstituted aralkyl group; or a salt thereof, or a solvate thereof.

公开(公告)号：US20170029389A1

公开(公告)日：2017-02-02

申请号：US15105985

申请日：2014-12-18

Applicant: KYOTO UNIVERSITY ,  NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY ,  KAGOSHIMA UNIVERSITY

Inventor： Masatoshi HAGIWARA ,  Masayasu TOYOMOTO ,  Takamitsu HOSOYA ,  Suguru YOSHIDA ,  Takashi KURIHARA

IPC: C07D277/64

CPC classification number: C07D277/64

Abstract: Provided is a pain-related compound, a pain-related pharmaceutical composition, and use of the same. Provided in one or more embodiments is a compound represented by Formula (I), a prodrug of the same, or a pharmaceutically permissible salt of any of the same.

Abstract translation: 提供疼痛相关化合物，疼痛相关药物组合物及其用途。 在一个或多个实施方案中提供由式（I）表示的化合物，其前体药物或其药学上可允许的盐。

公开(公告)号：US20210188841A1

公开(公告)日：2021-06-24

申请号：US16650133

申请日：2018-09-27

Applicant: KAGOSHIMA UNIVERSITY ,  SHOWA UNIVERSITY

Inventor： Takashi KURIHARA ,  Ichiro TAKASAKI ,  Naoki TOYOOKA ,  Hiroaki GOUDA

IPC: C07D471/04 ,  C07D403/14

Abstract: This invention relates to an analgesic drug comprising a compound represented by the following formula (I) or (II), wherein R1 is a C1-6-alkoxy group or a C1-6-haloalkoxy group; R2 is a hydrogen atom; and R is an indazolyl group substituted with a halogen atom; a substituted or unsubstituted phenyl group; a pyrazolyl group; or a substituted or unsubstituted aralkyl group; or a salt thereof, or a solvate thereof.

公开(公告)号：US20230181587A1

公开(公告)日：2023-06-15

申请号：US17997974

申请日：2021-05-07

Applicant: KAGOSHIMA UNIVERSITY ,  OSAKA UNIVERSITY

Inventor： Takashi KURIHARA ,  Ichiro TAKASAKI ,  Hitoshi HASHIMOTO ,  Atsuko HAYATA ,  Yusuke SHINTANI

IPC: A61K31/519 ,  A61K31/4178 ,  A61P25/24 ,  A61P25/22

CPC classification number: A61K31/519 ,  A61K31/4178 ,  A61P25/24 ,  A61P25/22

Abstract: This invention relates to an antidepressant/anxiolytic drug comprising a compound represented by the following formula (I) or (II),




wherein R1 is a hydrogen atom, a C1-6-alkyl group, a C1-6-alkoxy group, a C2-6-alkenyloxy group, a halogen atom, a C1-6-haloalkyl group, a C1-6-haloalkoxy group, or a substituted or unsubstituted phenyl group; R2 is a hydrogen atom, a C1-6-alkyl group, a C1-6-alkoxy group, a C2-6-alkenyloxy group, a halogen atom, a C1-6-haloalkyl group, a C1-6-haloalkoxy group, or a substituted or unsubstituted phenyl group; and R is an indazolyl group substituted with a halogen atom; a substituted or unsubstituted phenyl group; a pyrazolyl group; or a substituted or unsubstituted aralkyl group;

or a salt thereof, or a solvate thereof.