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公开(公告)号：US09982014B2
公开(公告)日：2018-05-29
申请号：US15031135
申请日：2014-10-23
Applicant: Kaneka Corporation , Stealth Bio Therapeutics Corp
Inventor： Yoshinori Hirai , Akira Nishiyama , Masaru Mitsuda
CPC classification number: C07K5/1021 , A61K38/00 , C07B2200/13 , C07K5/1019
Abstract: The present invention is to provide a method for the efficient production on an industrial scale of SS-31 (D-Arg-Dmt-Lys-Phe-NH2), which is an SS peptide. According to the present invention, the desired SS-31 is produced by efficiently synthesizing a tetrapeptide compound as a precursor of SS-31 and improving the tetrapeptide purity by crystallization.
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公开(公告)号：US20160264623A1
公开(公告)日：2016-09-15
申请号：US15031135
申请日：2014-10-23
Applicant: KANEKA CORPORATION , STEALTH PEPTIDES INTERNATIONAL, INC.
Inventor： Yoshinori Hirai , Akira Nishiyama , Masaru Mitsuda
IPC: C07K5/113
CPC classification number: C07K5/1021 , A61K38/00 , C07B2200/13 , C07K5/1019
Abstract: The present invention is to provide a method for the efficient production on an industrial scale of SS-31 (D-Arg-Dmt-Lys-Phe-NH2), which is an SS peptide. According to the present invention, the desired SS-31 is produced by efficiently synthesizing a tetrapeptide compound as a precursor of SS-31 and improving the tetrapeptide purity by crystallization.
Abstract translation: 本发明提供一种SS-31（D-Arg-Dmt-Lys-Phe-NH 2）在SS工业规模上有效生产的方法。 根据本发明，通过有效合成作为SS-31的前体的四肽化合物并通过结晶提高四肽纯度来制备所需的SS-31。
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公开(公告)号：US10781193B2
公开(公告)日：2020-09-22
申请号：US16244824
申请日：2019-01-10
Applicant: KANEKA CORPORATION
Inventor： Hiroaki Yasukouchi , Masaru Mitsuda , Akira Nishiyama , Makoto Funabashi
IPC: C07D513/02 , C07D301/00 , C07C67/14 , C07C231/02 , C07D263/44 , C07C233/64 , C07D303/16 , C07D235/02 , C07C69/78 , C07D217/06 , C07D471/08
Abstract: The present disclosure provides a reaction of a chlorine-containing compound using a flow reactor which is less restricted by a solvent to be used. In the present disclosure, an organic compound is produced by supplying a reaction substrate having at least one functional group which can react with chlorine and is selected from the group consisting of hydroxy group, a thiol group, an amino group, a carboxyl group, a thiocarboxyl group, and an acid amide group, and a chlorine-containing compound to a flow reactor together with a trialkyl amine having 9 to 40 carbon atoms and an organic solvent, and allowing the reaction substrate and the chlorine-containing compound to react with each other.
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公开(公告)号：US09346850B2
公开(公告)日：2016-05-24
申请号：US14204074
申请日：2014-03-11
Applicant: KANEKA CORPORATION
Inventor： Hiroshi Murao , Ken-ichiro Morio , Masaru Mitsuda
CPC classification number: C07K1/061 , C07K1/02 , C07K1/14 , C07K5/06078 , C07K5/06095 , C07K5/0806 , C07K5/0808 , C07K5/101
Abstract: The present invention is related to a method of producing a peptide, characterized in contacting a reaction mixture with a base after a condensation reaction to hydrolyze while a basic condition is maintained until a ratio of a remaining unreacted active ester of an acid component is decreased to 1% or less in a liquid phase peptide synthesis method. According to the invention, a target peptide of high purity can be simply and efficiently produced by a continuous liquid phase synthesis method. Further, the present invention is related to a method of producing a peptide, characterized in using an amide-type solvent immiscible with water in a liquid phase peptide synthesis method. According to the invention, various peptides can be produced by the liquid phase synthesis method without being restricted by the amino acid sequence of the target peptide.
Abstract translation: 本发明涉及一种生产肽的方法，其特征在于在缩合反应之后将反应混合物与碱反应以在碱性条件保持下进行水解，直到酸组分的剩余未反应的活性酯的比例降低至 在液相肽合成方法中为1％以下。 根据本发明，可以通过连续液相合成法简单有效地制备高纯度的靶肽。 此外，本发明涉及一种制备肽的方法，其特征在于在液相肽合成方法中使用与水不混溶的酰胺型溶剂。 根据本发明，可以通过液相合成法制备各种肽，而不受目标肽的氨基酸序列的限制。
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